• Reproductive and Developmental Biology
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• 제34권2호
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• pp.111-115
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• 2010

Erythropoietin (EPO), a glycoprotein hormone produced from primarily cells of the peritubular capillary endothelium of the kidney, is responsible for the regulation of red blood cell production. We have been investigating the roles of glycosylation site added in the biosynthesis and function of recombinant protein. In this study, we analyzed by immunohistochemical methods adaptive mechanisms to excessive erythrocytosis in transgenic (tg) mice expressing dimeric human erythropoietin (dHuEPO) gene. Splenomegaly was observed over 11~21 times in the tg mice. The 2,672 candidate spleen-derived genes were identified through the microarray analysis method, and decreased genes were higher than increased genes in the spleen. The specific proteins in the increased and decreased genes were analyzed by immunohistochemical methods. Our results demonstrate that problems of abnormal splenomegaly would solve in tg mice overexpressing dHuEPO gene.

• 한국임상수의학회지
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• 제23권3호
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• pp.263-266
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• 2006

The purpose of this study was to assess the usefulness of radiographic examination of the splenomegaly associated with drug-induced splenic congestion and to establish the standard goal of the splenomegaly in dogs. Radiographic images of spleen in normal dogs were collected to determine the maximum diameter prior to, and 15 minutes after, administration of acepromazine, ketamine/diazepam combination, or propofol. Significant splenic enlargement was seen after administration of acepromazine, but statistical signalficant was found in a ventrodorsal view only. Splenic size tended to decrease after administration of ketamine/diazepam combination. Significant splenic enlargement was not found after administration of propofol. These results suggest that measurable splenomegaly can be detected by radiographic examination after some kind of drug administration and the evaluation of splenomegaly is more useful at ventrodorsal view than lateral view.

• 한국임상수의학회지
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• 제25권1호
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• pp.52-57
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• 2008

An intact male, 3-year old, Sapsari, weighing 29 kg with a history of respiratory distress, anorexia, abdominal distension, and depression for 1 day was referred. Radiographic findings included a C-shaped soft tissue mass in the mid-abdominal cavity and loss of serosal detail. Ultrasonographs showed splenomegaly with hypoechoic coarse parenchyma, loss of venous flow in the dilated splenic veins, and thrombi. Based on image findings, acute isolated splenic torsion was diagnosed. Splenectomy and prophylactic gastropexy was performed. Another case was a spayed female, 8-year old, Shih-tzu, weighing 3.7 kg with a history of intermittent abdominal pain and a palpable abdominal mass for 1 year. Radiographic findings showed splenomegaly characterized by a soft tissue round mass. Ultrasonographs revealed displaced splenic hilum and absence of venous flow in the dilated splenic vein. Chronic isolated splenic torsion was diagnosed and also splenectomy and gastropexy was performed. Two dogs were recovered normally after surgery without any complications. Acute form of isolated splenic torsion showed acute systemic clinical signs, severe C-shaped splenomegaly on radiographs, and loss of all of splenic venous flow, perivenous hyperechoic triangle sign, and thrombi on ultrasonographs. Chronic form of isolated splenic torsion showed chronic obscure clinical signs, moderate splenomegaly on radiographs, and partial loss of splenic venous flow on ultrasonographs.

• 대한한방내과학회지
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• 제34권4호
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• pp.478-483
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• 2013

Objectives : To observe the therapeutic effects of an oriental herbal prescription in a hepatocellular carcinoma patient with splenomegaly and pancytopenia. Methods : Modified Sipjeondaebo-tang was prescribed three times a day to a hepatocellular carcinoma patient with splenomegaly and pancytopenia. Laboratory tests were carried out regularly to observe the therapeutic effects of the oriental herbal prescription for pancytopenia. Results : When treated with modified Sipjeondaebo-tang including Cinnamomi Cortex, the levels of white blood cells, red blood cells, hemoglobin, and hematocrit increased. However, aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma-glutamic transpeptidase, total bilirubin, direct bilirubin levels also increased. Conclusions : Administering modified Sipjeondaebo-tang with Cinnamomi Cortex showed effect in improving pancytopenia but an increase in liver enzyme levels was also observed.

• Parasites, Hosts and Diseases
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• 제52권2호
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• pp.189-191
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• 2014

Visceral leishmaniasis or kala-azar is an endemic parasitic disease in some parts of the world which is characterized by fever, splenomegaly, and pancytopenia in most of the cases. Herein we report an 11 month-old male infant with diagnosis of kala-azar who presented with pallor, hepatosplenomegaly, failure to gain weight, and no history of fever. Surprisingly, fever started after beginning of meglumine antimoniate treatment in this patient. As far as we are aware of, this is a rare presentation of visceral leishmaniasis. Therefore, clinicians especially in endemic areas are highly recommended to include kala-azar among differential diagnosis of unexplained anemia without fever to prevent misdiagnosis of this potentially fatal, but treatable condition.

• 대한핵의학회지
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• 제4권1호
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• pp.37-42
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• 1970

In an endeavor to help understand some typical scan findings and portal hemodynamics in liver cirrhosis, several commonly occurring scan changes and esophageal varices as demonstrated by esophagram were correlated one another from quantitative and qualitative stand points. Clinical materials consisted of 34 patients with proven diagnosis of liver cirrhosis and esophageal varices. Liver scan was performed with colloidal 198-Au and the changes in the size and internal architecture of the liver, splenic uptake and splenomegaly were graded and scored by repeated double-blind readings. The variceal changes on esophagrams were also graded according to the classification of Shanks and Kerley following modification. Of 34 patients, 91% showed definite reduction in liver volume (shrinkage) constituting the most frequent scan change. The splenic uptake and splenomegaly were noted in 73.5 and 79.4%, respectively. The present study revealed no positive correlation between the graded scan findings including shrinkage of the liver, splenic uptake or splenomegaly and severity of variceal changes of the esophagus. Exceptionally, however, apparently paradoxical correlation was noted between the severity of mottlings and varices. Thus, in the majority (73.5%) of patients mottlings were either absent or mild. This interesting observation is in favor of the view held by Christie et al. who consider the mottlings to be not faithful expression of actual scarring of the cirrhotic liver. This also would indicate that variceal changes are to be the results of intrahepatic arteriovenous shunting of blood with hypervolemic load to the portal system rather than simple hypertension secondary to fibrosis and shrinkage.

• Radiation Oncology Journal
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• 제6권2호
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• pp.259-262
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• 1988

만성 골수성 백혈병 치료에 있어서 비장의 방사선 조사는 화학요법에 반응이 없거나, 비종대가 심하여 비장 절제술을 시행할 수 없는 환자 그리고 통증을 동반한 비종대 환자에서 증상완화를 위하여 사용되고 있다. 가톨릭의대 성모병원 방사선과에서는 만성 골수성 백혈병에 있어 비장의 방사선 조준시 초음파를 이용하여 치료범위를 정하는 새로운 방법을 개발하여 이에 보고하는 바이다. 이 방법의 장점은 기존의 방사선 조준기를 사용하여 결정하는 방사선치료범위보다 작으며 비장만을 정확하게 포함 할 수 있으므로 효과적 인 비 장 조사 및 주변 장기의 방사선 보호, 그리고 부작용 등을 감소시킬 수 있다.

• Pediatric Infection and Vaccine
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• 제4권2호
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• pp.293-297
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• 1997

Malaria, caused by any of four species of protozoan parasites of the genus Plasmodium, is charaterized by high fever, anemia and splenomegaly. Although malaria is a cause of significant morbidity and mortality worldwide, in Korea indigenous malaria has been believed to be eradicated by 1984. However, since the case report of native malaria in 1993, reported cases have been increased annually, reaching more than 300 cases in 1996. We experienced a 2 years-old male with fever, severe anemia and splenomegaly who resided in Inchon city. He had the history of travelling to the area (Yunchon) near western Demilitarized Zone for 1 month this summer. After more than 2 weeks without special attention, he was presented with pallor, anemia and splenomegaly. He was diagnosed to have malaria by Plasmodium vivax with the help of peripheral blood smears which showed various forms of malaria, i.e., ring form, trophozoites, shizonts and gametocytes. He was treated successfully with hydroxychloroquine and primaquine. We report this case with brief review of related literature.

• 대한수의학회지
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• 제47권3호
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• pp.349-356
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• 2007

Isolated splenic torsion is a rare disease, which is usually produced in deep-chest large breed dogs. A five-year old Pitbull terrier and a four-year old Yorkshire terrier were diagnosed as isolated splenic torsion with chronic form. Leukocytosis, anemia and elevated hepatic enzyme level were found in blood test and a large amount of ascites was observed. Abdominal radiography revealed splenomegaly and ascites and ultrasonography showed diffuse hypoechoic change of spleen in case 1 and hyperechoic change of spleen with focal hypoechoic regions in case 2, thromboembolism of splenic vein and abnormal direction of spleen. To identify the underlying disease of isolated splenic torsion, the histopathologic examination of excised spleen is essential and splenic neoplasia was found in case 2. Chronic isolated splenic torsion shows nonspecific clinical signs and laboratory results. Through diagnostic procedure, particularly ultrasonography, prompt diagnosis may be achieved and improve the prognosis of the patient.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제10권2호
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• pp.221-225
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• 2007

저자들은 혈변을 호소하였던 3세된 여아에서 소아에서 비교적 드문 식도 정맥류와 비종대가 합병된 특발성 문맥 고혈압 1예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다.