• YAKHAK HOEJI
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• v.43 no.5
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• pp.614-622
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• 1999

The standard operation procedure of mouse lymphoma L5178Y $tk^{+/-}-3.7.2C$ gene mutation assay (MOLY) has been regarded as a sensitive in vitro mammalian cell gene mutation assay that is capable of detecting clastogens as well as mutagens. Using MOLY, one of natural sweetner, stevioside (5mg/ml) and its aglycon, steviol ($340{\;}\mu\textrm{g}/ml$) were evaluated the mutagenicity. Stevioside and steviol did not induce mutagenicity in MOLY. On the other hand, stevioside (250mg/kg, B.W.) and steviol (200mg/kg, B.W.) were also evaluated their ability to induce micronuclei in regenerating hepatocytes and bone marrow cells of ddY mice. From these results, stevioside and steviol did not induce any mutagenic effect both MOLY and in vivo micronucleus test.

• Journal of the military operations research society of Korea
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• v.31 no.2
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• pp.45-59
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• 2005

As more advanced and complicated equipments are introduced, effective operation and maintenance, along with acquisition of the equipments, commands more significance lately. In order to perform effective depot maintenance, the Republic of Korea Army is continually developing the concept, cycle and method for operating the depot maintenance. Not only the high-cost testing and maintenance equipments but the highly developed maintenance technologies are required for the depot maintenance of the latest weapon system. In order to have the depot maintenance capability, this paper provides the standard and procedure for estimating the development cost of the depot maintenance elements to be utilized in the depot maintenance elements development project.

• Journal of Ocean Engineering and Technology
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• v.26 no.2
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• pp.1-7
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• 2012

DNV-OS-F101 includes the concept development, design, construction, operation,and abandonment of offshore pipeline systems. The main objective of this offshore standard (OS) is to ensure that pipeline systems are safe during the installation and operational period. The pipeline design philosophy also includes public safety and environmental protection. The mechanical wall thickness design of a pipeline shall follow the design objectives and safety philosophy. This new design code includes a very sophisticated design procedure to ensure a safe pipeline, public safety, and environmental protection. This paper presents the results of a parametric study for the wall thickness design of offshore pipelines. A design matrix was developed to cover the many design factors of pipeline integrity, public safety, and environmental protection. Sensitivity analyses of the various parameters were carried out to identify the impacts on offshore pipeline design.

• The Journal of Engineering Research
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• v.4 no.1
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• pp.35-45
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• 2002

This paper deals with the scheduling problems which are the most important subtask in High-Level Synthesis. Especially, we have concentrated our attentions on the data-path scheduling which can get the structural informations from the behavioral algorithm as a first step in synthesis procedure. Suggest Forward scheduling methode is executed the ASAP and ALAP scheduling to use the fifth – order elliptic wave filter of a standard benchmark model, and then it is drawing up T.N matrix table by the number of resource and control-step, using the table extract of the simple than down-limit value of the control-step for the number of given resource to use this table. All of existing list scheduling techniques determine the priority functions first, and then do the operation scheduling, But, the suggested forward scheduling technique does the schedule first, and determines the priority functions if needed in scheduling process.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.28 no.4
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• pp.55-62
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• 2020

Special airworthiness certificates can be issued if the aircraft does not meet the airworthiness standards, but it is deemed that it can be operated safely by partially limiting the scope of operation and flight performance. Currently, Korea is subject to experimental special certification for UAS(Unmanned Aircraft Systems) exceeding 150 kg of its own weight, but detailed guidelines need to be prepared on how to prove that they can be operated safely in a limited range. Recently, Korea Airworthiness Standard(KAS) Part 21 has been revised to reflect this, but it needs to be supplemented. In this study, through an understanding and analysis of the FAA's procedure of expeirmental special airworthiness certifications for UAS, we would like to suggest what we should consider when developing relevant guidelines in our country.

• Journal of Digestive Cancer Research
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• v.5 no.1
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• pp.28-31
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• 2017

The number of laparosocpic liver resection performed every years has been increasing. There is a trend than more major hepatectomy and complex liver resection is being reported. However there has been a major obstacles in many centers because open liver resection is still considered as a gold standard and many surgeons are still getting used to the old method of liver resection. To start a new procedure, education and training is essential in order to achieve a good outcome without compromising the safety of the patients. A gradual progression is crucial in order to avoid dreadful complication. The development of the consensus meeting and difficulty score has facility the understanding of safe practice in the development of laparoscopic liver resection. In a long run, development of registry system will improve transparency and safety of this operation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.9
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• pp.1265-1272
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• 2010

In view of the frequent start-ups and load changes in the recent past, there is a need for fossil-fuel power plants to be more efficient and reliable for long-term operation. Under high-temperature and high-pressure conditions, severe creep and fatigue damages can occur in major plant facilities, particularly, turbines and boilers. For highly stable operation and better maintenance, various techniques that facilitate a systematic assessment of the service life of critical facilities have been developed. However, to date, in Korea, to evaluate the remaining life of major facilities of fossil power plant, qualitative or semiquantitative analyses are carried out without following any standard guidelines or procedure. In this study, a standard code for assessing the remaining life of major plant facilities is proposed. This code takes into account creep and fatigue damage, which are generally accepted as dominant causes of damage to facilities. KEPIC (Korea Electric Power Industry code) is scheduled to include this guideline in 2010.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.21 no.1
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• pp.113-124
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• 2008

Distributed operation of overall structural design process, by which product optimization and process parallelization are simultaneously implemented, is presented in this paper. The database-interacted hybrid method, which selectively takes the accustomed procedure of the conventional method in the framework of the optimal design, is utilized here. The staged application of design constraints reduces the computational burden for large complex optimization problems. Two kinds of numeric and graphic processes are simultaneously implemented by concurrent engineering approach in the distributed environment of PC networks. The former is based on finite element optimization method and the latter is represented by AutoCAD using AutoLISP programming language. Numerical computation and database interaction on servers and graphic works on independent clients are communicated through message passing. The numerical experiments for some steel truss models show the validity and usability of the method. This study has sufficient adaptability and expandability, in that it is based on general methodologies and industry standard platforms.

• Journal of Chest Surgery
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• v.44 no.1
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• pp.51-57
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• 2011

Background: Up to now, lobectomy, bilobectomy and pneumonectomy combined with extensive lymph node dissection have been regarded as the standard procedures for non-small cell lung cancer (NSCLC). In high-risk patients, however, limited resection (LR) has been attempted as a salvage procedure, and, recently, indication for LR has been extended to selected cases with early-stage NSCLC. Material and Methods: Among the 773 patients who underwent surgical procedures for NSCLC in Seoul National University Bundang Hospital from May 2003 to December 2008, 43 patients received LR. Medical records of these patients were retrospectively reviewed. Results: Mean age at operation was $66.0{\pm}12.4$ years, and there were 30 males. Twenty-five patients underwent conservative limited resection (CLR) and 18 underwent intentional limited resection (ILR). Indications for CLR were multiple primary lung cancer in 9 (9/25, 36%) and severe concomitant diseases in 5 (5/25, 20%). Of these, 6 patients underwent segmentectomy and 19 received wedge resection. During the follow-up period of $28.0{\pm}17.8$ months, 15 patient developed recurrent lung cancer. ILR was selectively performed in lesions almost purely composed of ground glass opacity (${\geq}$95%), or in small solid lesions (${\leq}$2 cm). Of these, 11 patients underwent segmentectomy and 7 underwent wedge resection. During the follow-up period of $31.7{\pm}11.6$ months, no patient developed recurrence. Conclusion: Intermediate-term outcome of LR for early-stage lung cancer is comparable to that of standard operation. For the delineation of the indications and appropriate surgical techniques for LR, prospective randomized multi-institutional study may be expedient.

• Journal of Korean Neurosurgical Society
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• v.49 no.4
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• pp.212-216
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• 2011

Objective : It is well known that plate-to-disc distance (POD) is closely related to adjacent-level ossification following anterior cervical plate placement. The study was undertaken to compare the outcomes of two different anterior cervical plating methods for degenerative cervical condition. Specifically, the new method involves making holes for plate screws first with an air drill and then choosing a plate size. The other method was standard, that is, decide on the plate size first, locate the plate on the anterior vertebral body, and then drilling the screw holes. Our hypothesis was that the new technical tip may increase POD as compared with the standard anterior cervical plating procedure. Methods : We retrospectively reviewed 49 patients who had a solid fusion after anterior cervical arthrodesis with a plate for the treatment of cervical disc degeneration. Twenty-three patients underwent the new anterior cervical plating technique (Group A) and 26 patients underwent the standard technique (Group B). POD and ratios between POD to anterior body heights (ABH) were measured using postoperative lateral radiographs. In addition, operating times and clinical results were reviewed in all cases. Results : The mean durations of follow-up were $16.42{\pm}5.99$ (Group A) and $19.83{\pm}6.71$ (Group B) months, range 12 to 35 months. Of these parameters mentioned above, cephalad POD (5.43 versus 3.46 mm, p=0.005) and cephalad POD/ABH (0.36 versus 0.23, p=0.004) were significantly greater in the Group A, whereas operation time for two segment arthrodesis (141.9 versus 170.6 minutes, p=0.047) was significantly lower in the Group A. There were no significant difference between the two groups in caudal POD (5.92 versus 5.06 mm), caudal POO/ABH (0.37 versus 0.32) and clinical results. Conclusion : The new anterior cervical plating method represents an improvement over the standard method in terms of cephalad plate-to-disc distance and operating time.