• 동의생리병리학회지
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• 제35권2호
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• pp.56-63
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• 2021

This study was conducted to find a candidate prescription with anti-inflammatory efficacy of 7 herbal prescriptions known to be effective in atopic dermatitis and sleep disorders in Korean medicine. The anti-inflammatory of the 7 herbal prescriptions extracts were evaluated by ELISA assay and Western blot assay. 7 herbal prescriptions, Seongyutang(SU), Danseontoetang(DST), Sotosajahwan(ST), Jisiljagyagsan(JJ), Seokchangpo(SCP), Wiryeongseon(WLS), Gogojohwan(GGJ) 30 % EtoH extract was used for in vitro experiments. In TNF-α + IFN-γ(TI) stimulated HaCaT cells, all 7 herbal prescriptions reduced TARC and MDC production, and JJ strongly reduced TARC and MDC production at 100 ㎍/ml concentration. SCP strongly reduced MDC production at 10 ㎍/ml and 100 ㎍/ml concentration. In addition, in substance P(SP)/CRH stimulated HMC-1 cells, JJ strongly inhibited VEGF production at both 10 and 100 ㎍/ml concentrations. In LPS/CRH stimulated Raw264.7 cells, all 7 herbal prescriptions significantly inhibited TNF-α. PMA + Ionomycin(PI)/CRH stimulated EL4 cells, SU significantly reduced IL-4 production at both concentrations of 10 and 100 ㎍/ml. WLS significantly reduced IL-17 production at both concentrations of 10 and 100㎍/ml. This suggests that 7 herbal prescriptions have anti-inflammatory effects by reducing inflammatory cytokines in keratinocytes, mast cells and macrophages caused by inflammation. Therefore, it is expected that 7 herbal prescriptions that are effective for sleep disorders and atopic dermatitis can be used as therapeutic materials for sleep disorders and diseases associated with atopic dermatitis.

• Advances in aircraft and spacecraft science
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• 제3권3호
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• pp.271-298
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• 2016

In this paper, we study a problem of passive suppression of helicopter Ground Resonance (GR) using a single degree freedom Nonlinear Energy Sink (NES), GR is a dynamic instability involving the coupling of the blades motion in the rotational plane (i.e. the lag motion) and the helicopter fuselage motion. A reduced linear system reproducing GR instability is used. It is obtained using successively Coleman transformation and binormal transformation. The analysis of the steadystate responses of this model is performed when a NES is attached on the helicopter fuselage. The NES involves an essential cubic restoring force and a linear damping force. The analysis is achieved applying complexification-averaging method. The resulting slow-flow model is finally analyzed using multiple scale approach. Four steady-state responses corresponding to complete suppression, partial suppression through strongly modulated response, partial suppression through periodic response and no suppression of the GR are highlighted. An algorithm based on simple criterions is developed to predict these steady-state response regimes. Numerical simulations of the complete system confirm this analysis of the slow-flow dynamics. A parametric analysis of the influence of the NES damping coefficient and the rotor speed on the response regime is finally proposed.

• Journal of Photoscience
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• 제6권2호
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• pp.61-65
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• 1999

The fluorescence properties and photoisomerization behavior of 1-(9-anthryl)-2-(n-quinolinyl)ethene (n-AQE, n=2-4) have been investigated in various solvents. t-3-AQE is strongly fluorescent, but does not accomplish photoisomerization, similar to parent hydrocarbon compound, t-1-(9-anthryl)-2-phenylethene (t-9-APE) or t-1-(9-anthryl)-2-(1-naphthyl)ethene (t-1-ANE). Fluorescence and photoisomerization oft-2-AQE and t-4-AQE are strongly affected by solvent polarity. Dependence of fluorescence quantum yield on the solvent polarity is moderate for t-2-AQE and large for t-4-AQE. In nonpolar solvent (in n-hexane), they exhibit relatively strong fluorescence, but do not isomerize to cis isomer on irradiation, even if inefficient isomerization is observed for t-4-AQE. However, as solvent polarity increases, their fluorescences become weak with efficient photoisomerization to corresponding cis isomer. Intramolecular charge-transfer excited state is presumed to contribute to photoisomerization. The S$_1$ decay parameters were found to be solvent-dependent due to the charge-transfer character of lowest S$_1$ state. In polar solvents, the activation barrier to twisting is reduced enhancing the isomerization of r-2-AQE and t-4-AQE in the singlet manifold.

• Journal of Photoscience
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• 제1권2호
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• pp.113-117
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• 1994

The quantum yields of fluorescence ($\Phi$$_f$) and trans $\to$ cis photoisomerization ($\Phi$$_{t$\to$ c}$), trans-4-(2-(9-anthryl)vinyl)pyridine, an aza analogue of 1-(9-anthryl)-2-phenylethylene, were measured in several solvents at room temperature. $\Phi$$_f$ and $\Phi$$_{t$\to$ c}$ are 0.38 and < 0.01 in hexane and 0.02 and 0.38 in acetonitrile, respectively. As solvent polarity decreases, $\Phi$$_{t$\to$ c}$ strongly reduced, whereas $\Phi$$_f$ strongly increased. A singlet mechanism of trans $\to$ cis photoisomerization is suggested since $\Phi$$_{t$\to$ c}$ and $\Phi$$_f$ change in opposite direction.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 1995년도 제4회 학술강연회논문집
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• pp.157-168
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• 1995

Ignition of a reactive solid with rough surface by constant heat flux is studied. The geometry of surface is represented by a protrusion in shape of cone of infinite length. Ignition time and ignition criterion versus apex angle are determined, with the use of heterogeneous model of ignition. To study the effect of geometry on ignition the results are compared with the known results for the one-dimensional ignition of the semi-infinite body. It is shown, that: a) ignition time depends strongly upon the apex angle and is proportional to the angle to the second power; b) ignition criterion and ignition temperature do not depend strongly on angle. The ignition delay and the energy required for the successful ignition are substantially reduced compared to the one-dimensional case.

• Journal of Photoscience
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• 제9권3호
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• pp.33-36
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• 2002

This study describes RT-PCR and in situ hybridisation protocols, and the immunohistochemical detection method that we have developed to detect and localise cells that express HO-1 in the skin. We found that HO-1 mRNA was absent in normal mouse skin, but after UVA irradiation HO-1 mRNA was expressed in the dermal fibroblasts, and strongly in basal epidermal cells. HO-1 protein was also induced strongly in dermal fibroblasts, and also in epidermal cells. In addition, the HO substrate heme was reduced in skin microsome at 72 hrs post UVA (when HO activity is high). At the same time, the HO products bilirubin and iron levels were elevated in the cutaneous tissue. Thus in addition to a dermal response, there appears to be an epidermal HO response to UVA in vivo that may be relevant for immune modulation by UVA radiation.

• 한국환경성돌연변이발암원학회지
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• 제19권1호
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• pp.20-27
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• 1999

In order to know the inhibitory effect of magnesium carbonate(MgCO3) on cytotoxicity, DNA damage, mutagenicity, and cell transforming ability of nickel subsulfide, the inhibition of cell proliferation, DNA-protein crosslinks formation (DPC), HGPRT point mutation, and cell transformation were evaluated. Nickel subsulfide(Ni3S2) and magnesium carbonate as insoluble compounds were used for this study. BALB/3T3 cell, CHO-K1 cell, and C3H10T1/2 cell were used in this experiment. Exposure concentration of nickel subsulfide was 1 $\mu\textrm{g}$/ml. The concentrations of magnesium carbonate in this study were 0.6 $\mu\textrm{g}$/ml, 1.2 $\mu\textrm{g}$/ml, 2.4 $\mu\textrm{g}$/ml and the molar ratio of magnesium to nickel when exposed simultanously were 0.5, 1.0 and 2.0 respectively. The results were as follows; 1. Magnesium carbonate reduced the inhibitory effect of nickel subsulfide on cell proliferation. 2. Magnesium carbonate also reduced the effect of nickel subsulfide on DNA-protein crosslinks formation. 3. HGPRT point mutagenicity of nickel subsulfide was reduced when magnesium carbonate treated simultaneously. 4. Magnesium carbonate reduced cell transforming ability of nickel subsulfide. Conclusively, nickel subsulfide showed cytotoxicity, cell transforming ability, and mutagenicity strongly and magnesium carbonate may have protective roles in these nickel effects.

• 지역연구
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• 제14권2호
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• pp.85-105
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• 1998

This paper examines spatial of industrial restructuring in Korea during the period of 1983 to 1993. Changes in manufacturing location are analyzed using both descriptive and statistical methods. The results strongly suggest that industrial restructuring has brought about a new locational trend of decentralization toward formerly less industrialized regions away from traditional centers. With reduced disparities between core and peripheral regions, the new process of spatial restructuring provides an opportunity for more balanced territorial development in Korea.

• Journal of applied mathematics & informatics
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• 제41권6호
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• pp.1173-1180
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• 2023

In this paper, rings in which essential maximal right ideals are GP-injective are studied. Whether the rings with this condition satisfy von Neumann regularity is the goal of this study. The obtained research results are twofold: First, it was shown that this regularity holds even when the reduced ring is replaced with π-IFP and NI-ring. Second, it was shown that this regularity also holds even when the maximal right ideal is changed to GW-ideal. This can be interpreted as an extension of the existing results.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1995년도 춘계학술대회 논문집
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• pp.208-211
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• 1995

This proper focuses on results of relative permeability(${\mu}$$\sub$r/), core loss(W) and magnetic induction [B] measurements on some of the most commonly used core materials(PN-18, 20, 30, 60, Pohang Iron '||'&'||' Steel Co., Ltd.) In case of Stress Relief Annealing(SRA). Results of magnetic induction[B] showed weak variations but core lass reduced strongly after SRA Core loss reduced from 3.071 ∼7.819(W/kg) and 11.377~3.988[W/kg] to 2.88~5.492[W/kg] and 1.213~2.134[W/kg] at 1.5[T] 50 Hz and 1.0 [T] 50Hz respectively after SRA. This SRA process leads to significant changes In magnetic properties and core loss of non-oriented silicon steel sheet.