• Molecules and Cells
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• v.26 no.2
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• pp.212-215
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• 2008

The GC-rich discriminator sequence between the -10 region and the transcription start site of the rnpB promoter is responsible for stringent control of M1 RNA synthesis. The rnpB promoter also contains a G nucleotide at the previously identified transcription start site. In this study, we examined by mutagenesis of G to A whether this +1G nucleotide is involved in the stringent response. We found that the change did not alter the stringent response. Since the +1 mutation might alter transcription initiation, we compared the transcription start sites of the wt and mutant promoters by primer extension analysis. Surprisingly, we found that wild type rnpB transcription starts at both the +1G position (70%) and the -1C position (30%), and that the +1A mutation led to transcription initiation exclusively at the -1C position. We also generated two transversion mutations at the -1 position, both of which led to transcription starting exclusively at that position. The -1G mutant promoter gave a stringent signal similar to the wild-type, whereas the -1A mutant generated a significantly less stringent signal. Base on these results, we propose that a short sequence, up to 7 bp downstream of the -10 region, is involved in the stringent response of the rnpB promoter.

• Korean Journal of Clinical Pharmacy
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• v.28 no.3
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• pp.194-203
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• 2018

Background: Bone fractures are high in elderly patients with type 2 diabetes mellitus (T2DM). Hyperglycemia and chronic kidney disease may increase the risk of fracture prevalence via altered bone metabolism, but whether glycemic control and kidney function are associated with the risk of fracture prevalence remains unclear. This study evaluated the relationship between glycemic control and baseline estimated glomerular filtration rate (eGFR) and risk of fracture prevalence in older and middle-aged patients with T2DM. Methods: Patients who underwent a general medical check-up between 2009 and 2013 were selected from the Korean National Health Insurance Sharing Service records. Chi-square test and multiple logistic regression analysis were used to assess the relationship between glycemic control and eGFR and risk of fracture prevalence. Results: Cumulative fracture prevalence were higher in patients with T2DM, irrespective of whether they had tight or less stringent glycemic control (fasting blood glucose [FBG] ${\geq}110mg/dL$). After adjustment for baseline age and FBG, tight and less stringent glycemic control was significantly associated with increased adjusted risk of fracture prevalence in middle-aged patients with T2DM (OR=1.13, 95% CI, 1.05-1.21, p=0.0005 vs OR=1.13, 95% CI, 1.06-1.20, p=0.0001), but not in older patients. Baseline eGFR was not significantly related to fracture prevalence in either older or middle-aged patients. Conclusion: Less stringent glycemic control significantly increased the adjusted risk of fracture prevalence in middle-aged patients with T2DM. Further studies are needed to confirm the effect of tight glycemic control on fracture prevalence.

• 제어로봇시스템학회:학술대회논문집
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• 1987.10b
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• pp.625-630
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• 1987

Technology associated with power plant control system has been heavily rely on foreign technology. The main reason is that the system has tomaintain stringent reliability and stability. Localization of this system can be started from localization of modules necessary for maintenance and repair in hydraulic and thermal power plant. Gradually and eventually system engineering capability can be built up to design and develop nuclear power plant control system through technology accumulation. Methods are presented to achieve this goal.

• Journal of environmental and Sanitary engineering
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• v.7 no.2
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• pp.83-94
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• 1992

Recently water demand is increasing as the industry prospers. The increase of water demand is followed by the increase of wastewater discharge which pollutes rivers and ground water extensively. These rivers, reservoirs and ground water are sources for drinking water and their contamination affects the quality of water supply and other potable water. In Korea there are 776 water treatment plants which supply drinking water from main rivers or reservoirs. Rivers are the biggest water source for drinking water is being contaminated, the innovation of treatment process is needed. The construction and operation of water supply facilities is under the control of the Ministry of Construction and the water supply offices of cities and provinces. However, drinking water quality is under the control of the bureau of sanitation in the Ministry of Health and Social Affairs. There are 33 items in drinking water quality standards of Korea. Trihalomethanes, Selenium, Diazinone and other three of pesticides have been included lately, The Ministry of Health and Social Affairs is planning to enhance. the level of $VOC_S$(Vola-tile Organic Compounds) standard. Drinking water quality standard is the goal to protect the quality of supply water and ground water. In order to protect the source water from domestic or industrial water, technological improvement and adequate investment should be urgently made. The ultimate goal of drinking water quality is safety and health of consumers. The more stringent the standard are, the better the water quality will be. As the drinking water quality standards become more stringent this year, various and positive solutions by the authorities concerned must be prepared.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1993.10a
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• pp.157-161
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• 1993

Optical devices and electronic equipments used in the laboratory of the synchrotron light source building of the accelerator have stringent vibration limits. In order to control the vibration of the building structure and HVAC systems which are main vibration sources are evaluated using experimental modal analysis. Double anti-vibration system is used for the HVAC system and results show that the double anti-vibration system reduces the vibrations of the building to acceptable levels.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.454-459
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• 2004

This paper considers the problem of satellite's orbit control and a solution based in Linear Matrix Inequalities (LMI) is proposed for the case of Low Earth Orbiters (LEO). In particular, the modelling procedure and the algorithm for control law synthesis are tested using as study case the European Gravity Field and Ocean Circulation Explorer satellite (GOCE), to be launched by the European Space Agency (ESA) in the year 2006. The scientific objective of this space mission is the recovering of the Earth gravity field with high accuracy (less than 10${\mu}m$/${\mu}m$) and spatial resolution (better than 100km). In order to meet these scientific requirements, the orbit control must guarantee stringent specifications in terms of environmental disturbances attenuation (atmospheric drag forces) even in presence of high levels of model uncertainty.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.16 no.11 s.116
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• pp.1100-1107
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• 2006

As environmental vibration requirements on precision equipment become more stringent, use of pneumatic isolators has become more popular and their performance is subsequently required to be further improved. Performance of passive pneumatic isolators is related to various design parameters in a complicated manner and, hence, is very limited especially in low frequency range by chamber volume. In this study, transmissibility behavior of the pneumatic isolators depending on frequency and dynamic amplitude are presented. Then, an active control technique, time delay control, which is adequate for a low frequency nonlinear system, is applied. A procedure of applying the time delay control law to a pneumatic isolator is presented and it's effectiveness in the transmissibility performance is shown. Comparison between passive and active pneumatic isolators is made based on simulation.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.11a
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• pp.903-908
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• 2006

As environmental vibration requirements on precision equipment become more stringent. use of pneumatic isolators has become more popular and their performance is subsequently required to be further improved. Dynamic performance of passive pneumatic isolators is related to various design parameters in a complicated manner and, hence, is very limited especially in low frequency range by volume of chambers. In this study, an active control technique, so called time delay control which is considered to be adequate for a low frequency or nonlinear system, is applied to a single chamber pneumatic isolator. The procedure of applying the time delay control law to the pneumatic isolator is presented and its effectiveness in enhancement of transmissibility performance is shown based on simulation and experiment. Comparison between passive and active pneumatic isolators is also presented.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.68.3-68
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• 2002

This paper presents a neural network approach to control exhaust gas recirculation(EGR) in a Liquefied Petroleum Gas(LPG) engine. In order to meet Increasingly stringent automotive exhaust emission regulations, alternative fuels such as LPG engines have been developed in many countries. HC&CO emissions of LPG engines can be easily reduced through air-fuel ratio control, but the control effect on NOx reduction is not good enough. Consequently EGR system is introduced to achieve a significant reduction in NOx emissions. Conventional EGR control uses the mapping method. The calibration time is long and the work is complex when adopting this mapping method. However neural networks are suitable f...

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.837-843
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• 2006

As environmental vibration requirements on precision equipment become more stringent, use of pneumatic isolators has become more popular and their performance is subsequently required to be further improved. Performance of passive pneumatic isolators is related to various design parameters in a complicated manner and, hence, is very limited especially in low frequency range by chamber volume. In this study, transmissibility behavior of the pneumatic isolators depending on frequency and dynamic amplitude are presented. Then, an active control technique, time delay control, which is adequate for a low frequency nonlinear system, is applied. A procedure of applying the time delay control law to a pneumatic isolator is presented and it's effectiveness in the transmissibility performance is shown. Comparison between passive and active pneumatic isolators is made based on simulation.