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Influence of Daejowhan-gamibang on Antioxidative Effects and Apoptosis Induction in Neuronal Cells  

Lee Young Chan (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Choi Ho Seung (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Lee Jun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1881-1891 More about this Journal
Abstract
Daejowhan-gamibang(DJG) is used to prevention and treatment of cerebrovascular disease, heart disease, dementia, hyperlipdemia circulatory disturbance. Korean traditional herbal prescriptions and herb medicines in neuronal cells, which have been used for the treatment of stroke and brain diseases in Korean traditional medicine were screened to study the antioxidant effects and its mechanism. Daejowhan-gamibang water extract(DJGWE) was tested on their antioxidant activity using radical scavenging effects against ABTS. It showed significant antioxidant capacities at 50㎍ concentration. The antioxidant activity of DJGWE was determined in the different concentration (10㎍, 50 ㎍, and 100㎍). At the same time, the antiperoxidation effects was determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was significantly inhibited by DJGWE in vitro. DJGWE showed a potent antioxidant and antiperoxidative activity, further investigation, in vitro and in vivo, will be needed for the confirm of possibility as an antioxidant therapeutic agents and their optimal treatment of brain diseases in human. In searching the mechanism of antioxidant effects of DJGWE, it showed the inhibition of activity of JNK, p38, ERK and caspase 3 induced by hypoxia. So, DJGWE should be surveyed for the use of the potential therapeutic prescription for stroke and brain degenerative diseases such as pakinson's disease, dementia.
Keywords
Daejowhan-gamibang(DJG);
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Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells /
[ Chanvitayapongs S;Draczynska-Lusiak B;Sun AY. ] / Neuroreport.   ScienceOn
2 NADPH-dependent and O2-dependent lipid-peroxidation /
[ Nizamuddin, A. ] / Biochem. Pharmacol.
3 A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish /
[ Takao, T.;F. Kitatani;N. Watanabe;A. Yagi;K. Sakata. ] / Biosic. Biotech. Biochem.
4 Free-radical scavenging action of medicinal herbs from Ghana Thonningia sanguinea on experimentally-induced liver injuries /
[ Gyamfi, M.A.;M. Yonamine;Y. Aniya. ] / Gen. Pharmacol.   ScienceOn
5 Comparative antioxidant potential of anaethetics and perioperative drugs in vitro /
[ Mantle, D.;F. Eddeb;K. Areni;C. Snowden;A.D. Mendelow. ] / Clin. Chim. Acta.
6 Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages /
[ Gupta D;Jin YP;Dziarski R. ] / J Immunol.
7 IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade /
[ Ogata A;Chauhan D;Teoh G;Treon SP;Urashima M;Schlossman RL;Anderson KC. ] / J Immunol.
8 CAMP inhibits mitogen-activated protein (MAP) kinase activation and resumption of meiosis, but exerts no effects after spontaneous germinal vesicle breakdown (GVBD) in mouse oocytes /
[ Sun QY;Lu Q;Breitbart H;Chen DY. ] / Reprod Fertil Dev.   ScienceOn
9 Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase /
[ Behrens MM;Strasser U;Koh JY;Gwag BJ;Choi DW. ] / Neuroscience.   ScienceOn
10 Total antioxidant status in plasma and body fluids /
[ Rice-Evans, C.;N.J. Patterson. ] / Meth. Enzymol.
11 Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells /
[ Satoh T;Enokido Y;Aoshima H;Uchiyama Y;Hatanaka H. ] / J Neurosci Res.   ScienceOn
12 Oxygen-derived free radicals in postischemic tissue injury /
[ McCord JM. ] / N Engl J Med.   ScienceOn
13 Oxygen-derived radicals: a link between reperfusion injury and inflammation /
[ McCord JM. ] / Fed Proc.
14 Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia /
[ Yang G;Chan PH;Chen J;Carlson E;Chen SF;Weinstein P;Epstein CJ;Kamii H. ] / Stroke.
15 Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production /
[ Jang DS;Kang BS;Ryu SY;Chang IM;Min KR;Kim Y. ] / Biochem Pharmacol.   ScienceOn
16 Reactive oxygen species and antioxidants in signal transduction and gene expression /
[ Palmer HJ;Paulson KE. ] / Nutr Rev.   ScienceOn
17 Protective effect of boldine on dopamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells /
[ Youn YC;Kwon OS;Han ES;Song JH;Shin YK;Lee CS. ] / Biochem Pharmacol.   ScienceOn
18 Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase /
[ Kinouchi H;Epstein CJ;Mizui T;Carlson E;Chen SF;Chan PH. ] / Proc Natl Acad Sci USA.   ScienceOn
19 Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide /
[ Koppenol WH;Moreno JJ;Pryoor WA;Ischiropoulos H;Beckman JS. ] / Chem Res Toxicol.   ScienceOn
20 Effects of Daejowhan on Hydrogen Peroxide-induced Apoptosis of H9c2 Cardiomyoblasts /
[ Yeong Hun Na;Sang Beom Bak;Seung Won Jeong;Jong Min Yun;In Lee;Byumg Soon Moon. ] / Korean J. Oriental Physiology & Pathology
21 Daejowhan water extract prevents apoptotic death by peroxynitrite and Nitric oxide in human dopaminergic beuroblastoma SH-SY5Y cell /
[ Myung Summy Kim;Jienny Lee;Homg Seob So;Kang Min Lee;Byung Soon Moon;Ho Sub Lee;Raekil Park ] / immunopharmacology and immunotoxicology   ScienceOn
22 Effects of Daejowhan on Oxidative Damage of Humam Berual Cell /
[ Sang Hyok Han;Myung Sunny Kim;Jienny Lee;Do Hwan Kim;Young Hoon Na;Kwang Ho Cho;Rae Kil Park;Byung Soon Moon. ] / J Korean Oriental Med KJ
23 Metal ion-catalyzed oxidation of proteins: biochemical mechanisms and biological consequences /
[ Stadtman, E.R. ] / Free Rad. Biol. Med.   ScienceOn
24 Oxy-radicals and cancer /
[ Cerutti, P.A. ] / Lancet.   ScienceOn
25 Oxidative stress: free radical production in neural degeneration /
[ Gtz, M.E.;G. Kunig;P. Riederer;M.B. Youdim. ] / Pharmacol. Thr.   ScienceOn
26 Oxidative damage to DNA in diabetes mellitus /
[ Dandona, P.;K. Thusu;S. Cook;B. Snyder;J. Makowski;D. Armstrong;T. Nicotera. ] / Lancet.   ScienceOn
27 Role of free radicals and catalytic metal ions in human disease: an overview /
[ Halliwell, B.;J.M.C. Gutteridge. ] / Meth. Enzymol.
28 Ras, superoxide and signal transduction /
[ Irani K;Goldschmidt-Clermont PJ. ] / Biochem Pharmacol.   ScienceOn
29 Maternal infusion of antioxidants (Trolox and ascorbic acid) protects the fetal heart in rabbit fetal hypoxia /
[ Tan S;Liu YY;Nielsen VG;Skinner K;Kirk KA;Baldwin ST;Parks DA. ] / Pediatr Res.   ScienceOn
30 Characteristics of the protective action of alpha-Tocopherol in vascular hypoxia /
[ Kelly MJ;Richardson W. ] / Pharmacol Toxicol.   ScienceOn
31 Magnolol protects cortical neuronal cells from chemical hypoxia in rats /
[ Lee MM;Hseih MT;Kuo JS;Yeh FT;Huang HM. ] / Neuroreport.   ScienceOn
32 Shortcomings of an automated assay for total antioxidant status in biological fluids /
[ Schofield, D.;J.M. Braganza. ] / Technical Briefs.
33 Analytical aspects of antioxidants and free radical activity in clinical biochemistry /
[ Rumley, A.G.;J.R. Patterson. ] / Ann. Clin. Biochem.
34 Is measuring serum antioxidant capacity clinically useful? /
[ Woodford, F.P.;T.P. Whitehead. ] / Ann. Clin. Biochem.
35 Hydroxyl radical scavenging activity of flavonoids /
[ Husain, S.R.;J., Cillard;P. Cillard. ] / Phytochem.   ScienceOn
36 Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes /
[ Rush, G.F;J.R. Gorski;M.G. Ripple;J. Sowinski;P. Bugelski;W.R. Hewitt. ] / Toxicol. Appl. Pharmacol.   ScienceOn
37 Oxidative stress and genetics in the pathogenesis of Parkinson's disease /
[ Zhang, Y.;V.L. Dawson;T.M. Dawson. ] / Neurobiol. Dis.   ScienceOn
38 Screening of the acetylcholinesterase inhibitors from medicinal plants /
[ Lee, B.H.;B.W. Choi;G.S. Ryu;E.S. Lee;K.J. Kang;D.Y. Hwang;N.D. Hong ] / Kor. J. Pharm.
39 Effective human cancer prevention as goal for the regulation of environmental chemicals /
[ Weisburger, J.H. ] / J. Environ. Health.
40 Protective effect of quaternary piperidinium salts on lipid oxidation in the erythrocyte membrane. Zeitschrift Fur Naturforschung Section C-A /
[ Kleszcynska, H.;M. Oswiecimska;J. Sarapuk;S. Witek;S. Przestalski. ] / J. Biosci.
41 Superoxide radicals: an endogenous toxicant /
[ Fridovich I. ] / Annu Rev Pharmacol Toxicol.   ScienceOn
42 Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere /
[ Enokido Y;Hatanaka H. ] / Neuroscience.   ScienceOn
43 Oxidative stress induces apoptosis in embryonic cortical neurons /
[ Raten RR;Murphy TH;Baraban JM. ] / J Neurosci.
44 Oxygen-induced apoptosis in PC12 cells with special reference to the role of Bcl-2 /
[ Kubo T;Enokido Y;Yamada M;Oka T;Uchiyama Y;Hatanaka H. ] / Brain Res.   ScienceOn
45 The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice /
[ Fujimura M;Morita-Fujimura Y;Noshita N;Sugawara T;Kawase M;Chan PH. ] / J Neurosci.
46 Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion /
[ Chan PH;Kawase M;Murakami K;Chen SF;Li Y;Calagui B;Reola L;Carlson E;Epstein CJ. ] / J Neurosci.
47 Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells /
[ Troy CM;Shelanski ML. ] / Proc Natl Acad Sci USA.   ScienceOn
48 Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection /
[ Ghadge GD;Lee JP;Bindokas VP;Jordan J;Ma L;Miller RJ;Roos RP. ] / J Neurosci.
49 Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death /
[ Tanaka M;Sotomatsu A;Yoshida T;Hirai S;Nishida A. ] / J Neurochem.   ScienceOn
50 Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats /
[ Li Y;Chopp M;Jiang N;Zhang ZG;Zaloga C. ] / Stroke.
51 Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity /
[ Charriaut-Marlangue C;Aggoun-Zouaoui D;Represa A;Ben-Ari Y. ] / Trends Neurosci.   ScienceOn
52 CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme /
[ Fernandes-Alnemri T;Litwack G;Alnemri ES. ] / J Biol Chem.
53 Cancer chemopreventive activity of resveratrol, a natural product derived from grapes /
[ Jang M;Cai L;Udeani GO;Slowing KV;Thomas CF;Beecher CW;Fong HH;Farnsworth NR;Kinghorn AD;Mehta RG;Moon RC;Pezzuto JM. ] / Science.
54 The in vitro effect of Helichrysi flos on microsomal lipid peroxidation /
[ Czinner, E.;K. Hagymasi;Blazovics;A. Kery;E, Szoke;E. Lemberkovics. ] / J. Ethnopharmacol.   ScienceOn
55 ICE-like proteases in apoptosis /
[ Kumar S. ] / Trends Biochem Sci.