• Food Science of Animal Resources
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• v.37 no.5
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• pp.646-653
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• 2017

Alcalase hydrolysis of liquid egg white was used to produce 5-hydroxytryptophan (HTP) under various conditions and investigate the sleep-potentiating activity of liquid egg white hydrolysate (LEH) on pentobarbital-induced sleep. Alcalase hydrolysis yielded the highest content of 5-HTP ($13.50{\mu}g/mL$), while neutrase hydrolysis showed the lowest 5-HTP content ($5.23{\mu}g/mL$). The liquid egg white to water ratio (1:1) was optimal for the production of 5-HTP with high amino-nitrogen (A-N) content and degree of hydrolysis. The 5-HTP, amino-nitrogen, and degree of hydrolysis increased until 24 h of hydrolysis and slightly increased thereafter during hydrolysis with 2% and 5% enzyme addition. 5-HTP administration at doses of 6 and 9 mg/kg significantly increased sleep duration and decreased sleep latency time compared to that in the control (p<0.05). LEH (150 mg/mouse), which was equivalent to 5-HTP at 6 mg/kg, significantly decreased sleep latency time and increased sleep duration time compared to that in the control (p<0.05). Oral administration of LEH showed sleep-potentiating effects because of 5-HTP. The sleep-potentiating activity of LEH may have occurred through 5-HTP in our pentobarbital-induced sleep model. LEH may be a valuable alternative to sleep enhancement and may be used as a sleep-potentiating agent.

• Journal of the Korean Data and Information Science Society
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• v.27 no.3
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• pp.773-789
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• 2016

This study was conducted to identify the sleep patterns and influencing factors of hospitalized elderly in a long-term care hospital. The sleep patterns of 142 subjects were recorded using Sleep Charts. The average sleep time of subjects was 10.7 hours a day (3.9 hours in daytime and 6.8 hours in nighttime). Sleep regularity among participants were 71.7% in all day (58.1% in day time and 80.5% in night time). The presence of dementia patients in the room (PDPR) has been identified to be a statistically significant predictor of all day sleep, and pain, PDPR, and physical function have been found to be a significant predictors of sleep regularity in all day among subjects. It suggested that elderly patients in a long-term care hospital do not slept well during night, which leads to increase in daytime sleep and decrease the quality of their sleep. Therefore, an intervention program should be developed to promote the quality of sleep among hospitalized elderly.

• Journal of the Korean Society of Industry Convergence
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• v.23 no.3
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• pp.433-444
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• 2020

This study proposes a method to improve the sleep stage and efficiency estimation of sleep apnea patients using a UWB (Ultra-Wideband) radar. Motion and respiration extracted from the radar signal were used. Respiratory signal disturbances by motion artifacts and irregular respiration patterns of sleep apnea patients are compensated for in the preprocessing stage. Preprocessing calculates the standard deviation of the respiration signal for a shift window of 15 seconds to estimate thresholds for compensation and applies it to the breathing signal. The method for estimating the sleep stage is based on the difference in amplitude of two kinds of smoothed respirations signals. In smoothing, the window size is set to 10 seconds and 34 seconds, respectively. The estimated feature was processed by the k-nearest neighbor classifier and the feature filtering model to discriminate between the sleep periods of the rapid eye movement (REM) and non-rapid eye movement (NREM). The feature filtering model reflects the characteristics of the REM sleep that occur continuously and the characteristics that mainly occur in the latter part of this stage. The sleep efficiency is estimated by using the sleep onset time and motion events. Sleep onset time uses estimated features from the gradient changes of the breathing signal. A motion event was applied based on the estimated energy change in the UWB signal. Sleep efficiency and sleep stage accuracy were assessed with polysomnography. The average sleep efficiency and sleep stage accuracy were estimated respectively to be about 96.3% and 88.8% in 18 sleep apnea subjects.

• Journal of Ginseng Research
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• v.34 no.1
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• pp.30-40
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• 2010

The present investigation was conducted to evaluate the regulation of sleep architecture by the red ginseng water extract (RGE) in acutely and chronically restraint stressed rats. Adult rats were fitted with sleep.wake recording electrodes. Following post-surgical recovery, rats were extensively habituated for freely moving polygraphic recording conditions. Polygraphic signs of sleep-wake activities were recorded for 24 h after RGE administration and induction of stress and were analyzed to understand the regulation of sleep architecture. Acute stress decreased wakefulness and increased total sleep, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep in both the daytime and nighttime recording. RGE shortened the daytime NREM and REM sleep, without changing the wakefulness and total sleep. RGE increased nighttime wakefulness, and decreased total, NREM and REM sleep. Chronic stress increased wakefulness and decreased total sleep in the daytime recording, and increased REM and decreased NREM sleep in both the day and night time recording. RGE ameliorated chronic stress and induced alterations of REM and NREM sleep in the day and night time sleep architecture. Acute and chronic stress could also induce alternations in cortex electroencephalogram (EEG) recording during NREM, REM sleep and wakefulness. These findings suggest that RGE may modulate the sleep behavior in acutely and chronically stressed rats and the ameliorating effect of RGE on the sleep architecture may involve in modulation of $\alpha$-, $\theta$- and $\delta$- wave activities of the cortical EEG.

• The Journal of Korean Academy of Sensory Integration
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• v.10 no.2
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• pp.23-32
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• 2012

Objective : The aim of the present single subject research was to identify the effect of sensory diet based on proprioception on toddler's sleep pattern and the continuance of the effect. Methods : The sensory diet based on proprioception consisted of 14 session was provided to a 13 months old girl for 2 weeks. The time taken to fall asleep, amount of sleep, bed time and severity of behavior before sleep were recorded by her mother who was taken the education about observation. Results : After the sensory diet, the child present change of time taken to fall asleep, amount of sleep, bed time and severity of behavior before sleep, and the effect on time taken to fall asleep, continued temporally. Conclusion : The sensory diet based on proprioception was related to stabilize the sleep pattern of a toddler, and the effect of the sensory diet continued temporally after the sensory diet. For future research, more subjects and methodical measure are need to generalize the result of sensory diet based on proprioception affecting to toddler's sleep pattern.

• Journal of Korea Multimedia Society
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• v.23 no.11
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• pp.1406-1417
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• 2020

Sounds that have been evaluated to be effective in inducing sleep are helpful to reduce sleep disorders. Generally, several sounds have been verified the effects by brainwave experiments, but it cannot be considered on all users because of individual variation for effects. Moreover, the effectiveness for inducing sleep is not known for all new sounds made by creative activities. Therefore, new classification system is required to collect new effective sounds with considering personal brainwave characteristics. In this paper, we propose a new sound classification method by applying improved MinHash cluster to brain waves. The proposed method will classify them through whether it is effective for sleep care by evaluation his brainwave during listening for each sound. In order to prove effectiveness of the proposed classification method, we conducted accuracy experiment for sleep sound classification using verified sleep induction sound. In addition, we have compared time for existing method and proposed method. The former is scored 85% accuracy in the experiment. We confirmed the latter one that the average processing time was reduced to 70%. It is expected to be one of method for pre-screening whether it is effective when a new sound is introduced as a sound for sleep induction.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.759-763
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• 2006

The World Health Organization(WHO) has recommended population of sleep disturbance as one of the environmental health indicators. But the percentage of respondents who felt highly sleep disturbed, that is, %HSD can???thave application to sleep disturbance from instantaneous noise. Therefore, this study has been carried out to present the technique for assessing sleep disturbance on instantaneous noise quantitatively. The study of sleep disturbance on night time instantaneous railway noise has been undertaken. Noise monitor has been in operation from 22 hours to 7 hours during 6 nights at 12 locations. To assess instantaneous noise induced sleep disturbance, it was decided to measure body movement by actiwatch. %motility was used as indicators of sleep disturbance. %motility is the expected value of probability of motility value during 7 epochs (105s) of any noise event. The measures of instantaneous motility have been related to measures of instantaneous railway noise events. The relationship shows that %motility is a good predictor for assessing sleep disturbance and Korean is more sensitive to noise than European although the railway noise have been considered in this study. This study can be extended to assessing long-term sleep disturbance and give a guideline far policy decision.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.24 no.7
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• pp.605-608
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• 2011

In this study, OSA (the obstructive sleep apnea) periods were detected in patients with OSA during sleep because of the treatment was different according to the frequency and symptoms of obstructive sleep apnea. ANS (autonomic nervous activity) was changed by obstructive sleep apnea periods so we intended to detect the periods to care the obstructive sleep apnea patients. RR intervals, SDNN (standard deviation of normal to normal) and RMSSD (root mean square standard deviation) were calculated in time domain analysis and LF (low frequency), HF (high frequency), NHF (normalized high frequency), NLF (normalized low frequency) were calculated in frequency domain analysis of HRV (heart rate variability) with obstructive sleep apnea patients. In this paper, SDNN (standard deviation of normal to normal) of time domain analysis were decreased in the obstructive sleep apnea periods. And NLF and LF/HF ratio were increased and NHF (normalized high frequency) was decreased in the frequency domain analysis. The parameters can be used to treat obstructive sleep apnea patients by detecting the obstructive sleep apnea periods such as CPAP (continuous positive airway pressure).

• Korean Parent-Child Health Journal
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• v.3 no.1
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• pp.46-59
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• 2000

The purpose of this study is to determine whether the NCASA (Nursing Child Assessment Sleep/Activity Record) would be suitable to evaluate and to provide the basic resources for a Korean model of sleep/activity patterns during the first 6 months Korean infants' lives and to provide a basis for nursing intervention for mothers of early infants. The subjects of this study were 94 normal infants from birth to 6 months of age who visited the postpartum care center and two general hospitals located in Pusan from February 1 to April 28, 2000. The method of data collection was through convenient sampling. The instrument of this study was the NCASA translated by the Korean parent Child Health Academic Association. The collected data were analysed by mean, standard deviation, frequency percentage and ANOVA, Post Hoc test by use of SPSS/PC. The conclusions obtained from this study are summarized as follows: 1. The mean amount of daytime sleep was 8.06 hours. The mean amount of nighttime sleep was 6.31 hours. The mean amount of total daily sleep was 14.37 hours. The mean of the longest sleep period was 5.20 hours. The mean regularity of daytime sleep was 25.84%. The mean regularity of nighttime sleep was 77.69%. The mean regularity of total daily sleep was 42.60%. The mean frequency of nighttime wakenings was 2.33 times. 2. The mean amount of daytime activity was 8.25 hours. The mean amount of nighttime activity was 1.39 hours. The mean amount of daily total activity was 9.64 hours. The mean of the longest activity period was 3.80 hours The mean frequency of daytime feeding was 5.69 times. The mean frequency of nighttime feeding was 2.08 times. The mean frequency of total daily feeding was 7.74 times. The mean frequency regularity of feeding was 54.62%. The mean frequency of wakenings was 5.14 times. The mean frequency of crying was 1.90 times. 3. According to an analysis of sleep patterns based on an infant's age, there were some significant differences in the following factors: amount of daytime sleep(p<.001), amount of night time sleep(p<.05), amount of total daily sleep (p<.001), longest sleep period(p<.001), regularity of daytime sleep(p<.001), regularity of nighttime sleep(p<.01), regularity of total daily sleep(p<.001), frequency of nighttime wakenings(p<.001). 4. According to an analysis of activity patterns based on an infant's age, there were some significant differences in the following factors: amount of daytime activity(p<.001), amount of nighttime activity(p<.01), amount of total daily activity(p<.001), longest activity period(p<.05), frequency of nighttime feeding(p<.01), frequency of wakenings(p<.001). 5. The mean amount of a mother's day time was 16.30 hours. The mean amount of a mother's night time was 7.70 hours. In conclusion, the initial irregular sleeping and activity patterns of the early infant became regurized as the infant grew older and estabilished firmer patterns of sleeping and of activity.

• Korean Journal of Clinical Laboratory Science
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• v.39 no.3
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• pp.264-270
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• 2007

Obstructive sleep apnea syndrome (OSAS) is defined by sleep apnea with decreased oxygen saturation, excessive snoring with daytime sleepiness, and frequent awakening during the night time sleep. The present study was performed to investigate how apnea-hypopnea, that possibly causes breathing disturbance during sleep, can affect sleep pattern in patients with OSAS. We included 115 patients (92 men, 23 women) who underwent a polysomnography from January 2006 to May 2007. As the frequency of sleep apnea-hypopnea increases, the proportion of non-rapid eye movement (REM) sleep (p<0.001), and stage I sleep (p<0.001) increased, while that of stage II sleep (p<0.001), stage III and IV sleep (p<0.01), and REM sleep (p<0.05) decreased. Furthermore, sleep apnea-hypopnea was closely correlated with REM sleep (r=0.314, p<0.001), stage I sleep (r=0.719, p<0.001), stage II sleep (p=-0.342, p<0.05), stage III and IV sleep (r=-0.414, p<0.001), and REM sleep (r=-0.342, p<0.05). Stage I sleep could account for the 51% of the variance of apnea-hyponea. Our study shows sleep apnea-hypopnea affects sleep pattern in pattern with OSAS significantly, and the change of stage I sleep is the most important factor in estimating the disturbance of sleep pattern.