• 대한통합의학회지
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• 제6권4호
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• pp.111-125
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• 2018

Purpose : Cachexia, is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass. Patients with cachxia shows various symptoms including fatigue, anxiety, pain, sleep disorders, and poor appetite. Medications therapy, dietary and exercise therapy, and emotional support are recommended to treat patients with cachexia. However, evidence-based research verifying the role of exercise therapy in patients with cachexia is limited. The purpose of this study was to investigate the effects of therapeutic exercise on fatigue and anxiety in patients with cachexia. Methods : Case report. A 29-year-old woman was diagnosed with cachexia. Following 2 weeks of inpatient and 4 weeks of out-patient treatment. we assessed her weight, as well as pain, fatigue, and anxiety level. As an the patient exercised for an hour 5 times a week for 2 weeks,-and during the outpatient visit, she exercised for an hour twice a week for 4 weeks. Her weight was measured using a weighting scale. Pain was assessed using the visual analog scale, and fatigue and anxiety levels were assessed using questionnaires. Results : Following 6 weeks of treatment, exercise therapy a positively affected the patient's weight, as well as pain, fatigue, and anxiety levels. We observed a weight gain of 4.5 kg, pain reduction of 5.1 points. Fatigue reduction of 43 points, anxiety reduction of total 41 points. Conclusion : Exercise therapy positively affects weight, as well as pain, fatigue, and anxiety levels in patients with cachexia. However, generalization of this observation is inappropriate based on this single case study.

• Journal of Genetic Medicine
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• 제19권1호
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• pp.32-37
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• 2022

Mucopolysaccharidosis type VI (MPS VI) is an autosomal recessive lysosomal disorder caused by the deficiency of arylsulfatase B due to mutations in the ARSB gene. Here, we report the case of a Korean female with a novel variant of MPS VI. A Korean female aged 5 years and 8 months, who is the only child of a healthy non-consanguineous Korean couple, presented at our hospital for severe short stature. She had a medical history of umbilical hernia and recurrent otitis media. Her symptoms included snoring and mouth breathing. Subtle dysmorphic features, including mild coarse face, joint contracture, hepatomegaly, and limited range of joint motion, were identified. Radiography revealed deformities, suggesting skeletal dysplasia. Growth hormone (GH) provocation tests revealed complete GH deficiency. Targeted exome sequencing revealed compound heterozygous mutations in the ARSB genes c.512G>A (p.Gly171Asp; a pathogenic variant inherited from her father) and c.1157C>T (p.Ser386Phe; a novel variant inherited from her mother in familial genetic testing). Quantitative tests revealed increased urine glycosaminoglycan (GAG) levels and decreased enzyme activity of arylsulfatase B. While on enzyme replacement therapy and GH therapy, her height increased drastically; her coarse face, joint contracture, snoring, and obstructive sleep apnea improved; urine GAG decreased; and left ventricular mass index was remarkably decreased. We report a novel variant-c.1157C>T (p.Ser386Phe)-of the ARSB gene in a patient with MPS VI; these findings will expand our knowledge of its clinical spectrum and molecular mechanisms.

• 동의신경정신과학회지
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• 제34권3호
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• pp.163-179
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• 2023

Objectives: The purpose of this study was to provide evidence for the clinical effects of foot bath therapy for insomnia disorder through a systematic review and meta-analysis. Methods: Studies were selected from seven domestic and international literature databases. Data on diagnostic tools, pattern identification, sample size, intervention methods, outcome measurements, results, and adverse events were extracted. The quality of the selected literature was assessed using Cochrane's risk of bias (RoB) assessment tool. Results: A total of 11 studies were included in this study. The primary diagnostic tool for insomnia dis- order was the criteria for the diagnosis and therapeutic effect of diseases and syndromes in traditional Chinese medicine (CDTDSTCM), along with the Chinese classification of mental disorders-3 (CCMD-3). Treatment effects were mainly evaluated by the effective rate and the Pittsburgh Sleep Quality Index (PSQI). The meta-analysis results showed statistically higher effectiveness rates for treating insomnia disorder in the experimental groups receiving herbal medicine foot bath therapy with sleeping or herbal medication compared to the control group. The PSQI was lower in the treatment group receiving herbal medicine foot bath therapy with sleeping medication. The herbal materials used in herbal medicine foot bath therapy mainly included Radix Angelicae Sinensis, Polygonum Multiflorum, Ziziphi Spinosae Semen, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, and Cortex Albizziae. The quality of the included studies was generally poor. Conclusions: This study found that foot bath therapy had clinical efficacy for treating insomnia disorder. The research findings could provide foundational evidence for establishing the clinical basis of foot bath therapy in the treatment of insomnia.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권5호
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• pp.249-265
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• 2023

Purpose: Infant regurgitation is associated with other functional gastrointestinal disorders and signs and symptoms that have a major impact on the quality of life of infants and their families. This study evaluated the safety, tolerance, and real-world effectiveness of an anti-regurgitation formula containing locust bean gum (LBG), prebiotics, and postbiotics to alleviate digestive symptoms beyond regurgitation. Methods: This 3-month study involved infants with regurgitation requiring the prescription of an anti-regurgitation formula according to usual clinical practice. Outcomes included evaluation of the evolution of stool consistency and frequency; occurrence of colic, constipation, and diarrhea; and assessment of regurgitation severity. Infant crying, parental assessment of infant well-being, and parental satisfaction with the stool consistency were also evaluated. Results: In total, 190 infants (average age: 1.9±1.1 months) were included. After three months, stool frequency and consistency remained within the normal physiological range, with 82.7% of infants passing one or two stools per day and 90.4% passing loose or formed stools. There was no significant increase in the number of infants with diarrhea, whereas a decrease was observed in the number of infants with constipation after 1 month (p=0.001) and with colic after both 1 and 3 months (p<0.001). Regurgitation severity and crying decreased and parental satisfaction with stool consistency, formula acceptability, infant well-being, and sleep quality increased. Monitoring of adverse events did not reveal any safety concerns. Conclusion: Formulas containing LBG, prebiotics, and postbiotics were well tolerated and provided an effective strategy for managing infant regurgitation and gastrointestinal discomfort.

• 임상간호연구
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• 제29권3호
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• pp.223-237
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• 2023

Purpose: This study aimed to investigate the impact of a nurse shift improvement pilot project on nurses' shift adjustment, work-life balance, and turnover intention, as well as nurses' experiences of participating in the pilot project. Methods: An explanatory sequential mixed-methods study was performed. Survey data was collected from a total of 1,051 nurses both in participant and non-participant groups. For the qualitative study, focus group interviews were conducted with 22 nurses who participated in the shift improvement pilot, including 12 staff nurses, 7 nurse managers, and 3 substitute nurses. Results: There were significant positive effects on the key variables of nurses' shift adjustment, work-life balance, and turnover intention in the group that participated in the nurse shift improvement pilot project. Based on the qualitative study, participants in the shift improvement pilot project indicated that it enabled nurses to recover their circadian rhythm, and achieve a better work-life balance, and they wanted to continue working as a nurse, and hoped expanded application of the pilot project. Conclusion: In order for expanded implementation of the pilot project and continued improvement in the shift system, we recommend establishing compensation standard, systematizing the use of substitute nurses, developing guidelines for shift schedules, and expanding the shift improvement pilot project to other departments such as the emergency room.

• 대한한방내과학회지
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• 제45권2호
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• pp.314-322
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• 2024

Objectives: We describe the clinical course in a 53-year-old female patient admitted to a Korean Medicine Hospital with insomnia disorder accompanied by a herniated intervertebral disc and managed with Korean medical treatments. Methods: The patient was treated with herbal medicines, including Shihogayonggolmoryo-tang, acupuncture, pharmacopuncture, and Chuna manual therapy for 33 days. The therapeutic effect was evaluated based on the Insomnia Severity Index, Numerical Rating Scale score, Oswestry Disability Index, and European Quality of Life 5 Dimensions Scale. Results: Post-treatment, the Insomnia Severity Index decreased from 21 to 6, the Numerical Rating Scale score decreased from 7 to 3, the Oswestry Disability Index decreased from 60 to 18, and the European Quality of Life 5 Dimensions Scale increased from 0.35 to 0.85. Conclusions: Korean medical treatments improved the symptoms of this patient with insomnia disorder accompanied by a herniated intervertebral disc. Further clinical research on patients with insomnia disorder is needed.

• 문화기술의 융합
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• 제10권3호
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• pp.121-130
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• 2024

건강한 노년을 위하여 중년의 건강을 관리하는 것이 필요하다. 본 연구는 주관적 건강인지와 건강관련 삶의 질에 영향을 미치는 요인을 2020년 국민건강영양조사(KNHANES) 제8기 자료를 이용하여 40-59세 중년 여성 1068명의 데이터를 분석하였다. 연구방법은 STATA 15.0을 이용하여 복합표본 평균과 표준편차, 복합표본 가중치 백분율, 복합표본 t-test, 다중회귀분석을 수행 하였다. 주관적 건강과 건강관련 삶의 질에 영향을 미치는 복합공통요인은 교육수준, 가구원수, 우울증, 스트레스이었다. 연령, 폭음, 신체활동은 주관적 건강인지, 보험유형, 취업여부, 수면장애는 건강관련 삶의 질에 영향을 미치는 요인이었다. 중년기는 노년기로 넘어가는 전 단계로 중년의 주관적 건강 및 건강 관련 삶의 질을 향상시킬 수 있는 보건정책 프로그램을 개발하여야 할 것이다.

• 중환자간호학회지
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• 제17권2호
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• pp.12-24
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• 2024

Purpose : This study aimed to identify factors influencing the quality of life of family caregivers of intensive care unit (ICU) patients. Methods : We conducted a study using a cross-sectional design. The study involved 109 family caregivers of ICU patients at a university-affiliated hospital in Gyeonggi-do, South Korea. Data were collected through self-report questionnaires between July 2020 and April 2021 and analyzed using descriptive statistics, independent t-tests, one-way ANOVA, Pearson's correlation coefficients, and multiple regression analysis. Results : The study revealed significant differences in quality of life based on economic status (F=11.63, p<.001), cohabitation with patients (t=-2.04, p=.044), sleep duration after patient's admission to the ICU (t=-2.48, p =.025), and subjective health status (F=30.06, p<.001). There were significant negative correlations observed between quality of life and post-traumatic stress symptoms (r=-.38, p<.001) as well as caregiver burden (r=-.46, p<.001). Factors affecting quality of life were subjective health status, economic status, and caregiver burden (adj. R²=0.52, F=15.64, p<.001). Conclusion : These findings underscore the need to develop and implement intervention programs tailored to the health conditions and economic status of family caregivers, with a focus on alleviating caregiver burden. Such initiatives are essential to ultimately improve the quality of life for family caregivers of ICU patients.

• 문화기술의 융합
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• 제10권5호
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• pp.537-545
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• 2024

본 연구는 코로나-19 팬데믹 상황에서 자영업자의 정신건강수준을 파악하기 위해 임금근로자와 비교하여 분석하였다. 연구대상은 한국근로환경조사 제6차(2020~2021년)자료를 이용하여 자영업자 6,736명, 임금근로자 15,196명을 대상으로 하였다. 연구결과 자영업자는 임금근로자에 비해 불안(F=-2.81, p=0.001)., 수면장애(F=-18.05, p=2.035), 우울수준이(F=19.80, p=1.176) 모두 높게 나타났고, 주관적 건강(F=29.70, p=1.020)에 대한 긍정적 인식도 임금근로자에 비해 낮은것으로 나타났다. 따라서 코로나-19에 의해 특별히 더 불리한 집단에 대한 장기적이고 실질적인 정부대책 및 사회보장제도 마련이 필요함을 제언한다.

• Safety and Health at Work
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• 제15권3호
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• pp.245-254
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• 2024

Background: In recent years, the rise of workplace racial discrimination and microaggressions has decreased the efficiency and productivity of organizations and institutions, and realization of organizational goals globally. Accordingly, it was decided to conduct a systematic review and meta-analysis in the present study with the aim of investigating the prevalence of microaggression and racial discrimination in the workplace. Methods: The PubMed, Scopus, Web of Science, ScienceDirect and Google Scholar databases were systematically searched for studies that had reported the effects of work stress among managers. The search did include a lower time limit and was conducted in June 2023. The heterogeneity of the studies was investigated using the I² index, and accordingly random effects method was adopted for meta-analysis. Data analysis was conducted with the Comprehensive Meta-Analysis (v.2) software. Results: In the review of seven studies with a sample size of 2998 people, the overall prevalence of microaggression and racial discrimination in the workplace was found to be 73.6% and 18.8%, respectively. Publication bias within the selected studies was examined with the Egger's test, which indicated the absence of publication bias for the pooled prevalence of workplace microaggression (p: 0.264) and for the pooled prevalence of workplace racial discrimination (p: 0.061). Conclusion: The results obtained from this report indicate the high impact of micro-aggression and racial discrimination in the workplace. Considering the negative effects of such behaviours, the findings from this study will be helpful to managers and health policymakers.