• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3477-3482
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• 2016

Background: Thyroid cancer is the most common endocrine malignancy, and exact causes remain unknown. The role of CYP450 1A1 (CYP1A1) in cancer initiation and progression has been investigated. The aim of this work was to analyze, for the first time, CYP1A1 gene expression and its relationship with several clinicopathological factors in Mexican patients diagnosed with thyroid cancer. Materials and Methods: Real-time PCR analysis was conducted on 32 sets of thyroid tumors and benign pathologies. Expression levels were tested for correlations with clinical and pathological data. All statistical analysis were performed using GraphPad Prism version 3.0 software. Results: We found that female gender was associated with thyroid cancer risk (P<0.05). A positive relationship was identified between CYP1A1 mRNA levels and the presence of chronic disease, alcohol use, tumor size, metastasis and an advanced clinical stage (P<0.05). Conclusions: The results suggest that CYP1A1 gene expression could be used as a marker for thyroid cancer.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제23권1호
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• pp.37-44
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• 2017

AOS(Aeon of Strife)장르의 게임들은 단순히 즐기는 컴퓨터 게임이 아닌 대표적인 e스포츠 종목으로 자리매김하고 있으며 전문성을 필요로 하는 스포츠의 특성상, 게임 플레이 패턴 및 시즌 별 캐릭터 선택 등 게임 운영에 필요한 통계 분석의 중요성이 증가하고 있다. 본 논문에서는 대표적인 AOS 게임 중의 하나인 리그오브레전드의 게임 데이터를 이용해 데이터 마이닝 기법을 이용한 게임의 전략적 분석을 실시한다. 통계적 승률 예측 기법인 로지스틱 회귀분석과 판별 분석 및 인공신경망을 이용하여 게임의 승패 예측 모형을 설계하고 실험한다. 게임 데이터 분석 결과는 확률을 표시한 그래프로 표현되어 게임 플레이를 돕기 위해 개발된 시각적 도구에 이용한다. 승패 예측 모형의 실험 결과, 평균적으로 95%의 높은 분류율을 보이고 시각화 도구를 통해 게임 플레이의 다양한 전략 수립에 이용됨을 보인다.

• 한국컴퓨터산업학회논문지
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• 제10권5호
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• pp.213-220
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• 2009

변수들간의 관계 모형을 설정하고 관계성 유무를 분석하는 회귀 분석은 거의 모든 조사 연구 및 실험연구들에서 필수적인 통계 분석 방법이다. 자료는 독립변수와 종속변수로 구성되므로 쌍으로 취급되며 모든 통계량 계산은 행렬 연산에 의하여 수행된다. 변수들 관계를 가장 잘 설명하는 모형 설정에 따라 회귀분석 결과의 정확성이 평가되므로 자료 수치들을 XY 평면상에서 점을 찍어 가장 적합한 함수 모형을 선택해야 한다. MS 엑셀의 그래픽 및 행렬 연산 기능의 메뉴들을 사용하면 수집된 자료에 가장 적합한 모형을 설정하고 필요한 모든 가설검정 작업을 쉽게 수행할 수 있다. 본 연구에서는 회귀 분석의 모형 설정 및 가설검정 결과들을 산출하는 엑셀 함수를 이용한 매크로를 개발하였다. 본 연구에서 개발한 회귀분석 매크로를 한 개의 종속변수와 3개의 독립 변수를 가진 지하철 전기요금 자료 분석에 적용하여 얻은 결과와 엑셀에 내장된 통계 회귀분석 메뉴를 적용한 결과를 비교한다.

• Journal of Gastric Cancer
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• 제15권4호
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• pp.256-261
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• 2015

Purpose: Gastric cancer is the third leading cause of cancer-related mortality, with the incidence and mortality being higher in men than in women. Various studies have shown that eating carrots may play a major role in the prevention of gastric cancer. We conducted a meta-analysis to determine the relationship between carrot consumption and gastric cancer. Materials and Methods: We searched multiple databases including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx. The following search terms were used: stomach or gastric, neoplasm or cancer, carcinoma or tumor, and carrot. Statistical analyses were performed using Comprehensive Meta Analysis/2.0 software. Results: We retrieved 81 articles by searching the databases. After considering the inclusion and exclusion criteria, 5 articles were included in this study. The odds ratio (OR) obtained by fixed effects model showed that a 26% reduction in the risk of gastric cancer has been associated with the consumption of carrots) OR=0.74; 95% confidence interval=0.68~0.81; P<0.0001). According to funnel graph, the results showed that the possibility of a publication bias does not exist in this study. Conclusions: The findings of this study showed an inverse relationship between the consumption of carrots and the risk of gastric cancer.

• 동의생리병리학회지
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• 제23권6호
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• pp.1241-1246
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• 2009

It has been suggested that Tae-Eum peoples are prone to obesity. Although extensive clinical observations have shown this tendency in Sasang Constitutional Medicine (SCM), no scientific hypothesis has been proposed to delineate its mechanism. According to SCM theory, Tae-Eum peoples have a hypoactive lung system and a hyperactive liver system. In this paper we propose a new hypothesis explaining the tendency of obesity in Tae-Eum people in the viewpoint of cell physiology. The hypoactive lung system might imply an attenuated 'respiration' at the cell/subcell level, namely mitochondrial oxygen consumption. Because a functional weakness in mitochondria energy metabolism indicates intrinsic hypo-activity in the consumption (or production) of metabolic energy, we deduced that the tendency can easily induce body weight gain via an increase in anabolism. This relation is also introduced in the graph of cellular metabolic power against body weight. To test this hypothesis, we analyzed the clinical data with 863 subjects. Statistical analysis of the data showed that Tae-Eum peoples had relatively a lower cellular metabolic power, and that the percentage of peoples with BMI>25 was significantly higher than that of the other constitutional types.

• 상하수도학회지
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• 제36권4호
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• pp.229-237
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• 2022

The sewer capacity design have been based on the Huff model or the rational equation in South Korea and often failed to determine optimal capacity, resulting in frequent urban flooding or over-sizing. A time distribution of rainfall (i.e., Huff or ABM method) could be used instead of a rainfall hyetograph obtained from statistical analysis of previous rainfalls. In this study, the Huff method and the ABM method, which predict the time distribution of rain intensity, which are widely used to calculate sewage pipe drainage capacity using the SWMM, were compared with the standard rainfall intensity hyetograph of Seoul. If the rainfall duration was 30 minutes to 180 minutes, the rainfall intensity value calculated by the Huff model tended to be less than the rainfall intensity value of the standard rainfall intensity in the initial 5-10 minutes. As a result, more than 10% to 30% of under-design would be made. In addition, the rainfall intensity value calculated by the Huff model from the section excluding the initial 5-10 minutes of rainfall to the rainfall duration was calculated larger than the value using the standard rainfall intensity equation, which would result in an over-design of 10% to 30%. In the case of a relatively long rainfall duration of 360 minutes (6 hours) to 1,440 minutes (24 hours), it showed an lower rainfall intensity of 60 to 90% in the early stages of rainfall, but the problem of under-design had been solved as the rainfall duration time had elapsed. On the other hand, in the alternating block method (ABM) method, it was found that the rainfall intensity at the entire period at each assumed rainfall duration accurately matched the standard rainfall intensity hyetograph of Seoul.

• Fisheries and Aquatic Sciences
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• 제26권1호
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• pp.24-34
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• 2023

Reactive oxygen species (ROS) at high concentrations induce oxidative stress, an imbalanced redox state that is a prevalent cause of neurodegenerative disorders. This study aimed to investigate the protective effect of Capsosiphon fulvescens (CF) extract on oxidative stress-induced impairment of cognitive function in models of neurodegenerative diseases. CF was extracted with subcritical water and several solvents and H₂O₂ (0.25 mM) or aluminum chloride (AlCl₃; 25 µM) as an inducer of ROS was treated in PC12 neuronal cells and zebrafish larvae. All statistical analyses were performed using one-way analysis of variance and Dunnett's test using GraphPad Prism. H₂O₂ and AlCl₃ were found to significantly induce ROS production in PC12 neuronal cells and zebrafish larvae. In addition, they strongly affected intracellular Ca²⁺ levels, antioxidant enzyme activity, brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) signaling, acetylcholinesterase (AChE) activity, and hallmarks of Alzheimer's disease. However, treatment of H₂O₂-induced PC12 cells or AlCl₃-induced zebrafish larvae with CF subcritical water extract at 90℃ and CF water extract effectively regulated excessive ROS production, intracellular Ca²⁺ levels, and mRNA expression of superoxide dismutase, glutathione peroxide, glycogen synthase kinase-3 beta, β-amyloid, tau, AChE, BDNF, and TrkB. Our study suggested that CF extracts can be a potential source of nutraceuticals that can improve the impairment of cognitive function and synaptic plasticity by regulating ROS generation in neurodegenerative diseases.

• Nuclear Engineering and Technology
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• 제55권2호
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• pp.717-724
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• 2023

An essential step in evaluating and comparing the performance of two passive radiation dosimeter types, thermosluminescent (TLD) and optically stimulated luminescence (OSL), used by workers in environments with ionizing radiation for individual radiological monitoring and control of external exposure at various times (cumulative dose for 1 month), is to compare the measured dose accuracy, energy response, and coefficient of variation. In fact this performance study consists in determining the accuracy of both R(10) and R(0.07) which are considered as the ratios of the measured dose (Hp(10) or Hp(0.07)) to the delivered dose (Hp(10) or Hp(0.07)) for each photon energy. The validity of the results of this test is based on the acceptance limits of the ICRP and the international standard IEC-62387. The relative energy response used is normalized to the ¹³⁷Cs 662 keV energy to find which energy response is closest to the ideal case, and the coefficient of variation that allows to determine the statistical fluctuation of the Hp(10) and Hp(0.07) doses. The results of the accuracy test for the OSL and TLD dosimeters are acceptable because they fall within the ICRP limits. For the energy response, the OSL performs better than the TLD for Hp(10) and Hp(0.07), and for the coefficient of variation, the OSL satisfies the requirements of ISO 62387 for both Hp(10) and Hp(0.07), while the TLD satisfies these requirements only for the measurement of Hp (0.07).

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송∙미디어공학회 2021년도 추계학술대회
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• pp.290-293
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• 2021

본 논문에서는 공부하는 사용자의 상황을 감지하여, 학습의욕을 고취시키고 집중력 향상을 도와주기 위한 학습능률 확인 시스템을 구현하고자 한다. 이를 위해 실시간 카메라를 통해 사용자의 얼굴이나 몸의 움직임을 추출하여 학습 태도, 집중력에 대한 데이터를 측정한다. 실시간 임베디드 시스템 구현을 위해 Jetson 보드를 사용하였으며, 영상인식을 위한 CNN(Convolution Neural Network)를 구현하였다. CNN 을 이용해 대상의 특징 부분을 검출한 후 움직임 검파를 수행한다. 캡처한 영상을 PYQT5 로 작성된 GUI 에서 영상을 보여주며, 각각 방해되는 행동을 했을 때 푸시메시지를 보내며 데이터를 수집한다. 또한 GUI 로 만든 메인 화면에서 각각의 기능들을 실행 가능하며, 수집한 데이터를 산출해주는 통계그래프와 작업관리 목록, 화이트 노이즈 등의 기능을 수행한다. 구축된 학습능률 확인 시스템을 통해 대상의 데이터를 수집 및 분석을 비롯한 다양한 기능을 사용자에게 제공하였다.

• 자원환경지질
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• 제50권3호
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• pp.195-214
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• 2017

산사태 위험도 분석에서 범용적으로 활용되고 있는 통계적 취약성 분석 기법은 과거에 발생한 산사태의 위치 정보와 산사태 영향 인자들 사이의 상관관계를 통계적으로 분석하여 산사태 발생 가능성이 있는 지역을 예측하는 기법이다. 이러한 취약성 분석 기법에는 다양한 불확실성이 개입되는데 이러한 불확실성을 고려하기 위한 방법의 하나로 퍼지 기법이 활용되고 있다. 퍼지 기법은 퍼지 집합 이론이라는 수학적인 개념을 통해 불확실성을 표현하는 방법으로 특정 인자가 나타날 수 있는 정도를 소속 함수로 표현한다. 퍼지 기법은 영향 인자들의 소속 함수를 결정하는 방법과 각 영향 인자들의 소속 함수를 결합하는 연산 과정에 다양한 접근 방식이 존재하며, 기존의 연구들은 다양한 접근 방식을 활용하여 분석을 수행하여 왔다. 그러나 이렇게 다양한 접근 방식이 어떠한 결과의 차이를 초래하는지를 비교하는 연구는 수행된 사례가 적은 편이다. 따라서 본 연구에서는 진부 지역을 대상으로 빈도비를 활용하여 소속 함수를 산정하는 기법과 코사인 진폭법을 활용하여 소속 함수를 산정하는 기법을 비교하여 보았다. 또한 다양한 퍼지 연산 기법을 활용하여 산사태 취약성을 산정하고 이들 결과를 비교해 보았으며 ROC 그래프 기법을 활용하여 결과의 정확도를 산정하고 분석 기법의 적절성을 분석하였다.