• Microbiology and Biotechnology Letters
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• v.31 no.3
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• pp.230-234
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• 2003

The Bacillus subtilis YvaE protein, the small multidrug resistance (SMR) family (TC #2.A. 7.1), is shown to catalyze efflux of multiple cationic drugs including many disinfectants, when it was cloned and expressed in Escherichia coli. When the yvaD gene was coexpressed with yvaE gene, the yvaD protein, encoded within a single operon with the yvaE gene, is shown to counteract the action ofYvaE. By ethidium efflux analysis, the cells harvoring a vector with yvaE gene showed a rapid ethidium efflux, compared with the control cells. These results clearly suggest that YvaE mediates drug export from the cell cytoplasm.

• Journal of Advanced Navigation Technology
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• v.13 no.2
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• pp.262-271
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• 2009

The purpose of this study was to propose the method to recognize gestures based on inertia sensor which recognizes the movements of the user using inertia sensor and lets the user enjoy the game by comparing the recognized movements with the pre-defined movements for the game contents production. Additionally, it was tried to provide users with various data entry methods by letting them wear small controllers using three-axis accelerator sensor. Users can proceed the game by moving according to the action list printed on the screen. They can proceed the experiential games according to the accuracy and timing of their movements. If they use multiple small wireless controllers together wearing them on the major parts of hands and feet and utilize the proposed methods, they will be more interested in the game and be absorbed in it.

• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.548-550
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• 2006

This paper deals with the implementation of a small humanoid robot controller on the basis of Real Time Operating System(RTOS) and the FPGA. This controller was adapted to the humanoid robot with 25 DOFs, which are 12 DOFs in each leg, 8 DOFs in each arm, 3 DOFs in waist, and 2 DOFs in head. The robot actuators were used DX-117 servo motors that have all of the controller components in one module in order to simplify the control structure. In addition, the main controller is FPGA of Virtex4-FX from Xilinx, and ported on VxWorks that is kind of RTOS. It is essential to install this RTOS on the complex control system and to do control activity at the multitasking environments. This paper suggested the method of distributing the computational load in the humanoid robot controller using the FPGA and RTOS concepts. All of the control process was verified through the real action of the humanoid.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.8
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• pp.843-850
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• 2011

In this paper, an effective path generation algorithm for obstacle avoidance producing small amount of steering action as possible is proposed. The proposed path generation algorithm can reduce unnecessary steering because of the small lateral changes in generated waypoints when UGV (Unmanned Ground Vehicle) encounters obstacles during its waypoint navigation. To verify this, the proposed algorithm and $A^*$ algorithm are analyzed through the simulation. The proposed algorithm shows good performance in terms of lateral changes in the generated waypoint, steering changes of the vehicle while driving and execution speed of the algorithm. Especially, due to the fast execution speed of the algorithm, the obstacles that encounter suddenly in front of the vehicle within short range can be avoided. This algorithm consider the waypoint navigation only. Therefore, in certain situations, the algorithm may generate the wrong path. In this case, a general path generation algorithm like $A^*$ is used instead. However, these special cases happen very rare during the vehicle waypoint navigation, so the proposed algorithm can be applied to most of the waypoint navigation for the unmanned ground vehicle.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4599-4602
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• 2013

We intended to study the mechanism of the inhibitory action of curcumin on human non-small cell lung cancer A549 cell. The cell growth was determined by CCK-8 assay, and the results indicated that curcumin inhibited the cell proliferation in a concentration dependent manner. And to further confirm the relative anti-cancer mechanism of curcumin, RT-PCR was carried out to analysis the expression of relative apoptotic proteins Bax, Bcl-2. We found that curcumin could up-regulate the expression of Bax but down-regulate the expression of Bcl-2 in A549 cells. In addition, curcumin affect the mitochondrial apoptosis pathway. These results suggested that curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrial apoptosis pathway.

• Proceedings of the Safety Management and Science Conference
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• 2013.11a
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• pp.221-230
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• 2013

This paper is written following an analysis of occurrence trend of industrial disaster in manufacturing industry. One of major reason of industrial accident is unsafe action caused by lack of work supervision. so we have surveyed the understanding level of supervisors for industrial safety and their education of industrial safety which is forced by industrial law. We have got the result that the supervisor's education is necessary to prevent industrial disaster but it's not fit for their own workplace for various reasons from the survey and analysis. I would like to suggest effective solutions. The institute of education should train that they can execute safety and health works themselves by classification of the industrial category, company scale and located region. Also, government should endow supervisors with authority and responsibility for the activation of education system. Finally, government should support the expense of education to medium and small-sized enterprises especially, and they should be interested in the attendance and execution of education. They will achieve the goal to prevent industrial disasters in manufacturing industry through the enforcement of effective supervisor system as per the remark mentioned above.

• Human Ecology Research
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• v.53 no.4
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• pp.447-461
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• 2015

This study developed an integrative curriculum design plan for Home Economics through a deliberation method. This study established a research framework to integrate the deliberation models of Schwab, Walker, and Reid that inherited the intellectual tradition of curriculum deliberation along with the practical reasoning process of Brown and Paolucci from a critical science perspective. The practical research problem was formulated as "What should be done to develop a Home Economics integrative curriculum?" To address this practical research problem, deliberation with deliberators of each small, medium, and large groups was processed for the development of integrative curriculum design plans. An initial proposal was developed from small group deliberation processes. An initial proposal was examined and an alternative plan was developed from medium group deliberation processes. An alternative plan and its consequence were re-examined from large group deliberation processes. The authors finalized a proposal organized on four valued ends of self-formation, intersubjectivity, social action, and life skills. A practical problem focused integrative curriculum was developed and proposed to pursue the four valued ends. The suggested final practical problem focused curriculum demonstrates the power of Home Economics to contribute to the advancement of individuals, families, and society as well as the practical empowerment of students.

• Biomolecules & Therapeutics
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• v.19 no.4
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• pp.371-389
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• 2011

A new strategy for cancer therapy has emerged during the past decade based on molecular targets that are less likely to be essential in all cells in the body, therefore confer a wider therapeutic window than traditional cytotoxic drugs which mechanism of action is to inhibit essential cellular functions. Exceptional heterogeneity and adaptability of cancer impose significant challenges in oncology drug discovery, and the concept of complex tumor biology has led the framework of developing many anticancer therapeutics. Protein kinases are the most pursued targets in oncology drug discovery. To date, 12 small molecule kinase inhibitors have been approved by US Food and Drug Administration, and many more are in clinical development. With demonstrated clinical efficacy of bortezomib, ubiquitin proteasome and ubiquitin-like protein conjugation systems are also emerging as new therapeutic targets in cancer therapy. In this review, strategies of targeted cancer therapies with inhibitors of kinases and proteasome systems are discussed. Combinational cancer therapy to overcome drug resistance and to achieve greater treatment benefit through the additive or synergistic effects of each individual agent is also discussed. Finally, the opportunities in the future cancer therapy with molecularly targeted anticancer therapeutics are addressed.

• Journal of Interdisciplinary Genomics
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• v.4 no.2
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• pp.24-30
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• 2022

Klinefelter's syndrome (KS) is a syndrome with extra X chromosome(s), in XY individuals, characterized by gynecomastia, small testes, and infertility. Additional X chromosomes can be present as variable karyotypic forms, including mosaicism (47,XXY/46,XY). The reported prevalence of KS ranges from one in 500 to one in 1,000 live males, but is probably underestimated. The classic phenotype is small, firm testes and infertility resulting from seminiferous tubule dysgenesis and androgen deficiency. The spectrum of KS includes tall stature with relatively long legs and arm span, decreased body hair, learning disabilities, behavioral problems, poor motor skills, and other important medical issues, such as metabolic syndrome, diabetes, autoimmune diseases, cardiovascular disease, certain neoplasia. The increased risk of certain medical problems in KS can be attributed to a direct effect of the extra X chromosome, the combined action of multiple genomic and epigenetic factors, or the hormonal imbalances. Typically, chromosome analysis is not ordered for adult patients with general medical conditions, except for suspected cases of hematologic and lymphoid disorders. Even though it was found during work-up for certain disorders in adult patient, most physicians do not suspect KS or consider its impact. Therefore, understanding the pathophysiology and variable manifestation in KS is necessary, and discussions with multidisciplinary teams will help to diagnose and treat males with KS.

• Geomechanics and Engineering
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• v.28 no.3
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• pp.209-224
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• 2022

In this study, the numerical analysis model of π-beam explosion is established to compare and analyze the failure modes of the π-beam under the action of explosive loads, thus verifying the accuracy of the numerical model. Then, based on the numerical analysis of different protection forms of π beams under explosive loads, the peak pressure of π beam under different protection conditions, the law of structural energy consumption, the damage pattern of the π beam after protection, and the protection efficiency of different protective layers was studied. The testing results indicate that the pressure peak of π beam is relatively small under the combined protection of steel plate and aluminum foam, and the peak value of pressure decays quickly along the beam longitudinal. Besides, as the longitudinal distance increases, the pressure peak attenuates most heavily on the roof's explosion-facing surface. Meanwhile, the combined protective layer has a strong energy consumption capacity, the energy consumed accounts for 90% of the three parts of the π beam (concrete, steel, and protective layer). The damaged area of π beam is relatively small under the combined protection of steel plate and aluminum foam. We also calculate the protection efficiency of π beams under different protection conditions using the maximum spalling area of concrete. The results show that the protective efficiency of the combined protective layer is 45%, demonstrating a relatively good protective ability.