• Archives of Reconstructive Microsurgery
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• 제24권2호
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• pp.56-61
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• 2015

Purpose: We report on the clinical result after coverage of a soft tissue defect on the medial foot and ankle with an adipofascial flap based on the perforator from the posterior tibia artery. Materials and Methods: Nine patients with soft tissue defects on the medial foot and ankle area from March 2009 to May 2014 underwent the procedure. Average age was 54 years old (range, 8~82 years). There were five male patients and four female patients. The causes of the defect were trauma (4), tumor (3), and infection (2). The pivot point of transposition of this flap is the lower perforator originating from the posterior tibia artery. The fatty tissue side of this flap could be used to resurface the defect. The donor site was closed primarily with the preserved skin, and a small caliber drain tube was used. The split-thickness skin graft was grafted to the flap and the wound. If the wound was still infected, this skin graft could be performed at a later date. Results: All flaps survived and normal soft tissue coverage was obtained for the medial foot and ankle of all patients after the skin graft. Normal footwear was possible for all cases because of thin coverage. There was an extension contracture on the medial ray of the foot, which was resolved by contracture release and skin graft. Conclusion: For the medial foot and ankle soft tissue defect, the medial crural adipofascial flap based on a perforator branch of the posterior tibia artery could be a good option to cover it.

• Bulletin of the Korean Chemical Society
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• 제27권5호
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• pp.657-662
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• 2006

Identification of accessible sites in targeted RNAs is a major limitation to the effectiveness of antisense oligonucleotides. A class of antisense oligodeoxynucleotides, known as the “10-23” DNA enzyme or DNAzyme, which is a small catalytic DNA, has been shown to efficiently cleave target RNA at purine-pyrimidine junctions in vitro. We have designed a strategy to identify accessible cleavage sites in the target RNA, which is hepatitis C virus nonstructural gene 3 (HCV NS3) RNA that encodes viral helicase and protease, from a pool of random DNAzyme library. A pool of DNAzymes of 58 nucleotides-length that possess randomized annealing arms, catalytic core sequence, and fixed 5'/3'-end flanking sequences was designed and screened for their ability to cleave the target RNA. The screening procedure, which includes binding of DNAzyme pool to the target RNA under inactive condition, selection and amplification of active DNAzymes, incubation of the selected DNAzymes with the target RNA, and target site identification on sequencing gels, identified 16 potential cleavage sites in the target RNA. Corresponding DNAzymes were constructed for the selected target sites and were tested for RNA-cleavage in terms of kinetics and accessibility. These selected DNAzymes were effective in cleaving the target RNA in the presence of $Mg^{2+}$. This strategy can be applicable to identify accessible sites in any target RNA for antisense oligonucleotides-based gene inactivation methods.

• 한국항공우주학회지
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• 제32권3호
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• pp.30-36
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• 2004

장섬유 복합재료는 항공우주 구조물, 로봇 팔 등의 구조물에 광범위하게 적용되고 있으며, 복합재료의 비파괴 검사방법에 대한 연구는 구조의 안전성과 신뢰성을 향상시키기 위하여 매우 중요한 연구 분야로 대두되고 있다. 본 논문에서는 AE 선호의 특정주파수 성분을 추출할 수 있는 풍조회로를 가진 AE 신호 분석 장비를 설계, 제작하였다. 제작된 AE 신호 분석 장비에 충격이나 기계적 진동 등과 같은 외란을 가하였을 때 제작된 AE 신호 분석 장비의 잡음레벨은 상용 AE 신호 분석 장비의 잡음레벨보다 매우 낮은 값을 나타내었다. 또한 복합재료 시편의 정, 동적 인장시험 하에서 제작된 AE 분석 장비는 상용 장비와 통일한 수준의 복합재료 파손감지능력을 나타냄을 확인할 수 있었다.

• 한국정보통신학회논문지
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• 제13권1호
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• pp.6-16
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• 2009

V/UHF대 방향 탐지(DF)용에 적용하기 위하여 9개의 다이폴 소자로 구성된 원형배열 안테나를 연구하였다. 배열 안테나의 전체 크기를 줄이기 위하여 소자는 top-hat 다이폴 형태를 이용하였다. 20-1,300Mhz인 매우 넓은 주파수 범위에서 동작하기 위하여 각 다이폴 소자의 팔(arm)의 중간에 pin diode를 삽입하였다. 이런 형태의 다이폴을 이용하므로 pin diode의 on/off에 따라 다이폴의 실효 길이를 증감할 수 있다. 능동 배열 안테나는 평형 푸시풀 증폭기와 직접 연결되게 설계하므로 수신 감도를 개선할 뿐만 아니라 발룬 역할을 하였다. 그리고 능동 배열 안테나를 설계 및 제작하였고, 측정 결과를 계산 결과와 비교하여 제시하였다.

• 한국콘텐츠학회논문지
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• 제11권6호
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• pp.33-41
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• 2011

RFID기술은 이미 신분증, 교통카드 등 다양한 응용분야에 사용되고 있으며, UHF 대역의 RFID 기술은 물류, 유통, 보안 분야에서 많은 시스템들이 개발되어 왔다. 또한, 사람에 의해서 관리되는 허점을 보완하기 위해서 총기, 보석과 의약품과 같은 특수자산을 효율적으로 통합 관리하고, 실시간 모니터링이 가능한 시스템을 필요로 한다. 본 연구에서는 특별하게 관리되어져야 하는 특수자산을 안전하게 보관하고, 상태를 실시간으로 모니터링 가능하며, 자산의 유통 경로 및 이력 관리를 할 수 있는 특수자산 관리 시스템을 개발하고자 한다. 시스템의 형태는 캐비닛의 형태를 가지고 있기 때문에 스마트 캐비닛이라고 한다. 스마트 캐비닛은 RFID, 다양한 센서, 지문 인식, 스마트카드 등의 기술을 통합하여 특수자산을 안전하게 보호하며, 관리 서버와의 통신을 통하여 자산의 실시간 감시, 이력 관리, 유통 경로, 보안로그 등을 제공한다. 본 연구에서는 특수자산 관리시스템을 구성하는데 있어서 총기 및 의약품 관리 스마트 캐비닛을 개발하였으며, 이에 대한 효용성 및 가능성을 제시하였다.

• 대한의용생체공학회:의공학회지
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• 제33권3호
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• pp.155-162
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• 2012

Devices to measure the blood pressure of patients are being used without any calibration in a hospital. It is an important to show consistent values when any medical devices measure the same patients regardless they are sphygmomanometer or fully automatic electronic blood pressure meter. We compared sphygmomanometer and fully automatic electronic blood pressure meters with standard digital blood pressure monitor (SDBPM) to evaluate the consistency of the small healthy subjects. We measured the blood pressure from six healthy subjects (three of 20~40 years and three of 40~60 years old). Two sphygmomanometer and two fully automatic electronic blood pressure meters were used and compared with the SDBPM. Blood pressures measured from right and left arms each and were compared. All six healthy subjects showed normal blood pressure values. In general, left blood pressure values showed higher values than right side. Comparing SDBPM, with the other monitors, the systolic pressure showed ${\pm}$ 34.8% difference and ${\pm}$ 33.3% for the diastolic pressure. Correlation between SDBPM and Sphygmomanometer was 0.59~0.71, and 0.50~0.70 for fully automated digital BP monitors. It fell in grade-D when we apply the BHS(British hypertension society). AAMI(American association for the advancement of medical instrumentation) also showed unsatisfactory results for the mean value (${\leq}$ 5 mmHg) and standard deviation (${\leq}$ 8 mmHg). We tested sphygmomanometer and fully automatic electronic blood pressure meters and compared with a standard digital blood pressure monitor. All devices showed inconsistent blood pressures. A reliable calibration system is highly needed for all devices in all hospitals.

• International Journal of Human Ecology
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• 제13권1호
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• pp.117-128
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• 2012

This study compares the net effect of wearing different shoulder/arm armor systems on garment impediment perception and wearer acceptability. Two independent variables in this study were armor systems and shoulder/ arm movements. There were four armor systems of control garment and arm armor systems A, B, and C as well as five types of arm/shoulder movements, (shoulder flexion, should extension, shoulder abduction, shoulder horizontal flexion, and shoulder horizontal extension). Ten male volunteers wearing size medium battle dress uniform (BDU) with recent relevant military experience participated in this study. The volunteers performed shoulder/arm movements (while wearing each armor treatments) and completed the garment impediment perception as well as wearer acceptability scales. The body areas of neck side, shoulder top, and armscye front showed the highest frequency of reported impediments. Resistance to movement and localized pressure were the most frequently mentioned types of impediment. The armor system B had the most areas of impediment, and was rated as more restrictive than the control garment and armor system A for each movement. For wearer acceptability, no significant differences were found between the control garment and armor system A for all eight items; this indicated that subjects did not perceive a difference between wearing the control garment and armor system A. There was a trend for wearer acceptability to decrease from wearing the control garment to armor systems A to C to B.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7885-7889
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• 2014

Background: Activating mutations of epidermal growth factor receptor (EGFR) could predict response to tyrosine kinase inhibitor (TKI) treatment in patients with non-small cell lung cancer (NSCLC). However, the detection of EGFR mutation is frequently challenging in clinical practice for the lack of tumor tissue. The aim of this study was to investigate the feasibility of performing EGFR mutation testing on various types of liquid-based cytology (LBC) samples. Materials and Methods: A total of 434 liquid-based cytology samples were collected from March 2010 and November 2013. Among them, 101 with diagnosis of lung adenocarcinoma had paired surgically resected specimens. The ADx Amplification Refractory Mutation System (ADx-ARMS) was used to determine EGFR mutation status both in LBC and resected samples. Results: All liquid-based cytology samples were adequate for EGFR mutation analysis. The mutation rate was 50.5% in the 434 NSCLC patients with LBC samples and the incidence rates of EGFR mutation were consistent among different specimens. We also detected EGFR positives in 52.5% (53/101) patients with paired histologic specimens. The concordance rate of EGFR mutation between LBC samples and paired histologic specimens was 92.1%. Conclusions: Our results suggest that liquid-based cytology samples are highly reliable for EGFR mutation testing in patients with NSCLC.

• 컴퓨터교육학회논문지
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• 제17권6호
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• pp.103-113
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• 2014

본 연구에서는 동적 다변량 그래프 데이터의 연속적 분석이 가능한 질의 모델을 설계 및 구현하였다. 먼저, 질의 모델을 판별함수 설정과 시간에 따른 통합 방법 선택의 두 단계로 설계하고, 질의 패널, 그래프 시각화 패널, 속성 패널로 구성된 질의 시스템으로 구현하였다. 또한, 그래프 표현에는 노드-링크 다이어그램과 Force-Directed Graph Drawing 알고리즘을 이용하였으며, 질의 결과로 선택된 대상들에 효과를 적용하여 사용자가 시각적으로 구분할 수 있도록 처리하였다. 마지막으로, 세계 소형 무기 거래량 데이터를 이용하여, 본 연구에서 설계한 동적 다변량 그래프 질의 모델을 검증하였다. 본 연구는 동적 그래프의 연속적 분석이 가능한 새로운 질의 모델을 설계하는 것을 통해, 기존 모델이 동적 그래프를 시점별로 이산적으로만 분석할 수 있는 한계를 개선하였다는데 의의가 있다. 본 연구는 추세 분석이나, 복잡계 네트워크 해석 등 동적 그래프를 사용하는 연구에 기여할 수 있을 것으로 기대된다.

• 한국운동역학회지
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• 제21권5호
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• pp.645-652
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• 2011

The purpose of this study was to analyze, in real time, the glide motion and release motion of domestic athletes and gold and bronze medalists employing the glide technique for the men's shot put at the Daegu World Athletic Championship in 2011. In the glide motion, the Korean athletes had a relatively high body center and shot put heights and lager stretching angles for their hips and knees. In the delivery phase, which shifts to the release phase, the Korean athletes showed slower vertical body center and shot put speeds, and they changed the phase, to the release phase by using a small body angle. In the release phase, the Korean athletes showed differences in their projection speeds and vertical body center speeds. The world-famous players showed high angle speeds, which refer to the composition of the rotation force at the moment of release (body, hip, and shoulder line). In the release phase, the Korean athletes did not have fully stretched hip and knee angles, which might have negatively influenced the vertical speed. Because the Korean athletes showed relatively low projection heights and projection angles. it was found that they need to enhance the muscular power of their, throwing arms and lower limbs.