• 대한소아치과학회지
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• 제45권4호
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• pp.418-425
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• 2018

이 연구의 목적은 고점도 글라스아이오노머와 레진 강화형 글라스아이오노머의 시간에 따른 불소 유리량, 미세경도, 용해도를 측정하고 비교하는 것이다. 고점도 글라스아이오노머인 Fuji IX GP EXTRA, Fuji IX GP, 레진 강화형 글라스아이오노머인 Fuji II LC를 실험군으로, Filtek$^{TM}$ Z350XT을 대조군으로 설정하였으며 탈이온수에 보관한 후 84일간 불소 유리량, 미세경도, 용해도를 측정하였다. 불소 유리량의 측정 결과 모든 글라스아이오노머는 1일에 불소 유리량이 가장 높았으며 서서히 감소하였다. 불소 유리량과 누적량은 Fuji IX GP EXTRA가 가장 높았으며 Fuji IX GP와 Fuji II LC는 유의한 차이를 보이지 않았다. 미세경도 측정 결과 모든 실험군에서 수분 노출 1일 후 측정에서 미세경도의 감소를 보였으며 84일 후 미세경도는 Fuji IX GP EXTRA와 Fuji IX GP가 유의한 차이를 보이지 않았고 Fuji II LC이 가장 낮았다. 용해도 측정에서 Fuji IX GP EXTRA, Fuji IX GP, Fuji II LC은 21일까지 급격히 증가하였으며 21일 이후에는 세 군이 유의한 차이를 보이지 않았다. 결과적으로 단기간의 불소 유리는 용해도와 미세경도에 영향을 미치지만 장기간의 불소 유리는 물성과 상관관계를 가지지 않았다. 이 연구를 통하여 여러 가지 글라스아이오노머의 불소 유리량, 미세경도, 용해도를 평가하였으며 이러한 특성을 임상적으로 적용 할 수 있을 것이다.

• 공업화학
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• 제20권3호
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• pp.346-350
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• 2009

자연상태의 물질들은 많은 유용한 성분들을 포함하고 있다. 이 성분들 중에서, 천연 영양 성분들은 기능성 식품 또는 화장품, 의약품의 첨가제로써 활용 되고 있다. 이러한 영양성분들을 유용하게 활용하기 위해 각 성분들에 대한 최적의 용매 선택방법을 제시하였다. 각 성분에 대한 용해도 파라미터를 계산하였으며 총 용해도 파라미터는 분산성, 극성, 수소결합 효과로 구성되고 이들 기여도가 각각 계산되었다. 용질과 용매의 용해도 파라미터에 의해 chi(${\chi}_{12}$)파라미터가 결정되었으며 chi파라미터에 의해 아미노산 성분들에 대한 최적의 용매-용질쌍이 선정되었다.

• 한국전기전자재료학회논문지
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• 제28권5호
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• pp.314-319
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• 2015

In this research, we focused on the development of cy3 dye with high thermal stability and good solubility for LCD color filter. Cy3 dyes were prepared through the synthetic procedure of two steps. The synthesized cy3 dyes were characterized by using NMR, FT-IR, UV/Vis spectroscopy, and TGA. These cy3 dyes showed maximum absorption wave length (${\lambda}_{max}$) in the range of 549~555 nm in UV/Vis spectrum. And we confirmed that solubility characteristics and thermal stability of cy3 dyes were dependent on the structure of counter cation. Cy3 dyes with methyl counter cation and ethyl counter cation have good solubility in organic solvents such as chloroform, ethanol, and PGME. Moreover, Cy3 dye with ethyl counter cation gave excellent thermal stability in TGA thermograms. And Cy3 dye with ethyl counter cation showed good result in photoresist film test.

• 설비공학논문집
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• 제9권2호
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• pp.163-170
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• 1997

Solubility on $(LiBr+CaCl_2)$ in water has been measured systematically and compared with those of pure LiBr. It has been observed that there exists optimum value of $CaCl_2(LiBr+CaCl_2)$ in solubility when total$(LiBr+CaCl_2)$ concentration is higher than 57wt%. As total concentration increases up to 65wt%, it is found that the optimum value also increases monotonically. From the experimental results, a master plot has been constructed, with which optimum ratio of LiBr to $CaCl_2$ can be found in terms of total concentration. Vapor pressure of $H_2O/(LiBr+CaCl_2)$ solution with optimum contents of $CaCl_2$ has been observed to be changed negligibly at relatiely low temperature. However, as temperature increases, it is found that increasement in vapor pressure is significant.

• 동아시아식생활학회지
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• 제16권4호
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• pp.453-457
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• 2006

This study investigated the extractability, solubility, Mg$^{2+}$-, Ca$^{2+}$- and EDTA-ATPase activity of actomyosin prepared from leg and breast muscle of dog meat. The actomyosin extractability of breast muscle(2,100.6 mg/l00 g) was higher than that of leg muscle(500.8 mg/l00 g). The Mg$^{2+}$-ATPase activity of actomyosin had a high ionic strength of 0.02$\sim$0.05 M KCI and did not differ between leg and breast muscle. The Ca$^{2+}$-ATPase activity of actomyosin had a high ionic strength of 0.02$\sim$0.10 M KCI and leg muscle had a higher level of Ca$^{2+}$-ATPase activity than breast muscle did. The EDTA-ATPase activity was lower in low ionic strength and showed higher in high ionic strength, and increased sharply with increasing ionic strength up to 0.3 M KCI. The solubility of actomyosin did not differ between leg and breast muscle, and the solubility started and ended at KCI concentrations of 0.35 M and 0.4 M, respectively.

• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.97-102
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• 2010

A novel surface-attached solid dispersion is designed to improve the solubility and oral bioavailability of poorly water-soluble drugs without crystalline change. Accordingly, it draws increasing interest because of excellent stability and no pollution for accomplishing enhanced solubility and bioavailability, which have recently been highlighted in connection with a number of higher value-added poorly water-soluble drugs. In addition, excellent stability can be attained when the poorly water-soluble drugs are not dissolved but dispersed in water and provide no crystallinity change. This solid dispersion is given by means of attaching the dissolved carriers such as hydrophilic polymer and surfactant to the surface of dispersed drug particles followed by changing the hydrophobic drug to hydrophilic form. The aim of the present review is to outline the preparation, physicochemical property and bioavailability of novel surface-attached solid dispersion with improved solubility and bioavailability of poorly water-soluble drugs without crystalline change.

• Journal of Pharmaceutical Investigation
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• 제22권2호
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• pp.105-113
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• 1992

To improve the solubility and dissolution rate of trimethoprim (TMP), which is slightly soluble drug, its inclusion complexes were prepared and studied in this experiment. Inclusion complexes of TMP with ${\beta}-cyclodextrin$ and ${\beta}-cyclodextrin$ polymer (CDPS) were prepared according to Fenyvesi method. These were compared with TMP and its physical mixture with CDPS. Water, diluted hydrochloric acid and phosphate buffer solution were used as dissolution media. And accelerated stability test was studied at $50,\;70\;and \;80^{\circ}C$. It was found that solubility and dissolution rate of inclusion complexes were increased in water. Especially, the solubility and dissolution rate of TMP was found to be markedly increased by inclusion complexation with CDPS. In stability test, ${\beta}-cyclodextrin$ inclusion complexes were more or less stable than TMP alone. This tendency was not led in CDPS. Consequently, CDPS was useful in increasing dissolution rate and stability of TMP.

• 한국의류산업학회지
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• 제11권4호
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• pp.672-677
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• 2009

To reduce the dependence of wool dyeing on the temperature several solvents with different properties and structures were added to the dye bath of C. I. Acid Yellow 42. Nearly the same total solubility parameters(${\delta}_t$) of solvents as those of wool fiber and hydrophobic part of the dyestuff were needed to increase disaggregation of dye molecules, loosening the wool fiber and wickabilty of dyeing solution; besides, the large surface tension(${\gamma}$) value of the solvents and the well balanced values of the three-component Hansen solubility parameters such as dispersion(${\delta}_d$), polar(${\delta}_p$), and hydrogen(${\delta}_h$) bonding parameters were required. Among the added solvents dimethyl phthalate(DMP) and acetophenone(AP) were satisfied with these conditions and worked the most successfully in the low temperature wool dyeing. Their effectiveness proven by the dyeing rate and the activation energy ($E_a$) of the dyeing was in the order of DMP > AP > DBE > CH > M >NONE. In conclusion the total solubility parameters(${\delta}_t$), the three-component Hansen parameters and the surface tension(${\gamma}$) of DMP and AP could be the guidelines to select suitable solvents for low temperature wool dyeing.

• Journal of Pharmaceutical Investigation
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• 제29권1호
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• pp.37-45
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• 1999

ABSTRACT-A self-microemulsifying drug delivery system (SMEDDS) was developed to enhance the solubility and dissolution rate of poorly water soluble drug, biphenyl dimethyl dicarboxylate, DDB. The system was optimized by evaluating the solubility of DDB and the microemulsion existence range after the preparation of microemulsions with varying compositions of triacetin and surfactant-cosurfactant mixtures (Labrasol as surfactant (S) and the combination of Transcutol, Cremophor RH 40 and Plurol oleique as cosurfactant (CoS)). SMEDDS in this study markedly improved the solubility of DDB in water up to 10 mg/ml and the size of the o/w microemulsion droplets measured by dynamic light scattering showed a narrow monodisperse size distribution with an average diameter less than 50 nm. The microemulsion existing range is increased proportional to the ratio of S/CoS, however, it decreased remarkably as the oil content was more than 20%. In vitro dissolution study of SMEDDS showed a significantly increased dissolution rate of DDB in water (> 12 fold over DDB powder), and SMEDDS also had significantly greater permeability of DDB in Caco-2 cell compared to powders.

• Journal of Pharmaceutical Investigation
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• 제34권1호
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• pp.29-34
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• 2004

The solubility and stability of quercetin in various vehicles were determined. The solubility of quercetin at $28^{\circ}C$ increased in the rank order of isopropyl myristate < oleyl alcohol < propylene glycol monolaurate < oleoyl macrogol­6 glycerides < linoleoyl macrogol-6 glycerides < propylene glycol laurate (PGL) < propylene glycol monocaprylate (PGMC) < polyethylene glycol-8 glyceryl linoleate < caprylocaproyl macrogol-6 glycerides < diethylene glycol mono ethyl ether (DGME). The addition of DGME to non-aqueous vehicles such as PGL ad PGMC markedly increased the solubility of quercetin. From the stability studies, it was found that quercetin was unstable due to rapid oxidation by dissoved oxygen. The addition of a combination of ascorbic acid and edetic acid (EDTA) at 0.1 % markedly decreased the degradation rates of quercetin in 40% polyethylene glycol 400 in saline. Quercetin was relatively unstable in non-aqueous vehicles such as PGL and PGMC alone, and PGL-PGMC co-solvent The degradation of quercetin in such non-aqueous vehicles was fast, depending on temperature. The addition of butylated, hydroxytoluene, butylated hydroxyanisole, citric acid and/or EDTA at 0.1 % was effective in retarding the degradation of quercetin.