• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.375-385
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• 2010

Conventional cancer chemotherapy is seriously limited by tumor cells exhibiting multidrug resistance (MDR), which is caused by changes in the levels or activity of membrane transporters that mediate energy-dependent drug efflux and of proteins that affect drug metabolism and/or drug action. Cancer scientists and oncologists have worked together for some time to understand anticancer drug resistance and develop pharmacological strategies to overcome such resistance. Much focus has been on the reversal of the MDR phenotype by inhibition of ATP-binding cassette (ABC) drug transporters. ABC transporters are a family of transporter proteins that mediate drug resistance and low drug bioavailability by pumping various drugs out of cells at the expense of ATP hydrolysis. Many inhibitors of MDR transporters have been identified, and though some are currently undergoing clinical trials, none are in clinical use. Herein, we briefly review the status of MDR in human cancer, explore the pathways of MDR in chemotherapy, and outline recent advances in the design and development of MDR modulators.

• Nuclear Engineering and Technology
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• v.28 no.4
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• pp.423-430
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• 1996

The improved and advanced Annulus Gas System(AGS) has been developed for Wolsong 2 to satisfy the requirements of the regulatory body. The Atomic Energy Control Board(AECB) required a shorter detection time following a small leak from a pressure tube and/or calandria tube. This paper describes licensing requirements, functional requirements and detail design description for the AGS. The Wolsong unit No. 1 AGS was designed to operate as a stagnant system normally requiring only pressure regulation and having provisions for purging. no improved AGS involves the adoption of gas recirculation in AGS, duplication of dew point indicators with additional instrumentation and sampling provisions to prompt operator action. The improved system operates in the recirculation mode with continuous dew point measurement for leak detection. An AGS with improved detection instrumentation is provided.

• Biomedical Science Letters
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• v.23 no.4
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• pp.380-387
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• 2017

Berchemia berchemiaefolia (BB) are climbing plants or small to medium-sized trees that live in Africa, Asia and America. We performed the present study to investigate whether oral administration of Berchemia berchemiaefolia extract (BBE) protects SD rats from pain. The SD rat experimental groups were divided into four groups. Two of the animal model groups were fed on BBE (200 mg/kg or 100 mg/kg). We performed oral acute toxicity test to determine the optimal oral dose of BBE. To explore if BBE alleviated pain in the SD rat, we undertook the tail flick latency test and formalin test. Additionally, we conducted the anti-oxidative test. The findings of the present study suggest that Berchemia berchemiaefolia extract exhibits strong antioxidant and analgesic activities.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.04c
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• pp.32-40
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• 2008

Recently, due to the onset of the information age, various high-priced, large-size machines have been invented such as intelligent building and high-tech computer operated facilities. Consequently, all kinds of electrical, electronic, and communication equipments and facilities have been found to be vulnerable even to small amounts of electrical shock. Interference between equipments and equipment malfunction occur because of various electromagnetic interferences. Galvanic action by direct current (D.C.) causes gas valve corrosion and other electrical problems such as static electricity and electromagnetic interference (EMI) occur as well. Most of the problems stated above occur because of problems in grounding.

• Journal of the Korean Vacuum Society
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• v.21 no.3
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• pp.130-135
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• 2012

The role of the electron diffusion on the stability of a Townsend discharge was investigated with the linear stability theory for the one-dimensional fluid equation with drift-diffusion approximation. It was proved that the discovered instability occurs as a result of the coupled action of electron diffusion and the perturbed electric field by space charge. The larger electron diffusion results in the faster growth rate at the regime of small perturbation of the electric field by space charges.

• CELLMED
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• v.3 no.2
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• pp.12.1-12.4
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• 2013

Identification of target protein is an important procedure in the course of drug discovery. Because of complexity, action mechanisms of herbal medicine are rather obscure, unlike small-molecular drugs. Inverse docking simulation is a reverse use of molecular docking involving multiple target searches for known chemical structure. This methodology can be applied in the field of target fishing and toxicity prediction for herbal compounds as well as known drug molecules. The aim of this review is to introduce a series of in silico works for predicting potential drug targets and side-effects based on inverse docking simulations.

• Structural Engineering and Mechanics
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• v.23 no.4
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• pp.369-386
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• 2006

The influence of reinforcement buckling on the flexural response of reinforced concrete members is studied. The stress-strain response of compression reinforcement is determined computationally using a large-strain finite element model for bars of varied diameter, length, and initial eccentricity, and a mathematical expression is fitted to the simulation results. This relationship is used to represent the response of bars in compression in a moment-curvature analysis of a reinforced concrete cross section. The compression bar may carry more or less force than a tension bar at a corresponding strain, depending on the relative influence of Poisson effects and bar slenderness. Several cross-section analyses indicate that, for the distances between stirrups prescribed in modern concrete codes, the influence of inelastic buckling of the longitudinal reinforcement on the monotonic moment capacity is very small and can be neglected in many circumstances.

• Proceedings of KOSOMES biannual meeting
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• 2003.05a
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• pp.153-158
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• 2003

Design of general steel structure had applied and achieve elastic design concept mainly so far. Because elastic design supposes that whole structure complies with elasticity formula as that achieve via allowable stress of material is concept that calculate stress distribution of construction about action external load and estimate load of when the maximum stress reaches equally with allowable stress that is established beforehand by maximum safety load of the structure. But, absence that compose actuality structure by deal with external load increase small success surrender and structure hardness falls and tell structure in limit state finally on the whole as showing complicated conduct by interference between these breakdown at buckling by compression. Examined closely about conduct of place since initial buckling through carbon vocal cords transformation finite element analysis series (ANSYS) that place mending condition supposes case that is boundary condition in this investigation.

• Korean Management Science Review
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• v.14 no.1
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• pp.151-176
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• 1997

This study addresses strategic issues related to the question of" how can a supply chain become more competivity\ulcorner" We examine several cases of manufacturing supply chains. Results show that each constituent firm is required to maintain different manufacturing capabilities and to play different roles by its position (up/mid/down-stream) in a chain. Furthermore, there are patterns of required capabilities by the positions in a chain. These findings imply that the "position in a chain" should be treated as one of the strategic factors when discussing the buyer-seller relationship. It is also shown that different action programs are required for building different manufacturing capabilities of individual firms in a supply chain. Additionally, we argue that some programs need to be done simultaneously, by all the members of the chain, while some need to be carried out by only a small group or an individual firm. Finally, we propose a direction for a theoretical framework for analyzing supply chain structures and strategies.ures and strategies.

• Journal of the Korean Institute of Navigation
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• v.15 no.1
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• pp.67-93
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• 1991

In general, marine casualities take palace by the composite action of three elements such as waterway condition, vessel condition and man condition. One of the important characteristics of most marie casualties for small cargo vessels in maritime transportation of near-coastal and greater-coasting seas in that the same kind of casualities take place repeatedly in spite of the apprent causes, Because, it takes much time and effort for seamen to master waterway, vessel or operatin technique only to the practical and sensible level. In these days, with the development of our economy, our shiypping industry has grown and therefore the demand of marine officers has increased. This economic growth brought about undesirable situation like the evasion of seamen and frequent casualities of Korea vessels. These marine casualities are being caused mainly by the unskilfulness of operating technique as well as the bad waterway condition and ship's installation condition. Therefore, I conclude, in this paper, that the most efficient and economic preventing measures of marine casualities are seeking causes and removing them in advance under the close coperation system among all concerned parties.