Nucleotide-binding oligomerization domain 1 (NOD1), a cytosolic pattern recognition receptor protein, plays a crucial role in innate immune responses. However, the functional expression of NOD1 in mesenchymal stem cells (MSCs) derived from endometriosis remains unclear. The aim of this study was to explore the functions of NOD1 in ectopic endometrial lesions. Tissues and MSCs were isolated from both normal endometrium and endometriosis. Immunohistochemistry and real time quantitative polymerase chain reaction (RT-qPCR) were used to determine the expression of NOD1 in the tissues/MSCs. Quantification of various cytokines was performed using RT-qPCR and enzyme-linked immunosorbent assay. To confirm the proliferation, invasion/migration, and apoptotic viabilities of the samples, Cell Counting Kit-8, clonogenic formation, transwell assays, and apoptotic experiments were conducted. Higher levels of NOD1 expression were detected in the ectopic-MSCs obtained from endometriosis compared to those from the endometrium. The expression of interleukin-8 was higher in the ectopic-MSCs than in the eutopic-MSCs. Pretreatment with NOD1 agonist significantly enhanced the proliferation and invasion/migration of eutopic-MSCs. Additionally, the NOD1 inhibitor ML-130 significantly reduced the proliferation, clone formation, invasion, and migration abilities of the ectopic-MSCs, having no effect on their apoptosis capacity. Our findings suggest that the expression of NOD1 in ectopic-MSCs may contribute to the progression of ectopic endometrial lesions.
Kim, Jeong-Tae;Na, Won-Bae;Hong, Dong-Soo;Lee, Byung-Jun
Journal of the Earthquake Engineering Society of Korea
/
v.10
no.6
s.52
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pp.57-65
/
2006
This paper presents hybrid structural damage monitoring system which performs both global damage assessment of structure and damage detection of local structural joints. Hybrid damage monitoring system is composed of vibration-based technique and electro/mechanic impedance technique. Vibration-based technique detects global characteristic change ot structure using modal characteristic change of structure, and electro/mechanical impedance technique detects damage existence of local structural joints using impedance change of PZT sensor. For the verification of the proposed hybrid monitoring system, a series of damage scenarios are designed to loosened bolts situations of the structural joints, and acceleration response and impedance response signatures are measured. The proposed hybrid monitoring system is implemented to monitor global damage-state and local damages in structural joints.
Comprehensive real estate taxes needs to be improved so that it performs its intended functions by realizing fair taxation and stabilizing the price of real estate, and ultimately attains social justice in Korea. This study analyzed the current state of comprehensive real estate taxes through a questionnaire survey, and the results are summarized as follows. First, in the analysis of people's perception on the adequacy of the tax rate of comprehensive real estate taxes, those who owned a house worthy of 600 million won or a higher value as an object of real estate tax perceived the adequacy of the tax rate more negatively than those who owned a house of less than 600 million won. The same result was observed for comprehensive real estate taxes on lands. Second, in the analysis of the contribution of comprehensive real estate taxes to the accomplishment of policies, the respondents showed a high frequency of positive replies to some of policies related to comprehensive real estate taxes.
It is a matter for debate that which types of dispute may be resolved by arbitration. This problem is concerning the arbitrability of the subject-matter of a dispute. National laws establish the domain of arbitration. Each state decides which matters may or may not be resolved by arbitration in accordance with its own political, social and economic policy. In response to complexity and diversity of a social phenomenon, the dispute also is various, therefore can not be settled efficiently by means of court adjudication to which applies a law strictly. To overcome such problems we are going to seek to make use of arbitration. According to Korean Arbitration Act Art. 3 (1), any dispute in private laws would be the object of arbitral proceedings. For the promotion of fair and free competition, it is increasingly wide-ranging antitrust legislation across the world. It is matter for debate what can an arbitral tribunal do when confronted with an allegation that the contract under which the arbitration is brought is itself an illegal restraint of trade or in some other way a breach of antitrust law. The underlying question is how to accommodate the conflicting congressional policies favoring resolution of private controversies by arbitration and encouraging private suits to protect the public interests served by the antitrust laws. It is necessary to inquire into the arbitrability of antitrust issues on case-by-case basis, because the types of them are quite diverse. If antitrust issues are the dispute in private laws and the contracting parties agreed to submit to arbitration disputes which have arisen or which may arise between them in the antitrust issues, the antitrust disputes are arbitrable. Not only international antitrust disputes but also domestic antitrust disputes are capable of being resolved by arbitration. When the public interests in the enforcement of antitrust legislation are asserted, it is possible to justify the annulment or the refusal of the recognition or the enforcement of an arbitral award that ignores public policy as a matter of it.
Purpose : This study was performed to identify the knowledge and educational wants for first-aid and its related factors of senior students in elementary schools. Methods : From July 11-25, 2008, this study surveyed 437 elementary school students using a structured questionnaire. Result : Of the study subjects, 47.6% of the subjects had experienced first-aid conditions 25.4% had injuries, 11.0% had indigestion, 10.5% had sprains, 6.2% had acute abdominal pains, 5.9% had brash, and 5.7% had fractures. The experience rates of first-aid conditions were significantly different according to gender, mothers' educational status, means of school attendance and amount of exercise. The experience rate of first-aid education was 71.4%. There was a significant difference with grade, and school reports. They had education about cardiopulmonary resuscitation (52.5%), injury treatment and desmology(48.7%) in a good order. The score of knowledge about first-aid was $13.95{\pm}4.1$ and it was converted on the basis of 100 points, the results were below 50points, and there was a significant difference in grades. Educational wants for first-aid was 64.3%, and as a result of multi-logistic regression analysis of characteristics relating to educational wants, there was a significant difference between gender, grade, mothers' educational status, and amount of exercise. Conclusion : The rate of first-aid experience of elementary school students was high, but as their recognition and knowledge on first-aid was low, the importance of first-aid education and educational wants should be reflected for practical and organized education.
This study analyzed newspaper reports in the United States and South Korea that focused on Parasite's unprecedented performance at the 2020 Academy Awards. The research focused on the power relationship between 'the established and the outsiders (Elias & Scotson, 1994)' as represented by the Academy Awards and Parasite, respectively. Qualitative content analysis and text analysis were conducted to examine the reporting of American and South Korean newspapers and illuminate three aspects of the power relations between the Academy Awards and Parasite. Three major findings were derived. First, the Academy traditionally has a reputation for marginalizing films with a non-English or Asian background, but recognition of Parasite at the 92nd ceremony changed the Academy's established position of power. Second, historically, the Academy Awards had been characterized by a group charisma that exerts stigmatization (through an English-oriented policy and language stigmatization) and accords North American films priority over non-English movies. Lastly, the reports of newspapers in the two countries are generally similar, but the Korean articles internalized the individual, society, and the state.
International Journal of Naval Architecture and Ocean Engineering
/
v.9
no.4
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pp.418-428
/
2017
In offshore area, newly deposited Quaternary loose seabed soils are widely distributed. There are a great number of offshore structures has been built on them in the past, or will be built on them in the future due to the fact that there would be no very dense seabed soil foundation could be chosen at planed sites sometimes. However, loosely deposited seabed foundation would bring great risk to the service ability of offshore structures after construction. Currently, the understanding on wave-induced liquefaction mechanism in loose seabed foundation has been greatly improved; however, the recognition on the consolidation characteristics and settlement estimation of loose seabed foundation under offshore structures is still limited. In this study, taking a semi-coupled numerical model FSSI-CAS 2D as the tool, the consolidation and settlement of loosely deposited sandy seabed foundation under an offshore breakwater is investigated. The advanced soil constitutive model Pastor-Zienkiewics Mark III (PZIII) is used to describe the quasi-static behavior of loose sandy seabed soil. The computational results show that PZIII model is capable of being used for settlement estimation problem of loosely deposited sandy seabed foundation. For loose sandy seabed foundation, elastic deformation is the dominant component in consolidation process. It is suggested that general elastic model is acceptable for subsidence estimation of offshore structures on loose seabed foundation; however, Young's modulus E must be dependent on the confining effective stress, rather than a constant in computation.
Plant species on oceanic islands comprise nearly 25% of described vascular plants on only 5% of the Earth's land surface yet are among the most rare and endangered plants. Conservation of plant biodiversity on islands poses particular challenges because many species occur in a few and/or small populations, and their habitats on islands are often disturbed by the activity of humans or by natural processes such as landslides and volcanoes. In addition to described species, evidence is accumulating that there are likely significant numbers of "cryptic" species in oceanic archipelagos. Plant systematists, in collaboration with others in the botanical disciplines, are critical to the discovery of the subtle diversity in oceanic island floras. Molecular data will play an ever increasing role in revealing variation in island lineages. However, the input from plant systematists and other organismal biologists will continue to be important in calling attention to morphological and ecological variation in natural populations and in the discovery of "new" populations that can inform sampling for molecular analyses. Conversely, organismal biologists can provide basic information necessary for understanding the biology of the molecular variants, including diagnostic morphological characters, reproductive biology, habitat, etc. Such basic information is important when describing new species and arguing for their protection. Hybridization presents one of the most challenging problems in the conservation of insular plant diversity, with the process having the potential to decrease diversity in several ways including the merging of species into hybrid swarms or conversely hybridization may generate stable novel recombinants that merit recognition as new species. These processes are often operative in recent radiations in which intrinsic barriers to gene flow have not evolved. The knowledge and continued monitoring of plant populations in the dynamic landscapes on oceanic islands are critical to the preservation of their plant diversity.
1. The status of nutrition hasn't been found a great difference between the model village and the compared one, so there should be a great need of the improvement of the traditional food life which is chiefty consisted of some cereal grains and vegetables, in a Larger sense, the mixing diet would diminish the burden of stomach and help us to get high nutrition with a bit of quantify. 2. The health of the oral cavity has a close relation with that of whole body. In order to keep a good dental health, there fore, we should study and try to get more calcium in another food group except in the vegetarian diet. The pregnant women must especially have much recognition to the necessity for getting a lot of calcium. 3. It is desirable to clean our teeth three times every day after having meals for every three minutes. The habit which is called 'three three three campaign' should clearly be kept for all of us.
Proceeding of Spring/Autumn Annual Conference of KHA
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2009.11a
/
pp.109-112
/
2009
Various environmental problems due to the rapid industralization and urbanization have been worsened as much as to threaten the environmental restitution of globe and become a critical international issue. Korean government presented the green growth as a new state vision for 60 years afterwards and is making efforts to solve the environmental problems. Daegu metropolitan city has faced various environmental problems including overpopulation of cities, traffic pollution, household wastes and green zone problem because of urbanization for the last decades. As such urbanism continues, the quality of residential environment is rapidly deteriorating and the intensive use of land leads to increase of building area raising the temperature of cities. Therefore there have been demands for the healthy, pleasant and satisfying residential environment and the improvement of residential environment and such recognition rises from society in full measure. Nevertheless the current residential complex concentrates only on raising the efficiency of land use. Related laws in the past(Daegu Metropolitan City, Urban Planning Municipal Ordinance as of October 10, 2003) tried to prepare a standard to segmentalize the building-to-land ratio, floor area ratio and regulations of number of floors vertically, but currently it is abolished and the regulations are becoming eased. The purpose of this study was to analyze the characteristics of the floating wind before and after the vertical segmentation of residential areas(Daegu Metropolitan City, Urban Planning Municipal Ordinance as of October 10, 2003) by using KLAM_21, a model that enables analysing and predicting the flow and generation of clod wind, and to present a plan to improve the quality of residential areas afterwards when developing building lot and re-developing housing areas.
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