• Journal of Korea Multimedia Society
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• v.23 no.7
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• pp.830-839
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• 2020

As a popular mathematical framework for modeling decision making, Markov decision process (MDP) has been widely used to solve problem in many engineering fields. MDP consists of a set of discrete states, a finite set of actions, and rewards received after reaching a new state by taking action from the previous state. The objective of MDP is to find an optimal policy, that is, to find the best action to be taken in each state to maximize the expected discounted reward of policy (EDR). In practice, MDP is typically unknown, so simulation-based policy improvement (SBPI), which improves a given base policy sequentially by selecting the best action in each state depending on rewards observed via simulation, can be a practical way to find the optimal policy. However, the efficiency of SBPI is still a concern since many simulation samples are required to precisely estimate EDR for each action in each state. In this paper, we propose a method to select the best action accurately in each state using a small number of simulation samples, thereby improving the efficiency of SBPI. The proposed method accumulates the simulation samples observed in the previous states, so it is possible to precisely estimate EDR even with a small number of samples in the current state. The results of comparative experiments on the existing method demonstrate that the proposed method can improve the efficiency of SBPI.

• Corrosion Science and Technology
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• v.17 no.2
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• pp.60-67
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• 2018

The compounds associated with corrosion, in metallic archaeological samples of carbon steel of insular origin were evaluated to establish their degree of deterioration and structural damage against air pollution. The iron phases present in samples of archaeological artifacts were detected by Raman spectroscopy and confocal Raman microcopy. These samples mainly exhibited ing mainly ${\beta}$-FeO(OH) type goethite oxyhydroxides and small amounts of akaganeite ${\alpha}$-FeO(OH) lepidocrocite ${\gamma}$-FeO(OH) due to dominant chloride in a marine environment and non-stoichiometric oxyhydroxides Fe (II + / III +) as indicators of early corrosion. Some parts showed the presence of magnetic maghemite indicating high corrosion. ${\gamma}$-FeO(OH) is a precursor of phases associated with advanced marine corrosion. By studying its decomposition by Raman spectroscopy, it was synthesized with the following sequence: ${\gamma}-FeO(OH){\rightarrow}{\alpha}-FeO(OH)+{\gamma}-FeO(OH)$, ${\rightarrow}{\gamma}-Fe_2O_3+Fe_3O_4$. Ferric compounds provided evidence for the effect of intensity of laser on them, constituting a very useful input for the characterization of oxidation of iron in this type of artifacts. Thus, destructive analysis techniques should be avoided in addition to the use of small amounts of specimen.

• Food Science of Animal Resources
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• v.38 no.2
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• pp.338-349
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• 2018

The objective of this study was to investigate comparison of physicochemical, microbiological, and sensory characteristics of Hanwoo eye of round by various packaging methods [wrapped packaging (WP), modified atmosphere packaging (MAP), vacuum packaging (VP) with three different vacuum films, and vacuum skin packaging (VSP)] at a small scale. Packaged Hanwoo beef samples were stored in refrigerated conditions ($4{\pm}1^{\circ}C$) for 28 days. Packaged beef was sampled on days 0, 7, 14, 21, and 28. Physicochemical [pH, surface color, thiobarbituric acid reactive substances (TBARS), and volatile basic nitrogen (VBN) values], microbiological, and sensory analysis of packaged beef samples were performed. VP and VSP samples showed low TBARS and VBN values, and pH and surface color did not change substantially during the 28-day period. For VSP, total viable bacteria, psychrotrophic bacteria, lactic acid bacteria, and coliform counts were lower than those for other packaging systems. Salmonella spp. and Escherichia coli O157:H7 were not detected in any packaged beef samples. A sensory analysis showed that the scores for appearance, flavor, color, and overall acceptability did not change significantly until day 7. In total, VSP was effective with respect to significantly higher $a^*$ values, physicochemical stability, and microbial safety in Hanwoo packaging (p<0.05).

• BMB Reports
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• v.54 no.7
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• pp.386-391
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• 2021

Owing to rapid advancements in NGS (next generation sequencing), genomic alteration is now considered an essential predictive biomarkers that impact the treatment decision in many cases of cancer. Among the various predictive biomarkers, tumor mutation burden (TMB) was identified by NGS and was considered to be useful in predicting a clinical response in cancer cases treated by immunotherapy. In this study, we directly compared the lab-developed-test (LDT) results by target sequencing panel, K-MASTER panel v3.0 and whole-exome sequencing (WES) to evaluate the concordance of TMB. As an initial step, the reference materials (n = 3) with known TMB status were used as an exploratory test. To validate and evaluate TMB, we used one hundred samples that were acquired from surgically resected tissues of non-small cell lung cancer (NSCLC) patients. The TMB of each sample was tested by using both LDT and WES methods, which extracted the DNA from samples at the same time. In addition, we evaluated the impact of capture region, which might lead to different values of TMB; the evaluation of capture region was based on the size of NGS and target sequencing panels. In this pilot study, TMB was evaluated by LDT and WES by using duplicated reference samples; the results of TMB showed high concordance rate (R² = 0.887). This was also reflected in clinical samples (n = 100), which showed R² of 0.71. The difference between the coding sequence ratio (3.49%) and the ratio of mutations (4.8%) indicated that the LDT panel identified a relatively higher number of mutations. It was feasible to calculate TMB with LDT panel, which can be useful in clinical practice. Furthermore, a customized approach must be developed for calculating TMB, which differs according to cancer types and specific clinical settings.

• Tuberculosis and Respiratory Diseases
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• v.75 no.5
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• pp.181-187
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• 2013

The emergence of new therapeutic agents for non-small cell lung cancer (NSCLC) implies that histologic subtyping and molecular predictive testing are now essential for therapeutic decisions. Histologic subtype predicts the efficacy and toxicity of some treatment agents, as do genetic alterations, which can be important predictive factors in treatment selection. Molecular markers, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement, are the best predictors of response to specific tyrosine kinase inhibitor treatment agents. As the majority of patients with NSCLC present with unresectable disease, it is therefore crucial to optimize the use of tissue samples for diagnostic and predictive examinations, particularly for small biopsy and cytology specimens. Therefore, each institution needs to develop a diagnostic approach requiring close communication between the pulmonologist, radiologist, pathologist, and oncologist in order to preserve sufficient biopsy materials for molecular analysis as well as to ensure rapid diagnosis. Currently, personalized medicine in NSCLC is based on the histologic subtype and molecular status. This review summarizes strategies for tissue acquisition, histologic subtyping and molecular analysis for predictive testing in NSCLC.

• Computers and Concrete
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• v.14 no.6
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• pp.675-694
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• 2014

Annular and solid concrete specimens with different aspect ratios and static unconfined compressive strengths were studied for impact loading using SHPB test setup. Numerical simulations in LSDYNA were also carried out and results were validated. The stress-strain curves obtained under dynamic loading were also compared with static compressive tests. The mode of failure of concrete specimen was a typical ductile failure at high strain rates. In general, the dynamic increase factor (DIF) of thin solid specimens was higher than thick samples. In the numerical study, the variation of axial, hydrostatic and radial stresses for solid and annular samples was studied. The core phenomenon due to confinement was observed for solid samples wherein the applied loads were primarily borne by the innermost concrete zone rather than the outer peripheral zone. In the annular samples, especially with large diameter inside hole, the distribution of stresses was relatively uniform along the radial distance. Qualitatively, only a small change in the distribution of stresses for annular samples with different internal diameters studied was observed.

• Journal of the Microelectronics and Packaging Society
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• v.17 no.2
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• pp.11-20
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• 2010

The effects of heat treatment on matte pure tin-plated Cu leadframes at high temperature and humidity conditions were investigated. After 1800 hrs of storage at $55^{\circ}C/85%$ RH, approximately 14.5 ${\mu}m$ long striation-shaped whiskers were observed on the surface of the without postbake treatment (WOPB) samples, while no whiskers were found in with postbake treatment (WPB) samples. The preferred orientations of Sn grains in WOPB and WPB sample did not change after the postbake treatment at $125^{\circ}C$ for 1 hr. However, both changed from (112) to (321) and (101), respectively, after 1800 hrs of storage at $55^{\circ}C/85%$ RH. The tensile stress of 8 MPa generated in as-plated sample was changed to a compression stress of 17 MPa after 2 days in room temperature storage. Due to the grain growth during postbake treatment, the WPB samples have more regular grains than the WOPB samples. In the as-plated sample, 0.32 ${\mu}m$ thickness of planar intermetallic compound (IMC) was observed. The IMCs in the WOPB and WPB samples had two distinct layers with large grains of $Cu_6Sn_5$ and with small grains of ${\eta}-Cu_{6.26}Sn_5$.

• Journal of the Korean Institute of Rural Architecture
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• v.12 no.2
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• pp.31-38
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• 2010

This study aims to present the basic criterions about the planning of local residential area in the middle or small city with an analysis of several samples in Paris, where is currently realizing many various housing projects and residential area development, especially theirs development methods, form and composition of theses samples and residential areas. At this object, this study was preceded with 3 main contents. Firstly, it has examined the development method, procedure and development samples, which is the precedence step for the organization of dwelling zone. Secondly, after presenting the criterions analysis of residential area's samples as drew the concept related with the presented residential area planning in corresponded cases, it has analyzed about the practical planning factors applied at each samples. Lastly, regarding precedent studies, it has examined the relation between planning factors and theory factors. The residential development in Paris, which was examined by this study, has been achieved through reasonable procedure from the superior concepts to detail planning and concept design for the project and the analysis result like this is expected to use as the basic criterions for the development and planning orientation of local residential area in Korea.

• 한국해양학회지
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• v.4 no.1
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• pp.17-35
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• 1969

This work concerns morphological studies of the Japaness jack mackerel, Trachurus japonicus(Temminck & Schlegel). A total of 48 random samples consisting of 2669 fish is examined, representing three geographic regions, namely, Kamakura, Nagasaki, and Tottori. Preservation affects length and weight of fish considerably, but the variability after 10 days is shown to be negligible. The variability in measuring the morphometric characters due to different measures and orders is found to be significant. They are relatively small, however, compared to the variability in mean length to be expected in samples drawn from the population. Two meristic characters, namely, anal and second dorsal fin rays and three morphometric characters, namely, head length, first and second dorsal insertion distances are chosen for the study. Results of the statistical analysis reveal that differences in the selected meristic characters among samples within and between regions are found to be significant. In general, it is reasonable to state that the jack mackerel collected in Nagasaki region, on the average, have greatest number of anal fin ray and second dorsal fin ray followed by Kamakura, and Tottori regions in that order. It is found that although no significant differences in the slope of regression line are noticed, the mean differences of the selected morphometric measurements in relation to fish length are found to be significant among samples within each region. Differences in the regression coefficients as well as the adjusted sample means are found to be significant between regions. The analysis suggests that samples from Nagasaki region, on the average, have longest head length and greatest distances from snout to the insertion of first dorsal and second dorsal fins followed by Kamakura, and Tottori regions in that order.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.5
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• pp.2523-2538
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• 2017

In most of the existing literature, the definition of the class label has the following characteristics. First, the class label of the samples from the same object has an absolutely fixed value. Second, the difference between class labels of the samples from different objects should be maximized. However, the appearance of a face varies greatly due to the variations of the illumination, pose, and expression. Therefore, the previous definition of class label is not quite reasonable. Inspired by discriminative least squares regression algorithm (DLSR), a noisy label based discriminative least squares regression algorithm (NLDLSR) is presented in this paper. In our algorithm, the maximization difference between the class labels of the samples from different objects should be satisfied. Meanwhile, the class label of the different samples from the same object is allowed to have small difference, which is consistent with the fact that the different samples from the same object have some differences. In addition, the proposed NLDLSR is expanded to the kernel space, and we further propose a novel kernel noisy label based discriminative least squares regression algorithm (KNLDLSR). A large number of experiments show that our proposed algorithms can achieve very good performance.