• Archives of Pharmacal Research
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• 제28권5호
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• pp.619-625
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• 2005

Beads loaded with the water-soluble drug, phenylpropanolamine HCl (PPA), were prepared using an extruder and double arm counter-rotating roller modified from a traditional pill machine. The mean diameter of the cylindrical rod-like extrudate from the ram extruder was 3 mm; that of the uncoated bead after cutting and spheronization by the modified double arm counter-rotating roller was 3.26~3.28 mm. Although the surface of the beads was moderately rough and irregular, some exhibited hump-shaped protrusions, the sphericity was acceptable (roundness 1.15) and adequate for the subsequent coating process. An increase in mean diameter of the coated beads and improvements in friability and sphericity were observed in proportion to the amount of coating material applied (ethylcellulose or Eudragit？？ RS 100). It was also found that the release rate of PPA from the coated beads could be controlled by the amount and type of coating materials applied or with the incorporation of Eudragit ？？ RS 100 into the core matrix. Further modifications to the double arm counter-rotating roller, including adjustment of the rotation speed and distance between the rollers, would yield smaller uncoated beads with improved roundness and surface roughness. In conclusion , the present method could be potentially applied to prepare controlled release drug delivery beads or pellet dosage forms.

• 대한기계학회논문집 C: 기술과 교육
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• 제3권1호
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• pp.1-13
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• 2015

실외 열교환기의 착상 및 제상조건 하에서 VRF 멀티형 히트펌프의 동적 거동의 해석을 위한 시뮬레이션 기법이 제안되었다. 이를 위해 열전달-물질전달 완벽 상사 가정에 기반한 간단한 착상모델과 제상 모델이 제안되었다. 제안된 착제상 모델은 용량가변 압축기 모델과, 미소면적에 대한 열 및 모멘텀 평형에 근거한 열교환기 모델을 채택한 동적 사이클 해석모델에 적용되었다. 따라서, 제안된 모델은 공간에 대해 비균질 착상을 자연스럽게 예측할 수 있다. 개발된 동적 사이클 해석 모델은 실험결과와 비교하여 능력 및 효율을 10% 이내에서 잘 예측함을 확인하였다. 최종적으로, 개발된 모델은 표준적인 건물의 난방시즌 운전 해석에 적용되었으며, 착상 및 제상으로 인하여 동절기의 계절 성능계수를 7% 가량 하락 시킴을 보일 수 있었다.

• 대한교통학회지
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• 제23권1호
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• pp.33-44
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• 2005

철도건널목사고는 일반 도로사고보다는 상대적으로 사고의 발생도는 적으나, 사고의 심각도면에서는 대형사고로 연결될 수 있다는 점에서 철도건널목에서의 안전성 확보는 결코 소홀히 다루어질 수 없다. 본 연구에서는 건널목 사고모델을 통해 건널목 사고에 영향을 미치는 요인들은 분석하고 이를 정량화하여 교차로 안전성 향상에 기여하고자 한다. 본 연구에서는 건널목사고 분석에 있어서 사고데이터 특성을 고려하여 비선형 회귀분석 중 적정 모델식을 적용하였다. 철도건널목 관련 변수들을 이용하여 분석한 결과, 분산값이 0에 가까운 값을 나타내어 포아송 회귀분석이 적합한 것으로 나타났다. 또한 본 연구에서는 주 모델과 후보모델 통해 건널목 사고에 영향을 미치는 7개의 주요설명변수들을 규명했는데 그 변수들은 차량 교통량과 철도교통량, 상업지역, 제어거리, 경보시간차, 건널목유형, 과속방지턱으로 분석되었다.

• 대한교통학회지
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• 제35권4호
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• pp.321-331
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• 2017

이 연구는 원형교차로의 안전성을 다루고 있다. 연구의 목적은 학교와 인접한 원형교차로에서의 보행자 사고에 영향을 미치는 요인을 분석하는데 있으며, 이를 위해 이 연구는 학교 위치에 따른 보행자 사고를 비교분석하는데 중점을 두고 있다. 교통사고자료는 도로교통공단의 '교통사고분석시스템(TAAS)'를 이용하여 8개년도(2007-2014년) 자료이다. 보행자 사고모형을 개발하기 위해 다중선형회귀모형이 이용되며, 종속변수는 교통사고율이다. 독립변수에는 교차로의 기하구조 요인과 교통량 등이 포함된 28개 변수가 선정된다. 연구의 주요결과는 다음과 같다. 첫째, 모형개발에 앞서 학교와 인접한 원형교차로와 인접하지 않은 원형교차로의 사고가 차이가 있는지 확인하기 위해 가설검정을 실시한 결과, 차이가 있는 것으로 분석된다. 학교와 인접한 원형교차로일수록 사고가 오히려 적게 발생하는 것으로 평가된다. 둘째, 수정된 $R^2$값이 0.651-0.788으로 통계적으로 유의한 총 5개의 모형이 개발된다. 셋째, 학교와 인접한 원형교차로(모형 I-III)의 공통변수로는 분리교통섬 유무와 횡단보도 유무, 그리고 특정변수로는 원형교차로 유형, 초등학교 유무 및 정류장 유무가 채택된다. 넷째, 학교와 인접한 원형교차로와 인접하지 않은 원형교차로(모형 III-V)의 공통변수에는 분리교통섬 유무, 그리고 특정변수로는 원형교차로 유형, 초등학교유무, 횡단보도 유무, 감속시설 유무, 제한속도표지판 유무 및 유입차로 수가 선정된다. 따라서 학교 인접 원형교차로 유무에 따라 학생들의 안전을 확보하기 위해서는 학생들이 원형교차로 횡단 시 대기할 수 있는 공간을 제공해주는 분리교통섬과 안전하게 횡단할 수 있는 횡단보도의 설치가 권장된다.

• 대한조선학회지
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• 제6권1호
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• pp.25-34
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• 1969

From viewpoints of over-all ship economy the straight framed V-bottom hull forms with chines are considered to be attractive even for usual commercial vessels, because increments of resistance over that of round hull forms, if any, can be well compensated with reduction in construction cost.[1] To investigate the influences of both prismatic coefficient and chine elevation on resistance performance, three models of straight-framed V-bottom hull forms which are similar to Prof. C. Ridgely-Nevitt's W-18, W-8, and W-20[2],[3] in size and hull form coefficients were tested at the SNU Ship Model Towing Tank for resistance measurements. They are of Cp=0.60, 0.65 and 0.70 and of ${\Delta}/(0.01L)^3=300$. Influence of variation of chine elevation on resistance performance were observed with the test results obtained at normal condition, and at the trimed by the stern by 2% and 4% of $L_{bp}$ at normal condition under same displacement. The hull form characteristics are shown in Table 1, and in Fig. 1, 2, 3, 4 and 5. The test results are shown in Fig 8, 9 and 10 in the form of Cr vs. $V/\sqrt{L}$ curves taking Cp as a parameter for normal condition, trim by the stern in 2% and 4% $L_{bp}$ at normal condition , respectively. Cr vs. $V/\sqrt{L}$ curves taking trim condition as a parameter are also shown in Fig 11, 12 and 13 for Cp=0.60 and 0.70, respectively. The best and the worst trim condition at given $V/\sqrt{L}$ in viewpoint of Cr are plotted for each Cp-value as shown in Fig 14, 15 and 16. From the above results the following conclusions are derived: (1) In general, the resistance performance of the straight-framed V-bottom hull forms are not inferior to those of round hull forms. At a certain range of $V/\sqrt{L}$ the former gives less resistance than the latter. (2) Regarding influences of Cp on Cr, it is observed that, at $V/\sqrt{L}$ less than about 0.925, the greater Cp-value gives the more increment of Cr, and that, at $V/\sqrt{L}$ greater than about 0.925 the smaller Cp-value gives the more increment of Cr. It is also noteworthy that the model of Cp=0.70 has remarkable hump on Cr vs. $V/\sqrt{L}$ curve between $V/\sqrt{L}=0.80$ and 0.90. (3) For higher speed within the test range, the chine elevation having the steeper slope around bow and the easier slope around amidship and stern, refered to watering, give the better results in resistance performance. (4) Assuming the chine elevations adopted for the tested models were not of the best, we would expect further improvement of resistance performance for such form. Hence, a systematic study on chine elevation is very disirable to prepare design data of general purpose for the such hull forms.

• 대한소아치과학회지
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• 제25권2호
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• pp.400-420
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• 1998

We already know that it is very difficult to obtain an "isolated field" for direct bonding during the surgical exposure of unerupted teeth. The aim of this in-vitro study is to simulate the clinical situation of forced eruption and to evaluate the tensile strengths of preligatured button with several types of contamination which can happen during the surgical exposure of unerupted teeth. Four orthodontic direct bonding systems were used. ($Ortho-One^{TM}$, $Rely-a-Bond^{(R)}$, $Ortho-Two^{TM}$, Phase $II^{(R)}$) Each material was divided into four groups(n=20) : Group 1. (Control, no contamination), Group 2. (Rinse etching agent with saline instead of water), Group 3. (Blood contamination of etched surface for 30 seconds), Group 4. (Blood contamination of primed surface for 30 seconds) 320 bovine anterior permanent teeth were divided into the above mentioned 16 groups. Enamel surface was flattened and ground under water coolant. Pre-ligatured buttons were prepared to the same form. (Cut 0.25 ligature wire 10 cm in length. Twist the ligature wire 30 times clockwise. Mark the wire 15mm and 35mm points from button. Make a loop sticking two points together and twist the loop 6 times counterclockwise.) The bonded specimens were stored at $37^{\circ}C$ saline solution for 3 days. Then the tensile strength of each sample was measured with Instron universal testing machine, crosshead speed of 0.5mm/min. The following results were obtained: 1. As compared to control groups (Group 1) of each material, Rely-a-Bond had a significantly lower mean tensile strengths than other material. (p<0.01) 2. In Group 2. of Ortho-One and Rely-a-Bond, the mean tensile strengths decreased about 7.7% and 11.1%, respectively with statistical significances. (p<0.05) 3. In Group 2. of Ortho-Two and Phase II, the mean tensile strengths did not decrease. 4. In Group 3. of Ortho-One, Rely-a-Bond, Ortho-Two, and Phase II, the mean tensile strengths decreased about 60.8%, 56.1%, 60.2%, and 46.0%, respectively with statistical significances. (p<0.01) 5. In Group 4. of Ortho-One and Rely-a-Bond, the mean tensile strengths did not decrease. 6. In Group 4. of Ortho-Two and Phase II, the mean tensile strengths were decreased about 20.95% and 22.28%, respectively with statistical significances. (p<0.01) There were formations of a hump shaped mass from bonding resin under blood contamination which disturbed direct bonding procedure. According to Reynolds, the proper bond strength for clinical manipulation should be at least 45N or about 4.5Kg.F. According to these results, it can be concluded that Ortho-One could be used during surgical exposure of unerupted teeth. In any case, blood contamination of the etched surface should be avoided, but the blood contamination of primed surface of Ortho-One may not decrease bond strength. Just 'blowing-out' is enough to remove blood from primed surface of Ortho-One. You can verify the clean surface of the primer of Ortho-One after blowing out the blood contamination.