• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 춘계학술발표대회
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• pp.541-545
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• 2000

For the sustained release formulation of recombinant human growth hormone (rhGH), dissociable rhGH aggregates were microencapsulated within poly(D,L-lactic-co-glycolic acid) [PLGA] microparticles. rhGH aggregates with 2 - 3 m Particle diameter were first produced by adding a small volume of aqueous rhGH solution into a partially water miscible organic solvent phase(ethyl acetate) containing PLGA. These rhGH aggregates were then microencapsulated within PLGA polymer phase by extracting ethyl acetate into an aqueous phase pre-saturated with ethyl acetate. The resultant microparticles were 2 - 3 m in diameter similar to the size of rhGH aggregates, suggesting that PLGA polymer was coated around the protein aggregates. Release profiles of rhGH from these microparticles were greatly affected by changing the volume of the incubation medium. The release rhGH species consisted of mostly monomeric form with having a correct conformation. This study reveals that sustained rhGH release could be achieved by microencapsulating reversibly dissociable protein aggregates within biodegradable polymers.

• Journal of Astronomy and Space Sciences
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• 제19권2호
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• pp.107-122
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• 2002

Multi-body spacecraft attitude and configuration control formulations based on the use of collaborative control theory are considered. The control formulations are based on two-player, nonzero-sum, differential game theory applied using a Nash strategy. It is desired that the control laws allow different components of the multi-body system to perform different tasks. For example, it may be desired that one body points toward a fixed star while another body in the system slews to track another satellite. Although similar to the linear quadratic regulator formulation, the collaborative control formulation contains a number of additional design parameters because the problem is formulated as two control problems coupled together. The use of the freedom of the partitioning of the total problem into two coupled control problems and the selection of the elements of the cross-coupling matrices are specific problems ad-dressed in this paper. Examples are used to show that significant improvement in performance, as measured by realistic criteria, of collaborative control over conventional linear quadratic regulator control can be achieved by using proposed design guidelines.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1998년도 봄 학술발표회 논문집
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• pp.53-59
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• 1998

A new algorithm using meshless particle method for the analysis of crack propagation problems is presented. The meshless particle method requires only a set of nodes and the description of boundaries in its formulation. The method is particulary useful for crack propagation problems due to the absence of any predefined element connectivity. Formulation procedures for the construction of displacement and shape functions are described. A numerical integration scheme and a strategy for the consideration of crack propagation are also described. Numerical examples show that the proposed method is very convenient and efficient in modeling crack problems and can guarantee the accuracy of solution in crack propagation analysis.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2005년도 공동추계학술대회
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• pp.379-390
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• 2005

In this paper, we introduce a new combinatorial auction mechanism - N-Bilateral Optimized Combinatorial Auction (N-BOCA). N-BOCA is a flexible iterative combinatorial auction model that offers optimized trading for multi-suppliers and multi-purchasers in the supply chain. We design the N-BOCA system from the perspectives of architecture, protocol, and trading strategy. Under the given N-BOCA architecture and protocol, auctioneers and bidders have diverse decision strategies for winner determination. This needs flexible modeling environments. Hence, we propose an optimization modeling agent for bid and auctioneer selection. The agent has the capability to automatic model formulation for Integer Programming modeling. Finally, we show the viability of N-BOCA through prototype and experiments. The results say both higher allocation efficiency and effectiveness compared with I-to-N general combinatorial auction mechanisms.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.248-250
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• 2003

An automatic approach and strategy for extracting building information from aerial images using combined image analysis and interpretation techniques is described in this paper. A dense DSM is obtained by stereo image matching. Multi-band classification, DSM, texture segmentation and Normalised Difference Vegetation Index (NDVI) are used to reveal building interest areas. Then, based on the derived approximate building areas, a shape modelling algorithm based on the level set formulation of curve and surface motion has been used to precisely delineate the building boundaries. Data fusion, based on the Dempster-Shafer technique, is used to interpret simultaneously knowledge from several data sources of the same region, to find the intersection of propositions on extracted information derived from several datasets, together with their associated probabilities. A number of test areas, which include buildings with different sizes, shape and roof colour have been investigated. The tests are encouraging and demonstrate that the system is effective for building extraction, and the determination of more accurate elevations of the terrain surface.

• Advances in aircraft and spacecraft science
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• 제3권3호
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• pp.317-330
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• 2016

Nowadays, the interest of aerospace and automotive industries on virtual testing of medium-frequency vibrational behavior of shallow shell structures is growing. The development of software capable of predicting the vibrational response in such frequency range is still an open question because classical methods (i.e., FEM, SEA) are not fully suitable for the medium-frequency bandwidth. In this context the Variational Theory of Complex Rays (VTCR) is taking place as an ad-hoc technique to address medium-frequency problems. It is a Trefftz method based on a weak variational formulation. It allows great flexibility because any shape function that satisfies the governing equations can be used. This work further develops such theory. In particular, orthotropic materials are introduced in the VTCR formulation for shallow shell structures. A significant numerical example is proposed to show the strategy.

• 기술혁신학회지
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• 제14권4호
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• pp.983-999
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• 2011

본 논문에서는 기술융합화에 따른 경기도 농업분야의 블루오션 전략으로 경기도 식물공장(vertical farm) 추진의 전략방향을 고찰하고, 이를 위한 과학기술 유관기관간 협력방안을 모색하여 본다. 기술 융복합 성격이 매우 강한 사업의 추진은 사업추진 초기부터 협력을 위한 전략 프레임을 설정하고 이에 따라 협력체계를 구축하는 것이 성공의 열쇠가 될 수 있다. 본 논문에서는 경기도 식물공장의 추진의 미래상을 시나리오플래닝을 통하여 고찰하여 보고, 이의 달성을 위한 향후 식물공장 추진 방향을 고찰한다. 농업기술 융복합 혁신의 산물인 식물공장 추진의 전략방향을 시나리오플래닝을 통하여 다차원적으로 고찰한 본 논문은 융복합 기술관련 연구 조직에게 큰 함의를 제공할 수 있을 것으로 기대한다.

• Journal of Ginseng Research
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• 제42권4호
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• pp.512-523
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• 2018

Background: 20(S)-Protopanaxadiol (20S-PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal antiaging activity. However, because of its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20S-PPD. Methods: MEs and MEHs were formulated and evaluated for their particle size distribution, morphology, drug loading capacity, and stability. Then, the deposition profiles of the selected 20S-PPD-loaded MEH formulation were studied using a hairless mouse skin model and Strat-M membrane as an artificial skin model. Results: A Carbopol-based MEH system of 20S-PPD was successfully prepared with a mean droplet size of 110 nm and narrow size distribution. The formulation was stable for 56 d, and its viscosity was high enough for its topical application. It significantly enhanced the in vitro and in vivo skin deposition of 20S-PPD with no influence on its systemic absorption in hairless mice. Notably, it was found that the Strat-M membrane provided skin deposition data well correlated to those obtained from the in vitro and in vivo mouse skin studies on 20S-PPD (correlation coefficient $r^2=0.929-0.947$). Conclusion: The MEH formulation developed in this study could serve as an effective topical delivery system for poorly soluble ginsenosides and their deglycosylated metabolites, including 20S-PPD.

• 품질경영학회지
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• 제28권1호
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• pp.132-150
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• 2000

TQM is considered as a kind management innovation tools. Managers are apt to be embarrassed in face of too many emerging and diminishing faddish management innovation tools. In spite of their expected usefulness, the result of implementation used to be depressing. One of the most important things for successful implementation is to understand their correct usefulness and characteristics. This paper analyzes the characteristics of TQM as innovation tool by comparing TQM with other management innovation tools in terms of criteria derived in view of competitive strategy formulation.

• 한국항해학회지
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• 제24권5호
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• pp.361-371
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• 2000

This paper treats a genetic algorithm for ship scheduling problem in set packing formulation. We newly devised a partition based representation of solution and compose initial population using a domain knowledge of problem which results in saving calculation cost. We established replacement strategy which makes each individual not to degenerate during evolutionary process and applied adaptive mutate operator to improve feasibility of individual. If offspring is feasible then an improve operator is applied to increase objective value without loss of feasibility. A computational experiment was carried out with real data and showed a useful result for a large size real world problem.