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The Regulation of Lipolysis in Adipose Tissue

  • Serr, Julie;Li, Xiang;Lee, Kichoon
    • Journal of Animal Science and Technology
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    • v.55 no.4
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    • pp.303-314
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    • 2013
  • Knowledge regarding lipid catabolism has been of great interest in the field of animal sciences. In the livestock industry, excess fat accretion in meat is costly to the producer and undesirable to the consumer. However, intramuscular fat (marbling) is desirable to enhance carcass and product quality. The manipulation of lipid content to meet the goals of animal production requires an understanding of the detailed mechanisms of lipid catabolism to help meticulously design nutritional, pharmacological, and physiological approaches to regulate fat accretion. The concept of a basic system of lipases and their co-regulators has been identified. The major lipases cleave triacylglycerol (TAG) stored in lipid droplets in a sequential manner. In adipose tissue, adipose triglyceride lipase (ATGL) performs the first and rate-limiting step of TAG breakdown through hydrolysis at the sn-1 position of TAG to release a non-esterified fatty acid (NEFA) and diacylglycerol (DAG). Subsequently, cleavage of DAG occurs via the rate-limiting enzyme hormone-sensitive lipase (HSL) for DAG catabolism, which is followed by monoglyceride lipase (MGL) for monoacylglycerol (MAG) hydrolysis. Recent identification of the co-activator (Comparative Gene Identification-58) and inhibitor [G(0)/G(1) Switch Gene 2] of ATGL have helped elucidate this important initial step of TAG breakdown, while also generating more questions. Additionally, the roles of these lipolysis-related enzymes in muscle, liver and skin tissue have also been found to be of great importance for the investigation of systemic lipolytic regulation.

Corrosion Protection from Inhibitors and Inhibitor Combinations Delivered by Synthetic Ion Exchange Compound Pigments in Organic Coatings

  • Chrisanti, S.;Ralston, K.A.;Buchheit, R.G.
    • Corrosion Science and Technology
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    • v.7 no.4
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    • pp.212-218
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    • 2008
  • Inorganic ion exchange compounds (IECs) including hydrotalcites and bentonite clays are a well known classes of layered mixed metal hydroxides or silicates that demonstrate ion exchange properties. These compounds have a range of applications from water purification to catalyst supports. The use of synthetic versions of these compounds as environmentally friendly additives to paints for storage and release of inhibitors is a new and emerging application. In this paper, the general concept of storage and release of inhibiting ions from IEC-based particulate pigments added to organic coatings is presented. The unique aspects of the IEC structure and the ion exchange phenomenon that form the basis of the storage and release characteristic are illustrated in two examples comprising an anion exchanging hydrotalcite compound and a cation exchanging bentonite compound. Examples of the levels of corrosion protection imparted by use of these types of pigments in organic coatings applied to aluminum alloy substrates is shown. How corrosion inhibition translates to corrosion protection during accelerated exposure testing by organic coatings containing these compounds is also presented.

Store Attributes as Determinants of Store Loyalty - Moderating Effect of Rural versus Urban Apparel Shoppers -

  • Lee, Jung-Eun;Cho, Jung-Rim;Stoel, Leslie
    • The Research Journal of the Costume Culture
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    • v.20 no.1
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    • pp.99-110
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    • 2012
  • The purpose of this study was to explore differences in determinants of loyalty, including years of loyalty and use of word-of-Mouth (WOM), across rural and urban apparel shoppers. The secondary data used for this study was collected by BIG research in their Consumer Intentions and Actions Study. Hierarchical multiple regression analysis was conducted, and the results showed that four store attributes (fashionability, promotion, shopping environment, and retail basics) were positively related to store loyalty. Findings of the study also revealed that the effect of fashionability and retail basics on store loyalty differed significantly across rural and urban consumers while promotion and shopping environment were not different predictors of store loyalty between rural and urban apparel shoppers. Specifically, store attributes of fashionability were stronger antecedents of loyalty for women's clothing shoppers in urban areas than rural shoppers. The retail basics had a greater influence on store loyalty among women's apparel customers in rural areas than customers in urban areas.

Broadband Finite-Difference Time-Domain Modeling of Plasmonic Organic Photovoltaics

  • Jung, Kyung-Young;Yoon, Woo-Jun;Park, Yong Bae;Berger, Paul R.;Teixeira, Fernando L.
    • ETRI Journal
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    • v.36 no.4
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    • pp.654-661
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    • 2014
  • We develop accurate finite-difference time-domain (FDTD) modeling of polymer bulk heterojunction solar cells containing Ag nanoparticles between the hole-transporting layer and the transparent conducting oxide-coated glass substrate in the wavelength range of 300 nm to 800 nm. The Drude dispersion modeling technique is used to model the frequency dispersion behavior of Ag nanoparticles, the hole-transporting layer, and indium tin oxide. The perfectly matched layer boundary condition is used for the top and bottom regions of the computational domain, and the periodic boundary condition is used for the lateral regions of the same domain. The developed FDTD modeling is employed to investigate the effect of geometrical parameters of Ag nanospheres on electromagnetic fields in devices. Although negative plasmonic effects are observed in the considered device, absorption enhancement can be achieved when favorable geometrical parameters are obtained.

Ultrastructure and Mrphological Fatures of Mcoplasma pneumoniae during Clture Dvelopment (Mycoplasma Pnemoniae 세포의 발달과정 중 미세구조 및 형태학적 특징)

  • Kim, Chi-Kyung;Pfister Robert M.;Somerson Norman L.
    • Korean Journal of Microbiology
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    • v.17 no.1
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    • pp.1-15
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    • 1979
  • Mycoplasma pneumoniae strain CL-s attached to broth-covered surfaces was examined sequentially during growth from single cells for morphologic and ultrastructural changes using several different electron microscopic techniques. Changes in morphology revealed both round and spindle shapes and observation of cell transitions suggested some type of morphological cycle. The round to-ovoid cells observed in the early stages of growth appeared to be viable, and morphologically and ultrastructurally different from the spherical fors which were produced during the latter stage of growth. The spindle segments were detected appeared to be structurally the same as the terminal cored structure seen in thin sections and may be a growing point or an attachment site of the cell. A tubular structure was observed in the core of the terminal structure and a microtubule-like element appeared to bridge between some spindle segments. A matrix sunstance was observed around single cells as well in the intercellular space of the colonies prepared by critical point metrical triple-layered cytoplasmic mermbranes, surfaces, of which appeared to be structurally different each other, were observed in young cells, whereas symmetrical and thicker membranes were seen in older cells. Small bodies were found in 4d or older cultures and did not appear to contain any internal structures or an easily detectable unit membrane.

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