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Mitochondria Hypothesis on the Obesity-Prone Tendency in Tae-Eum People  

Shim, Eun-Bo (Department of Mechanical & Biomedical Engineering, Kangwon National University)
Lee, Si-Woo (Korea Institute of Oriental Medicine)
Kim, Sung-Joon (Department of Physiology, College of Medicine, Seoul National University)
Leem, Chae-Hun (Department of Physiology, College of Medicine, University of Ulsan)
Kwon, Young-Kyu (School of Oriental Medicine, Pusan National University)
Baik, You-Sang (Department of Oriental Medicine Classics, College of Oriental Medicine, Kyunghee University)
Kim, Jong-Yeol (Korea Institute of Oriental Medicine)
Earm, Yung-E. (Department of Physiology, College of Medicine, Seoul National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.6, 2009 , pp. 1241-1246 More about this Journal
Abstract
It has been suggested that Tae-Eum peoples are prone to obesity. Although extensive clinical observations have shown this tendency in Sasang Constitutional Medicine (SCM), no scientific hypothesis has been proposed to delineate its mechanism. According to SCM theory, Tae-Eum peoples have a hypoactive lung system and a hyperactive liver system. In this paper we propose a new hypothesis explaining the tendency of obesity in Tae-Eum people in the viewpoint of cell physiology. The hypoactive lung system might imply an attenuated 'respiration' at the cell/subcell level, namely mitochondrial oxygen consumption. Because a functional weakness in mitochondria energy metabolism indicates intrinsic hypo-activity in the consumption (or production) of metabolic energy, we deduced that the tendency can easily induce body weight gain via an increase in anabolism. This relation is also introduced in the graph of cellular metabolic power against body weight. To test this hypothesis, we analyzed the clinical data with 863 subjects. Statistical analysis of the data showed that Tae-Eum peoples had relatively a lower cellular metabolic power, and that the percentage of peoples with BMI>25 was significantly higher than that of the other constitutional types.
Keywords
sasang constitutional medicine; obesity; mitochondria hypothesis; scaling law of metabolic rate;
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1 Becker, S., Dossus, L., Kaaks, R. Obesity related hyperinsulinaemia and hyperglycaemia and cancer development. Arch Physiol Biochem 115(2):86-96, 2009   DOI   PUBMED   ScienceOn
2 Um, J.Y., Kim, H.M., Mun, S.W., Song, Y.S., Hong, S.H. Interleukin-1 receptor antagonist gene polymorphism and traditional classification in obese women. Int J Neurosci 116(1):39-53, 2006   DOI   ScienceOn
3 채 한, 박수잔, 이수진, 고광찬. 사상 유형학의 성격심리학적. 고찰. 대한한의학회지 25(2):151-164, 2004   과학기술학회마을
4 Kim, K.S., Cho, D.Y., Kim, Y.J., Choi, S.M., Kim, J.Y., Shin, S.U., Yoon, Y.S. The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation. Biochim Biophys Acta 1741(1-2):149-155, 2005   DOI   PUBMED
5 Shim, E.B., Lee, S., Kim, J.Y., Earm, Y.E. Physiome and Sasang constitutional medicine. J Physiol Sci. 58(7):433-440, 2008   DOI   ScienceOn
6 Fuku, N., Park, K.S., Yamada, Y., Nishigaki, Y., Cho, Y.M., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yokoi, K., Nozawa, Y., Lee, H.K., Tanaka M. Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet 80(3):407-415, 2007   DOI   ScienceOn
7 West, G.B., Brown, J.H., Enquist, B.J. A general model for the origin of allometric scaling laws in biology. Science 276: 122-126, 1997   DOI   PUBMED   ScienceOn
8 Chae, H., Lyoo, I.K., Lee, S.J., Cho, S.H., Bae, H.S., Hong, M.C., Shin, M.K. An alternative way to individualized medicine: psychological and physical traits of Sasang typology. J Altern Complement Med 9(4):519-528, 2003   DOI   ScienceOn
9 Rising, R., Keys, A., Ravussin, E., Bogardus, C. Concomitant interindividual variation in body temperature and metabolic rate. Am J Physiol 263: E730-E734, 1992   PUBMED
10 West, G.B., Woodruff, W.H., Brown, J.H. Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals. Proc Natl Acad Sci USA 99: 2473-2478, 2002   DOI   ScienceOn
11 Jansky, L. Total cytochrome oxidase activity and its relation to basal and maximal metabolism. Nature 18, 189: 921-922, 1961
12 Rutkowski, J.M., Davis, K.E., Scherer, P.E. Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue. FEBS J. 276(20): 5738-5746, 2009   DOI   ScienceOn
13 Song, J.S., Jeong, H.J., Kim, S.J., Son, M.S., Na, H.J., Song, Y.S., Hong, S.H., Kim, H.M., Um, J.Y. Interleukin-1alpha polymorphism –889C/T related to obesity in Korean Taeumin women. Am J Chinese Med 36(1):71-80, 2008   DOI   ScienceOn
14 Avenell, A., Broom, J., Brown, T.J., Poobalan, A., Aucott, L., Stearns, S.C., Smith W.C., Jung, R.T., Campbell, M.K. Grant A.M. Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technol Assess 8(21):1-182, 2004.
15 Graff, C., Clayton, D.A., Larsson, N.G. Mitochondrial medicine- recent advances. J Intern Med. 246(1):11-23, 1999   DOI   ScienceOn
16 Lee, J.M. Douguisusebowon, Seoul, Korea, 1894
17 Schreider, E. Geographical distribution of the bodyweight/ body-surface ratio. Nature 165: 286, 1950   PUBMED
18 Dulloo, A.G., Seydoux, J., Jacquet, J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiol Behav 83: 587-602, 2004   DOI   ScienceOn
19 Kim, J.Y., Pham, D.D. Sasang constitutional medicine as a holistic tailored medicine. Evid Based Complement Alternat Med. 6 Suppl 1: 11-19, 2009   PUBMED
20 Frankenfield, D.C., Rowe, W.A., Smith, J.S., Cooney, R.N. Validation of several established equations for resting metabolic rate in obese and nonobese people. J Am Diet Assoc. 103(9):1152-1159, 2003   DOI   ScienceOn
21 Rising, R., Fontvieille, A.M., Larson, D.E., Fonpraul, M., Bogardus, C., Ravussin, E. Racial difference in body core temperature betwusn Pima Indian and Caucasian msn. Int J Obes Relat Metab Disord 19: 1-5, 1995   PUBMED
22 Jequier, E., Gygax, P.H., Pittet, P., Vannotti, A. Increased thermal body insulation: relationship to the development of obesity. J Appl Physiol 36: 674-678, 1974   DOI   PUBMED
23 Mathieu, O., Krauer, R., Hoppeler, H., Gehr, P., Lindstedt, S.L., Alexander, R.M., Taylor, C.R., Weibel, E.R. Design of the mammalian respiratory system. VII. Scaling mitochondrial volume in skeletal muscle to body mass. Respir Physiol 44(1):113-128, 1981   DOI   ScienceOn
24 Campbell, N.A. Biology, Benjamin Cummings, Menlo Park, CA, 1987