• Title/Summary/Keyword: sodium level

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Nonhemolytic entrapping method into red blood cells and its release pattern (적혈구내 비용혈 약물봉입과 약물방출)

  • Ham Seong ho;Ko Geon Il;Kim Jae Baek;Sohn Dong Hwan
    • Korean Journal of Clinical Pharmacy
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    • v.5 no.2
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    • pp.75-84
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    • 1995
  • Drug delivery by red cells was established to maintain the release of drugs in the blood. The entrapment method by amphotericin B was re-examined and evaluated for obtaining the suitable entrapping conditions without hemolysis. The amphotericin B treatment below $10{\mu}g/ml$ induced the non-hemolysis to entrap daunorubicin into red cells within 10min. Under these conditions intracellular ATP level was decreased as $18\%$. Membrane fluidity and the shape factor of red cells were maintained. To maintain intracellular ATP, ATP and sodium pyruvate were added during the entrapment procedure because hemolysis during the release test would reflect the loss of intracellular ATP that would be postulate the decrease of the viability invivo. Consequently, the addition of ATP in the reaction solution can raise the intracellular level of ATP.

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Quality Changes of Sterilized Soybean Paste during Its Storage (살균 된장의 저장과정 중 품질변화)

  • 오만진;김종생;최성현;이상덕;이규희
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.28 no.5
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    • pp.1069-1075
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    • 1999
  • The sterilization was attempted to improve the quality deterioration of soybean paste during its storage. For this experiment, soybean paste was sterilized at 80oC for 30 minutes and stored during 6 months at 15oC and 30oC, respectively. The total approximate composition contents were moisture 52.5%, crude protein 11.94%, crude fat 2.0%, amino nitrogen 413.3mg%, sodium chloride 11.61% and ash 15.5%. According to the increase of storage period, pH was decreased gradually because of the increase of organic acids by the metabolism of microorganisms and the acid accumulation by acid forming bacteria, but titratable acidity was increased during storage. Amino nitrogen was rapidly increased for the first one or two month storage period and maintained as the same level for the rest of them. Each amino acid contents of soybean paste, which were glutamic acid, tryptophan, proline, arginine, and aspartic acid, had much higher level than others. In color changes sterilized soybean paste(SSP) was much lower than that of raw ones(RSP). Hunter L and b values on the surface of soybean paste were decreased during storage, and the decreasing levels were higher at 30oC than at 15oC. Hunter a value, however, was increased a little in the initial storage, and thereafter it was decreased. Lactic acid bacteria, yeasts, and molds were disappeared completely by the sterilization. However, the bacteria of aerobes and anaerobes were not disappeared by this processing.

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Direct Effects of Copper and Selenium Supplementation and Its Subsequent Effects on Other Plasma Minerals, Body Weight and Hematocrit Count of Grazing Philippine Goats

  • Orden, E.A.;Serra, A.B.;Serra, S.D.;Nakamura, K.;Cruz, L.C.;Fujihara, T.
    • Asian-Australasian Journal of Animal Sciences
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    • v.13 no.3
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    • pp.323-328
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    • 2000
  • The administration of soluble glass bolus (SGB) with cobalt (Co), selenium (Se) and copper (Cu), among 50 upgraded does in the farm of Central Luzon State University, Philippines, was effective in improving the mineral status of the animals. After one year, blood Se and plasma Cu had been significantly increased; subsequently plasma molybdenum (Mo) level had been reduced, but other macro-minerals were not affected. Soluble glass bolus supplementation did not affect plasma calcium (Ca), magnesium (Mg), and sodium (Na), although the treated does had higher plasma phosphorus (P), potassium (K), and zinc (Zn) in some parts of the year. Hematocrit count of the animals was also improved reaching 32% level after 9 months; although it was still 6% below the lower limit of a normal range of 38 to 45%. The desired improvement in Se, Cu and Mo was not able to influence live weight among the animals. After one year, body weight was not significantly different from the control group of animals. Nevertheless, the study showed the effectiveness of SGB in improving Cu and Se levels, and subsequently reducing the plasma Mo levels of grazing goats in a typical Philippine farm.

The Effects of High Pressure and Various Binders on the Physico-chemical Properties of Restructured Pork Meat

  • Hong, Geun-Pyo;Park, Sung-Hee;Kim, Jee-Yeon;Min, Sang-Gi
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.10
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    • pp.1484-1489
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    • 2006
  • This study was carried out to investigate the effect of high pressure and the addition of non-meat proteins on the physico-chemical and binding properties of restructured pork. Pressurizations were carried out at up to 200 MPa and non-meat proteins used as a binder were isolated soy protein (ISP), sodium caseinate (SC), whey protein concentrate (WPC) and egg white powder (EWP). The pH values of all treatments were affected by the level of pressure. $L^*$-value of all treatments increased significantly (p<0.05), while both $a^*$-value and $b^*$-value of all treatments showed a significant decrease (p<0.05) with increasing pressure level. Binders could contribute only additive effects on both pH and color of the treatments. It was found that high pressure improved the water binding capacities and binding strength of the treatments. Binders also improved the binding strength of restructured pork. However, SC and WPC had no effect on water binding properties under high pressure. These results indicate that the application of high pressure had more significant effect on restructuring meat than binders.

Chemical Treatment of Low-level Radioactive Liquid Waste (I)

  • Lee, Sang-Hoon;Choe, Jong-In;Kim, Yong-Eak
    • Nuclear Engineering and Technology
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    • v.8 no.2
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    • pp.69-76
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    • 1976
  • This experiment has been carried out for the removal of long-lived radioactive-nuclides (Sr-90, Ru-106, Cs-137 and Ce-144) contained in the low-level radioactive effluents from the spent fuel reprocessing plant and nuclear power plant, in order to determine the decontaminability of various chemical coagulants and domestic clay mineral (montmorillonite). Phosphate process showed prominent efficiency for the removal of Ce-144, and lime-soda process did good removal efficiency for Sr-90. About Cs-137 copper-ferrocyanide process is much desirable. In phosphate or lime-soda process, most favorable removal efficiency was obtained at more than pH 11. The montmorillonite treated with sodium chloride showed a considerable improvement in the removal of the radioactive-nuclides. By a combined chemicals-montmorillionite process, the radioactive-nuclides could be more effectively removed than by the only chemicals process.

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Effect of Dietary Ca and Na Levels on Blood Pressure and Mineral Metabolism in Spontaneously Hypertensive Rats Fed High Fat Diet (고지방식을 섭취한 본태성 고혈압쥐에서 칼슘과 소디움 섭취가 혈압과 무기질 대사에 미치는 영향)

  • 이연숙;김은미
    • Journal of Nutrition and Health
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    • v.35 no.8
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    • pp.840-847
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    • 2002
  • This study explored the effect of dietary levels of Na and Ca on spontaneously hypertensive rats (SHR). SHR were randomly divided into 5 groups and fed a high fat/cholesterol diet containing three levels of Na (0.05, 0.1, 1.5%) and Ca (0.1, 0.5, 1.5%) for 9 weeks. Body weight gain was not influenced by dietary intake but water intake significantly increased in high Na supplementation. Systolic blood pressure was not influenced by dietary Na and Ca levels but was decreased by dietary low Na/high Ca levels at 9 weeks. Angiotensin-II level was affected by dietary Na level but not by Ca levels. Plasma Ca, Mg, K and Na levels were in the normal range regardless of dietary Na and Ca levels. Weight, and K and Na contents of the heart and kidney were not significantly different among those with different dietary Na and Ca levels. Ca and Mg contents of the heart and kidney were significantly higher in the normal Na/normal Ca group. Ca and Mg in the feces were higher in those with high Ca intake. Na in the feces was higher in those with high Na intake. Therefore, Na and Ca had different mechanisms in the hypertension/hyperlipidemia models, respectively. And we suggested that Mg must be supplemented when Ca intake was high because Mg excretion was increased by Ca supplementation.

Effect of Calcium Intake on Calcium, Sodium and Potassium Metabolism in Young and Adult Female Rats (칼슘의 섭취수준이 연령이 다른 암쥐의 칼슘, 나트륨 및 칼륨대사에 미치는 영향)

  • 승정자
    • Journal of Nutrition and Health
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    • v.28 no.4
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    • pp.309-320
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    • 1995
  • The purpose of this research was to investigate the effect of calcium levels(50, 100 and 200% of requirement) on metabolism of Ca, Na and K in Young and adult female rats for 3 weeks. There was no significant difference in feed intake, body weight gain and feed efficiency ratio among the groups of different Ca intake level. Serum Na level of high-Ca group was significantly lower than that of low-Ca or normal-Ca group in Young rats. There was no significant difference in liver Ca and K contents among the groups of different Ca intake levels. But, Na content in liver was decreased by the increase of dietary Ca intake. Ca content in kidney of high-Ca group in young rats and normal-Ca group in adult rats were significantly higher than those of other groups. Na content in kidney of low-Ca group was lower than those of normal-Ca and high-Ca groups. Urinary excretions of Na and K and fecal excretion of Ca were increased by the increase of dietary Ca intake. But, fecal excretions of Na and K were not affected by dietary Ca intake. According to this study, it was found that the high Ca consumption promotes excretions of fecal Ca and urinary Na and K in rats. The study verifies the need for more study on the interrelationship among Ca, Na and K metabolism and bood pressure.

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Modification of Physicochemical Properties of Naked Barley Starch by Heat-Moisture Treatment (수분-열처리에 따른 쌀보리 전분의 물리화학적 성질)

  • Kang, Kil-Jin;Park, Yang-Kyun;Lho, Il-Hwan;Kim, Kwan;Kim, Sung-Kon
    • Korean Journal of Food Science and Technology
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    • v.19 no.2
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    • pp.97-101
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    • 1987
  • Physicochemical properties of heat-moisture (18, 21, 24 and 27%) treated naked barley (Youngsanbori) starch indicated that crystailinity of the starch was decreased upon treatment and water-binding capacity drastically increased as the moisture level increased. The swelling power was decreased, but the solubility increased by heat-moisture treatment. Apparent viscosity in aqueous sodium hydroxide solution was repressed as moisture-treatment level increased. Amylograph hot paste vicosities were decreased upon treatment except initial pasting temperature.

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The Analysis of Physical and Chemistry Properties on the Reclaimed Area for Replantation - A Case Study on the YOULCHON 1'st Industrial Complex - (임해매립지 녹화를 위한 토양의 물리·화학적 특성 분석 - 율촌제1산업단지를 중심으로 -)

  • Jun, Hyung-Soon
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.14 no.6
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    • pp.87-95
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    • 2011
  • This study investigates Youl Chon Industrial Complex 1 by dividing into three regions : the drainage site, the area inside the complex, and the seaside. Then each region was subdivided into three areas resulting in a total of nine areas for soil sampling and analysis. After analyzing the physical and chemical properties of the soil, all nine area's pH and EC readings indicated that the soil condition is not suitable for vegetation growth (according to the previous study, the pH level was 5.8 and EC was 2.0dS/m). Therefore, for Youl Chon Industrial Complex 1 to become green, the neutralization and reduction of pH and EC level is needed; first, vegetation through dredging soil, and second, introduction of halophytes is suggested. This study finds out that vertical changes in physical and chemical properties of soils in reclaimed sites are very variable and the result depends on surrounding environments, so it suggested the basic data for building vegetation or reclaimed sites. However, the additional study aiming at various reclaimed sites is required as this study was conducted only to limited areas, and this study has left monitoring analysis as the follow-up task to check the relations between a plant community and soils.

Isolation and Characterization of a Thermophilic Bacillus sp. producing a Thermostable $\alpha$-glucosidase (내열성$\alpha$-glucosidase를 생산하는 호열성 Bacillus sp. 균주의 분리 및 특성)

  • 이용억
    • Journal of Life Science
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    • v.8 no.4
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    • pp.387-394
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    • 1998
  • A thermophilic bacterium (strain DG0303) producing a thermostable $\alpha$-glucosidase was isolated from manure and identified as Bacillus sp. Strain DG0303 produced high level of $\alpha$-glucosidase compared with other thermophilic Bacillus strains. The cellular protein patterns were also compared with other Bacillus strains by sodium dodecyl sulfatepolyacrylamide gel electrophoresis(SDS-PAGE). On the basis of 16S rDNA analysis the Bacillus sp. DG0303 was found to be a member of Bacillus rDNA group 5. The optimum temperature for growth was 65$\circ$C and no growth was obtained at 40$\circ$C or 75$\circ$C. The optimum pH for growth was 5.5 to 8.5. $\alpha$-glucosidase activity was produced during growth and most activity was detected in the culture supernatant. The $\alpha$-glucosidase production was constitutive in the absence of carbohydrates. High level of enzyme activity was detected when the culture was grown on medium containing starch. Addition of glucose resulted in the repression of the $\alpha$-glucosidase production. The optimum pH and tempoerature for enzyme activity were pH 5.0 and 65$\circ$C, respectively. When analyzed by zymogram, the culture supernatant showed a single $\alpha$-glucosidase band with a molecular weight of approximately 60,000.

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