• 통합자연과학논문집
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• 제11권2호
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• pp.101-106
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• 2018

Corticotropin - releasing hormone receptor 1 (CRHR1) forms an integral part of the pathophysiology of disorders like post-traumatic stress disorder, stress, anxiety, addiction, and depression. Hence it is essential to look for new, potent and structure-specific inhibitors of CRHR1. We have analysed the protein-protein interaction complexes of the CRHR1 receptor with its native ligand CRF and full agonist Sauvagine. The structure of Sauvagine was predicted using homology modelling. We have identified that the residues TYR253, ASP254, GLU256, GLY265, ARG1014 and LY1060 are important in the formation of protein-protein complex formation. Future studies on these residues could throw light on the crucial structural features required for the formation of CRHR1-inhibitor complex and in studies that try to solve the structural complexities of CRHR1.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.474-474
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• 2011

Graphene is considered as a potential candidate for the key material in the ideal 2D nanoelectronics. Recently, it is reported that graphene has an interesting sensitivity to molecular adsorption on it. Such properties are believed to be enhanced by the existence of disorders and ripples inside graphene as well as by the interaction with the substrate underneath. Here, we report the effect of introducing structural disorders to the graphene on its electrical properties such as conductance, transconductance, low frequency noise, which can be successfully described by a simple model of the continuum percolation. In addition, the response of the graphene device to gaseous molecular adsorption was systematically investigated and the results were discussed along with the change in Raman spectra.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2011년도 자성 및 자성재료 국제학술대회
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• pp.55-56
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• 2011

We have carried out spectroscopic studies on the physical properties of graphite tiles modified by electron and proton irradiation. While increase in local order was observed in the electron-irradiated sample, structural disorder and amorphization were revealed in the proton-irradiated sample, with considerably decreased electrical conductivity. Besides, C-OH bond with a sp3 configuration was identified in the proton-irradiated sample, apparently giving rise to a narrow ESR peak ascribed to localized spins.

• Structural Engineering and Mechanics
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• 제8권2호
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• pp.181-191
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• 1999

This paper presents an investigation of the mode localization and frequency loci veering phenomena in an aircraft with disordered external stores. Two theoretical analyses are carried out to study the occurring mechanism of the two phenomena: condensation technique in the subspace spanned by modes of interest and geometric mapping theory in the complex plane. Two simple criteria for predicting the occurrence of the mode localization and frequency loci veering are put forward. The prediction of the phenomena by our theoretically proposed criteria is in good agreement with that obtained through numerical calculations of characteristic solutions of the disordered system.

• 대한금속재료학회지
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• 제47권11호
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• pp.773-785
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• 2009

Studies of a number of Cu-Zr amorphous alloys have demonstrated that those exhibiting greater plastic strain during homogeneous deformation at room temperature show lower global plasticity associated with inhomogeneous deformation in a typical compression test. Using a combination of experiments and molecular dynamics simulations, we clarify this seeming paradox between the homogeneous and inhomogeneous deformation by exploring the microstructural aspects in view of the structural disordering, disorder-induced softening, and shear localization and relate these findings to the global plasticity of bulk amorphous alloys. Additional analyses were conducted to derive a simple structural parameter that allows the prediction of the global plasticity of bulk amorphous alloys.

• 대한금속재료학회지
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• 제46권11호
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• pp.701-707
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• 2008

This study examined the creation mechanism of free volume during homogeneous deformation induced by the elastostatic compression at room temperature. Experiments demonstrated that amorphous alloys subjected to the elastostatic compression underwent structural disordering, during which densely packed polyhedra breakdown to form new, loosely packed ones, resulting in the creation of excess free volume. A combination of experiments and molecular dynamics simulations are used to explore fundamental issues on how free volume is created during elastostatic compression.

• 대한교통학회지
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• 제29권1호
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• pp.57-67
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• 2011

본 연구는 교통사고 야기자의 PTSD(Posttraumatic Stress Disorder) 발생 구조와 원인, 치료방법 선택에 기초적인 자료를 제공하기 위하여 연구를 진행하였다. 연구 결과, 첫째, 교통사고 피해자가 아닌 가해자를 대상으로 추정만 하던 교통사고 가해자의 PTSD 현황을 전국적인 설문조사를 통하여 파악할 수 있었다. 둘째, 교통사고 야기자를 대상으로 교통사고의 발생과 밀접한 20가지의 운전 상황에서 교통사고 이후의 운전태도 변화를 요인분석으로 3가지로 유형화할 수 있었다. 셋째, PTSD 유 무별로 주요 운전 상황에서의 운전태도 변화의 차이가 있음을 t검정을 통하여 파악할 수 있었다. 또한 t검정을 통하여 유의하다고 나타난 6가지의 운전 상황을 구조방정식 모형에 적용하여 PTSD 관련 변수와 운전태도 변화와의 관계를 분석하는 모형을 구축할 수 있었다. 구축된 모형의 분석을 통해, PTSD 저감 예방을 위한 대책 마련 및 PTSD 저감을 위한 기초자료를 제공하였다.

• Journal of Yeungnam Medical Science
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• 제40권1호
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• pp.91-95
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• 2023

Psychogenic dysphagia is a deglutition disorder characterized by a fear of swallowing, with no structural or functional causes. This report presents the case of a young male patient who had severe malnutrition due to psychogenic dysphagia and was provided visual biofeedback using fiberoptic endoscopic evaluation of swallowing (FEES). A healthy 25-year-old man presented to our clinic with a complaint of throat discomfort when swallowing that had started 6 months prior. As the symptoms worsened, he became fearful of food spreading to his lungs after swallowing and the development of respiratory difficulties. His food intake gradually decreased, resulting in a weight loss of 20 kg within 2 months. Evaluation of organic and other functional causes of dysphagia was performed, but no abnormalities were detected. The sensation of a lump in his throat, fear of swallowing, and anxiety were transformed into somatic symptoms. The patient was diagnosed with psychogenic dysphagia. After visual biofeedback by a physician who performed FEES, the patient resumed eating normally and increased his food intake. If routine tests do not reveal structural or functional causes of dysphagia, assessment of a psychogenic swallowing disorder should be considered. FEES can help in the diagnosis and management of psychogenic dysphagia.

• Journal of health informatics and statistics
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• 제42권2호
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• pp.192-198
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• 2017

Objectives: This study was designed to construct and test the structural equation model for the alcohol-related problem of alcohol use disorders. Methods: Data were collected by structured self-questionnaires from 229 male subjects who received > 8 (greater than 8) score on Alcohol Use Disorder Identification Test (AUDIT). The Data were analyzed by SPSS 21.0 and AMOS 21.0. Results: The model fit indices for the modified hypothetical model showed Q = 2.50, GFI = 0.90, and CFI = 0.94. As a result, Life position, parent's drinking problem, and alcohol expectancy had significantly direct effect on alcohol-related problem. Alcohol expectancy also had mediator effect between life position and alcohol-related problem. Conclusions: Consequently, the more positive life position, the less alcohol-related problem occurred. It is necessary to change their life position, which is individual factor, to prevent or reduce the alcohol related problem of alcohol use disorders.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제12권1호
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• pp.103-114
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• 2001

뚜렛씨 장애는 근육틱과 음성틱이 만성적으로 지속되는 질환이다. 만성 틱장애는 근육틱 혹은 음성틱중 하나만 지속적으로 나타나는 질환이다. 본 연구에서는 1998년 4월 1일부터 1999년 4월 1일까지 서울대학교병원 소아정신과 병동에 입원한 만성 틱 장애 아동과 뚜렛씨 장애 아동의 임상적 특징을 조사하고 두 질환 사이의 관계를 비교하고자 시행되었다. 이들의 특성을 확인하기 위해 대조군으로 학습장애 환자를 선정하였다. 조사 결과는 다음과 같다. 첫째, 만성 틱장애(n=13)와 뚜렛씨 장애 환자(n=29)의 평균 발병연령은 각각 $7.3{\pm}2.5$, $7.2{\pm}2.2$세, 입원시 연령은 평균 $11.7{\pm}2.7$, $11.5{\pm}2.6$세, 입원기간은 $5.7{\pm}5.4$, $11.0{\pm}8.7$주였고 두 군 사이에 의미 있는 차이는 없었다. 학습장애의 경우 발병연령($4.2{\pm}1.9$세)이 두 장애보다 빠르고 의료기관을 찾는 시기($9.8{\pm}3.2$세)도 빨랐다. 출생 계절은 틱장애 환자들에서 6월에서 9월 사이가 가장 적었지만 의미 있는 차이는 없었다. 남녀의 성비율은 각각 10：3, 26：3, 11：5였고 의미 있는 차이는 보이지 않았다. 환자가 출생할 때의 아버지와 어머니 연령은 세 군 모두 차이가 없었다. 둘째, 정신과적 가족력이 있는 경우도 세 군 사이에 차이가 없었고 각각 24.1%, 46.2%, 56.3%였다. 발병전 유발 요인이 확인된 경우는 만성틱장애와 뚜렛씨 장애에서 11.1%와 35.7%로서 의미 있는 차이를 보이지는 않았지만 학습장애(56.3%)에 비해서는 적었다. 셋째, 만성 틱장애와 뚜렛씨 장애, 그리고 학습장애 환자의 지능지수는 각각 언어성 지능 $92.3{\pm}10.7$, $94.7{\pm}14.9$, $94.3{\pm}13.8$이었고, 동작성 지능은 $93.0{\pm}20.5$, $97.5{\pm}13.0$, $95.0{\pm}16.9$이었으며, 전체 지능은 $91.9{\pm}20.1$, $95.8{\pm}14.5$, $93.9{\pm}15.1$로서 세 군 사이에 의미 있는 차이는 없었다. 기질적 뇌장애 소견은 CT/MRI 등에서 0%, 27.3%, 6.3%, 뇌파 이상은 8.3%, 17.2%, 12.5%에서 나타났고 차이는 발견하지 못하였다. 넷째, 항도파민 약물에 대한 반응은 만성 틱장애와 뚜렛씨 장애 환자에서 각각 84.6%, 77.0%가 부분관해를 보였고 완전 관해된 경우는 한 명도 없었으며 두 군 사이에 차이가 없었다. 다섯째, 공동 유병현황을 조사한 결과 주의력결핍·과잉운동장애가 학습장애에서 의미 있게 많은 것을 제외하고는 세 군 사이에 통계적으로 의미 있는 차이를 보이지 않았다. 조사 결과 입원한 환자의 경우 만성 틱장애와 뚜렛씨 장애를 가진 환자들은 임상적으로 학습장애를 가진 환자와 많은 부분에서 차이를 보였으나 만성 틱장애와 뚜렛씨 장애를 구분해야 하는 근거를 찾지 못하였다.