• Journal of Pharmaceutical Investigation
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• 제16권3호
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• pp.124-131
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• 1986

Pharmacological activities of Paeoniae Radix alba were studied with water extract (F-I), parched preparation (F-II) and 25% ethanol-treated preparation (F-III) of it. The results were summerized as follows; 1) Analgesic actions were recognized with F-I, F-II and F-III. 2) Sedative actions were recognized with F-I and F-III. 3) Prolonged effect of sleeping time were recognized significantly with F-I and F-III. 4) Antipyretic actions were recognized with F-1, F-II and F-III in rabbits. 5) F-I, F-II and F-III showed the antagonic action against contraction of isolated-ileum induced by acetylcholine, barium chloride and histamine in mice and guinea-pigs.

• 생약학회지
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• 제28권4호
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• pp.252-256
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• 1997

Verbascoside has inhibition activity on carrageenan induced edema in rat paw, enhancement of bile juice secretion, and hepatoprotective activity. The hepatoprotective functions were improved on serumtransaminase activities (s-GPT and s-GOT), liver weight, and even sleeping time in mice treated with verbascoside. In addtion, the mice toxicated with carbon tetrachloride are signiflcantly recovered by the administration of verbascoside. This is the first report shown their biological activity of verbascoside.

• 생약학회지
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• 제24권3호
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• pp.231-234
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• 1993

Neuropharmacological profile of Humulus lupulus (hop) extract was studied in mice. At doses above 100 mg/kg(i.p.), it decreased spontaneous locomotor activity and raised the nociceptive threshold in the hot-plate test. At doses above 250 mg/kg (i.p.), it increased pentobarbital-induced sleeping time and produced muscle relaxant effect. At the dose of 500 mg/kg, anticonvulsive effect against pentylenetetrazole-induced convulsion and hypothermic effect was observed.

• 약학회지
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• 제39권5호
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• pp.471-479
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• 1995

The recombinant human epidermal growth factor(DWP 401) was investigated on the pharrnacological actions. DWP 401 had no effects on the hexobarbital-induced sleeping time, locomotor activity, rotarod test, body temperature, analgesic action and anticonvulsant action in mice. It also had no influences on the isolated tracheal muscle and ileum of guinea-pig, isolated uterus and fundus strip of rats. Slight hypotensive action with effect on respiration was revealed at a dose of 8 g/kg i.v. of DWP 401 in rabbits. DWP 401 exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats at .a concentration of 160 g,/kg, and produced a significant inhibitory effect on leucocyte migration in CMC-pouch of rats at a concentration of 32 g/rat. Furthermore, DWP 401 showed a significant decrease on gastric juice volume and acidity. However. DWP 401 had no intestinal propulsion rate and influence on urine excretion.

• 정신간호학회지
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• 제28권2호
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• pp.156-164
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• 2019

Purpose: The aim of this study was to identify factors influencing on the mental health in bereaved adults. Methods: A descriptive and correlational study was conducted in 160 adults who had experienced bereavement. The collected data was analyzed using descriptive statistics, Pearson's correlation, and hierarchical multiple linear regression analyses with SPSS 26.0. Results: The participants' mental health showed a positive correlation with complicated grief (r=.31, p<.001) and a negative correlation with grief and meaning reconstruction (r=-.30, p<.001). Sex, sleeping time, intimacy with the deceased, grief reaction, and grief and meaning reconstruction were significant factors influencing on the mental health. The total explanatory power of these variables was 31.8%. Conclusion: It is necessary to explore the persistent and impairing grief after experiencing bereavement. Our study findings will be fundamental evidence to develop nursing interventions to improve adult mental health dealing with bereavement and grief.

• 한방안이비인후피부과학회지
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• 제37권2호
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• pp.113-122
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• 2024

Objectives : To report the R/O CRPS patient after Korean medicine treatment, suffering severe buring pain and insomnia. Methods : The patient was a 56-year-old female patient and treated with herbal medicines and acupuncture in 32 days. The treatment effect was evaluated by measuring VNRS of pain, sleeping time and change in mood status. Results : The Korean Medical therapy had good effect on the patient. Especially, relaxing mental treatment is effective in improving and maintaining symptoms. Conclusions : The Korean medical treatments appeared to be effective in reducing R/O CRPS symptoms. Further clinical research of patients with CRPS is needed.

• Archives of Pharmacal Research
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• 제16권1호
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• pp.6-12
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• 1993

To evaluate KR-10876, a new fluoroquinolone antibacterial agent, its effects on the central nervous system(CNS) were investigated in mmice as part of phamacological study, and the results were compared with those for ciprofloxacin and ofloxacin, two prototypes of quinolone antiabctrial agents. All the parameters indicative of CNS function and acute toxicity were measured by close observation of the animals at regular time intervals after oral treatment of test compounds. KR-10876 did not have any effect on the parameters measured at lower does (100, 300 mg/kg, p.o.), it caused ptosis, suppressed spontaneous locomotor activity, hypothemia, and prolonged hexobarbital-induced sleeping time. KR-10876 also had a slight effect on motor coordination only at high dose. Simialr to ciprofloxacin, KR-10876 did not protect mice from pentylenetetrazol-strychnine-, and electroshock-inducedl convulsions at doses tested. These findings demonstrate that KR-10876 affects CNS functions only at high doses. The rank order for effects is ofloxacin$\le$KR-10876>ciprofloxacin.

• 한국학교보건학회지
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• 제27권3호
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• pp.159-168
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• 2014

Purpose: The purpose of this study is to provide implications for National Curriculum design for elementary and secondary school, by analyzing social indices of students' real life based on Oliva's three types of demand for education. Three types of demand are physical, social-psychological and educational demand. Methods: This study mainly analyzed recent research data and existing studies relevant to social indices to show students' real life. Results: Three types of social indices about educational demand showed that students have many difficulties in much learning time, lacking in sleeping time and physical activities, much stress and suicide attempt. It is supposed that learning and academic achievement is the main factor to make such kind of stress. Conclusion: Health & safety education, self-esteem inspiring education, reduction of learning burden, physical activities etc are needed to be more reflected in National Curriculum design in the future.

• 건축역사연구
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• 제26권1호
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• pp.93-104
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• 2017

This study is about the Changdeokgung Palace and detached palaces of architect Park Jacheong who was a representative supervisor having framed the palace architecture of the Joseon Dynasty. The results are as follows. First, Park Jacheong had been in charge of Changdeokgung Palace for 15 years since its founding. The palace was continued to run for the longest time and was the palace on the frame made by him for the years, so Changdeokgung Palace's status has become as good as Gyeongbokgung Palace's. Second, he built a lot of palaces besides Changdeokgung. They were completed about the same time in accordance with the political intentions of King Taejong. Park Jacheong was a former military officer and was well skilled in mobilization of manpower and materials by making good use of the military power. Third, the detached palaces constructed by him were located in the places where military training and testing of new weapons were possible. They were also used as sleeping, dining and office spaces. This can be regarded as a result of the tradition of the storied-pavilion that had been since the Goryeo Dynasty, with the method of approaching to the main hall of the palace.

• 대한물리치료과학회지
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• 제20권1호
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• pp.77-88
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• 2013

Purpose : The purpose of this study was to examine the levels and influencing factors of the perceived stress and life-satisfaction among mothers of children with disability. Methods : 55 mothers were selected for this study and the self-reporting method to the structured questionnaire were used to collect the data. The data were analyzed with the frequency, t-test, one-way ANOVA, Duncan test using SPSS 14.0 for window programs. Results : Firstly, the level of total perceived stress of the mothers of children with cerebral palsy was 44.28/75, and the average of the items of the perceived stress was 2.95/5. The highest level of subcategory of the perceived stress, 10.82/15, was in parent role stress, and the lowest level of subcategory of the perceived stress, 3.88/10, was in children developmental stress. There were statistically significant differences in the mother's level of stress according to their ages, employment, occupation, and daily activity time and sleeping time. Secondly, the level of life-satisfaction was 3.17/7, and statistically significant difference was found by the treatment cost. Conclusions : We suggest that these variables need to be considered when the stress intervention programs for the mothers of children with cerebral palsy are developed.