• Journal of Integrative Natural Science
• /
• v.11 no.2
• /
• pp.101-106
• /
• 2018

Corticotropin - releasing hormone receptor 1 (CRHR1) forms an integral part of the pathophysiology of disorders like post-traumatic stress disorder, stress, anxiety, addiction, and depression. Hence it is essential to look for new, potent and structure-specific inhibitors of CRHR1. We have analysed the protein-protein interaction complexes of the CRHR1 receptor with its native ligand CRF and full agonist Sauvagine. The structure of Sauvagine was predicted using homology modelling. We have identified that the residues TYR253, ASP254, GLU256, GLY265, ARG1014 and LY1060 are important in the formation of protein-protein complex formation. Future studies on these residues could throw light on the crucial structural features required for the formation of CRHR1-inhibitor complex and in studies that try to solve the structural complexities of CRHR1.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2011.02a
• /
• pp.474-474
• /
• 2011

Graphene is considered as a potential candidate for the key material in the ideal 2D nanoelectronics. Recently, it is reported that graphene has an interesting sensitivity to molecular adsorption on it. Such properties are believed to be enhanced by the existence of disorders and ripples inside graphene as well as by the interaction with the substrate underneath. Here, we report the effect of introducing structural disorders to the graphene on its electrical properties such as conductance, transconductance, low frequency noise, which can be successfully described by a simple model of the continuum percolation. In addition, the response of the graphene device to gaseous molecular adsorption was systematically investigated and the results were discussed along with the change in Raman spectra.

• Proceedings of the Korean Magnestics Society Conference
• /
• 2011.12a
• /
• pp.55-56
• /
• 2011

We have carried out spectroscopic studies on the physical properties of graphite tiles modified by electron and proton irradiation. While increase in local order was observed in the electron-irradiated sample, structural disorder and amorphization were revealed in the proton-irradiated sample, with considerably decreased electrical conductivity. Besides, C-OH bond with a sp3 configuration was identified in the proton-irradiated sample, apparently giving rise to a narrow ESR peak ascribed to localized spins.

• Structural Engineering and Mechanics
• /
• v.8 no.2
• /
• pp.181-191
• /
• 1999

This paper presents an investigation of the mode localization and frequency loci veering phenomena in an aircraft with disordered external stores. Two theoretical analyses are carried out to study the occurring mechanism of the two phenomena: condensation technique in the subspace spanned by modes of interest and geometric mapping theory in the complex plane. Two simple criteria for predicting the occurrence of the mode localization and frequency loci veering are put forward. The prediction of the phenomena by our theoretically proposed criteria is in good agreement with that obtained through numerical calculations of characteristic solutions of the disordered system.

• Korean Journal of Metals and Materials
• /
• v.47 no.11
• /
• pp.773-785
• /
• 2009

Studies of a number of Cu-Zr amorphous alloys have demonstrated that those exhibiting greater plastic strain during homogeneous deformation at room temperature show lower global plasticity associated with inhomogeneous deformation in a typical compression test. Using a combination of experiments and molecular dynamics simulations, we clarify this seeming paradox between the homogeneous and inhomogeneous deformation by exploring the microstructural aspects in view of the structural disordering, disorder-induced softening, and shear localization and relate these findings to the global plasticity of bulk amorphous alloys. Additional analyses were conducted to derive a simple structural parameter that allows the prediction of the global plasticity of bulk amorphous alloys.

• Korean Journal of Metals and Materials
• /
• v.46 no.11
• /
• pp.701-707
• /
• 2008

This study examined the creation mechanism of free volume during homogeneous deformation induced by the elastostatic compression at room temperature. Experiments demonstrated that amorphous alloys subjected to the elastostatic compression underwent structural disordering, during which densely packed polyhedra breakdown to form new, loosely packed ones, resulting in the creation of excess free volume. A combination of experiments and molecular dynamics simulations are used to explore fundamental issues on how free volume is created during elastostatic compression.

• Journal of Korean Society of Transportation
• /
• v.29 no.1
• /
• pp.57-67
• /
• 2011

This study has been conducted to provide the basic materials about the occurrence structures, causes and choice of treatments of the traffic accident offenders' PTSD(Posttraumatic Stress Disorder). The results of this study can be summarized as follows. First, accident offenders', not victims', PTSD conditions, which has been only estimated until now, are measured by nationwide questioning survey. Second, accident offenders' changes of driving attitude after accidents could be typed by factors analysis in the 20 driving situations closely connected to the occurrence of traffic accidents. Third, by the t-test, the difference of driving attitudes in primary driving situations according to existence of PTSD is distinguished. Six driving situations, which are found significant by t-test, are applied to structural equation. So the variables related to PTSD and the models which analyze the attitude changes of driving are constructed. This study provides the basic materials to help the reduction and prevention of the occurrence of PTSD.

• Journal of Yeungnam Medical Science
• /
• v.40 no.1
• /
• pp.91-95
• /
• 2023

Psychogenic dysphagia is a deglutition disorder characterized by a fear of swallowing, with no structural or functional causes. This report presents the case of a young male patient who had severe malnutrition due to psychogenic dysphagia and was provided visual biofeedback using fiberoptic endoscopic evaluation of swallowing (FEES). A healthy 25-year-old man presented to our clinic with a complaint of throat discomfort when swallowing that had started 6 months prior. As the symptoms worsened, he became fearful of food spreading to his lungs after swallowing and the development of respiratory difficulties. His food intake gradually decreased, resulting in a weight loss of 20 kg within 2 months. Evaluation of organic and other functional causes of dysphagia was performed, but no abnormalities were detected. The sensation of a lump in his throat, fear of swallowing, and anxiety were transformed into somatic symptoms. The patient was diagnosed with psychogenic dysphagia. After visual biofeedback by a physician who performed FEES, the patient resumed eating normally and increased his food intake. If routine tests do not reveal structural or functional causes of dysphagia, assessment of a psychogenic swallowing disorder should be considered. FEES can help in the diagnosis and management of psychogenic dysphagia.

• Journal of health informatics and statistics
• /
• v.42 no.2
• /
• pp.192-198
• /
• 2017

Objectives: This study was designed to construct and test the structural equation model for the alcohol-related problem of alcohol use disorders. Methods: Data were collected by structured self-questionnaires from 229 male subjects who received > 8 (greater than 8) score on Alcohol Use Disorder Identification Test (AUDIT). The Data were analyzed by SPSS 21.0 and AMOS 21.0. Results: The model fit indices for the modified hypothetical model showed Q = 2.50, GFI = 0.90, and CFI = 0.94. As a result, Life position, parent's drinking problem, and alcohol expectancy had significantly direct effect on alcohol-related problem. Alcohol expectancy also had mediator effect between life position and alcohol-related problem. Conclusions: Consequently, the more positive life position, the less alcohol-related problem occurred. It is necessary to change their life position, which is individual factor, to prevent or reduce the alcohol related problem of alcohol use disorders.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.12 no.1
• /
• pp.103-114
• /
• 2001

Tourette's disorder is a disease which manifests one or more motor tics and vocal tics for more than a year. Chronic motor tic or vocal tic disorders are characterized by only one kind of tics for more than a year. We intended to investigate the clinical characteristics of the patients with chronic motor tic disorders or Tourette's disorders who had admitted from May 1, 1998 to May 1, 1999 to Seoul National University Hospital Child and Adolescent Psychiatry ward. In addition, we compared the clinical characteristics of the patients in order to elucidate the relationship between the two disorders. The patients with learning disabilities were selected as controls. There was no statistically significant difference between the onsets of the patients with chronic motor tic disorders(n=13, $7.3{\pm}2.5$ years), and Tourette's disorder(n=39, $7.2{\pm}2.2$ years), but with learning disability($4.2{\pm}1.9$ years). Also, the patients with chronic motor tic disorder and Tourette's disorder showed similar age at admission($11.7{\pm}2.7$ versus $11.5{\pm}2.6$ years), duration of admission($5.7{\pm}5.4$ versus $11.0{\pm}8.7$ weeks), mothers' ages at child birth($27.3{\pm}2.9$ versus $28.3{\pm}6.7$ years old),and fathers' age at child birth($32.2{\pm}3.2$ versus $33.3{\pm}5.2$ years old). We observed that those who had learning disabilities were alike in those aspects, except for age at visit to clinic($9.8{\pm}3.2$ years old). Family history of psychiatric illnesses(24.1% versus 46.2%), recognized precipitating factors(11.1% versus 35.7%) and response to pharmacological treatments(77.8% versus 76.9%) of the patients with chronic motor tic disorders and Tourette's disorders were observed and no differences were found. Comorbid patterns of diseases were noted. Intrafamilial conflicts were more common in the patients with learning disabilities than those with chronic tic disorders or Tourette's disorders. Precipitating factors were observed more frequent in chronic tic disorder and Tourette's disorder than learning disability. Neurocognitive profiles were investigated, and verbal IQs of the patients with chronic motor tic disorder, Tourette's disorder and learning disability were $92.3{\pm}10.7$, $94.7{\pm}14.9$, $94.3{\pm}13.8$, performance IQs $93.0{\pm}20.5$, $97.5{\pm}13.0$, $95.0{\pm}16.9$ and full-scale IQs $91.9{\pm}20.1$, $95.8{\pm}14.5$, $93.9{\pm}15.1$, respectively, which were found to be not significantly different. No difference was found in structural neurological abnormalities and EEG profiles. The patients with learning disabilities showed more common Bender-Gestalt test abnormalities. In conclusion, we have not found any affirmative clues for the division of chronic motor tic disorder and Tourette's disorder in clinical perspective.