• Journal of Pharmaceutical Investigation
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• 제34권5호
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• pp.379-383
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• 2004

Statistical interpretations in a bioequivalence trial are considered and studied when the missing observations occurred in $2\;{\times}\;2$ crossover experiment. Patel (1985) suggested the approximate test procedures for carryover effect and drug effect in $2\;{\times}\;2$ crossover design when some of data are missing in the second period. A modified Patel method is newly proposed to the bioequivalence trial and it is compared with the current method through the simulation study.

• Journal of the Korean Statistical Society
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• 제24권2호
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• pp.453-470
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• 1995

We describe a constrained optimal classification rule for the case when the prior probability of an observation belonging to one of the two populations is unknown. This is done by suggesting a balanced design for the classification experiment and constructing the optimal rule under the balanced design condition. The rule si characterized by a constrained minimization of total risk of misclassification; the constraint of the rule is constructed by the process of equation between Kullback-Leibler's directed divergence measures obtained from the two population conditional densities. The efficacy of the suggested rule is examined through two-group normal classification. This indicates that, in case little is known about the relative population sizes, dramatic gains in accuracy of classification result can be achieved.

• 응용통계연구
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• 제11권2호
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• pp.303-315
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• 1998

요인실험에서 어떤 처리조합은 조작상 또는 경제적인 이유로 실험할 수 없는 경우가 있다. 이러한 실험불가능한 처리조합을 포함하고 있는 일부실시법은 불균형적인 처리조합을 구성하게 되어 어떤 요인효과에 대해 추론할 수 없게 된다. 본 논문은 실험불가능한 처리조합을 포함하지 않는 3$^{n-p}$ 일부실시법을 실행하기 위한 정의 대비의 선택 방법을 논한다한다

• 품질경영학회지
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• 제40권1호
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• pp.15-24
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• 2012

For the construction of fractional factorial designs, the various arrays can be widely used. In this paper we review the statistical properties of fractional designs constructed by two arrays such as orthogonal array and partially balanced array, and develop a quick and easy method for analyzing unreplicated saturated designs. The proposed method can be characterized that we control the error rate by experiment-wise way and exploit the multivariate Student $t$-distribution. Especially the proposed method can be used efficiently together with some exploratory analysis methods, such as half normal probability plot method.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1990년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 26-27 Oct. 1990
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• pp.1204-1209
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• 1990

This paper offers the theory and method for regression analysis of the regression model with operational parameter variables based on the fundamentals of mathematical statistics. Regression coefficients are usually constants related to the problem of regression analysis. This paper considers that regression coefficients are not constants but the functions of some operational parameter variables. This is a kind of method of two-step fitting regression model. The second part of this paper considers the experimental step numbers as recursive variables, the recursive identification with unknown operational parameter variables, which includes two recursive variables, is deduced. Then the optimization and the recursive identification are combined to obtain the sequential experiment optimum design with operational parameter variables. This paper also offers a fast recursive algorithm for a large number of sequential experiments.

• 응용통계연구
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• 제11권2호
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• pp.451-459
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• 1998

반응표면분석에서 다반응값의 최적화 문제는 단반응값 최적화문제보다 복잡하다. 이런 다반응값 문제에서 반응변수들이나 설명변수 상호간의 관계나 중요성 등을 평가하는 것은 중요하다. 이러한 평가를 위하여 biplot를 이용할 수 있는데, 1차 회귀모형이 적합치 않은 경 우, 2차 회귀모형을 위한 순차적 실험계획을 이용하여 2차 회귀 모형에 대응되는 biplot를 그려 선형 및 비선형효과를 알 수 없게 된다.

• 응용통계연구
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• 제20권2호
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• pp.267-280
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• 2007

혼합물 성분들의 비율의 상한과 하한에 대한제한조건이 부과된 제한된 혼합물 실험 공간 R에서의 혼합물 실험을 위한 최적 설계를 찾는 데에 D-, G-, V- 최적기준 등과 같은 다양한 최적 설계 기준이 사용된다. 각각의 실험 설계는 선택된 최적 기준에 대해서는 최적이지만, 제한된 혼합물 실험 공간에서의 예측력에 대해서는 만족스럽지 못하다는 것은 잘 알려진 사실이다. (Vining 등, 1993; Khuri 등, 1999). 우리의 관심사는 2차 혼합물 반응표면모형을 가정한 경우에 제한된 혼합물 공간에서의 효율적인 실험 설계를 찾는 것이다. 이 논문에서는 꼭지점, 선중심점, 면중심점, 중앙점과 내부점으로 구성된 확장된 후보 실험점 그룹을 구성한 다음에, D-최적기준, G-최적기준, V-최적기준과 실험점들 간의 거리에 근거한 U-최적기준에 강건한 실험 설계를 제안한다. Khuri 등(1999)에서 분석된 비료 혼합물 실험과Vining과 Cornell(1993)이 분석한 조명탄 혼합물 실험의 사례에서 강건한 실험설계들과 두 논문에서 추천된 실험 설계들에 대한 예측치의 표준화된 분산의 분위수의 그림(SVPQP)을 비교한 결과 강건한 설계가 상대적으로 우월함이 판명되었다.

• Corrosion Science and Technology
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• 제20권2호
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• pp.77-84
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• 2021

This study aims to optimize the DL-EPR test solution for duplex stainless steel S31083 using the Taguchi design. The test solution parameters applied to the Taguchi design are H₂SO₄, NaCl, KSCN concentration, and temperature. In the experimental design, an orthogonal array of 4 levels 4 factor L₁₆(4⁴) was used. Output values for the orthogonal array were used for resolution (degree of sensitization) and selective etch (I_a) values. The optimal test solution conditions were selected by comparing the normalized S/N ratio for the two reaction properties. As a result, the H₂SO₄ and NaCl were identified as the main factors influencing the sensitivity measurement, but the delta statistics showed that the KSCN concentration and temperature had relatively low influence. The optimal condition was identified as 1.5 M H₂SO₄+0.03 M KSCN+1.5M NaCl at 30 ℃. The degree of sensitization presented a tendency to depend on the heat treatment temperature and time in the optimal test solution. This investigation confirmed the possibility of optimizing the experiment solution for the DL-EPR test of stainless steel using the Taguchi technique.

• 산업공학
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• 제23권2호
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• pp.118-125
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• 2010

The determination of a regression model is important in using statistical designs of experiments. Generally, the exact regression model is not known, and experimenters suppose that a certain model form will be fit. Then an experimental design suitable for that predetermined model form is selected and the experiment is conducted. However, the initially chosen regression model may not be correct, and this can result in undesirable statistical properties. We develop model-robust experimental designs that have stable prediction variance for a family of candidate regression models over a cuboidal region by using genetic algorithms and the desirability function method. We then compare the stability of prediction variance of model-robust experimental designs with those of the 3-level face centered cube. These model-robust experimental designs have moderately high G-efficiencies for all candidate models that the experimenter may potentially wish to fit, and outperform the cuboidal design for the second-order model. The G-efficiencies are provided for the model-robust experimental designs and the face centered cube.

• Journal of the Korean Statistical Society
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• 제36권2호
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• pp.201-208
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• 2007

Evolutionary operation (EVOP) proposed by Box (1957) is a method for continuous monitoring and improvement of a full-scale manufacturing process with the objective of moving the operating conditions toward the better ones. EVOP consists of systematically making small changes in the levels of the two or three process variables under consideration. Data are collected on the response variable at each point of two level factorial design with the center point and a cycle is said to have been completed. The cycles are replicated sequentially until the decision is made on whether further cycle of experiments is needed to conclude the significance of any of main effects or interaction effects or the curvature. In this paper, an improved flow chart of EVOP is proposed and how to determine the number of cycles is studied based on the size of type II error. In order to reject the alternative hypothesis of interests with more confidence and conclude that we believe in the null hypothesis of no effects, we propose a counter measure $p^*-value$ corresponding to the p-value. The relationship of $p^*-value$ to the probability of type II error ${\beta}$ under the alternative hypothesis of interests is analogous to that of p-value to the probability of type I error ${\alpha}$. Also the implementation of EVOP with a mixture experiment is discussed.