• BMB Reports
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• v.50 no.11
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• pp.539-545
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• 2017

The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated $eIF2{\alpha}$ kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understand how stressed cells coordinate gene expression at translational and transcriptional levels. The translational attenuation associated with this pathway has been largely attributed to the phosphorylation of the translational initiation factor $eIF2{\alpha}$. However, independent studies are now pointing to a second translational regulation step involving a downstream ISR target, 4E-BP, in the inhibition of eIF4E and specifically cap-dependent translation. The activation of 4E-BP is consistent with previous reports implicating the roles of 4E-BP resistant, Internal Ribosome Entry Site (IRES) dependent translation in ISR active cells. In this review, we provide an overview of the translation inhibition mechanisms engaged by the ISR and how they impact the translation of stress response genes.

• Computers and Concrete
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• v.3 no.1
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• pp.43-64
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• 2006

A tendon model that can effectively be used in finite element analyses of prestressed concrete (PSC) structures with bonded tendons is proposed on the basis of the bond characteristics between a tendon and its surrounding concrete. Since tensile forces between adjacent cracks are transmitted from a tendon to concrete by bond forces, the constitutive law of a bonded tendon stiffened by grouting is different from that of a bare tendon. Accordingly, the apparent yield stress of an embedded tendon is determined from the bond-slip relationship. The definition of the multi-linear average stress-strain relationship is then obtained through a linear interpolation of the stress difference at the post-yielding stage. Unlike in the case of a bonded tendon, on the other hand, a stress increase beyond the effective prestress in an unbonded tendon is not section-dependent but member-dependent. The tendon stress unequivocally represents a uniform distribution along the length when the friction loss is excluded. Thus, using a strain reduction factor, the modified stress-strain curve of an unbonded tendon is derived by successive iterations. The validity of the proposed two tendon models is verified through correlation studies between analytical and experimental results for PSC beams and slabs.

• Structural Engineering and Mechanics
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• v.65 no.1
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• pp.33-41
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• 2018

In this paper, using modified couple stress theory in place of classical continuum theory, and using shell model in place of beam model, vibrational behavior of nanotubes is investigated via the finite element method. Accordingly classical continuum theory is unable to correctly compute stiffness and account for size effects in micro/nanostructures, higher order continuum theories such as modified couple stress theory have taken on great appeal. In the present work the mass-stiffness matrix for cylindrical shell element is developed, and by means of size-dependent finite element formulation is extended to more precisely account for nanotube vibration. In addition to modified couple stress cylindrical shell element, the classical cylindrical shell element can also be defined by setting length scale parameter to zero in the equations. The boundary condition were assumed simply supported at both ends and it is shown that the natural frequency of nano-scale shell using the modified coupled stress theory is larger than that using the classical shell theory and the results of Ansys. The results have indicated using the modified couple stress cylindrical shell element, the rigidity of the nano-shell is greater than that in the classical continuum theory, which results in increase in natural frequencies. Besides, in addition to reducing the number of elements required, the use of this type of element also increases convergence speed and accuracy.

• Computational Structural Engineering
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• v.10 no.4
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• pp.229-238
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• 1997

Mechanical behavior of asphalt concrete that accounts for viscoelasticity and damage evolution under cyclic loading conditions is modeled and presented in this paper. An elastic-viscoelastic correspondence principle in terms of pseudo variables is applied to separately evaluate viscoelasticity and time-dependent damage growth in asphalt concrete. A microcrack growth law, which is commonly employed in linear viscoelastic fracture mechanics, is successfully used for describing the damage growth in the body. A constitutive equation in terms of stress and pseudo strain is first established for controlled-strain mode, and then transformed to controlled-stress constitutive equation by simply replacing stress and pseudo strain with pseudo stress and strain. The transformed constitutive equation in terms of pseudo stress satisfactorily predicts the mechanical behavior of asphalt concrete all the way up to failure under controlled-stress modes.

• The Journal of the Korea Contents Association
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• v.13 no.9
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• pp.193-203
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• 2013

Home care services, this study dependent family resilience and family stress, family adaptation through any route in order to examine the impact the Gwangju JeonNam home care services for elderly dependents, a survey of 203 people was conducted. The study of home care services dependent family adaptation family stress family tension without affecting the direct communication of the factors affecting indirectly through was. Based on the results of these studies look more family stress, family resilience to adapt because it affects family adaptability in order to improve the existing defects to reduce family stress perspective rather than focusing on the strengths of family resilience must be done in terms of the transition is proposed.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.28 no.1
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• pp.71-78
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• 1992

Zr-4 used for a cladding and an end plug of reactor component has creep deformation under operation at high temperature. Creep is regarded as the time dependent deformation of a material under constant applied stress. Although the major source of the deformation of zirconium component in water-cooled reactors is irradiation creep, the thermal creep may give a rise to significant deformation in reactor component especially at relatively high temperatures and at various constant stresses, and therefore it must be predicted accurately. Stress relaxation is the time dependent change of stress at constant strain and it is a process related intimately to creep. In this paper, the creep behavior and stress relaxation of Zr-4 is examined at the temperature of 50$0^{\circ}C$ that is 40% of the absolute melting temperature of Zr-4 under the stress below yield stress and under the various constant strains. The results obtained are summarized as follows: 1) With an increase of stress, the steady state creep rate increases and the creep rupture time decreases. 2) The steady state creep rate $\varepsilon$(%/s) for the stress $\sigma$sub(c) (kgf/mm super(2)) of Zr-4 increases outstandingly. All the empirical equations computed for Zr-4 increases outstandingly. All the empirical equations computed for Zr-4 are in accord with Norton's model equation($\varepsilon$=K$\sigma$ sub(c) super (n)). The constants of materials computed are as follows: K=3.9881$\times$10 super(-5), n=1.9608 3) The rupture time T sub(r) (hr) decreases linearly with the increase of stress on the log-log scaled graph. The empirical equations computed for Zr-4 are in accord with Bailey's model equation (T sub(r)=K sub(1)$\sigma$sub(c) super(m)). The constants of materials computed are as follows: K sub(1)=1.2875$\times$10 super(16), m=-3.467 4) It seems clear that the strain could be quantitatively dependent on the high temperature creep properties such as creep stress, rupture time, steady state creep rate and total creep rate. It is found that these relationships are linear on the log-log graph. 5) In stress relaxation test, as the critical constant strain that can be allowed to the specimen is larger, stress relaxation becomes more rapid, and as the constant strain is smaller, the stress relaxation becomes slower.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.05a
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• pp.316-322
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• 2002

This paper presents the temperature-dependent hysteresis identification of an electro-rheological (ER) fluid under various operating temperatures using the Preisach model. As a first step, polymethylaniline (PMA) particles are prepared and mixed with silicone oil to make an ER fluid. A couette type electroviscometer is then employed to obtain the field-dependent shear stress. In order to show the suitability of the Preisach model to predict a physical hysteresis phenomenon of the ER fluid, two significant properties; the minor loop property and the wiping-out property are experimentally examined under three dominant temperature conditions. Subsequently, the Preisach model fur the PMA-based ER fluid is identified using experimental first order descending (FOD) curves. The effectiveness of the identified hysteresis model is verified in the time domain by comparing the predicted field-dependent shear stress with the measured one under the both specified and unspecified temperatures. In addition, the hysteresis model proposed in this work is compared to Bingham model.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.12 no.8
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• pp.648-656
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• 2002

This paper presents the identification of temperature-dependent hysteresis of an electro-rheological (ER) fluid under various operating temperatures using the Preisach model. As a first step, polymethylaniline (PMA) particles are prepared and mixed with silicone oil to make an ER fluid. A couette type electroviscometer is then employed to obtain the field-dependent shear stress. In order to show the suitability of the Preisach model to predict a physical hysteresis phenomenon of the ER fluid, two significant properties; the minor loop property and the wiping-out property are experimentally examined under three dominant temperature conditions. Subsequently, the Preisach model for the PMA-based ER fluid is identified using experimental multiple first order descending (FOD) curves. The effectiveness of the identified hysteresis model is verified in the time domain by comparing the predicted field-dependent shear stress with the measured one under the both specified and unspecified temperatures. In addition, the hysteresis model proposed in this work is compared to Bingham model.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2002.04a
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• pp.41-47
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• 2002

Adverse environmental conditions such as drought, high salt and cold/freezing are major factors that reduces crop productivity worldwide. According to a survey, $50-80\%$ of the maximum potential yield is lost by these 'environmental or abiotic stresses', which is approximately ten times higher than the loss by biotic stresses. Thus, Improving stress-tolerance of crop plants is an important way to improve agricultural productivity. In order to develop such stress-tolerant crop plants, we set out to identify key stress signaling components that can be used to develop commercially viable crop varieties with enhanced stress tolerance. Our primary focus so far has been on the identification of transcription factors that regulate stress responsive gene expression, especially those involved in ABA-mediated stress response. Be sessile, plants have the unique capability to adapt themselves to the abiotic stresses. This adaptive capability is largely dependent on the plant hormone abscisic acid (ABA), whose level increases under various stress conditions, triggering adaptive response. Central to the response is ABA-regulated gene expression, which ultimately leads to physiological changes at the whole plant level. Thus, once identified, it would be possible to enhance stress tolerance of crop plants by manipulating the expression of the factors that mediate ABA-dependent stress response. Here, we present our work on the isolation and functional characterization of the transcription factors.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2002.04b
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• pp.41-47
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• 2002

Adverse environmental conditions such as drought, high salt and cold/freezing are major factors that reduces crop productivity worldwide. According to a survey, 50-80% of the maximum potential yield is lost by these 'environmental or abiotic stresses', which is approximately ten times higher than the loss by biotic stresses. Thus, improving stress-tolerance of crop plants is an important way to improve agricultural productivity. In order to develop such stress-tolerant crop plants, we set out to identify key stress signaling components that can be used to develop commercially viable crop varieties with enhanced stress tolerance. Our primary focus so far has been on the identification of transcription factors that regulate stress responsive gene expression, especially those involved in ABA-mediated stress response. Be sessile, plants have the unique capability to adapt themselves to the abiotic stresses. This adaptive capability is largely dependent on the plant hormone abscisic acid (ABA), whose level increases under various stress conditions, triggering adaptive response. Central to the response is ABA-regulated gene expression, which ultimately leads to physiological changes at the whole plant level. Thus, once identified, it would be possible to enhance stress tolerance of crop plants by manipulating the expression of the factors that mediate ABA-dependent stress response. Here, we present our work on the isolation and functional characterization of the transcription factors.