• 대한방사성의약품학회지
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• 제1권1호
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• pp.46-52
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• 2015

Herein we present the synthesis of $^{68}Ga$-labeled gold nanoparticles for in vivo PET imaging. A novel chelator DTPA-Cys was easily prepared from diethylenetriaminepentaacetic dianhydride in high yield. The ${\alpha}_v{\beta}_3$ integrin receptor targeted gold nanoparticle probe was synthesized by using DTPA-Cys, polyethylene glycol and cRGD peptide. $^{68}Ga$ labeling of cRGD conjugated gold nanoparticle was carried out at $40^{\circ}C$ for 30 min. Observed radiochemical yield was more than 75% as determined by radio-TLC and the probe was purified by centrifugation. In vitro stability test showed that 90% of $^{68}Ga$-labeled gold nanoparticle probe was stable in FBS for 1 h. Those results demonstrated that $^{68}Ga$-labeled gold nanoparticle could be used as a potentially useful probe for specific tumor imaging.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2009년도 춘계학술발표대회
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• pp.14.1-14.1
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• 2009

We found a high yield synthetic route to organic-soluble metal nanoparticles in the concentrated organic phase. The organic phase contains metal salt, amines, fatty acids, nonpolar solvent, and reducing agent. Even using only generic chemicals, organic-soluble silver and copper nanoparticles could be easily obtained by this simple and rapid reaction scheme at large scale. The hydrocarbon-protected metal nanoparticles showed excellent dispersion properties and were successfully printed onto polymer substrates. The printed pattern was heated at $200^{\circ}C$, which showed very low specific electrical resistance (< 10 uOhm$\cdot$cm), sufficient for conducting line of various printable devices.

• 반도체디스플레이기술학회지
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• 제13권4호
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• pp.83-90
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• 2014

This paper is about the yield rate of lower temperature furnace for wafer heat-treatment. The flat-zone that the temperature in furnace has uniform distribution specific area is the significant variable to the yield rate. In this study, we researched about the ways how to widen the flat zone in the furnace using CFD. As a result, we confirmed that the characteristic of the flat-zone was changed when SCU(Super Cooling Unit) was used. We considered temperature control with above.

• Food Science and Biotechnology
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• 제16권1호
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• pp.110-115
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• 2007

In this study we investigated the volatile compounds that are generated in sesame and contribute to its characteristic flavor. Different reaction systems were used to examine how certain amino acids influenced flavor profiles, and also to evaluate the effects of sugar types on the distribution of those volatile compounds. The volatiles that were generated in each reaction system were selectively isolated and analyzed by gas chromatography and gas chromatography-mass spectrometry, respectively. Among the 20 identified compounds, nitrogen-containing alkylpyrazines were found to be the predominant volatiles. The alkylpyrazine amounts varied across the different model systems, with the total yield being highest in the arginine reaction mixture, followed by the alanine, serine, and lysine mixtures. In general, fructose generated the most extensive amount of volatiles compared to glucose and sucrose. However, the yield of specific flavor compounds varied according to the type of sugar used. Finally, the results clearly showed that a reaction temperature of $135^{\circ}C$ and a reaction time of 20 min generated the highest amount of volatile compounds.

• 펄프종이기술
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• 제42권5호
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• pp.1-14
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• 2010

Bio-ethanol is a promising alternative energy source for reducing both consumption of crude oil and environmental pollution from renewable resources like lignocellulosic biomass such as wood, forest residuals, agricultural leftovers and urban wastes. Based on current technologies, the cost of ethanol production from lignocellulosic materials is relatively high, and the main challenges are the low yield and high cost of the hydrolysis process. Development of more efficient pretreatment technology (physical, chemical, physico-chemical, and biological pretreatment), integration of several microbiological conversions into fewer reactors, and increasing ethanol production capacity may decrease specific investment for ethanol producing plants. The purpose of pretreatment of lignocellulosic material is to improve the accessible surface area of cellulose for hydrolytic enzymes and enhance the conversion of cellulose to glucose and finally high yield ethanol production which is economic and environmental friendly.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 춘계학술대회 논문집
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• pp.64-68
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• 2005

In recent years, there has been a growth of the manufacture and application of magnesium products because of its small specific gravity as well as its relatively high strength. However, there are so many studies to assure good formability because magnesium sheet alloy is difficult to form. In this study, uniaxial tensile and biaxial tensile test of AZ31 magnesium sheet alloy with thickness of 1.2mm were performed at room temperature. Uniaxial tensile test were performed until $7\%$ of engineering strain. R-values and stress-strain curve were obtained. Biaxial tensile tests with cruciform specimen were performed until the breakdown of the specimen occurs. The yield loci are made by application of plastic work theory. The results are compared with the theoretical predictions based on the Hill and Logan-Hosford model. However, next study will be performed at warm-temperature because the specimens are broken under the $0.5\%$ of equivalent strain at biaxial tensile test.

• 한국연초학회지
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• 제6권1호
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• pp.3-11
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• 1984

In order to obtain the basic information for the successful breeding of aromatic tobacco (Nicotiana tabacum L.), the heterosis, combining ability and gene distributions in 28 Fl hybrids by diallel crosses between Korea local and Oriental varieties were investigated. The yield were higher, stalk height, leaf length and leaf width were larger and days to flower was shorter for the Fl hybrids when compared to mid-parent. Estimates of general combining ability were significant for all characters investigated, and specific combining ability were significant for yield, stalk height, leaves Per Plant, leaf width and days to flower. In vr-wr graph, partial dominane was exhibited by all characters investigated.

• Journal of Ginseng Research
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• 제43권3호
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• pp.482-487
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• 2019

Background: The mixed-cultivation of different Panax ginseng cultivars can cause adverse effects on stability of yield and quality. K-1 is a superior cultivar with good root shape and stronger disease resistance. DNA markers mined from functional genes are clearly desirable for K-1, as they may associate with major traits and can be used for marker-assisted selection to maintain the high quality of Korean ginseng. Methods: Five genes encoding pathogenesis-related (PR) proteins of P. ginseng were amplified and compared for polymorphism mining. Primary, secondary, and tertiary structures of PR5 protein were analyzed by ExPASy-ProtParam, PSSpred, and I-TASSER methods, respectively. A coding single nucleotide polymorphism (SNP)-based specific primer was designed for K-1 by introducing a destabilizing mismatch within the 3' end. Allele-specific polymerase chain reaction (PCR) and real-time allele-specific PCR assays were conducted for molecular discrimination of K-1 from other cultivars and landraces. Results: A coding SNP leading to the modification of amino acid residue from aspartic acid to asparagine was exploited in PR5 gene of K-1 cultivar. Bioinformatics analysis showed that the modification of amino acid residue changed the secondary and tertiary structures of the PR5 protein. Primer KSR was designed for specific discrimination of K-1 from other ginseng cultivars and landraces. The developed real-time allele-specific PCR assay enabled easier automation and accurate genotyping of K-1 from a large number of ginseng samples. Conclusion: The SNP marker and the developed real-time allele-specific PCR assay will be useful not only for marker-assisted selection of K-1 cultivar but also for quality control in breeding and seed programs of P. ginseng.

• 핵의학기술
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• 제12권3호
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• pp.176-180
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• 2008

Department of Nuclear Medicine in Seoul National University Hospital (SNUH) had developed $^{18}F$-Flumazenil as Benzodiazepine receptor imaging agent for PET diagnosis of Epilepsy. But production Activity of $^{18}F$-Flumazenil is decreased owing to this method has difficult synthesis procedures and pretty long synthesis time. In this study, we can modify synthesizing method to have more simple procedure and less spend time and help to increase production Activity. Old method: Radioactivity was produced by cyclotron was captured by QMA cartridge that was activated. Captured radioactivity was eluted into the reaction vial by using kryptofix solution and delivered. After evaporation of eluent, the azeotrophic drying step repeated two times. tosylflumazenil in anhydrous Acetonitrile was added to a reaction vial while bubbling. The reaction mixture was evaporated until the mixture volume was 0.5 mL. Reaction vial washed with 20 % Acetonitrile and that solution went into the reaction vial. The reaction mixture was loaded to the HPLC loop by hand and purified $^{18}F$-Flumazenil by HPLC column. New method: We used $TBAHCO_3$ solution as a eluent. After the eluent was evaporated, tosylflumazenil in anhydrous acetonitrile was added to a reaction vial and the reaction mixture was bubbled for 15 minutes. It was evaporated until the mixture volume became 0.5 mL. It was loaded to the HPLC loop. In old method, $^{18}F$-Flumazenil was synthesized via 6 steps synthesis procedures in 105 minutes with 30~35% synthesizing yield (non-decay correction) and specific activity was about $0.5{\sim}2{\times}10^5$ Ci/mole. In new method, It had 3 steps synthesis procedures in 53 minutes with 40~45% synthesizing yield and specific activity was about $3{\sim}8{\times}10^5$ Ci/mole. This method leads to improve of minimizing synthesis time, increasing synthesis yield and specific activity. While we can load reaction mixture to the HPLC loop, we can expose high radiation field thanks to used by hand.

• 한국수자원학회논문집
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• 제52권9호
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• pp.637-645
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• 2019

본 연구는 유역에서 제공하는 다양한 생태서비스 가운데 네팔의 Bagmati 유역의 물생산량(Water yield)을 산정하였다. 물 공급, 관개 수력 등 다양한 시설에 사용되는 물생산량 지도는 계획 및 관리에 도움이 되며 생태서비스의 공급과 생산에 의도하지 않은 부정적 영향을 줄일 수 있다. 여러 문헌들은 네팔 Bagmati유역에 대한 탄소저장과 식수공급과 같은 생태서비스 제공 연구에 중점을 두었으나 토양피복별 혹은 소유역별 물 생산량에 대한 연구는 매우 미흡했다. 따라서 본 연구에서는 네팔 바그 마티 유역에서 소유역 규모와 함께 유역의 총 물생산량을 계산하고 유역의 토지피복 유형별로 물생산량을 산정하기 위해 시작되었다. 이를 위해, 생태서비스 평가를 위해 가장 많이 사용되는 Budyko 수문학적 방법에 바탕을 둔 ArcGIS기반 InVEST Water Yield 모형이 사용되었다. 본 연구로부터의 결과는 단위면적(ha)e당 물 생산량이 소유역 5 ($15216.32m^3/ha$)에서 가장 높았으며 소유역 6 ($10847.15m^3/ha$)에서 가장 낮았다. 토지피복별 물생산량은 도시화지역에서 가장 높게 산정되었으며, 초원과 농경지가 도시화지역 다음으로 높게 산정되었다. 본 연구에서 산정된 소유역별, 토지피복별 물생산량은 지역 규모의 상호 관련 서비스 개발을 위한 효율적인 시나리오를 제공하고 지속 가능한 토지 이용 정책 및 상호 관련된 물 관리 서비스를 촉진시킬 것으로 기대한다.