• 제목/요약/키워드: stroke prevention

검색결과 198건 처리시간 0.024초

뇌졸중에 영향을 미치는 위험요인 : 국민건강영양조사 제7기(2016-2018) 자료를 활용하여 (Risk Factors Influencing Stroke : using data from the 7th(2016-2018) Korea National Health and Nutrition Examination Survey)

  • 정명실;서문경애
    • 디지털융복합연구
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    • 제18권9호
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    • pp.277-283
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    • 2020
  • 본 연구의 목적은 뇌졸중에 영향을 미치는 위험요인을 파악 하고자 한다. 연구방법은 국민건강영양조사 제7기(2016-2018) 자료를 활용하여 2단계 층화집락표본추출방법을 사용하였다. 연구대상자는 만 19세이상 성인을 대상으로 복합표본 교차분석 및 복합표본 로지스틱 회귀분석을 실시하였다. 연구결과는 일반적특성및 질환특성과 뇌졸중과의 차이검정 결과 연령대(p<.001), 주관적건강상태(p<.001), 현재흡연(p=0.003), BMI(p=0.005), 고혈압진단(p<.001), 당뇨병진단(p<.001), 이상지질형증진단(p<.001)에 따른 뇌졸중 진단유무와의 차이검정은 통계적으로 유의한 차이가 나타났다. 뇌졸중에 영향하는 위험요인으로는 70세이상에서 오즈비가 8.861배, 주관적건강상태가 나쁜그룹에서 오즈비가 4.501배, 고혈압진단을 받은 그룹에서 오즈비가 3.158배, 당뇨병진단을 받은 그룹에서 오즈비가 1.598배 더 높게 나타났다. 뇌졸중은 위험한 만큼 예방을 통해서 관리를 할 수 있으므로 고혈압이나 당뇨병과 같은 만성질환과 노인들의 건강에 대한 관리가 중요함이 연구결과를 통해서 나타났다.

가정환경 수정과 과제기반 중재의 융복합 접근이 지역사회 뇌졸중 환자의 낙상 효능감 및 활동 수준에 미치는 영향 (The Effect of a Convergence Approach of Home Environment Modification and Task-oriented Intervention on Fall Efficacy and Activity Level of Person with Stroke in the Community)

  • 김수경
    • 한국융합학회논문지
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    • 제13권2호
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    • pp.39-46
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    • 2022
  • 본 연구의 목적은 보조공학 기술을 적용한 가정환경 수정과 낙상 안전 체크리스트를 이용한 과제기반 중재를 함께 적용하는 융복합 접근법이 뇌졸중 환자의 낙상 효능감과 활동 수준에 미치는 효과를 확인하는 것이다. 뇌졸중 환자 41명 대상자(실험군 21명, 대조군 20명)는 실험군과 대조군으로 나누어졌다. 실험군에는 환경수정과 낙상 안전 체크리스트를 활용한 과제기반 중재를 4주간 적용하였다. 대조군에는 가정환경 수정만 실시하였다. 중재 전과 후에 한국형 활동분류카드(Korean Activity Card Sort, KACS), 한국형 낙상효능감 측정도구(Falls Efficacy Scale-Korean version, FES-K)를 이용하여 평가하였다. 실험군과 대조군의 낙상효능감과 활동수준의 변화량은 유의한 차이가 없었다. 실험군과 대조군은 모두 중재 이후에 낙상효능감과 활동 수준이 유의하게 향상되었다. 이러한 연구의 결과를 임상 현장에 적용하여 뇌졸중 환자가 지역사회에서 안전하게 생활하고 적극적으로 참여하는 삶을 유지할 수 있도록 지원할 수 있을 것이다.

An in silico Appraisal to Identify High Affinity Anti-Apoptotic Synthetic Tetrapeptide Inhibitors Targeting the Mammalian Caspase 3 Enzyme

  • Kelotra, Seema;Jain, Meeta;Kelotra, Ankit;Jain, Ish;Bandaru, Srinivas;Nayarisseri, Anuraj;Bidwai, Anil
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권23호
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    • pp.10137-10142
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    • 2015
  • Apoptosis is a general phenomenon of all multicellular organisms and caspases form a group of important proteins central to suicide of cells. Pathologies like cancer, Myocardial infarction, Stroke, Sepsis, Alzheimer's, Psoriasis, Parkinson and Huntington diseases are often associated with change in caspase 3 mediated apoptosis and therefore, caspases may serve as potential inhibitory targets for drug development. In the present study, two series of synthetic acetylated tetrapeptides containing aldehyde and fluromethyl keto groups respectively at the C terminus were proposed. All these compounds were evaluated for binding affinity against caspase 3 structure. In series 1 compound Ac-DEHD-CHO demonstrated appreciable and high binding affinity (Rerank Score: -138.899) against caspase 3. While in series 2 it was Ac-WEVD-FMK which showed higher binding affinity (Rerank Score: -139.317). Further these two compounds met ADMET properties and demonstrated to be non-toxic.

A Cross-Country Comparison of Knowledge, Attitudes and Practices about Tobacco Use: Findings from the Global Adult Tobacco Survey

  • Gupta, Bhawna;Kumar, Narinder
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권12호
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    • pp.5035-5042
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    • 2014
  • Background: Knowledge and individual perceptions about adverse effects of all forms of tobacco exert direct influence on the level of tobacco consumption in various socio-demographic groups. The objective of this study was to determine the nature, extent and demographic correlates of knowledge, attitudes and perceptions of use of tobacco among adults in low and middle income countries. Materials and Methods: The Global Adult Tobacco Survey, conducted in fourteen different countries from 2008-2010, was sourced for the data analyzed in this study. Descriptive statistical analyses were conducted to determine the prevalent knowledge and individual perceptions amongst adults about all forms of tobacco consumption. Results: There was relatively high awareness about the harmful effects of smoking tobacco with main awareness being about its relationship with lung cancer (>90% in most countries). In contrast, there was relatively low awareness about harmful effects of smokeless tobacco (< 90% in all countries except India and Bangladesh), and observed correlation of smoking tobacco with heart attack (40.6% in China, 65.1% in India) and stroke (28.2% in China, 50.5% in India). Conclusions: A large proportion of adults living in low and middle income countries possess adequate knowledge about smoking tobacco but have inadequate awareness as well as false perceptions about smokeless forms of tobacco. Popular beliefs of inverse relationships of tobacco consumption with knowledge, attitudes and perception of populations towards tobacco are challenged by the findings of this study.

New Oral Anticoagulants를 복용하는 환자들에서 위장관 출혈의 위험인자 (Risk Factors of Gastrointestinal Bleeding in Patients Receiving New Oral Anticoagulants)

  • 이주엽
    • 대한상부위장관⦁헬리코박터학회지
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    • 제18권4호
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    • pp.219-224
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    • 2018
  • New oral anticoagulants (NOACs) are now widely used for the prevention and treatment of venous thrombosis, and for the prevention of stroke and systemic embolism in patients with atrial fibrillation. As compared with warfarin, NOACs have the advantage of rapid onset of action and less drug interaction. However, they carry a higher risk of gastrointestinal (GI) bleeding than warfarin. The risk of GI bleeding in patients using NOACs varies according to the type and dose of the drug. By contrast, apixaban and edoxaban are reported to carry similar risks as warfarin, and the risks with dabigatran and rivaroxaban are higher than that with warfarin. In patients using NOACs, old age, impaired renal function, impaired liver function, concurrent use of antiplatelet agents, and nonsteroidal anti-inflammatory drugs are considered major risk factors of GI bleeding, and gastroprotective agents such as histamine-2 receptor antagonist and proton pump inhibitor have preventive effects. To prevent GI bleeding associated with NOACs, the characteristics of each NOAC and the risk factors of bleeding should be recognized.

성별, 연령별, 월소득차이에 따른 질병발생의 위험성 차이연구;암, 고혈압, 중풍, 당뇨병, 관절염, 심장병을 중심으로 (The Risk of Onset of the Illnesses Based on Gender, Age, and Monthly Income;Focusing on cancer, hypertension, stroke, diabetes, arthritis, cardiac disorders)

  • 이준오;김세진;이선동
    • 대한예방한의학회지
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    • 제12권1호
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    • pp.19-48
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    • 2008
  • In order to verify the risk of onset of the illnesses based on gender, age, and monthly income 1,739 subjects from Hongcheon county, Gangwon province were selected. Questionnaire on demographic sociology, health condition, existence of illnesses(cancer, hypertension, stroke, diabetes, arthritis, cardiac disorders), and usage of public health services was surveyed from October 1, 2006 to October 20, 2006. Following conclusions were reached on the basis of the questionnaire : - For demographic sociological peculiarities, gender, age, occupation, and education level were evenly distributed. Most were under normal marriage(67.38%), health insurance(86.39%), 494(36.0%) individuals with less than monthly income of 1 million won, 494(36.0%) individuals with monthly income between 1 and 2 million won, 219(16.0%) with monthly income between 2 and 3 million won, and 164(12.0%) individuals with more than 3 million won, thus showing relatively low income. - For health status, 1,199(70.28%) individuals are non-smokers, 209(45.63%) individuals smoke $10{\sim}20$ cigarettes a day, 754(44.02%) individuals exercise less than twice a week are the major sector of the population. 1,518(88.10%) individuals have regular checkup more than once and 1,131(65.49%) stated their health condition less than average. - For comparison of existence of illnesses between genders, there was no statistical significance on cancer, stroke, and diabetes. But statistical significance was shown on hypertension(P value 0.025), arthritis(P value 0.000), and cardiac disorders(P value 0.016). Statistical significance was seen in the age comparison, and OR(confidence interval) drastically increased with increase in age. - There was no difference between the primary health clinic(P value 0.000), most visited clinic(P value 0.000), selection criteria(P value 0.000), and satisfaction on efficacy(P value 0.000). There was a tendency preferring hospital than public health center with increase in income. - For correlation between the existence of illnesses among different income levels, except for cancer(P value 0.172), statistical significance was seen in hypertension(P value 0.000), stroke(P value 0.003), diabetes (P value 0.001), arthritis(P value 0.000), and cardiac disorders(P value 0.000). The number of individuals suffering from illnesses and ratio all decreased for all illnesses with increase in income. - After adjusting confounding factors(gender, age, income, marriage, occupation, education) and male (1) as the standard, OR (confidence interval) of cancer, hypertension, stroke, diabetes, arthritis, cardiac disorders were 0.47(0.11${\sim}$2.05), 1.27(0.89${\sim}$1.81), 0.58(0.21${\sim}$1.59), 0.71(0.41${\sim}$1.23), 1.79(1.34${\sim}$2.39, P<0.01), and 1.46(0.72${\sim}$2.96), respectively. Risk of arthritis is significantly high in female and 20's (1) as the standard, OR(confidence interval) of cancer, hypertension, stroke, diabetes, arthritis, cardiac disorders were 1.01(0.96${\sim}$1.07), 1.06(1.04${\sim}$1.07, P<0.01), 1.05(1.01${\sim}$1.10, P<0.01), 1.06(1.03${\sim}$1.08, P<0.01), 1.05(1.03${\sim}$1.06, P<0.01), and 1.06(1.04${\sim}$1.09, P<0.01), respectively. Risk of onset for illnesses significantly increased with yearly aging except for cancer. - For comparison between monthly income after adjusting confounding factors(gender, age, income, marriage, occupation, education), with less than 1 million won (1) as the standard, OR(confidence interval) of cancer for 1 to 2 million won, 2 to 3 million won, and more than 3 million won were 0.23(0.03${\sim}$2.16), 2.53(0.41${\sim}$15.43), and 1.73(0.15${\sim}$19.50), respectively. OR(confidence interval) of hypertension were 1.12(0.76 ${\sim}$1.66), 0.68(0.34${\sim}$1.34), and 2.04(1.08${\sim}$3.86, P<0.01), respectively. OR(confidence interval) of stroke were 0.96(0.30${\sim}$3.08) for 1 to 2 million won, and 0.80(0.08${\sim}$8.46) for 2 to 3 million won. OR(confidence interval) of diabetes were 0.73(0.38${\sim}$1.38), 0.65(0.24${\sim}$1.71), and 0.69(0.24${\sim}$2.01), respectively. The values were 0.76(0.55${\sim}$1.03), 1.14(0.75${\sim}$1.73), and 0.90(0.56${\sim}$1.46), respectively for arthritis. OR(confidence interval) of cardiac disorders were 1.15(0.53${\sim}$2.48), 0.63(0.13${\sim}$3.12), and 1.20(0.28${\sim}$5.14), respectively. Risks of cancer, hypertension, stroke, diabetes, arthritis, and cardiac disorders were dependent of monthly income, and stroke and diabetes decreased with increase in income. Summarizing above data, arthritis was significantly higher in women and increase in age by each year brought significant increase in the chance of onset in hypertension, stroke, diabetes, arthritis, and cardiac disorders except for cancer. Stroke and diabetes decreased with increase in income. Above findings can be applied and reflected in public health policies at the national level, and it can also be applied at the personal level for individual health maintenance and prevention.

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기존 건축물을 용도변경한 노인의료복지시설의 화재 인명피해 예방과 피난 대책 -광주·전남 농촌지역을 중심으로- (Prevention of Human injury and Countermeasure of evacuation about Fire of Nursing Homes by Conversion of existing buildings - Focused on rural areas in Gwangju and Jeonnam -)

  • 김현태;김원진
    • 한국농촌건축학회논문집
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    • 제20권1호
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    • pp.27-36
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    • 2018
  • At present, the elderly population in Korea is 14% of the total population and then We has entered an the society of advanced age. Along with this, elderly people with dementia and palsy are also increasing. The demand for elderly nursing homes for elderly people with severe diseases such as dementia and stroke is also increasing, and the existing buildings are being secured by Conversion of existing buildings. However, it is difficult to evacuate and fire due to the out of date of buildings by Conversion of existing buildings. For example, there is a fire in the Indukukwon, Pohang City and Hyosung Geriatric Hospital, Jangseong in Korea, which have changed the use of existing buildings. Many elderly people died in a night fire. It was because of the sandwich panel walls and PVC flooring material produced toxic gas instantly. In this study, we investigated the nursing home that changing the use and established fire prevention of human injury and countermeasure of evacuation. First, the sandwich panels which leading to deaths due to the toxic gas were installed in most nursing home. We recommend the RC, the masonry wall, and the glass fiber panel instead of the sandwich panels, In addition, the PVC flooring is most used in nursing home, the flooring material is considered such as the building stones, the tile, and the yellow soil closing instead of the PVC flooring. Second, we investigated the installation status of fire fighting equipment. As a result, the automatic-emergency open&shut equipment, the smoke ventilator and the evacuation slide were rarely installed. In order to secure the golden time in case of fire and to prevent the asphyxia caused by the toxic gas, the law should be amended to install the equipment.

수술중 경두개 초음파 집중감시 (Intraoperative Transcranial Doppler Monitoring)

  • 서대원
    • Annals of Clinical Neurophysiology
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    • 제1권1호
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    • pp.70-75
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    • 1999
  • Trancranial Doppler(TCD) monitoring is a new application of ultrasonography which allows the nonivasive detection of blood flow velocity in the horizontal (M1) segment of the middle cerebral artery (MCA) and detects microembolic phenomena in the cerebral circulation. Recent studies emphasized the potential of using this technique in vascular surgery (carotid endarterectomy, cardiopulmonary bypass), interventional and intensive care setting. Although the disparity between CBF and blood flow velocity and number of microemboli could be used to prevent cerebral ischemic and embolism based on clinical studies. A reduction of more than 60% of MCA can reflex hemodynamic ischemic state and acoustic feedback of high intensity transient signals(HITS) from the TCD monitoring unit has a direct influence on surgical technique. TCD monitoring can immediately provide information about thromboembolism and hemodynamic changes, which may be a useful tool in the study and prevention of stroke.

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선박디젤기관에서 바이오디젤연료의 연소특성에 대한 실험적 연구 (An Experimental Study on Combustion Characteristics of Biodiesel Fuel in Marine Diesel Engine)

  • 조상곤
    • 동력기계공학회지
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    • 제19권3호
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    • pp.29-35
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    • 2015
  • Environmental pollution is produced by consumption of fossil fuel, therefore alternative fuels is interested for development of new energy resources and reduction of exhaust emissions for air pollution prevention. Biofuels are produced from new vegetable oil and animal fat, may be used as fuel without change of engine structure in diesel engine. In this paper, the test results on specific fuel consumption, combustion characteristics of neat diesel oil and biodiesel blends(10 vol.% biodiesel and 20 vol.% biodiesel) were presented using four stroke, direct injection diesel engine, especially this biodiesel was produced from biodiesel fuel at our laboratory by ourselves. This study showed that specific fuel consumption is increased slightly, on the other hand cylinder pressure, rate of pressure rise, rate of heat release and soot were decreased slightly in the case of biodiesel blends than neat diesel oil.