• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.17 no.2
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• pp.183-202
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• 2019

For design and performance assessment of a high-level radioactive waste (HLW) disposal system, it is necessary to understand the characteristics of coupled thermo-hydro-mechanical (THM) behavior. However, in previous studies for the Korean Reference HLW Disposal System (KRS), thermal analysis was performed to determine the spacing of disposal tunnels and interval of disposition holes without consideration of the coupled THM behavior. Therefore, in this study, TOUGH2-MP/FLAC3D is used to conduct THM modeling for performance assessment of the Korean Reference HLW Disposal System (KRS). The peak temperature remains below the temperature limit of $100^{\circ}C$ for the whole period. A rapid rise of temperature caused by decay heat occurs in the early years, and then temperature begins to decrease as decay heat from the waste decreases. The peak temperature at the bentonite buffer is around $96.2^{\circ}C$ after about 3 years, and peak temperature at the rockmass is $68.2^{\circ}C$ after about 17 years. Saturation of the bentonite block near the canister decreases in the early stage, because water evaporation occurs owing to temperature increase. Then, saturation of the bentonite buffer and backfill increases because of water intake from the rockmass, and bentonite buffer and backfill are fully saturated after about 266 years. The stress is calculated to investigate the effect of thermal stress and swelling pressure on the mechanical behavior of the rockmass. The calculated stress is compared to a spalling criterion and the Mohr-Coulumb criterion for investigation of potential failure. The stress at the rockmass remains below the spalling strength and Mohr-Coulumb criterion for the whole period. The methodology of using the TOUGH2-MP/FLAC3D simulator can be applied to predict the long-term behavior of the KRS under various conditions; these methods will be useful for the design and performance assessment of alternative concepts such as multi-layer and multi-canister concepts for geological spent fuel repositories.

• Journal of Life Science
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• v.23 no.9
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• pp.1079-1087
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• 2013

Speed germination success and robust vegetative growth of citrus rootstock through improved sowing methods and fertilizer inputs offer the usage of root system for the citrus. The current study evaluated the influence of seed coat removal and different fertilizer concentrations on plant germination and plant growth of spontaneous rootstock siblings. Decoated and coated seeds of diploid and tetraploid plants were sown in tubes. Commercial fertilizer concentrations of 0, 2, 4, 6, 8 and $10g{\cdot}l^{-1}$ were added. The experimental layout followed a randomized block $2{\times}6$ factorial design (seed coat removal ${\times}$ fertilizer concentration) for each rootstock. Fertilizer concentrations were 0, 10, 20 and $30g{\cdot}l^{-1}$ of the fertilizer for the resistance of the strength on the salt level. The germination rate of seeds without testa sown in vitro was improved (67-80%) compared to that of nontreated seeds. The eventual tree height of the seeds without testa in the diploid group was increased due to higher fertilization compared to that in the nontreated group. The removal of seed testa promoted the seed germination of both diploid and tetraploid trifoliate orange and resulted in greater height. Their vegetative development was also increased due to the increased fertilization of the rootstock. The Fv/Fm value for the diploid plants was 0.4 and 0.8 for the tetraploid ones under salt stress after 11 days of treatment. The removal of seed testa may improve the seed germination of trifoliate orange. Tetraploid trifoliate orange appears to possess resistance to salt stress compared to the diploid variety.

• The Journal of the Petrological Society of Korea
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• v.15 no.4 s.46
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• pp.180-193
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• 2006

The Gilan area in the central-northern part of Uiseong Block of Cretaceous Gyeongsang Basin is composed of Precambrian metamorphic rocks, Triassic Cheongsong granite, Early Cretaceous Hayans Group, and Late Cretaceous-Paleocene igneous rocks. In this area, the faults of various directions are developed: Oksan fault of $NS{\sim}NNW$ trend, Gilan fault of NW trend, Hwanghaksan fault of WNW trend, and Imbongsan fault of EW trend. Several fracture sets with various geometric indicators, which determine their relative timing (sequence and coexistence relationships) and shear sense, we well observed in the Cheongsong granite, the basement of Gyeongsang Basin. The aim of this study is to determine the development sequence of extension fractures and the movement sense of shear fractures in the Gitan area on the basis of detailed analysis of their geometric indicators (connection, termination, intersection patterns, and cross-cutting relations). This study suggests that the fracture system of the Gilan area was formed at least through seven different fracturing events, named as Pre-Dn to Dn +5 phases. The orientations of fracture sets show (W) NW, NNW, NNE, EW, NE in descending order of frequency. The orientation and frequency patterns are concordant with those of faults around and in the Gilan area on a geological map scale. The development sequence and movement sense of fracture sets are summarized as follows. (1) Pre-Dn phase: extension fracturing event of $NS{\sim}NNW$ and/or $WNW{\sim}ENE$ trend. The joint sets of $NS{\sim}NNW$ trend and of $WNW{\sim}ENE$ trend underwent the reactivation histories of sinistral ${\rightarrow}$dextral${\rightarrow}$sinistral shearing and of (dextral${\rightarrow}$) sinistral shearing with the change of stress field afterward, respectively. (2) Dn phase: that of NW trend. The joint set experienced the reactivations of sinistral${\rightarrow}$dextral shearing. (3) Dn + 1 phase: that of $NNE{\sim}NE$ trend. The joint set was reactivated as a sinistral shear fracture afterward. (4) Dn +2 phase: that of $ENE{\sim}EW$ trend. (5) Dn +3 phase: that of $WNW{\sim}NW$ trend. (6) Dn+4 phase: that of NNW trend. The joint set underwent a dextral shearing after this. (7) The last Dn +5 phase: that of NNE trend.

• The Korean Journal of Petroleum Geology
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• v.2 no.2 s.3
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• pp.59-70
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• 1994

The Cenozoic geological structures and the tectonic evolution of the southern Ulleung Basin were studied with seismic profiles and exploration well data. Basement structure of the Korea Strait is distinctly characterized by normal faults trending northeast to southwest. The normal faults of the basement are most likely related to the initial liking and extensional tectonics of Ulleung Basin. Tsushima fault along the west coast of Tsushima islands runs northeastward to the central Ulleung Basin. The Middle Miocene and older sequences in the Tsushima Strait show folds and faults mostly trending northeast to southwest. These folds and faults may be interpreted as a result of compressional tectonics. The Late Miocene to Qauternary sequences are not much deformed, but numerous faults mostly N-S trending are dominated in the Tsushima Strait. The Ulleung Basin was in intial rifting during Oligocene, and then active extension and subsidence from Early to early Middle Miocene. Therefore SW Japan separated from Korea Peninsula and drifted toward southeast, and Ulleung Basin was formed as a pull-apart basin under dextral transtensional tectonic regime. During rifting and extensional stage, Tsushima fault as a main tectonic line separating SW Japan block from the Korean Peninsula acted as a normal faulting with right-lateral strike-slip motion as SW Japan drifted southeastward. During middle Middle Miocene to early Late Miocene, the opening of Ulleung basin stopped and uplifted due to compressional tectonics. The southwest Japan block converging on the Korean Peninsula caused compressional stress to the southern margin of Ulleung Basin, resulting in strong deformation under sinistral transpressional tectonic regime. Tsushima fault acted as thrust fault with left-lateral strike-slip motion. From middle Late Miocene to Quaternary, the southern margin of Ulleung Basin has been controlled by compressional motion. Thus the Tsushima fault still appears to be an active thrust fault by compressional tectonic regime.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.8
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• pp.1035-1041
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• 2013

To evaluate the structural integrity and dynamic characteristic of the knuckle part of a KTX anti-roll bar, an experimental and a numerical approach were used in this study. In the experimental approach, the acceleration and strain data for the knuckle parts of the KTX and KTX-SANCHUN anti-roll bar were respectively measured to evaluate and compare its structural dynamic characteristics under the operating environments of the Honam line. In the numerical approach, the evaluation of its structural integrity was conducted using LS-DYNA 3D, and then, the reliability of the finite element model used was ensured by a comparative evaluation with the experiment. The numerical results showed that the stress and velocity field of the knuckle part composed of a layered structure of a thin steel plate and rubber were more moderate than those of the knuckle part made of only a thick steel block owing to the reduction of relative contact between the knuckle and the connecting rod. It was found that the knuckle part made of a thin steel plate and rubber was recommended as the best solution to improve its structural integrity resulting from the elastic behavior of the KTX anti-roll bar being enabled under a repeating external force.

• Journal of the Korea institute for structural maintenance and inspection
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• v.9 no.4
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• pp.119-126
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• 2005

The objective of this paper is to evaluate the flexural tensile strength of unreinforced concrete masonry wall to ensure the structural safety in out-of-plane behaviors under the wind or earthquake loads. Flexural tensile strength of unreinforced concrete masonry wall has been obtained from the full scale tests of total 327 specimens and the statistical analysis are performed for each of the cases. The flexural tensile strength derived from experiments is classified as 13 groups according to masorny units, mortar ingredients, and the direction of tensile stresses and the mean tensile strength and the variable coefficient are obtained for each case. The uniform and concentrated transverse loads have been applied over the face of the wall specimens. The ultimate mean flexural tensile strengths are distributed from 1,564 kPa to 363 kPa according to masonry units, mortar ingredients, and other factors. The allowable flexural tension stress criteria will be established based on the mean flexural tensile strengths in the future.

• Journal of the Korean Society for Heat Treatment
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• v.14 no.3
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• pp.160-166
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• 2001

The change of ribbon geometry, microstructure and shape recovery with Mn contents, wheel speed and various annealing temperature have been studied in Fe-X%Mn-5Cr-5Co-4Si (X%=15, 20, 24) shape memory alloy (SMA) ribbons rapidly solidfied by single roll chill-block melt-spinning process. The thickness and width of melt-spun ribbons are reduced, results in refining and uniformalizing grains with increasing wheel speed. In the ribbons melt-spun at a wheel speed of 15m/sec, both ${\varepsilon}$ and ${\alpha}^{\prime}$martensites are formed in ribbon 1 (15.5wt%Mn), while only ${\varepsilon}$ martensite is revealed in ribbon 2 (20.2wt%Mn) and ribbon 3 (23.5wt%Mn). The volume fraction of ${\varepsilon}$ martensite is decreased with increasing Mn contents, and those of ${\varepsilon}$ as well ${\alpha}^{\prime}$martensites are increased due to thermal stress relief and grain growth with increasing annealing temperature. Ms temperatures of the ribbons 1, 2 and 3 are fallen with increasing Mn contents. $M_s$ temperatures of the ribbons 1, 2 and 3 annealed at $300^{\circ}C$ for 3 min are risen abruptly, but are nearly constant even at higher annealing temperature, i.e., 400, 500 and $600^{\circ}C$ for 3 min. Shape recovery of the ribbons 1, 2 and 3 increased 30%, 52% and 69% with Mn contents, respectively. Shape recovery of ribbon 1 (15.5wt%Mn) formed ${\varepsilon}$ and ${\alpha}^{\prime}$martensites decreased because of the presence of ${\alpha}^{\prime}$martensite but those of ribbon 2 (20.2wt%Mn) and ribbon 3 (23.5wt%Mn) formed ${\varepsilon}$ martensite increased with increasing annealing temperature.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.3
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• pp.315-324
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• 2016

Human cardiac fibroblasts (HCFs) have various voltage-dependent $K^+$ channels (VDKCs) that can induce apoptosis. Hydrogen peroxide ($H_2O_2$) modulates VDKCs and induces oxidative stress, which is the main contributor to cardiac injury and cardiac remodeling. We investigated whether $H_2O_2$ could modulate VDKCs in HCFs and induce cell injury through this process. In whole-cell mode patch-clamp recordings, application of $H_2O_2$ stimulated $Ca^{2+}-activated$ $K^+$ ($K_{Ca}$) currents but not delayed rectifier $K^+$ or transient outward $K^+$ currents, all of which are VDKCs. $H_2O_2-stimulated$ $K_{Ca}$ currents were blocked by iberiotoxin (IbTX, a large conductance $K_{Ca}$ blocker). The $H_2O_2-stimulating$ effect on large-conductance $K_{Ca}$ ($BK_{Ca}$) currents was also blocked by KT5823 (a protein kinase G inhibitor) and 1 H-[1, 2, 4] oxadiazolo-[4, 3-a] quinoxalin-1-one (ODQ, a soluble guanylate cyclase inhibitor). In addition, 8-bromo-cyclic guanosine 3', 5'-monophosphate (8-Br-cGMP) stimulated $BK_{Ca}$ currents. In contrast, KT5720 and H-89 (protein kinase A inhibitors) did not block the $H_2O_2-stimulating$ effect on $BK_{Ca}$ currents. Using RT-PCR and western blot analysis, three subtypes of $K_{Ca}$ channels were detected in HCFs: $BK_{Ca}$ channels, small-conductance $K_{Ca}$ ($SK_{Ca}$) channels, and intermediate-conductance $K_{Ca}$ ($IK_{Ca}$) channels. In the annexin V/propidium iodide assay, apoptotic changes in HCFs increased in response to $H_2O_2$, but IbTX decreased $H_2O_2$-induced apoptosis. These data suggest that among the VDKCs of HCFs, $H_2O_2$ only enhances $BK_{Ca}$ currents through the protein kinase G pathway but not the protein kinase A pathway, and is involved in cell injury through $BK_{Ca}$ channels.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.12
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• pp.1796-1802
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• 2017

Objective: This experiment was conducted to evaluate the optimal space allowance on growth performance, blood profile and pork quality of growing-finishing pigs. Methods: A total of ninety crossbred pigs [$(Yorkshire{\times}Landrace){\times}Duroc$, $30.25{\pm}1.13kg$] were allocated into three treatments (0.96: four pigs/pen, $0.96m^2/pig$; 0.80: five pigs/pen, $0.80m^2/pig$; 0.69: six pigs/pen, $0.69m^2/pig$) in a randomized complete block design. Pigs were housed in balanced sex and had free access to feed in all phases for 14 weeks (growing phase I, growing phase II, finishing phase I, and finishing phase II). Results: There was no statistical difference in growing phase, but a linear decrease was observed on average daily gain (ADG, p<0.01), average daily feed intake (ADFI, p<0.01), and body weight (BW, p<0.01) with decreasing space allowance in late finishing phase. On the other hand, a quadratic effect was observed on gain to feed ratio in early finishing phase (p<0.03). Consequently, overall ADG, ADFI, and final BW linearly declined in response to decreased space allowance (p<0.01). The pH of pork had no significant difference in 1 hour after slaughter, whereas there was a linear decrease in 24 h after slaughter with decreasing space allowance. Floor area allowance did not affect pork colors, but shear force linearly increased as floor space decreased (p<0.01). There was a linear increase in serum cortisol concentration on 14 week (p<0.05) with decreased space allocation. Serum IgG was linearly ameliorated as space allowance increased on 10 week (p<0.05) and 14 week (p<0.01). Conclusion: Data from current study indicated that stress derived from reduced space allowance deteriorates the immune system as well as growth performance of pigs, resulting in poor pork quality. Recommended adequate space allowance in a grow-to-finish production system is more than $0.80m^2/pig$ for maximizing growth performance and production efficiency.