• Proceedings of the KSME Conference
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• 2002.08a
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• pp.707-708
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• 2002

Catheters are used to measure translesional pressure gradients in the stenosed coronary arteries. Catheter insertions during coronary angioplasty cause flow obstructions. A narrowed flow cross section with catheter present effectively introduced a tighter stenosis than the enlarged residual stenoses after balloon angiplasty. In general, the form of stenoses are no uniform. Sometimes, these are occurred the irregularly eccentricity If the analyses are conducted for uniform stenosed artery, the results will be underestimated. Thus, in this study, three dimensional computer simulations are conducted to investigate the flow blockage effects due to the catheter insertion during the coronary angioplasty. The results for the eccentric stenosed artery are compared with those of the concentric stenosed artery.

• Journal of Biomedical Engineering Research
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• v.20 no.5
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• pp.617-624
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• 1999

• Journal of Mechanical Science and Technology
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• v.19 no.6
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• pp.1313-1320
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• 2005

Stenosed coronary artery may play an important role in various coronary heart diseases. However, it has not been known how much stenosed coronary artery affects coronary circulation system, quantitatively. The present study developed a mathematical model for microcirculation in the left common coronary artery (LCCA) with adopting a previously measured morphological data and mechanical properties of the coronary vessels. We examine the effect of percent diameter stenosis on blood flow rate and shear stress for two cases. Case I comprised of one-stenosed element at $10^{th}$ order ($\%$ diameter stenosis are 10, 30, and 50, respectively). Case II consisted of completely occluded element at $10^{th}$ order (number of occluded elements are 0, 1, and 2 out of 8, respectively). As the level of stenosis becomes severe, the shear stress increases significantly but the flow rate reduction was relatively small. However, for the occluded case, there was linearly proportional reduction of flow rate according to number of occluded elements. Either such high shear stress associated with coronary artery stenosis or reduced flow rate due to occlusion may cause atherosclerosis and myocardial ischemia.

• Korea-Australia Rheology Journal
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• v.20 no.4
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• pp.189-196
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• 2008

The pulsatile flow of blood through a stenosed artery under the influence of external periodic body acceleration is studied. The effect of non-Newtonian nature of blood in small blood vessels has been taken into account by modeling blood as a Casson fluid. The non-linear coupled equations governing the flow are solved using perturbation analysis assuming that the Womersley frequency parameter is small which is valid for physiological situations in small blood vessels. The effect of pulsatility, stenosis, body acceleration, yield stress of the fluid and pressure gradient on the yield plane locations, velocity distribution, flow rate, shear stress and frictional resistance are investigated. It is noticed that the effect of yield stress and stenosis is to reduce flow rate and increase flow resistance. The impact of body acceleration is to enhance the flow rate and reduces resistance to flow.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1919-1922
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• 2003

Bypass anastomosis are frequently adopted for surgical treatments. After the bypass grafting, the bypass artery is often occluded due to restenosis and/or anastomotic neointimal fibrous hyperplasia phenomena. Optimal coronary bypass anastomosis should be investigated to improve the patency for the arterial bypass techniques. The objective of this study is to investigate the influence of bypass with sequential bypass effects in the stenosed coronary artery. Numerical analyses are focused on the understanding of the flow patterns for different sequential anastomosis techniques. Blood flow field is treated as two-dimensional incompressible laminar flow. The finite volume method is adopted for discretization of the governing equations. The Carreau model is employed as the constitutive equation for blood. To find the optimal sequential bypass anastomotic configurations, the mass flow rates at the outlet of different models are compared quantitatively.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.2
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• pp.153-159
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• 2012

Bypass anastomosis is frequently adopted for surgical treatments of stenosed coronary arteries. Optimal coronary bypass grafting should be investigated to improve the patency in arterial bypass techniques. The objective of this study is to analyze the effects of Y-grafting bypasses and T-grafting bypasses for various bifurcation and anastomotic angles. In order to find the optimal geometric configuration, the hemodynamic characteristics are obtained and compared with each other for different geometries. We found that both the left anterior descending artery (LAD) and left circumflex artery (LCX) blood flows were distributed evenly when the bypass grafting angle and bifurcated angle were $30^{\circ}$ and $15^{\circ}$, respectively,.

• Korea-Australia Rheology Journal
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• v.21 no.3
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• pp.175-183
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• 2009

This article describes the numerical investigation of blood flow in the stenosed artery bifurcation with acceleration of the human body. Using the commercial software FLUENT, three-dimensional analyses were performed for six simulation cases with different body accelerations and bifurcation angles. The blood flow was considered to be pulsation flow, and the blood was considered to be a non-Newtonian fluid based on the Carreau viscosity model. In order to consider periodic body acceleration, a modified, time-dependent, gravitational-force term was used in the momentum equation. As a result, flow variables, such as flow rate and wall shear stress, increase with body acceleration and decrease with bifurcation angle. High values of body acceleration generate back flow during the diastolic period, which increases flow fluctuation and the oscillatory shear index at the stenosis.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.717-720
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• 2002

The present study is to evaluate the performances of flow velocity and wall shear stress in the stenosed coronary artery using human in vivo hemodynamic Parameters and computer simulation. Initial and follow-up coronary angiographics in the patients with angulated coronary stenosis are performed. Follow-up coronary angiogram demonstrated significant difference in the percent of diameter in the stenosed coronary between two groups ($Group\;1:\;40.3{\%},\;Group\;2:\;25.5{\%}$). Flow-velocity wave obtained from in vivo intracoronary Doppler ultrasound data is used for the boundary condition for the computer simulation. Spatial and temporal variations of flow velocity vector and recirculation area are drawn throughout the selected segment of coronary models. The WSS of pre- and post-intracoronary stenting are calculated from three-dimensional computer simulation. Then negative shear stresses area on 3D simulation we noted on the inner wall of the post-stenotic area before stenting. The negative WSS is disappeared after stenting. High spatial and temporal WSS before stenting fell into within physiologic WSS after stenting. This finding was prominent in Model 2. The present study suggest that hemodynamic forces exerted by pulsatile coronary circulation termed WSS might affect on the evolution of atherosclerosis within the angulated vascular curvature. The local recirculation area which has low or negative WSS, might lead to progression of atherosclerosis.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.111-115
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• 1997

The objective of present study is to obtain information about stenosis effects on the blood flow in the coronary artery bifurcation. The three dimensional steady of blood in the coronary artery bifurcation with stenosis and without stenosis are simulated using the finite volume method. Apparent viscosity of blood is represented as a function of shear rate by the Carreau models. Velocities vectors and wall shear stresses along the branch tubes with stenosis are compared with those of without stenosis for steady flows. Flow phenomena in the stenosed branch tubes are discussed extensively.

• 순환기질환의공학회:학술대회논문집
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• 2002.11a
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• pp.50-51
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• 2002