• 제목/요약/키워드: social tolerance

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SWAT 모형과 BFlow를 이용한 지하수 함양, 기저유출의 시공간적 변화 분석 (Analysis of Spatiotemporal Changes in Groundwater Recharge and Baseflow using SWAT and BFlow Models)

  • 이지민;박윤식;정영훈;조재필;양재의;이관재;김기성;임경재
    • 한국물환경학회지
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    • 제30권5호
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    • pp.549-558
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    • 2014
  • Occurrence frequency of flood and drought tends to increase in last a few decades, leading to social and economic damage since the abnormality of climate changes is one of the causes for hydrologic facilities by exceedance its designed tolerance. Soil and Water Assessment Tool (SWAT) model was used in the study to estimate temporal variance of groundwater recharge and baseflow. It was limited to consider recession curve coefficients in SWAT model calibration process, thus the recession curve coefficient was estimated by the Baseflow Filter Program (BFLOW) before SWAT model calibration. Precipitation data were estimated for 2014 to 2100 using three models which are GFDL-ESM2G, IPSL-CM5A-LR, and MIROC-ESM with Representative Concentration Pathways (RCP) scenario. SWAT model was calibrated for the Soyang watershed with NSE of 0.83, and $R^2$ of 0.89. The percentage to precipitation of groundwater recharge and baseflow were 27.6% and 17.1% respectively in 2009. Streamflow, groundwater recharge, and baseflow were estimated to be increased with the estimated precipitation data. GFDL-ESM2g model provided the most large precipitation data in the 2025s, and IPSL-CM5A-LR provided the most large precipitation data in the 2055s and 2085s. Overall, groundwater recharge and baseflow displayed similar trend to the estimated precipitation data.

당뇨병 및 골다공증 치료제의 효율적인 신약개발을 위한 생체표지자 및 대리 결과 변수의 역할 및 활용 (The Role and Application of Biomarkers and Surrogate Endpoints for New Drug Development : Focused on Diabetes Mellitus and Osteoporosis)

  • 성수현;윤휘열;백인환;강원구;장정윤;서경원;권광일
    • 약학회지
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    • 제52권5호
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    • pp.331-344
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    • 2008
  • Recently, the FDA (Food and Drug Administration) of the United States and many advanced countries remark biomarkers and surrogate endpoints as a critical path tool on model based drug development. Economic, technical and social profit on model based drug development like a reduction of the length of research and development have been achieved. Therefore we summarize previous studies about biomarkers and surrogate endpoints and suggest a development direction of therapeutic agents. In diabetes mellitus (DM) and osteoporosis, there are remarkable increases in number of patients and most of patients take medicine during their whole lifetime. For this reason, many patients with DM and osteoporosis have a tolerance on their medicine. We expect that research and development on biomarkers and surrogate endpoints will contribute to new drug development on DM and osteoporosis. Biomarkers for DM are blood levels of glucose, insulin, ${HbA}_{1c}$, CRP, alpha-glucosidase, adiponectin and DPP-4. Among these, validated surrogate endpoints for DM are blood levels of glucose, insulin and ${HbA}_{1c}$ Biomarkers for osteoporosis are BMD, BMC, trabecular volume, ICTP, DPD, osteocalcin, the activity of osteoclast and production of osteoblast. The validated surrogate endpoints for osteoporosis are BMD only. This review summarizes all suggested biomarkers and surrogate endpoints in DM and osteoporosis. The biomarkers are classified by drugs, and the method of validation for surrogate endpoints is suggested. This information would contribute to suggest a direction of DM and osteoporosis therapeutic agent development.

Pub/Sub-based Sensor virtualization framework for Cloud environment

  • Ullah, Mohammad Hasmat;Park, Sung-Soon;Nob, Jaechun;Kim, Gyeong Hun
    • International journal of advanced smart convergence
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    • 제4권2호
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    • pp.109-119
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    • 2015
  • The interaction between wireless sensors such as Internet of Things (IoT) and Cloud is a new paradigm of communication virtualization to overcome resource and efficiency restriction. Cloud computing provides unlimited platform, resources, services and also covers almost every area of computing. On the other hand, Wireless Sensor Networks (WSN) has gained attention for their potential supports and attractive solutions such as IoT, environment monitoring, healthcare, military, critical infrastructure monitoring, home and industrial automation, transportation, business, etc. Besides, our virtual groups and social networks are in main role of information sharing. However, this sensor network lacks resource, storage capacity and computational power along with extensibility, fault-tolerance, reliability and openness. These data are not available to community groups or cloud environment for general purpose research or utilization yet. If we reduce the gap between real and virtual world by adding this WSN driven data to cloud environment and virtual communities, then it can gain a remarkable attention from all over, along with giving us the benefit in various sectors. We have proposed a Pub/Sub-based sensor virtualization framework Cloud environment. This integration provides resource, service, and storage with sensor driven data to the community. We have virtualized physical sensors as virtual sensors on cloud computing, while this middleware and virtual sensors are provisioned automatically to end users whenever they required. Our architecture provides service to end users without being concerned about its implementation details. Furthermore, we have proposed an efficient content-based event matching algorithm to analyze subscriptions and to publish proper contents in a cost-effective manner. We have evaluated our algorithm which shows better performance while comparing to that of previously proposed algorithms.

알콜리즘 환자(患者)의 인격특성(人格特性)에 관(關)한 임상적(臨床的) 고찰(考察) -MMPI와 사상체질(四象體質)을 중심(中心)으로- (Clinical Study on Personality Characteristics of the Alcoholic Patients -with MMPI & Sasang Constitution(四象體質)-)

  • 김종우;김지혁;황의완
    • 동의신경정신과학회지
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    • 제3권2호
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    • pp.65-85
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    • 1992
  • To study the personality characteristics of alcoholic patients, they were screned with the MAST(Michigan Alcoholism Screening Test) and administered with the MMPI (Minnesota Multiphasic Personality Inventory) in the Dept. of Neuropsychiatry, Oriental Medical Hospital in Kyung Hee Univ. form March 1991 to June 1991. Patients admitted for alcoholism were examined and analyzed using the above tests and then studied by Sasang Constitutional approach. Results were as follows; 1. In the MAST score, the cases of obvious alcohol dependence was 53.3% and overall mean score was 28.1 point. 2. In the MMPI scale, the mean of the T-scores for 2(D)-4(Pd) profile was high, but it was not statistically significant. 3. The results obtained by multivariate cluster analysis of MMPI T-scores can be divided into 3 subgroups; 1) 9% showed the psychiatric tendency of F-6(Pa)-9(Ma)profile, 2) 44.2% showed no significant profile, 3)46.5% showed the neurotic tendency of 1(Hs)-2(D)-3(Hy)-4(Pd) profile. 4. Since 44.2% showed no significant profile on the MMPI, much more alcoholic patients were caused not by personality factors but by social tolerance, and also by increasing apportunities of drinking in Korean society. 5. When analyzed with Sasang Constituional approach, 1) for the Soyangin (少陽人): 6(Pa) scale was particularly high, 1(Hs) and 3(Hy) scales were low compared to others, 2) for the Taiumin(太陰人): 1(Hs)-2(D)-3(Hy)-4(Pd) neurotic profile was high, the K-scale and 4(Pd)scale were high compared to the Soyangin, 3) for the Soumin(少陰人): 1(Hs)-2(D)-3(Hy)-4(Pd) neurotic profile and 7(Pt) scale were also high.

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Extracorporeal Shock Wave Therapy for Hypertrophic Scars

  • Chuangsuwanich, Apirag;Kongkunnavat, Natthapong;Kamanamool, Malika;Maipeng, Gulradar;Kamanamool, Nanticha;Tonaree, Warangkana
    • Archives of Plastic Surgery
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    • 제49권4호
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    • pp.554-560
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    • 2022
  • Background Hypertrophic scars cause aesthetic concerns and negatively affect the quality of life. A gold standard treatment for hypertrophic scars has not been established due to various responses of modalities. Extracorporeal shock wave therapy (ESWT) is a noninvasive and affects scar remodeling by fibroblast regulation. This study investigated the effectiveness of ESWT for hypertrophic scars. Methods Twenty-nine patients were enrolled. All patients underwent ESWT once a week for 6 consecutive weeks. Their scars were assessed using the Patient and Observer Scar Assessment Scale (POSAS), erythema index, melanin index, and scar pliability before treatment and again 4 weeks after treatment completion. Results Thirty-four hypertrophic scars in this study had persisted for between 6 months and 30 years. Most scars developed after surgical incision (55.88%). The chest and upper extremities were the predominant areas of occurrence (35.29% each). Most of the POSAS subscales and total scores were significantly improved 4 weeks after treatment (p < 0.05). Furthermore, the pain, itching, and pigmentation subscale were improved. The pliability, melanin index, and erythema index were also improved, but without significance. The patients were satisfied with the results and symptoms alleviation, although subjective score changes were insignificant. No serious adverse events were found. The patients reported pruritus in 62.5% and good pain tolerance in 37.5%. Subgroup analyses found no differences in scar etiologies or properties at different parts of the body. Conclusion The ESWT is a modality for hypertrophic scar treatment with promising results. Most of POSAS subscales were significantly improved.

대학생의 소외에 대한 두려움, SNS 중독경향성과 우울의 구조적 관계에 관한 조사연구 (Structural Relationships Between Fear of Missing Out, SNS-addictive Tendencies, and Depression in Colleges)

  • 장철;김인섭
    • 대한통합의학회지
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    • 제10권3호
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    • pp.151-159
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    • 2022
  • Purpose : The purpose of this study was to investigate the structural relationships between fear of missing out, addictive tendencies toward social network services (SNSs), and depression in colleges. Methods : The target subjects were students in colleges across gyeongnam & busan, to whom the purpose of the study was explained and who spontaneously agreed to participate. A survey was conducted with 302 participants over 31 days from March 7, 2022, and data from 299 responses was analyzed. Results : 1. Women felt a higher fear of missing out than men. 2. Women showed greater inability to control their use of SNSs, more SNS-related disorders in daily life, and greater immersion in and tolerance of SNSs when compared to men. 3. Women were more depressed than men. 4. Positive correlations were observed between the fear of missing out and SNS-addictive tendencies, between the fear of missing out and depression, and between SNS-addictive tendencies and depression. Conclusion : A comprehensive review of these findings suggests that women had overall higher levels of isolation fear, SNS-addictive tendencies, and depression than men. Based on this, universities should provide gender-specific educational programs around these issues; this student cohort will ultimately work in healthcare, and this kind of awareness will be essential for treating patients. Considering that the current situation poses unusual challenges due to the COVID-19 pandemic, the study's results can serve as basic data for planning educational programs in the future. Over the coming years, comprehensive and continuous education and counselling relating to the fear of missing out, SNS addiction, and depression will be urgently required.

마리화나 남용환자의 역동적인 발달요인과 문제해결 (Dynamic Developmental Factors and their Problem Solving of Patients that Abuse Marihuana)

  • 원정숙
    • 대한간호학회지
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    • 제4권3호
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    • pp.105-116
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    • 1974
  • This study was made on patients who were Hospitalized due to sickness caused by the abuse of marihuana at the Psychiatric Section of a hospital during the period from Feb. to Oct., 1974. The following conclusion was obtained by reviewing the literature with respect to the nursing, and problem solving of those patients. 1. It appears that marihuana is a comparatively mild intoxicant in ordinary preparation without causing physical dependence or tolerance. 2. According to the status of men who are marihuana smokers, approximately 20% of them were college students, those preparing to retake college entrance examinations, non-employed and pharmacists. The men belong mostly to the middle foreigner′s mistress of higher, income bracket, and in the case of women, most of the smokers were US. servicemen entertainers. 3. Dynamic developmental factors: Case 1. : The patient had a characteristic, hysterical and emotionally unitable character, and was of low intelligence, In addition, to this already existing problem, the added uses of marihuana caused a mental illness to develope. Case 2 : The character, was reserved and introspective, her creative power and sentiment was fading and his ability of self-control was weakened. She used the smoking of marihuana to get rid of her own feeling of inferiority complex and tensions coming from interpersonal relationships. Case 3 : The patient was unconditionally resistive to the authoritativeness of superiors and irresponsible in his relationship with women, in his attitude concerning sex in general. He smoked marihuana because he felt become peace-loving and get enchanted experience through smoking it. 4. The points of issue appearing from the above case; (1) Movement of anti-social feelings against the "established system" by the youngsters. (2) Family problem. (3) Shamelessness, loss of motivation, disorderly attitude toward the sex, (4) Worries concerning the future. (5) Lack of knowledge concerning smoking of cigarette and marihuana. Chronic use of marihuana made, those youngman who had originally been ambitions to achieve something in life, lazy, inefficient, unable to make long-term plans, are such weak mined persons that they did not try to overcome problems when encountered. This will pose a great and important question in the mental health of the society, 5. Treatment and Problem sieving According to the literature, we will have to place importance upon hospitalized treatment The phases of treatment were divided into five parts. (1) Prehospital phase (2) Withdrawal Phase (3) Rehabilitation phase (4) Transitional phase (5) After-care phase The experiments have proved that there was much progress in the recovery of patients through environment therapy, supportive therapy and group psychotherapy. This was the above mentioned 5 phases of treating process in accordance with the weekly schedule of the hospital. It was thought that the patients would require prolonged after care management even after they were released from the hospital and that they will also require periodic visit, to the hospital and doctor′s interview with their family. In conclusion, the question of the young generation and marihuana smoking is becoming a great social problem in which their resistances to the "established system" and society is growing in the from of antiestablishment movements. In our country, the smoking of marihuana is gradually developing, therefore, I think, that it would be a very fortunate thing for us, if this report could be helpful for the motivation of further study on the questions of the young generation and its problems.

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일본의 다문화사회로의 사회공간적 전환과정과 다문화공생 정책의 한계 (The Socio-spatial Transformation Process Towards Multicultural Society and Limitations of 'Multicultural Coexistence' Policy of Japan)

  • 최병두
    • 한국지역지리학회지
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    • 제17권1호
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    • pp.17-39
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    • 2011
  • 최근 상대적으로 경제가 발전한 동북아 국가들로 외국인 이주자들의 유입이 급증하고 있으며, 특히 일본은 이에 따른 다문화사회로의 전환에 대처하기 위하여 '다문화공생'을 외국인 이주자 관련 담론과 정책의 핵심적 개념으로 사용하고 있다. 이 논문은 우선 한국이나 일본이 겪고 있는 다문화사회의 유형이 서구의 경우와는 다르다는 점을 보이기 위해 다문화사회의 유형 구분을 제시한다. 그리고 한 국가 내에서도 외국인 이주자들은 유형에 따라 상이한 특성을 가지며, 일본 문화와의 결합 정도도 차별적임음 강조한다. 이러한 다문화사회로의 전환은 사회적 과정일 뿐만 아니라 동시에 지리적 과정으로 전개되며, 또한 지역별로 다르게 진행되고 특히 외국인 이주자들의 출신과 유입 유형에 따른 지역별 분화를 동반한다. 다문화사회로의 전환의 사회공간적 과정을 일정하게 통제하고자 하는 일본의 다문화공생 정책은 서구에서 발달한 다문화주의를 원용하여 외국인 이주자들과 일본인들 간의 공생을 위해 지역사회가 주도하는 정책이라는 점에서 의의를 가지지만, 대체로 일계인(日系人)의 유입이 많은 지자체들에서 우선적으로 전개되면서 주로 문화적 측면을 강조하며, 결국 외국인 이주자 통제 전략의 성격을 내포하고 있는 것으로 평가된다. 이념적으로 일본의 다문화공생 개념은 '기회 평등'으로서의 '자유주의적 다문화주의'와 가깝고 '결과 평등'으로서의 '조합주의적 다문화주의'와는 거리가 먼 것으로 이해된다. 또한 진정한 다문화주의 실현을 위한 단계별 진행에서 보면, 이 개념의 실제 실행은 관용의 단계에서 비차별의 법제화 단계로 나아가 가는 과정에 있으며 아직 인정을 위한 사회적 패러다임화되지 않음으로써 보수적 정권이 등장할 경우 동화주의로 쉽게 퇴행할 가능성을 가지는 것으로 추정된다.

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실패기업인의 재창업지원 제도에 관한 국제비교연구 (International Comparison of Re-start up Support system for Failed Businessmen)

  • 김형호;윤현덕
    • 벤처창업연구
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    • 제10권6호
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    • pp.235-252
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    • 2015
  • 정부는 역동적 혁신경제로 경제 대도약을 위해 선순환 벤처 창업 생태계를 구축하고 있다. 이와 같은 생태계 구축은 실패를 두려워 하지 않는 기업가정신을 지닌 우수인력의 도전적 벤처창업과 실패를 관용하고 이를 경험으로 재창업할 수 있는 사회적 환경이 마련되어야 가능하다. 정부의 벤처 창업 붐 조성 노력으로 벤처기업 및 신설법인 수 등이 매년 증가 하고 있으나, 이들 기업이 실패할 경우 재창업 등으로 재기 할 수 있는 사회적 환경 조성과 지원제도 마련의 노력은 최근에야 시작되었다. 실패기업에 대한 정확한 실태조사, 지원제도가 부족한 상황에서 본 연구는 실패한 기업에 대한 그간의 선행연구를 기반으로 국내 실패기업인의 재도전, 재창업과 관련된 현황을 파악 후 해외 선진국 사례와 국제비교를 통해 적용 가능한 정책적 시사점을 도출하여 국내 실패기업의 재창업을 원활히 할 수 있는 정책적 방향을 제시하고자 한다. 미국과 같이 실패를 성공의 한 단계로 인식하는 창업문화가 형성되기 전까지는 EU의 SBA법과 같은 재도전 정책을 지속적으로 추진할 수 있는 법적근거 마련과 일본의 민간 중심의 중소기업재생지원협의회 구성 운영을 참고할 필요가 있다. 또한 실패기업인의 삶의 질 보장도 함께 고려하는 것이 필요하다. 도출된 시사점을 바탕으로 내린 결론에 대한 추가 연구와 정부 정책이 보완된다면 국내 재창업 활성화를 위한 깊은 통찰을 제공할 수 있을 것이다.

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정당방위 유형, 신문기사의 정당방위 인정비율, 판단자 개인 특성이 정당방위 판단에 미치는 영향 (The Effects of Self-Defense Categories, Rate of Self-Defense recognition in News Article, and the Individual Characteristics of Mock Jurors on the Self-Defense Judgment)

  • 김용애;김민지
    • 한국심리학회지:법
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    • 제12권2호
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    • pp.171-197
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    • 2021
  • 본 연구는 일반인이 정당방위를 어떻게 판단하고 있으며 판단시 영향을 줄 수 있는 요인들은 어떤 것이 있는지 실증적으로 고찰하고자 하였다. 정당방위 판단에 영향을 주는 요인을 정당방위 유형, 정당방위에 대한 기사, 판단자 개인 특성인 폭력 허용도, 법적 태도로 나누어 만 20세 이상의 성인 남녀 총 651명을 대상으로 연구자료를 수집 및 분석하였다. 참가자들은 정당방위가 주장되는 상황을 유형화하여 작성된 세 유형 중 하나의 유형에 할당되고, 각 유형에 해당하는 정당방위 관련 기사와 시나리오를 제공받은 후 정당방위 판단을 하였다. 또한, 개인적 요소인 법에 대해 가지는 태도, 폭력 허용도가 측정된 후 정당방위 판단에 미치는 영향을 분석하였다. 연구 결과, 자신을 위한 정당방위 유형에서는 정당방위를 인정하는 비율이 가장 높았으나, 국가기관에 대항하는 정당방위 유형에서는 정당방위를 불인정하는 비율이 훨씬 높은 반대 양상을 나타내었다. 또한, 정당방위에 대한 기사 중 정당방위가 잘 인정되지 않는다는 부정적인 기사가 정당방위 판단에 영향을 미치는 것으로 나타났다. 더불어 참가자 개인의 폭력 허용도, 법적 태도가 정당방위 판단에 영향을 미칠 수 있음을 확인하였다. 본 연구를 통해 확인한 일반인들의 정당방위 판단 과정과 정당방위 판단에 영향을 줄 수 있는 제반 요소들은 실제 배심 재판에서의 편향적인 판단을 방지하기 위한 고려 요소가 될 수 있을 것이다. 마지막으로 본 연구의 의의와 한계점, 후속 연구를 제언하였다.