• Animal cells and systems
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• v.8 no.1
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• pp.27-32
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• 2004

Endothellial cells are subjected to hemodynamic shear stress, the dragging force generated by blood flow. Shear stress regulates endothelial cell shape, structure, and function, including gene expression. Since endothelial cells must be anchored to their extracellular matrices(ECM) for their survival and growth, we hypothesized that ECMs are crucial for shear-dependent activation of extracellular signalactivated regulated kinase(ERK) that is important for cell proliferation. Shear stress-dependent activation of ERK was observed in cells plated on two different matrices, fibronectin and vitronectin(the two most physiologically relevant ECM in endothelial cells). We then treated bovine aortic endothelial cells(BAECs) with Arg-Gly-Asp(RGD) peptides that block the functional activation of integrin binding to fibronectin and vitronectin, and a nonfunctional peptide as a control. Treatment of cells with the RGD peptides, but not the control peptide, significantly inhibited ERK activity in a concentration-dependent manner. This supports the idea that integrin adhesion to the ligands, fibronectin and vitronectin, mediates shear stress-dependent activation of ERK. Subsequently, whereas antagonists of vitronectin(LM 609, an antibody for integrin ${\alpha}_{\gamma}$/${\beta}_3$ and XT 199, an antagonist specific for integrin ${\alpha}_{\gamma}$/${\beta}_3$) did not have any effect on shear-dependent activation of ERK, antagonists of fibronectin(a neutralizing antibody for integrin ${\alpha}_5$/${\beta}_1$or ${\alpha}_4$${\beta}_1$ and SM256) had an inhibitory effect. These results clearly demonstrate that mechanoactivation of ERK requires anchoring of endothelial cells to fibronectin through integrins.

• Steel and Composite Structures
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• v.38 no.4
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• pp.355-363
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• 2021

The present paper attempts to investigate the propagation of plane waves in an isotropic elastic medium under the effect of initial stress and temperature-dependent properties. The modulus of elasticity is taken as a linear function of the reference temperature. The formulation is applied under the thermoelasticity theory with dual-phase-lag; the normal mode analysis is used to obtain the expressions for the displacement components, the temperature, the stress, and the strain components. Numerical results for the field quantities are given in the physical domain and illustrated graphically. Comparisons are made with the results predicted by different theories (Lord-Shulman theory, the classical coupled theory of thermoelasticity and the dual-phase-lag model) in the absence and presence of the initial stress as well as the case where the modulus of elasticity is independent of temperature.

• Journal of Korean Society for Quality Management
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• v.24 no.3
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• pp.19-30
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• 1996

We treat problems of estimating reliability R(t) = P[Y(t) ＞ X(t)] in the time dependent strength-stress model in which a unit of stress X(t) is subjected to environmental strength Y(t) at time t. In this paper we introduce a special model of R(t) with fixed strength and unaccumulated stress case, and propose a Mann-Whitney-Wilcoxon type estimator of R(t).

• Journal of the Korean Data and Information Science Society
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• v.10 no.1
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• pp.111-118
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• 1999

We treat the problem of estimating reliability R(t) = P[Y(t) < X(t)] in the time dependent strength-stress model in which a unit of strength X(t) is subjected to environmental stress Y(t) at time t. In this paper two nonparametric approaches to estimate of R(t) are analyzed and compared with parametric method by simulation.

• Structural Engineering and Mechanics
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• v.62 no.3
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• pp.281-289
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• 2017

Damping value has considerable influence on the dynamic and seismic behaviors of bridges. However, currently the constant damping ratios that are prescribed by most bridge seismic design codes can't truly represent the complicated damping character of actual structures. In this paper, a cyclic loading experiment was conducted to study the effect of stress amplitude on material damping of concrete to present an analyzing model of the material damping of concrete. Furthermore, based on the fundamental damping of structure measured under ambient vibration, combined with the presented stress-dependent material damping concrete, the seismic response of a bridge pier was calculated. Comparison between the calculated and experiment results verified the validity of the presented damping model. Finally, a modified design and analysis method for bridge was proposed based on stress-dependent damping theory, and a continuous rigid frame bridge was selected as the example to calculate the actual damping values and the dynamic response of the bridge under different earthquake intensities. The calculation results indicated that using the constant damping given by the Chinese seismic design code of bridges would overestimate the energy dissipation capacity of the bridge.

• Journal of Korean Society for Quality Management
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• v.18 no.1
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• pp.129-147
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• 1990

This study is to refer to the optimization problems when the stress and strength follow the time dependent model, considering a decision making process in the design methodology from reliability viewpoint. Reliability of a component can be expressed and computed if the probability distributions for the stress and strength in the time dependent case are known. The factors which determine the parameters of the distributions for stress and strength random variables can be controlled in design problems. This leads to the problem of finding the optimal values of these parameters subject to resources and design constraints. This paper is to present techniques for solving the optimization problems at the design stage like as minimizing the total cost to be spent on controlling the stress and strength parameters for random variables subject to the constraint that the component must have a specified reliability, alternatively, maximizing the component reliability subject to certain constraints on amount of resources available to control the parameters. The derived expressions and computations of reliability in the time dependent case and some optimization models of these cases are discussed. The special structure of these models is exploited to develop the optimization techniques which are illustrated by design examples.

• Structural Engineering and Mechanics
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• v.58 no.4
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• pp.731-743
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• 2016

Plastic behaviors, based on the von Mises yield criterion, of circular discs containing a purely elastic, circular inclusion under uniform temperature loading are studied with the finite element analysis. Temperature-dependent mechanical properties are considered for the matrix material only. In addition to analyzing the plane stress and plane strain disc, a 3D thin disc and cylinder are also analyzed to compare the plane problems. We determined the elastic irreversible temperature and global plastic collapse temperature by the finite element calculations for the plane and 3D problem. In addition to the global plastic collapse, for the elastically hard case, the plane stress problem and 3D thin disc may exhibit a local plastic collapse, i.e. significant pile up along the thickness direction, near the inclusion-matrix interface. The pileup cannot be correctly modeled by the plane stress analysis. Furthermore, due to numerical difficulties originated from large deformation, only the lower bound of global plastic collapse temperature of the plane stress problem can be identified. Without considerations of temperature-dependent mechanical properties, the von Mises stress in the matrix would be largely overestimated.

• Magazine of the Korean Society of Agricultural Engineers
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• v.38 no.2
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• pp.133-144
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• 1996

To get accurate results, the realistic stress-strain relationships of soils are dependent on a number of factors such as soil types, density, stress levels and stress path. Such attempts are continuously being made by the developement of analytical models for soils incorporating all such factors. Isotropic compression-expansion test and a series of drained conventional triaxial tests with several stress path for Baekma river sand were performed to investigate parameters characteristics of Lade's single work hardening model dependant on the stress path. Using the computer program based on the regression analysis, the values of parameters for the model were determined. In conclusion, the parameters of Lade's model are little influenced by the stress paths. Though yield criterion parameters ( h, ${\alpha}$a) are much influenced by stress level and stress path, the parameters don't have influence on stress-strain behavior.

• Coupled systems mechanics
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• v.8 no.3
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• pp.273-287
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• 2019

Elastoplastic analysis of an annular disc, being fully constrained on its outer rim and interacting with a purely elastic inclusion perfectly bonded with its inner rim, is conducted to study its plastic deformation and residual stress under thermal cycles. The system is termed the composite disc. Quasi-static plane-strain deformation is assumed, and the von Mises yield criterion with or without the Ludwik hardening rule is adopted in our finite element calculations. Effects of multiple material properties simultaneously being temperature dependent on the plastic behavior of the composite disc are considered. Residual stress is analyzed from a complete loading and unloading cycle. Results are discussed for various inclusion radii. It is found that when temperature dependent material properties are considered, the maximum residual stress may be greater than the maximum stress inside the disc at the temperature-loaded state due to lower temperature having larger yield stress. Temperature independent material properties overestimate stresses inside materials, as well as the elastic irreversible temperature and plastic collapse temperature.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.6
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• pp.104-112
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• 2014

Generally, numerical approaches of evaluation for vehicle seat comfort have been studied without considering time-dependent characteristics and the only seating moment have been considered in seat design. However, the comfort not only at the seating moment but also in the long-term should be evaluated because the passengers are sitting repeatedly on the seat to drive the vehicle for hours. So, the aim of this paper is to carry out a quantitative evaluation of the time-dependent mechanical characteristics of seat foams and to suggest a process for predicting the viscoelastic deformation of seat foam in response to long-term driving. To characterize the seat materials, uniaxial compression and tension tests were carried out for the seat foam and stress relaxation tests were performed for evaluating the viscoelastic behavior of the seat foam. A unit solid element model was used to verify the reliability of the material model with respect to the compression behavior of the seat foam. It is not straightforward to evaluate the time-dependent compression of foams using the explicit solver because the viscoelastic material model is limited. To use the explicit solver, the material model must be modified using stress-degradation data. Normalized stress relaxation moduli were added to the stress-strain curves obtained under static conditions to achieve a time-dependent set of stress-strain relations that were compatible with the implicit solver. There was good agreement between the analysis results and experimental data.