• 동위원소회보
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• 제21권3호
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• pp.46-60
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• 2006

In recent years the progress of nuclear medicine advanced dramatically in imaging and targeted radionuclide therapy is able to open op exciting perspectives as standard diagnostic and therapeutic modalities, complementing conventional modalities. Positron emission tomography/computed tomography (PET/CT) technology with FDG has been developed clinically in less than 10 years as a routine standard in oncological imaging, including a number of other fluorinated radiopharmaceuticals being evaluated for their ability to complement FDG. However, the limitation of FDG-PET such as non-specific uptake and its short half-life is not compatible with the time necessary for optimal tumour targeting. Therefore, a development of innovative positron-emitting radionuclides with half-lives longer than 10 h is needed. For therapeutic applications, the injection of higher activities is required to reach efficient adsorbed doses in radioresistant solid tumours, while limiting the irradiation of vital organs. In this application, the longer half-life of radiolsotopes are more fit well for radionuclide therapy. To achieve this, researches have to be carried in a largor spectrum of radionuclides for diagnosis and therapy. In the context of rapidly growing nuclear medicine and strong demanding innovative radionuclides, a high-energy (100 MeV), high-intensity (-mA) accelerator with proton (PEFF at KAFRI). will be operating in 2011. The priorities of PEFP will include supporting the nuclear medicine research community by providing those radionuclides with current limited availability by means of a high-energy, high-intensity accelerator.

• 대한방사선기술학회지:방사선기술과학
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• 제42권5호
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• pp.345-350
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• 2019

Liver biopsy is the gold standard for diagnosing liver fibrosis, but it is invasive and has a risk for complications. For this reason, recently, study has been actively conducted on non-invasive liver fibrosis evaluation method. But, there is no established standard for the type of diffuse liver disease. Therefore, this study was suggest the usefulness and cut-off values of Fibroscan, FIB-4, APRI and AAR of patients with hepatitis C in Korea. According to the diagnosis, 240 people in hepatitis C are classified into fatty liver, chronic hepatitis, and liver cirrhosis. The statistical analysis was performed by ANOVA to verify difference between groups. The ROC curve was analyzed to determine the usefulness and practical cut-off value. As a result, for all diseases, the AUC value for Fibroscan was 0.8 over and the APRI was 0.7 over. Cut-off value of serum based liver fibrosis markers was increased in order of fatty liver, chronic hepatitis and liver cirrhosis. If Fibroscan and serological liver fibrosis markers are applied to predict liver fibrosis, it is expected that excessive liver biopsy can be reduced.

• Nuclear Engineering and Technology
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• 제53권6호
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• pp.2038-2045
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• 2021

The main objective of this work is to propose a reliable routine standard operation procedures (SOP) for structural health monitoring and diagnosis of nuclear power plants (NPPs). At present, NPPs have monitoring systems that can be used to obtain the quantitative health record of containment (CTMT) buildings through system identification technology. However, because the measurement signals are often interfered with by noise, the identification results may introduce erroneous conclusions if the measured data is directly adopted. Therefore, this paper recommends the SOP for signal screening and the required identification procedures to identify the dynamic characteristics of the CTMT of NPPs. In the SOP, three recommend methods are proposed including the Recursive Least Squares (RLS), the Observer Kalman Filter Identification/Eigensystem Realization Algorithm (OKID/ERA), and the Frequency Response Function (FRF). The identification results can be verified by comparing the results of different methods. Finally, a preliminary CTMT healthy record can be established based on the limited number of earthquake records. It can be served as the quantitative reference to expedite the restart procedure. If the fundamental frequency of the CTMT drops significantly after the Operating Basis Earthquake and Safe Shutdown Earthquake (OBE/SSE), it means that the restart actions suggested by the regulatory guide should be taken in place immediately.

• 방사선산업학회지
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• 제12권4호
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• pp.287-290
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• 2018

Nowadays, diseases related with breast are increasing rapidly and because of this high quality of resolution images is required to get clear detail specially for early detection and diagnosis. It has a tendency to use digital equipments than analog one in clinic. In this experiment, DR, CR, and Film are used for the resolution applied by AEC. Resolution phantom in DR was $7LP{\cdot}mm^{-1}$ in both verticality and horizontality. In CR, however, it was $6LP{\cdot}mm^{-1}$ in both which was lower this standard. The resolution stayed in range of standard in Film but it showed differences between $11{\sim}14LP{\cdot}mm^{-1}$ Overall, the difference of resolution was displayed Film, DR and CR, in order, which means the study is needed for more high quality of digital images.

• Journal of Digestive Cancer Research
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• 제2권2호
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• pp.45-51
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• 2014

Gastric cancer is the second most common cancer and the third leading cause of cancer-related deaths in Korea. Many cases of gastric cancer are detected in the early stages on standard medical examinations; complete surgical and endoscopic resection is the most recommended treatment for early-stage gastric cancer. Nevertheless, many patients have already progressed to advanced gastric cancer (AGC) upon diagnosis, and the prognosis of such patients is very poor. Combination chemotherapy has been shown to produce a better quality of life (QOL) and to increase overall survival in AGC patients. However, approximately 50% of patients do not respond to the current first-line chemotherapy, while most patients who do respond eventually show disease progression. Accordingly, various second-line regimens have been investigated, and active salvage chemotherapy has been shown to improve the QOL and clinical outcomes in select AGS patients who can tolerate it. There is also an increasing need for neoadjuvant therapy for treating gastric cancer; therefore, various clinical trials have been set up to investigate different regimens. Neoadjuvant therapy is currently established as the standard treatment for locally AGC in Europe; it has contributed to lowering the nodal stages and has reduced overall mortality rates. Despite these benefits, many uncertainties remain. Therefore, further prospective, high quality randomized controlled trials for neoadjuvant therapies are needed to clarify their clinical benefits and to establish the most effective treatment strategies for AGC.

• 조명전기설비학회논문지
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• 제21권6호
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• pp.94-101
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• 2007

하드 디스크(Hard Disk) 결함의 표준 패턴 클래스는 6가지로 분류되며, 이는 하드 디스크 생산 공정의 불량 처리 과정에서 중요한 역할을 수행한다. 본 논문에서는 다층 퍼셉트론(Multi-Layer Perceptron)을 이용한 하드 디스크 결함 분포의 패턴 인식 기법을 제시한다. 결함 분포로부터 5가지의 특징들을 추출하고, 이를 이용하여 퍼셉트론의 입력을 구성하였으며, 미리 분류된 표준 패턴 클래스를 이용하여 퍼셉트론의 출력을 구성하였다. 구성된 입출력 데이터들은 오차 역전파(Error Back-Propagation) 알고리듬을 통하여 다층 퍼셉트론의 학습에 사용되었다. 테스트 결과 제시된 신경망은 하드 디스크의 패턴 분류에 만족할 만한 성능을 나타내었다.

• 품질경영학회지
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• 제44권2호
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• pp.277-296
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• 2016

Purpose: Propose model to diagnose and assess National Defense Industry and quality management by investigating and analyzing established standard model. Methods: Research on established internal model including MB, EQA and JQA model and make standard index for quality index extraction and quantitative index to test objectively for internal state. Results: Extract advantage and disadvantage by performance of National Defense Industry level diagnose and build foundation for quality management policy and road map. Conclusion: Due to result of diagnostic assesment of quality management of national defense industry, dependability, SCQM and safety part shows vulnerability and require improvement and support.

• 재활복지공학회논문지
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• 제4권1호
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• pp.35-41
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• 2010

의료장비의 발달로 인해 병원에서의 영상진단, 고주파 수술기를 통한 위생적 치료, 고주파 온열기를 통한 암 치료 등 우리 생활에 가까운 곳에서 고주파를 이용한 의료기기들이 넓게 활용되고 있는 시점에 고주파를 이용한 응용기기들 간의 RF상호 간섭 문제에 대한 대책이 미흡한 실정이다. "그러므로 향후기술개발과 고주파응용 의료기기의 산업발전에 문제가 될 수 있는 요인을 방지하기 위하여 고주파응용의료기기의 사용 현장에서 발생될 수 있는 상호 간섭 문제를 합리적이고 적합한 시험방법개발이 필요하다." 본 논문에서는 고주파응용 의료기기에 대한 상호 간섭문제를 해결하기위해 전자파 평가를 위한 표준시험방법을 연구하였다.

• 한국치위생학회지
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• 제9권2호
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• pp.111-124
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• 2009

This study analyzes through the review of literature and laws the exposure time, clinical frequency, and radiation exposure of intraoral and extraoral radiography as well as of panoramic radiography performed by dental hygienists in dental clinics, compares the dental radiology curriculums of radiological science and dental hygiene departments, and proposes the expansion of dental hygienists' radiography operations. The radiology curriculums were compared between the radiological science and dental hygiene departments of colleges. For new analysis by radiography for dental diagnosis, the exposure time, radiation absorbed dose, effective dose, and number of days of natural radiation were compared by the type of oral radiation films and radiographical techniques proposed by domestic and international studies. The exposure time of panoramic radiography is 15 seconds and it takes about two minutes for completion, whereas the exposure time of the standard radiography is 0.2~0.8 seconds and it takes 10 times longer for completion of the radiography of full mouth than the panoramic radiography. The standard radiography can cause distortions of radiation at severely curved parts of dental arch and palatopharyngeal reflex. However, panoramic radiography can be performed even for lock jaw patients, causes less inconvenience to patients and is much simpler than the standard radiography. The percentage of dental clinics where radiography is performed by dental hygienists was 92.0%, and the percentage of standard film radiography by dental hygienists was 98% whereas the percentage of panoramic radiography by dental hygienists was 92%. For the absorbed dose which is an indicator of radiation exposure, the When the effective dose which is an indicator of the danger of radiation exposure was converted to the number of days of natural radiation, it was 3.3 days for panoramic radiography, but 13.9 days for the full mouth standard radiography by bisecting angle technique which was 4.2 times longer than the panoramic radiography. There were two colleges that had a dental radiology course with two credits in the departments of radiological science. The credits for dental radiology courses in the department of dental hygiene ranged varied by college, ranging from 3 to 8; on average, the theory course was 2.2 credits and the practice course was 2.02 credits. To summarize the above results, the percentage of dental clinics where panoramic radiography is performed by dental hygienists under the guidance of dentists is high. Panoramic radiography has become an essential facility for dental clinics. It is faster than standard film radiography and less dangerous due to low radiation exposure. Panoramic radiography is a simple mechanical job that does not require training of oral radiography by radiotechnologist. Because panoramic radiography is one of major operations which must be performed at all times in dental clinics, it must be designated as intraoral technique rather than extraoral technique, or legalized for inclusion in the scope of operations of dental hygienists.

• Tuberculosis and Respiratory Diseases
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• 제46권1호
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• pp.65-74
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• 1999

연구배경: 간질성폐질환의 진단을 위해 개흉폐생검이 전통적으로 이용되어 왔으나, 수술적검사로 인한 합병증의 위험성이 크다. 최근 간질성폐질환의 진단에 있어서 고해상도 전산화단층촬영(HRCT)과 경기관지폐생검이 널리 이용되고 있으며, 비교적 안전하고 진단율 또한 높은 것으로 알려져있다. 이에 저자들은 간질성폐질환의 진단에 있어서 이들 검사방법들의 유용성을 비교하여보고자 하였다. 방 법: 1995년 5월부터 1998년 6 월까지 단국대학교부속병원에서 급성 및 만성 간질성폐질환의 진단을 위해 HRCT와 개흉폐생검을 시행한 19명의 환자들의 의무기록을 후향적으로 조사하여 이들 환자들의 임상소견, 기저질환, HRCT소견, 경기관지폐생검소견, 개흉폐생검소견, 개흉폐생검의 합병증, 개흉폐생검 후의 치료방법 등을 분석하여 다음과 같은 결과를 얻었다. 결 과: 대상 환자 중에서 증상의 시작에서 개흉폐생검까지의 기간이 2주 이상인 만성 간질성폐질환 환자는 13명(68.4%)이었으며, 2주 미만인 급성 간질성폐질환 환자는 6명(31.6%)이었다. 개흉폐생검으로 만성 간질성폐질환 환자중 92%(12/13)에서 특정진단이 가능하였고(Bronchiolitis obliterans organizing pneumonia 5명, Constrictive bronchiolitis 2명, Usual interstitial pneumonia 3명, 과민성폐장염 1명, 호산구성폐장염 1명), 급성 간질성폐질환 환자들은 모두에서 특정진단이 가능하였다(급성 간질성폐렴 5명, 카리니 주폐포자충폐렴 l명). 개흉폐생검으로 특정진단이 가능하였던 12명의 만성 간질성폐질환 환자에서 HRCT의 첫 번째 가능한 진단명이 옳았던 경우는 50%(6/12)였다. 개흉폐생검 후 만성 간질성폐질환 환자의 62%(8/13)에서 특정 치료를 받았고(스테로이드치료 : 7명, 이사: 1명), 급성 간질성폐질환 환자들은 모두에서 특정 치료를 받았다(스테로이드치료 : 5명, 스테로이드와 항생제치료: 1명). 개흉폐생검 후 병원내 사망율은 5.3%(1/19)였다. 결 론: 간질성폐질환에서 HRCT와 경기관지폐생검에서 특정진단을 못 내릴 경우 개흉폐생검은 비교적 합병증이 적으면서 유용한 진단방법이며, 특히 급성 간질성폐질환에서는 치료에 많은 도움을 줄 수 있다.