• Child Health Nursing Research
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• 제8권4호
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• pp.449-457
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• 2002

The main purpose of this study is to examine the concepts appeared on researches and provide the future research directions in field of child health nursing. A descriptive study was conducted. 205 studies were included in an analysis the concepts in terms of the domain of client for a total 321 researches. All were originally published between 1990 and 2000 in Korea. An analysis of concepts for this study was used the metaparadigm framework for nursing proposed by H.S. Kim(2000). The concepts for this study were categorized by essentialistic concepts, problematic concepts, health-care experiential concepts with the following results. 1. Based on the four domains suggested Kim (2000), 205 studies(63.9％) belong to the domain of client ; 109 studies(34％) belong to the practice domain of nursing; 3 studies(0.9％) belong to the client-nurse domain; and 4 studies belong to the domain of environment, respectively. 2. In the domain of client, 117(57.1％) studies used concept of parent. Among them, mother was the prevailing research population(103 studies). 64 studies(31.2％) used child population and the developmental stage of children varied from preterm to puberty but school aged children was the most target population(28 studies). Family as a concept of client was used in 20 studies(9.8％) but most primary care provider was the mother. 3. In terms of research design, non-experimental design(83.5％) is the most and among them survey was 159 studies(77.6％). Qualitative research(23 studies) and experimental research(10 studies) methods were used relatively few. 4. In terms of the categories of concepts, 196 (61.4％) studies included the essentialistic concepts like stress and coping(20.4％), mothering role and child care(7.8％), health (5.6％), breast feeding(4.7％). 31 studies included problematic concepts like power-lessness, safety, obesity, pain, anxiety. And 65 studies included health-care experiential concepts like compliance, growth, hope, environment but relatively few. The findings of this study provide the evidence that research related problematic concept and health-care experiential concept should be conducted actively to improve the practice of child health nursing. Also to deeply understand the phenomena of client in field of child health nursing, interpretive research methods should be conducted actively, too.

• 분석과학
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• 제28권5호
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• pp.331-340
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• 2015

DNA/RNA결합 단백질로 다양한 기능을 한다고 알려진Fused in Sarcoma (FUS)의 유전자 돌연변이가 루게릭병 및 전측두엽성 치매 환자에서 발견되었다. 정상적인 FUS는 핵에 위치하지만 병리상황에서 FUS는 세포질로 잘못 타기팅 되어 스트레스 응집체와 결합된 단백질 응집체를 형성하는 것으로 알려졌다. 그러나 이들에 의한 스트레스 응집체 형성 기전 및 응집체 형성에 관여하는 FUS의 도메인은 정확히 알려지지 않았다. 따라서, 본 연구에서는 루게릭병 연관 FUS 미스센스 돌연변이(P525L, R521C, R521H, R521G)의 세포내 위치 및 세포질 FUS의 응집체 형성에 관여하는 FUS내 도메인을 분석하고 동정하고자 하였다. 이를 위해 먼저, FUS 미스센스 돌연변이의 세포내 위치를 분석한 결과, P525L대부분은 세포질로 위치하여 스트레스 응집체를 형성하는 반면, R521C, R521H, R521G는 핵과 세포질에 위치하였다. 이를 통해 FUS의 핵으로의 이동에는 FUS의 마지막 2개의 아미노산이 매우 중요함을 확인할 수 있었다. 세포질로 빠져 나온 FUS의 응집체 형성에 관여하는 FUS도메인 분석을 위해서 핵 위치서열이 결손되어 대부분 세포질 응집체를 형성하는 FUS-∆17를 이용하여, 다양한 도메인 결손 돌연변이를 제작하고, 이들의 응집체 형성여부를 분석하였다. 그 결과, SYGQ-RGG1나 RGG2-ZnF-RGG3없는 세포질 FUS (FUS-∆SYGQ-RGG1-∆17, FUS-∆RGG2-ZnF-RGG3-∆17)는 스트레스 응집체를 형성하지 않은 반면, RRM이 없는 FUS-∆RRM-∆17은 FUS-∆17에 비해 많은 스트레스 응집체를 형성함을 알 수 있었다. 따라서, 도메인 분석결과 세포질의 FUS는 SYGQ-RGG1나 RGG2-ZnF-RGG3 도메인을 통해 FUS 스트레스 응집체 형성이 촉진되고, RRM도메인은 FUS 응집체 형성을 저해하고 있는 것으로 생각된다. 이러한 연구 결과는 FUS의 스트레스 응집체 형성과 연관된 다양한 퇴행성 뇌질환의 발병기전에 대한 이해뿐만이 아니라 이들 질환 치료를 위한 치료 후보 타겟 물질 발굴에 중요한 단서를 제공할 수 있을 것이다.

• Journal of Theoretical and Applied Mechanics
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• 제3권1호
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• pp.16-33
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• 2002

A concept of hierarchical modeling, the newest modeling technology. has been introduced early In 1990. This nu technology has a goat potential to advance the capabilities of current computational mechanics. A first step to Implement this concept is to construct hierarchical models, a family of mathematical models which are sequentially connected by a key parameter of the problem under consideration and have different levels in modeling accuracy, and to investigate characteristics In their numerical simulation aspects. Among representative model problems to explore this concept are elastic structures such as beam-, arch-. plate- and shell-like structures because the mechanical behavior through the thickness can be approximated with sequential accuracy by varying the order of thickness polynomials in the displacement or stress fields. But, in the numerical analysis of hierarchical models, two kinds of errors prevail: the modeling error and the numerical approximation errors. To ensure numerical simulation quality, an accurate estimation of these two errors Is definitely essential. Here, a local a posteriori error estimator for elastic structures with thin domain such as plate- and shell-like structures Is derived using element residuals and flux balancing technique. This method guarantees upper bounds for the global error, and also provides accurate local error Indicators for two types of errors, in the energy norm. Comparing to the classical error estimators using flux averaging technique, this shows considerably reliable and accurate effectivity indices. To illustrate the theoretical results and to verify the validity of the proposed error estimator, representative numerical examples are provided.

• Geomechanics and Engineering
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• 제13권1호
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• pp.161-171
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• 2017

The underlying ground state of a railway plays a significant role in maintaining the integrity of the overlying concrete slab and ultimately supporting the train load. While effective nondestructive tests have been used to evaluate the rail track system, they can only be performed during non-operating time due to the stress wave generated by active sources. In this study, finite element numerical simulations are conducted to investigate the feasibility of detecting unfavorable substructure conditions by using a moving train load. First, a train load module is developed by converting the train load into time-variant equivalent forces. The moving forces based on the shape functions are applied at the nodes. A parametric study that takes into account the bonding state and the train class is then performed. All the synthetic signals obtained from numerical simulations are analyzed at the frequency domain using a Fast Fourier transform (FFT) and at the time-frequency domain using a Short-Time Fourier transform (STFT). The presence of a void condition amplifies the acceleration amplitude and the vibration response. This study confirms the feasibility of using a moving train load to systematically evaluate a rail track system.

• Structural Engineering and Mechanics
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• 제8권5호
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• pp.513-529
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• 1999

A concept of hierarchical modeling, the newest modeling technology, has been introduced in early 1990's. This new technology has a great potential to advance the capabilities of current computational mechanics. A first step to implement this concept is to construct hierarchical models, a family of mathematical models sequentially connected by a key parameter of the problem under consideration and have different levels in modeling accuracy, and to investigate characteristics in their numerical simulation aspects. Among representative model problems to explore this concept are elastic structures such as beam-, arch-, plate- and shell-like structures because the mechanical behavior through the thickness can be approximated with sequential accuracy by varying the order of thickness polynomials in the displacement or stress fields. But, in the numerical, analysis of hierarchical models, two kinds of errors prevail, the modeling error and the numerical approximation error. To ensure numerical simulation quality, an accurate estimation of these two errors is definitely essential. Here, a local a posteriori error estimator for elastic structures with thin domain such as plate- and shell-like structures is derived using the element residuals and the flux balancing technique. This method guarantees upper bounds for the global error, and also provides accurate local error indicators for two types of errors, in the energy norm. Compared to the classical error estimators using the flux averaging technique, this shows considerably reliable and accurate effectivity indices. To illustrate the theoretical results and to verify the validity of the proposed error estimator, representative numerical examples are provided.

• 한국공작기계학회논문집
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• 제16권1호
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• pp.26-32
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• 2007

This study was carried out fusion-welded butt joints in SWS 490A high strength steel subjected to tensile test that load-deflection curve. The windowed or short-time Fourier transform(WFT or STFT) makes possible for the analysis of non-stationary or transient signals into a joint time-frequency domain and the wavelet transform(WT) is used to decompose the acoustic emission(AE) signal into various discrete series of sequences over different frequency bands. In this paper, for acoustic emission signal analysis to use a continuous wavelet transform, in which the Gabor wavelet base on a Gaussian window function is applied to the time-frequency domain. A wavelet transform is demonstrated and the plots are very powerful in the recognition of the acoustic emission features. As a result, the technique of acoustic emission is ideally suited to study variables which control time and stress dependent fracture or damage process in metallic materials.

• 한국전산유체공학회지
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• 제22권1호
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• pp.26-36
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• 2017

A numerical study has been performed to evaluate thermal-hydraulic performance of a finger type cooling module with multiple-jet impingement in a divertor of nuclear fusion reactor. To analyze conjugate heat transfer in both solid and fluid domains, numerical analysis of the flow using three-dimensional Reynolds-averaged Navier-Stokes equations has been performed with shear stress transport turbulence model. The computational domain for the cooling module consisted of a single fluid domain and three solid domains; tile, thimble, and cartridge. The numerical results for the temperature variation on the tile were validated in comparison with experimental data under the same conditions. A parametric study was performed with four geometric parameters, i.e., angles between x-axis and centerlines of hole 1, 2, 3 and 4. The results indicate that the heat transfer rate was increased by 2.7% and 0.7% by the angle ${\theta}_1$ and angle ${\theta}_2$, respectively, and that the pressure drop was decreased by up to 1.8% by the angle ${\theta}_3$.

• Korea-Australia Rheology Journal
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• 제18권4호
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• pp.171-181
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• 2006

We present a short review for authors' previous work on direct numerical simulations for inertialess hard particle suspensions formulated either with a Newtonian fluid or with viscoelastic polymeric fluids to understand the microstructural evolution and the bulk material behavior. We employ two well-defined bi-periodic domain concepts such that a single cell problem with a small number of particles may represent a large number of repeated structures: one is the sliding bi-periodic frame for simple shear flow and the other is the extensional bi-periodic frame for planar elongational flow. For implicit treatment of hydrodynamic interaction between particle and fluid, we use the finite-element/fictitious-domain method similar to the distributed Lagrangian multiplier (DLM) method together with the rigid ring description. The bi-periodic boundary conditions can be effectively incorportated as constraint equations and implemented by Lagrangian multipliers. The bulk stress can be evaluated by simple boundary integrals of stresslets on the particle boundary in such formulations. Some 2-D example results are presented to show effects of the solid fraction and the particle configuration on the shear and elongational viscosity along with the micro-structural evolution for both particles and fluid. Effects of the fluid elasticity has been also presented.

• 가정간호학회지
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• 제22권1호
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• pp.5-13
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• 2015

Purpose: The purpose of this study was to identify the relationship between sense of coherence and quality of life in the freshman nursing students. Method: The subjects of this study were 377 freshmen of nursing colleges. Data were collected through structured questionnaires of sense of coherence and quality of life. Data analysis was done using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient and canonical correlation analysis. Result: There was static correlation between sense of coherence and quality of life in the freshman nursing students. And high correlation with quality of life were meaningfulness in sense of coherence and psychological domain in quality of life. Conclusion: These results were shown very important to improve meaningfulness in sense of coherence and psychological domain in quality of life to raise the quality of life in the freshman nursing students. Therefore, in order to improve the quality of life, it is necessary to develop a nursing intervention program that focus on stress, and psychological health.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2005년도 춘계학술대회 논문집
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• pp.342-348
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• 2005

This study was carried out fusion-welded butt joints in SWS 490A high strength steel subjected to tensile test that load-deflection curve. The windowed or short-time Fourier transform (WFT or SIFT) makes possible for the analysis of non-stationary or transient signals into a joint time-frequency domain and the wavelet transform (WT) is used to decompose the acoustic emission (AE) signal into various discrete series of sequences over different frequency bands. In this paper, for acoustic emission signal analysis to use a continuous wavelet transform, in which the Gabor wavelet base on a Gaussian window function is applied to the time-frequency domain. A wavelet transform is demonstrated and the plots are very powerful in the recognition of the acoustic emission features. As a result, the technique of acoustic emission is ideally suited to study variables which control time and stress dependent fracture or damage process in metallic materials.