• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.41-49
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• 1994

The most common conventional method of discovering a drug involves a massive screening of a large number of compounds in chemical libraries or in the extracts from natural sources such as plants or microbial broths followed by chemical modification of one or more active compounds to improve their properties as a drug. When the three-dimensional structure of the target molecule for which the drug is searched is known the drug discovery process can be significantly simplified, This is especially true when the three-dimensional structure of a complex between the target and a lead compound is known. In this lecture our experience on the structure-based drug design for human CDK2(cyclin-dependent protein kinase 2) will be discussed with special emphasis on the strength and weakness of this approach of drug discovery. The regulation of the activity of CDK2 plays an important role in the cell proliferation of normal and cancer cells.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 춘계학술대회 논문집
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• pp.565-568
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• 2009

Most of the historic hot springs are artesian wells in Korea. However, many boreholes have been drilled due to the shortage of hot water, and hot water is now being pumped by submersible pump installed at most of hot spring areas. The distribution of boreholes are expected to be related to the geological structure, and the study was carried out to interpret the relationship between two factors. The distributional maps of boreholes were made and the geological structures were interpreted at eight hot spring areas. Some distributions of boreholes have no special direction, and these are not related to the geological structure at Dogo, Suanbo, and Deoksan. The others are consistent with the direction of the geological structure at Goseong, Onyang, Sokcho, Yuseong, and Bugok.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2015년도 제46회 하계학술대회
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• pp.848-849
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• 2015

This paper presents the structure design for optimizing output power density and efficiency to develop a spoke-type interior permanent magnet synchronous generator (IPMSG). To obtain the optimal structure, the combination of response surface method (RSM) and 2-D finite element analysis can solve the problem effectively for reducing the volume of permanent magnets (PMs) and maximizing the ratio between power density and efficiency. The effectiveness of this proposed structure design is verified by the simulation and experiment according to the comparison of the electromagnetic characteristics between the initial and modified structure.

• 대한조선학회 특별논문집
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• 대한조선학회 2005년도 특별논문집
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• pp.206-210
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• 2005

As design trends has changed to have flexible aft hull structure, increased power output and stiffer shafting system, owners and classification societies have more concerned about shaft alignment. In the shaft alignment analysis, there are many uncertainties which are related in propeller generated force, bearing stiffness, crank shaft model and etc. in this study, it is focused on the effect of crankshaft model by comparing between equivalent model and actual crankshaft model.

• 대한조선학회 특별논문집
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• 대한조선학회 2007년도 특별논문집
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• pp.7-13
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• 2007

The purpose of this study is to develop a structural analysis system of LNG pump tower structure. The system affords to build optimized finite element model and analysis procedure of the pump tower structure. The pump tower structure is one of the most important components of LNG (liquefied natural gas) carriers. The pump tower structure is subject to sloshing load of LNG induced by ship motion depending on filling ratio. Three types of loading components, which are thermal, inertia and self-gravity are considered in the system. All these design and analysis procedures are embedded in to the analysis system successfully.

• 대한조선학회 특별논문집
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• 대한조선학회 2011년도 특별논문집
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• pp.47-50
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• 2011

E/R bulkhead is watertight bulkhead between engine room and cargo hold. So, it must have sufficient strength about cargo load of aft hold. Especially, partial stringer deck between tank top and $2^{nd}$ deck of engine room must have sufficient strength because it has function of primary supporting member. Generally, cargo hold structure is verified through the direct calculation as finite element analysis of cargo hold, but engine room structure doesn't perform it. Therefore, we have performed finite element analysis of engine room stringer deck which considered cargo hold load. And then, it will be able to apply similar ship design.

• Structural Engineering and Mechanics
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• 제29권4호
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• pp.381-390
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• 2008

This paper proposed a conceptual design of bascule bridge, which is a new kind of movable bridge with an aim of reducing the weight of superstructure. Compared with the traditional bascule bridge, the light bascule bridge chooses cable-stayed bridge with inclined pylon as its superstructure; therefore, the functions of balance-weight and structure will fuse into one. Otherwise, it adopts moving counterweight to adjust its center of gravity (CG) to open or close the bridge. In order to lighten the superstructure, it uses contact springs to auxiliary retract, and intelligent prestressing system (IPS) to control the main girder's deformation. Simultaneously the vibration control scheme of structure is discussed. Starting from establishing the mechanical model of bridge, this article tries to analyze the conditions that the design parameters of structure and attachments should satisfy to. After the design procedure was presented, an example was also adopted to explain the primary design process of this kind bridge.

• 한국ITS학회 논문지
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• 제15권5호
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• pp.1-11
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• 2016

본 연구는 고령자와 임산부 등 교통약자의 이동권 증진과 사회참여 여건 확대 측면에서 운영 중인 특별교통서비스(이하 STS)의 이용증진 기여를 목적으로 한다. 이를 위해 수원시에서 운영 중인 STS시스템의 이용자 DB를 분석하였으며, 고령자와 임산부 이용자 대상의 진술 선호도를 조사하였다. 구체적으로는 STS 중심의 선호도 모형을 구축하고, 그 영향인자들을 비교하여 STS의 이용 활성화 방안을 모색하였다. 연구결과, STS 이용자의 약 23%는 고령자와 임산부이며, 병원 통행목적의 이용자는 31%, 2~5km의 단거리 통행자는 70% 수준인 것으로 나타났다. STS와 버스 대상의 진술 선호도 조사결과, 고령자의 경우 통행요금이 가장 영향력 있는 인자이며 연령이 많을수록 STS를 선호하는 것으로 확인되었다. 임산부의 경우 통행시간과 통행요금이 수단선택의 주요 영향인자이며, 통행빈도가 많을수록 STS를 선호하는 것으로 확인되었다. 그리고 STS의 이용요금이 일반택시 요금의 약 70% 수준일 경우, 고령자와 임산부의 버스 대비 STS 분담률은 각 51.1%, 63.6%으로 분석되어, STS 이용 활성화를 위한 이용요금 조정은 효과적인 것으로 확인되었다. 본 연구결과는 STS의 합리적인 요금체계를 정립하기 위한 근거로 활용될 수 있으며, 고령자와 임산부의 STS 이용을 증진하여 고령자의 승용차 운전에 따른 교통사고 감소 및 임산부의 버스 이용에 따른 위험성 예방에 기여할 것으로 기대된다.

• 한국융합학회논문지
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• 제10권8호
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• pp.181-193
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• 2019

제주특별자치도 출범, 순유입입구 증가 등으로 제주 지역경제는 2011년부터 전국보다 높은 경제성장세를 보이고 있으나, 2016년 이후 경제성장이 둔화되고 있다. 본 연구에서는 지역경제의 변화요인이 많았던 제주도를 대상으로 2010년부터 2016년까지 산업별 생산액과 종사자수를 이용하여 동태적 변이할당분석을 실시하였다. 분석결과 제주 지역경제는 국가성장에 의존하는 산업구조에서 벗어나 산업구조와 지역의 경쟁력에 의한 산업구조로 성장하고 있다고 할 수 있다. 생산액과 종사자수에 대해 산업구조 효과와 경쟁 효과가 모두 양(+)의 값을 갖는 산업으로 전기 가스 증기 및 수도사업, 건설업, 숙박 및 음식점업, 사업서비스업으로 분석되었다. 이들 산업은 제주 지역경제에 긍정적인 영향을 미치고 있는 산업들이라 할 수 있다. 앞에서 언급한 산업들은 여타 지역에 비해 성장률이 높을 뿐만 아니라 제주 지역경제를 견인하는 사업이라 할 수 있다. 이 산업들이 지속적으로 제주 지역경제에 기여할 수 있도록 장기적인 관점에서 정책적 제도적 지원이 필요하다고 하겠다.

• Structural Engineering and Mechanics
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• 제50권5호
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• pp.605-616
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• 2014

When the periodic cellular structure is loaded or swelling beyond the critical value, the structure may undergo a pattern transformation owing to the local elastic instabilities, thus leading to structural collapse and the structure changing to a new configuration. Based on this deformation-triggered pattern, we have proposed the novel composite gel materials. This designed material is a type of architectural material possessing special mechanical properties. In this study, the mechanical behavior of the composite gel periodic structure with various gel inclusions is studied further through numerical simulations. When pattern transformation occurs, it results in a different elastic relationship compared with the material at untransformed state. Based on the obtained nominal stress versus nominal strain behavior, the Poisson's ratio and corresponding deformed structure patterns, we investigate the performance of designed composite materials and the effects of the uniformly distributed gel inclusions on composite materials. A better understanding of the characteristics of these composite gel materials is a key to develop its potential applications on new soft machines.