• Journal of Genetic Medicine
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• 제15권2호
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• pp.97-101
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• 2018

Tricho-rhino-phalangeal syndrome (TRPS) is a hereditary disorder characterized by craniofacial and skeletal abnormalities. A mutation of the TRPS1 gene leads to TRPS type I or type III. A 20-year-old male patient visited our neurologic department with chronic fatigue. He presented with short stature, sparse hair, pear-shaped nose, and brachydactyly. Radiologic study showed short metacarpals, metatarsals with cone-shaped epiphyses, hypoplastic femur and hip joint. Panel sequencing for OMIM (Online Mendelian Inheritance in Man) listed genes revealed a de novo heterozygous frameshift mutation of c.1801_1802delGA (p.Arg601Lysfs*3) of exon 4 of the TRPS1 gene. The diagnosis of TRPS can be challenging due to the rarity and variable phenotype of the disease, clinicians should be aware of its characteristic clinical features that will lead a higher rate of diagnosis.

• Parasites, Hosts and Diseases
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• 제24권1호
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• pp.63-70
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• 1986

The tegumental ultrastructures oi Echinostoma hortense adults were observed by scanning electron microscopy. The worms of 4 weeks of age were harvested from albino rats experimentally infected with the metacercariae obtained from the loach. The results were as follows: 1. The worms were leaf-like and their anterior end portion, including oral sucker and head crown, ventrally curved to face posteriorly. The tegument of whole body was wrinkled transversely and covered with cobblestone-like cytoplasmic processes. 2. The oral sucker had roundly swollen (type I ) sensory papillae on the ventral half of its lip and mini-ciliated knob-like (type I ) sensory papillae, arranged in 2∼3 rows, on the dorsal outer surface. 3. Aspinous ventral sucker had many of type I papillae arranged in a circular band on its outer surface. The tegument around the genital opening was of similar feature to the ventral sucker, but sensory papillae were hardly found around the former. 4. Scale-like spines with broad base and round tip were distributed densely on the tegument anterior to the ventral sucker but they became sparse in posterior half of the ventral surface, finally to disappear at posterior extremity. A few number of type I papillae were observed on the ventral surface. The results suggest that the tegument of 5. hortense is similar to that of other echinostomes etapecially 5. revolutum. But the number and arrangement of collar spines, and/or the type and distribution of sensory papillae seem characteristic features of E. hortense differed from other echinostomes.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 학술대회 논문집 전문대학교육위원
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• pp.134-140
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• 2001

Parallel processing has the potential to be cost effectively used on computationally intense power system problems. But this technology is not still available is not only parallel computer but also parallel processing scheme. Testing these algorithms to ensure accuracy, and evaluation of their performance is also an issue. Although a significant amount of parallel algorithms of power system problem have been developed in last decade, actual testing on processor architectures lies in the beginning stages. This paper presents the parallel processing algorithm to supply the base being able to treat power flow by newton's method by the distributed memory type parallel computer. This method is to assign and to compute teared blocks of sparse matrix at each parallel processors. The testing to insure accuracy of developed method have been done on serial computer by trying to simulate a parallel environment.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1861-1864
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• 2016

Although early diagnosis of thyroid nodule type is very important, the diagnostic accuracy of standard tests is a challenging issue. We here aimed to find an optimal combination of factors to improve diagnostic accuracy for distinguishing malignant from benign thyroid nodules before surgery. In a prospective study from 2008 to 2012, 345 patients referred for thyroidectomy were enrolled. The sample size was split into a training set and testing set as a ratio of 7:3. The former was used for estimation and variable selection and obtaining a linear combination of factors. We utilized smoothly clipped absolute deviation (SCAD) logistic regression to achieve the sparse optimal combination of factors. To evaluate the performance of the estimated model in the testing set, a receiver operating characteristic (ROC) curve was utilized. The mean age of the examined patients (66 male and 279 female) was $40.9{\pm}13.4years$ (range 15- 90 years). Some 54.8% of the patients (24.3% male and 75.7% female) had benign and 45.2% (14% male and 86% female) malignant thyroid nodules. In addition to maximum diameters of nodules and lobes, their volumes were considered as related factors for malignancy prediction (a total of 16 factors). However, the SCAD method estimated the coefficients of 8 factors to be zero and eliminated them from the model. Hence a sparse model which combined the effects of 8 factors to distinguish malignant from benign thyroid nodules was generated. An optimal cut off point of the ROC curve for our estimated model was obtained (p=0.44) and the area under the curve (AUC) was equal to 77% (95% CI: 68%-85%). Sensitivity, specificity, positive predictive value and negative predictive values for this model were 70%, 72%, 71% and 76%, respectively. An increase of 10 percent and a greater accuracy rate in early diagnosis of thyroid nodule type by statistical methods (SCAD and ANN methods) compared with the results of FNA testing revealed that the statistical modeling methods are helpful in disease diagnosis. In addition, the factor ranking offered by these methods is valuable in the clinical context.

• 복식
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• 제55권5호
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• pp.65-77
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• 2005

This stuffy is to understand the symbolic meaning of Korean traditional animal Patterns, to analyze their figurative characteristics focusing on fabric relics of Chosun Dynasty, and to search their internal beauty as well as their external beauty. Animal patterns can be classified as Individual type, the type that only animal patterns are used, and Compound type, the type that animal patterns are used with other patterns. The Individual type was not found at all. Only the Compound type, compounded with two or three other patterns, were found. Among the other patterns used in the Compound type, botanical patterns and heaven-and-earth-shaped patterns were the majority while letters patterns were rarely used. Bird patterns take enormously large part of the animal patterns. In terms of the arrangement, animal patterns are classified as Dense type, Sparse type, and Picturesque type.'rho three types are almost equal in their quantity. Picturesque type is found comparatively a lot. Animal patterns are much more frequently used in female clothes than in male clothes. For female clothes, they are mostly used in some parts of the clothes with ornamental effect. But, for male clothes, they are mainly used all over the fabric by weaving animal patterns on it. Not just their external beauty, animal patterns have also internally beautiful characteristics, such as keeping away from wicked ghosts, hoping for good luck, emblematic features, having ideological meanings, and so on.

• 한국정보과학회논문지:소프트웨어및응용
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• 제29권11호
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• pp.775-784
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• 2002

DNA chip 기술에 의해 얻어지는 마이크로어레이(microarray) 데이타는 세포나 조직 내의 수천 개 유전자의 발현도(expression level)를 한번에 측정한 것으로, 유전자 발현 양상에 기반한 암의 진단, 유전자의 기능 예측 등에 이용되고 있다. 다양한 데이타 분석 기법들 중 베이지안망(Bayesian network)은 데이타의 각 속성들간의 관계를 그래프 형태로 표현할 수 있는 특징을 가지고 있다. 이는 마이크로어레이 데이타의 분석을 통해 여러 유전자와 조직의 특성(암의 종류 등) 사이의 관계를 밝히는데 유용하다 하지만 대부분의 마이크로어레이 데이타는 sparse data로 베이지안망을 비롯한 각종 분석 기법의 적용을 어렵게 하고 있다. 본 논문에서는 베이지안망에 기반한 마이크로어레이 데이타 분석을 위해 효율적 구조 학습 알고리즘과 데이타 차원 축소를 이용한다. 제시되는 분석법은 실제 마이크로어레이 데이타인 NC160 data set에 적용되었으며, 그 유용성은 데이타로부터 학습된 베이지안망이 실제 생물학적으로 알려진 사실들을 어느 정도 정확하게 표현하는지에 의해 평가되었다.

• Journal of applied mathematics & informatics
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• 제11권1_2호
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• pp.305-316
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• 2003

Recently, an iterative algorithm for finding the interior eigenvalues of a definite matrix by CG-type method has been proposed. This method compares to the inverse power method. The given matrices A, and B are assumed to be large and sparse, and SPD( Symmetric Positive Definite) The CG scheme for the optimization of the Rayleigh quotient has been proven a very attractive and promising technique for large sparse eigenproblems for smallest eigenvalue. Also, it is very amenable to parallel computations, like the CG method for the linear systems. A proper choice of the preconditioner significantly improves the convergence of the CG scheme. But for parallel computations we need to find an efficient parallel preconditioner. Our candidates we ILU(0) in the wave-front order, ILU(0) in the multi-coloring order, Point-SSOR(Symmetric Successive Overrelaxation), and Multi-Color Block SSOR preconditioner. Wavefront order is a simple way to increase parallelism in the natural order, and Multi-coloring realizes a parallelism of order(N), where N is the order of the matrix. Another choice is the Multi-Color Block SSOR(Symmetric Successive OverRelaxation) preconditioning. Block SSOR is a symmetric preconditioner which is expected to minimize the interprocessor communication due to the blocking. We implemented the results on the CRAY-T3E with 128 nodes. The MPI (Message Passing Interface) library was adopted for the interprocessor communications. The test problem was drawn from the discretizations of partial differential equations by finite difference methods. The results show that for small number of processors Multi-Color ILU(0) has the best performance, while for large number of processors Multi-Color Block SSOR performs the best.

• Smart Structures and Systems
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• 제20권1호
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• pp.35-42
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• 2017

Recently, compressive sensing based data loss recovery techniques have become popular for Structural Health Monitoring (SHM) applications. These techniques involve an encoding process which is onerous to sensor node because of random sensing matrices used in compressive sensing. In this paper, we are presenting a model where the sampled raw acceleration data is directly transmitted to base station/receiver without performing any type of encoding at transmitter. The received incomplete acceleration data after data losses can be reconstructed faithfully using compressive sensing based reconstruction techniques. An in-depth simulated analysis is presented on how random losses and continuous losses affects the reconstruction of acceleration signals (obtained from a real bridge). Along with performance analysis for different simulated data losses (from 10 to 50%), advantages of performing interleaving before transmission are also presented.

• 응용통계연구
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• 제10권2호
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• pp.339-352
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• 1997

소표본으로부터 형성되는 2원 분할표에는 빈도가 작은 칸들이 적지 않기 때문에 대표본이론에 근거한 카이제곱 검증 등 기존 통계적 방법의 적용이 적절하지 않응 수가 있다. 이런 경우에 한 대안으로서 정확검증법(exact tests)이 개발되어 있으나 이것이 너무 많은 계산을 요구하므로 사용하기가 쉽지 않다. 본 연구는 소표본 2원 분할표에서, 단순한 몬테칼로 알로리즘에 의한 행 균일성 가설의 카이제곱 임의화 검증법(randomization test)을 제안하고 튜키(Tukey) 형의 행간 다중비교법을 제안한다. 아울러 열 범주가 순서형인 2원 분할표에 대하여도 유사한 방법론을 적용할 수 있음을 밝힌다.

• 대한소아치과학회지
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• 제21권2호
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• pp.570-576
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• 1994

Ectodermal dysplasia is characterized by a partial or complete lack of primary and permanent teeth, other ectodermal structures that may be affected include the skin, hair, and sweat glands. The patient with the so-called anhidrotic type of ectodermal dysplasia exhibits dry skin, lack of sweat glands, sparse eyebrows, body hair, saddle nose, and everted lips. Genetic basis of anhidrotic ectodermal dysplasia is recessive and sex-linked, being manifested chiefly in males, but this is debatable. A 6-year-old boy, with typical signs of anhidrotic ectodermal dysplasia, was presented. Prosthetic restoratoins are of great value to these patients, both from the standpoint of function and for psychologic reasons. The need for complete denture is critical during preschool periods and continues into adulthood. The following case report is an approach to the management of a patient with anhidrotic ectodermal dysplasia.