• 방사선산업학회지
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• 제5권2호
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• pp.125-130
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• 2011

The purpose of this study was to evaluate the protective effect of the Perilla frutescens cv. Chookyoupjaso mutant water extract (PFWE) on gamma ray-induced oxidative stress in mice. Gamma-ray is one of the sources for inducing oxidative stress. The study was divided into 6 groups with 6 mice for each treatment. Groups I and II were treated with saline (vehicle) only, groups III, IV, V, and VI were pretreated with PFWE 10, 20, 50, $50mg\;kg^{-1}$ respectively for 2 weeks before gamma radiation. And then groups II, III, IV, V were irradiated. We found that the activities of aspartate transaminase (AST) and alanine transaminase (ALT) were increased and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) were decreased by irradiation in mice. However, treatment of PFWE attenuated the activities of AST and ALT in a dose-dependent manner in irradiated mice. Furthermore, treatment of PFWE significantly increased the activities of SOD, GPx, and GR in a dose-dependent manner in irradiated mice, except for the CAT. Interestingly, the activities of GPx and GR were significantly increased by PFWE treatment. Taken together, PFWE could be effective in protecting on gamma ray-induced oxidative stress in mice.

• 동의생리병리학회지
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• 제38권1호
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• pp.10-15
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• 2024

Previous studies have highlighted the pivotal role of the β-adrenergic receptor (β-AR) signaling pathway in stimulating cancer metastasis induced by chronic stress. According to the theory of traditional Korean medicine, chronic stress can induce Qi stagnation. Based on the traditional role of premature citrus unshiu peel in moving Qi, we hypothesized that an ethanol extract of premature citrus unshiu peel (EPCU) can attenuate chronic stress-induced cancer progression. In this study, we investigated the potential role of EPCU on modulating the adrenergic agonists-induced metastatic properties of liver cancer cells. Our findings revealed that adrenergic agonists, including norepinephrine (NE), epinephrine (E), and isoproterenol (ISO), augmented the migratory capacity of Hep3B human hepatocellular carcinoma cells, which was completely abrogated by EPCU treatment in a concentration-dependent manner. Consistently, EPCU inhibited the E-induced invasive property of Hep3B cells in a dose-dependent manner. These results suggest that EPCU efficiently attenuates adrenergic agonists-induced metastatic abilities of liver cancer cells. As a molecular mechanism, EPF suppressed the phosphorylation of major components of β-AR signaling pathway, including Src, signal transducer and activator of transcription 3 (STAT3) and ERK, induced by E treatment. Taken together, our results demonstrate that EPCU impedes the adrenergic agonists-driven metastatic potential of cancer cells by inhibiting β-AR signaling pathway. This study provides basic evidence supporting the probable use of premature citrus unshiu peel to prevent metastasis in liver cancer patients under chronic stress.

• Advances in materials Research
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• 제12권1호
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• pp.15-29
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• 2023

In this paper, fracture analysis of a continuously inhomogeneous arch structure with two longitudinal cracks is developed in terms of the time-dependent strain energy release rate. The arch under consideration exhibits non-linear creep behavior. The cross-section of the arch is a rectangle. The material is continuously inhomogeneous along the thickness of the cross-section. The arch is loaded by two bending moments applied at its end sections. The mechanical behavior of the material is described by using a non-linear stress-strain-time relationship. The two longitudinal cracks are located symmetrically with respect to the mid-span of the arch. Due to the symmetry, only half of the arch is considered. Time-dependent solutions to strain energy release rate are obtained by analyzing the balance of the energy. For verification, time-dependent solutions to the strain energy release rate are derived also by considering the time-dependent complementary strain energy. The evolution of the strain energy release rate with the time is analyzed. The effects of material inhomogeneity, locations of the two cracks along the thickness of the arch and the magnitude of the external loading on the time-dependent strain energy release rate are evaluated.

• 터널과지하공간
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• 제14권1호
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• pp.69-77
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• 2004

암석의 시간 의존 변형거동은 암석의 가장 근본적인 역학적 성질 중의 하나이며, 크립거동의 특성과 메커니즘에 대한 연구는 지하 암반 구조물의 장기적 안정성을 평가하는데 필수적이라 할 수 있다. 이에 본 연구에서는 국내 화강암을 대상으로 단축압축하중 하에서 크립시험을 실시하였고, 수분과 응력 수준을 달리하여 각각의 조건에 따른 크립 특성을 비교, 분석하였다. 크립시험 결과 화강암은 1차, 2차 및 3차로 확연히 구분된 크립거동을 보였다. 1차 크립거동은 대체로 24시간 내에 종결되었으며, 2차 크립 변형률은 단축압축강도에 대한 재하응력의 비율이 증가함에 따라 증가하였다. 일정 응력하에서 화강암의 최대강도는 시간에 따라 감소하는 경향을 보였다. 완전 포화된 시료는 자연 건조된 시료보다 훨씬 큰 크립 변형량 및 변형률을 보였으며, 포화시료의 파괴강도 및 파괴시간은 급격히 감소하였다. 본 연구의 크립시험 결과를 버거모델(Burger's model) 및 이전 연구자들에 의해 제안된 두 개의 경험적 모델에 적용하여 크립의 유동상수를 구하였다. 세 개의 모델 모두 화강암의 크립거동을 잘 나타내었으나, 그 중 버거모델이 실험결과와 가장 잘 일치하였다. 각각의 모델에서 결정된 유동상수들은 함수량과 응력 수준에 영향을 받았다. 또한 본 실험결과에 기초하여 자연건조 및 완전 포화된 화강암 시료에 대하여 응력 수준과 시간의존변형의 경험적 관계식을 유도하였다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2003년도 봄 학술발표회 논문집
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• pp.537-544
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• 2003

This paper deals with stress corrosion cracking behavior of high strength steel exposed to marine environments. The objective is to determine the time to failure as a function of hydrogen concentration and tensile stress in the wires. A crack growth curve is modeled using finite element method (FEM) program. The coupled hydrogen diffusion-stress analyses of SCC were programmed separately. The first part is calculating stress and stress intensity /sup 1)/factor of a cylindrical shell, prestressing tendon or suspension bridge wires, from the initiation of cracks to rupture. Virtual crack extension method, contour integral method, and crack tip elements are used for the calculation of stresses in front of the crack tip. Comparisons of the result show a good agreement with the analytical equations and wire tests. The second part of the study deals with the programming of hydrogen diffusion, affected by hydrostatic stress, calculated at the location of boundary of plastic area around the crack tip. The results of paper can be used in the design and management of prestressed structures, cable stayed and suspension bridges. Time dependent correlated parallel reliabilities of a cable, composed of 36 wires, were evaluated by the consideration of the deterioration of stress corrosion cracking.

• Journal of Microbiology and Biotechnology
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• 제25권1호
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• pp.50-56
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• 2015

During pretreatment of lignocellulosic biomass, a variety of fermentation inhibitors, including acetic acid and vanillin, are released. Using DNA microarray analysis, this study explored genes of the budding yeast Saccharomyces cerevisiae that respond to vanillin-induced stress. The expression of 273 genes was upregulated and that of 205 genes was downregulated under vanillin stress. Significantly induced genes included MCH2, SNG1, GPH1, and TMA10, whereas NOP2, UTP18, FUR1, and SPR1 were down regulated. Sequence analysis of the 5'-flanking region of upregulated genes suggested that vanillin might regulate gene expression in a stress response element (STRE)-dependent manner, in addition to a pathway that involved the transcription factor Yap1p. Retardation in the cell growth of mutant strains indicated that MCH2, SNG1, and GPH1 are intimately involved in vanillin stress response. Deletion of the genes whose expression levels were decreased under vanillin stress did not result in a notable change in S. cerevisiae growth under vanillin stress. This study will provide the basis for a better understanding of the stress response of the yeast S. cerevisiae to fermentation inhibitors.

• 동아시아식생활학회지
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• 제20권3호
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• pp.352-362
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• 2010

This study was conducted to investigate the influence of obesity stress on the eating behavior of elementary school students. Using a questionnaire, 300 students in the sixth grade from 2 schools in Kyunggi-do were surveyed (Boys: N=145, Girls: N=155). Data analysis was managed by SPSS software (version 13.0). The link between obesity stress and eating habits or behaviors was dependent on physical discomfort. There was also a large group of students experienced irregularity in their meal times during the day. Furthermore, there were significant differences in mealtime among boys under psychic stress caused by obesity. In the case of dairy intake during breakfast, the significant signs of obesity stress for were physical discomfort for boys and psychic stress for the girls. It was found for both boys and girls that more frequent midnight snacking decreased the efforts to overcome obesity stress. Therefore, a professional nutrition program that can educate school children must be implemented both in school and at home. In addition to overweight or obesity children, normal weight and underweight children can also benefit from this program that includes health counseling for weight and eating behaviors.

• Computers and Concrete
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• 제16권2호
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• pp.209-222
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• 2015

This paper presents results of biaxial compressive tests and strength criterion on two replacement percentages of recycled coarse aggregate (RPRCA) by mass for plain structural recycled aggregate concrete (RAC) at all kinds of stress ratios. The failure mode characteristic of specimens and the direction of the cracks were observed and described. The two principally static strengths in the corresponding stress state were measured. The influence of the stress ratios on the biaxial strengths of RAC was also analyzed. The experimental results showed that the ratios of the biaxial compressive strength ${\sigma}_{3f}$ to the corresponding uniaxial compressive strength $f_c$ for the two RAC are higher than that of the conventional concrete (CC), and dependent on the replacement percentages of recycled coarse aggregate, stress states and stress ratios; however, the differences of tensile-compressive ratios for the two RAC and CC are smaller. On this basis, a new failure criterion with the stress ratios is proposed for plain RAC under biaxial compressive stress states. It provides the experimental and theoretical foundations for strength analysis of RAC structures subject to complex loads.

• 산경연구논집
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• 제15권3호
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• pp.31-46
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• 2024

Purpose: Employees in the beauty industry, where emotional labor is essential, are exhausted due to stress from excessive working hours and low pay, and ultimately consider changing jobs. This study analyzed the structural relationship of turnover intention according to job stress of beauty industry employees. We tried to present implications by verifying the methods necessary for conflict management in the beauty industry from an empirical point of view. Research design, data and methodology: This study selected 518 workers in the beauty industry as a sample. Frequency analysis, validity and reliability analysis, factor analysis, correlation analysis, and regression analysis were performed using SPSS (Statistical Package for Social Science) WIN23.0. Results: The moderating effect of work experience, a moderating variable, was found to be significant in the effect of job stress of beauty industry employees following changes in the employment environment on the dependent variable, turnover intention. Conclusion: This study revealed that changes in the employment environment negatively affect the job stress of beauty workers. To reduce the job stress of employees in the beauty industry, a systematic response at the organizational level will be necessary. In addition, it is expected that it will help establish differentiated strategies such as compensation system, service training, and service management to reduce job stress.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.319-322
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• 2005

When a concrete structure is subjected to load, its response is both immediate and time dependent. Under sustained load, the deformation of a structure gradually increases with time and eventually may be many time greater than its instantanneous value. The gradual development of strain with time is caused by creep and shrinkage. On this study, to estimate of stress variations on time effects in partially prestressed concrete composite girder bridges, computer program applied Age-adjusted Effective Modulus Method(AEMM) in used.