• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1881-1891
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• 2004

Daejowhan-gamibang(DJG) is used to prevention and treatment of cerebrovascular disease, heart disease, dementia, hyperlipdemia circulatory disturbance. Korean traditional herbal prescriptions and herb medicines in neuronal cells, which have been used for the treatment of stroke and brain diseases in Korean traditional medicine were screened to study the antioxidant effects and its mechanism. Daejowhan-gamibang water extract(DJGWE) was tested on their antioxidant activity using radical scavenging effects against ABTS. It showed significant antioxidant capacities at 50㎍ concentration. The antioxidant activity of DJGWE was determined in the different concentration (10㎍, 50 ㎍, and 100㎍). At the same time, the antiperoxidation effects was determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was significantly inhibited by DJGWE in vitro. DJGWE showed a potent antioxidant and antiperoxidative activity, further investigation, in vitro and in vivo, will be needed for the confirm of possibility as an antioxidant therapeutic agents and their optimal treatment of brain diseases in human. In searching the mechanism of antioxidant effects of DJGWE, it showed the inhibition of activity of JNK, p38, ERK and caspase 3 induced by hypoxia. So, DJGWE should be surveyed for the use of the potential therapeutic prescription for stroke and brain degenerative diseases such as pakinson's disease, dementia.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.10
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• pp.1472-1479
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• 2002

Environmental protection on the ocean has been interested and nowadays the International Maritime Organization(IMO) has advanced on the prevention of air pollution from ships. This study presents the emission characteristics of 4 stroke marine diesel engines in E3 cycle (propulsion application) and D2 cycle (generation application). Also the effects of important operating parameters in terms of intake air pressure and temperature, and maximum combustion pressure on the specific emissions are described. Emissions measurement and calculation are processed according to IMO Technical Code. The results show that NOx emission level in E3 cycle is higher than that in D2 cycle due to lower engine speed at low load and the maximum combustion pressure by fuel injection timing control and intake air temperature has strong influence on NOx emission production. And CO, HC emissions are not affected by maximum combustion pressure and intake air pressure and temperature.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2002.05a
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• pp.121-127
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• 2002

Environmental protection on the ocean has been interested and nowadays the International Maritime Organization(IMO) has advanced on the prevention of air pollution from ships. This study presents the emission characteristics of 4 stroke propulsion diesel engine in E2 cycle (constant speed) and E3 cycle (propeller curved speed). Also the effects of important operating parameters in terms of intake air pressure and temperature, and maximum combustion pressure are described on the specific emissions. Emissions measurement and calculation are processed according to IMO Technical Code. The results show that NOx emission level in E3 cycle is higher than E2 cycle due to lower engine speed and lower maximum combustion pressure by retarding fuel injection timing. Intake air temperature has strong influence on NOx emission production. And CO, HC emissions are not affected by maximum combustion pressure and intake air pressure and temperature.

• Natural Product Sciences
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• v.7 no.2
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• pp.53-59
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• 2001

The possibility of Chungpesagan-tang, which has been recommended on the stroke patients with constipation in Korean traditional clinic, and its ingredients as a novel antithrombotic agent was evaluated. Most of its ingredients except Puerariae Radix exhibited in vitro antiplatelet aggregation activity. However, Puerariae Radix was significantly effective on ex vivo anti-platelet aggregation activity, whereas Angelicae Tenuissimae Radix, Raphani Semen and Angelicae Dahuricae Radix was not effective. Plasma recalcification was potently inhibited only by Puerariae Radix and Rhei Rhizoma treated with intestinal bacteria. Urokinase was also activated only by Chungpesagan-tang, Angelicae Tenuissimae Radix and Puerariae Radix treated with intestinal bacteria. Chungpesagan-tang exhibited the potent anti-thromboembolic activity activity in vitro. These results suggest that anti-thrombotic activity of Chungpesagan-tang should be activated by intestinal bacteria and may be important in the prevention of thrombosis and cardiovascular diseases, such as myocardial infraction stroke and arteriosclerosis.

• The Journal of the Society of Stroke on Korean Medicine
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• v.15 no.1
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• pp.13-28
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• 2014

■ Objectives The berries of Schisandra chinensis (Schisandra Fructus) are given the name Omiza in Koreane(五味子), and have been used asremedies for many ailments: to resist infections, increase skin health, and combat insomnia, coughing, and thirst. This study was designed to investigate the effects of Schisandra Fructus hexane fraction (SFH) on serum lipid levels in Hyperlipidemic mice. ■ Methods In this experiment, effects on total cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured. And in addition, histopathological and gene expression changes in liver tissue was also observed. ■ Results SFH did not affects weight gain, serum AST and ALT in hyperlipidemic mice. Oral administration of SFH lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. Finally, administration of SFH lowered fasting blood glucose significantly. And SFH also ameliorates anti-oxidative stress systems in internal organs which play key role in disease prevention. ■ Conclusion Results in our study suggest that SFH can prevent obese through regulation of dyslipidemia and hyperglycaemia.

• Physical Therapy Rehabilitation Science
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• v.9 no.3
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• pp.178-183
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• 2020

Objective: This study conducted in order to investigate the correlations between fall experience, balance, mobility, and confidence. We examined the difference between fall experience, and Berg Balance Scale (BBS), Timed-Up-and-Go test (TUG), Tinetti balance assessment (Tinetti balance [TiB], Tinetti gait [TiG]), and Activities-specific Balance Confidence (ABC) scale scores to see how fall experience, balance, mobility, and confidence of the persons with stroke affects their balance. Design: Cross-sectional study. Methods: Forty-one subjects participated in this study. The BBS includes 14 items, consisting of a 5-point scale from 0 to 4, totaling up to 56 points. The Timed Up and Go-Alone (TUGA) was used to measure the average time to take a 3 m round-trip by getting up and down from a 46-cm high chair with an armrest on a flat floor. The Timed-Up-and-Go-Cognitive (TUGC) was performed by counting backwards and the Timed Up and Go-Manual (TUGM) is performed by holding a cup full of water. The total score for the TiB is 16 points, and the TiG is 12 points, making a total of 28 points. There are 16 items total for the ABC scale. Results: According to the fall experience, BBS, the TUGA and TUGC values were significantly higher in the inexperienced group compared to the experienced group (p<0.05). The number of falls was significantly correlated with BBS, TUGA, TUGC, TUGM, TiB, TiG, TiB+TiG (p<0.05). Conclusions: This study supports that falls experience is strongly related to balance, mobility, and confidence. Optimal balance training programs for fall prevention is still insufficient and must be developed.

• Journal of Korean Physical Therapy Science
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• v.10 no.1
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• pp.30-37
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• 2003

Purpose : The purpose of this study is giving the healthy promotion and it's related data base for out-patients who had stroke via evaluating the general characters of their active daily living and physical therapy Method : This study researched 81 patients who had received physical therapy service in 6 general hospitals located Pusan city responded to the self-assessment questionnaires from July 2002 to August 2002. Conclusion : In this study, patients were composed of 61.7% of male, 65.4% of 50's-60's in the age, 56.8% of cerebral infarction, and 60.5% of right hemiplegia. 74.1% of patients received physical therapy after 6 months from an attack, only 62.9% used orthosis & gait aids, and 59.2% received medical care 2 or 3 times per week. 40.7% of patients had over 9 hours sleeping time and 22% had reduced $1{\sim}2hours$ before hospitalization. 90% did not have drinking and smoking. 91.4% had 3 times eating per day, and 67.7% did not have good nutrition. The reasons of that were their eating habit, 542% of eating-giver, 3.7% of economic problem. 46.9% of patients used healthy food. In active daily living, patients can't do drinking by cup, voiding & defication by themselves, however patients can't do wearing/take off, etiquette for dressing, bathing, stepping by themselves. 40.7% of patients don't wear orthosis, 55.6% of patients don't use W/C. Part of physical therapy that patients concerned importantly exercise for prevention of joint distortion, management of affected side, and 80% of patients was also concerned other's part, significantly. 71.8% of patients & care-givers want to receive physical therapy at home, and 74% of patients do physical therapy by themselves at home along teached hospitalization.

• The Journal of the Society of Stroke on Korean Medicine
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• v.12 no.1
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• pp.1-7
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• 2011

Objectives : The purpose is to discuss the clinical applications of Orungsan(Goreisan: 五苓散) as an alternative management for increased intracranial pressure in the field of neurosurgery in Japan. Methods and Results : Attention has focused on Kampo medicine(traditional Japanese medicine) for some cerebral disease including chronic subdural hematoma(CSDH) and cerebral infarction in Japan. Orungsan and one of its classes, Sirungtang(Saireto: 柴苓湯) are well known their effects on brain edema. After some studies of Orungsan has the anti-edemic effects by the inhibition of aquaporin, this herbal medicine has been used widely in the neurosurgery field in Japan. It is high time to think about where we are and we go ahead for the progress and the integration in medicine. We have reviewed the studies using Orungsan or Sirungtang, that was reported at the 20th annual meeting of 'the Japan society for Kampo medicine and neurological surgery' was held on November 5, 2011 in Tokyo. Fifteen studies related with Orungsan or Sirungtang were reported among all 32 studies at the meeting. Orungsan in ten, and Sirungtang in five among 14 studies contained specific clinical case. In the aspects of disease, thirteen papers were related with SDH, including CSDH(11), SSDH(1), aneurism clipping for SDH prevention(1), and one was acute cerebral infarction and one was multiple metastatic brain tumor. In the report style, case control study was 7(mostly retrospective), and the case report was 8. Conclusions : Orungsan may be plausible to be an alternative method to reduce brain edema after SDH and other brain injury in the field of neurosurgery.

• Therapeutic Science for Rehabilitation
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• v.9 no.2
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• pp.119-135
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• 2020

Objective : The purpose of this study was to investigate the effects of bimanual intensive training on Upper Extremity Function and activities of daily living in stroke patients. Methods : The subjects were 18 patients who were diagnosed with hemiplegic stroke. They were randomly assigned to bimanual intensive training group (n=9) and unilateral intensive group (n=9). Bimanual training group performed bimanual task and unilateral training group performed one hand task for 1 hour per session, 5 times a week, for 4 weeks. Chi-square test, Wilcoxon signed rank test, and Mann-Whitney U test were used for analysis. Results : The results showed that, upper extremity motor function and bimanual coordination were significantly improved in patients in the bimanual training group (p<.05). Additionally, the ratio of affected hand use and amount of use/quality of movement in the hemiplegic upper extremity in activities of daily living for patients in the bimanual training group were significantly improved (p<.05). Although the unilateral group improved motor upper extremity function and activities of daily living in the upper extremity (p<.05), it was not significantly different from that in the bimanual training group. In between-group comparison, bimanual coordination and ratio of the affected hand use in a day were significantly different (p<.05). Conclusion : It is reasonable to conclude that bimanual intensive training therapy is an effective intervention method to improve upper extremity motor function, and activities of daily living in stroke patients.

• Journal of Digital Convergence
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• v.18 no.9
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• pp.277-283
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• 2020

The purpose of this study was to identify the risk factors influencing stroke. The research method was used two-stage stratified cluster sampling using data from the National Health and Nutrition Survey (2016-2018). This study subjects performed a complex sample logistic regression analysis on adults aged 19 or older. Risk factors affecting stroke were shown as follows: in age groups, odds ratio were conformed when people are in their 70s, the rate is 8.861 times higher; when they are in their subjective health conditions, the odds ratio are 4.501 times higher in the bad groups; odds ratio was 3.158 times higher in the group diagnosed with hypertension and 1.598 times higher in the group diagnosed with diabetes. The result of this study found that chronic diseases such as high blood pressure and diabetes and the management of senior citizens are important because stroke is dangerous and can be managed through prevention.