• 한국의류산업학회지
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• 제7권4호
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• pp.413-418
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• 2005

The purpose of this study was for the adult woman that provides the investigation, analysis, consideration of the relationship with clothing behavior and self-efficacy depends on their skin care grade. Data were collected from 477 adult females and analyzed by using frequency, dispersion analysis, ANOVA, t-test, Duncan test utilizing SPSS 10.0 program. The results were as follows: The younger and the more educated respondents were the better their skin care. Also, the more they spent on clothes, the more they spent on cosmetic products. For occupations, professionals were to have better skin care. It was expose that 20s and 30s are shown difference for all low rank leading persons except conformity in the midst of it is clothing behavior main point by skin care management degree, 40s appeared that difference is seen in interest, psychological dependence, aesthetics, management. It was expose that difference does not exist in liver that is clothing behavior main point by skin care administration degree in 50s. 20s appeared difference in general self-efficacy divination in self-efficacy, and 30s appeared that skin care degree is high as general self-efficacy and physical self-efficacy are high. It was expose that 40s and 50s are no difference of self-efficacy in between group by skin care degree.

• 한방안이비인후피부과학회지
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• 제20권2호통권33호
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• pp.199-212
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• 2007

Objective : The purpose of this clinical research was to investigate the effects of Seunggaltang on patients with atopic dermatitis. Methods : Thirteen patients were treated with Seunggaltang and ten patients were treated with placebo for 8 weeks. We observed skin humidity, skin sebum,, transepidermal water loss, skin melanin, skin erythema, total IgE class and number of allergen. And Clinic Index of Atopic Dermatitis(Extent, Intensity, Subjective symptoms, Total score) was used to evaluate the effects of Seunggaltang. Statistical analysis was performed by using paired sample T-test. Statistical significance was achieved if the probability was less than 5%(P<0.05). The result were as follows : 1. Statistically, Seunggaltang didn't showed significant effect on skin humidity, skin sebum, skin transepidermal water loss, skin melanin and skin erythema. 2. Statistically, Seunggaltang showed significant effect on Clinic Index of atopic dermatitis. 3. Statistically, Seunggaltang didn't showed significant effect on total IgE class and number of allergen. 4. Before and after treatment, the results of blood test and urinalysis were normal. Conclusion : We speculate that Seunggaltang has some therapeutic effects in mitigating the symptoms of atopic dermatitis.

• 대한본초학회지
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• 제37권2호
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• pp.23-31
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• 2022

Objectives : The purpose of this research was to find out the efficacy of Castanea crenata Inner Shell (CCIS) on the skin by comparing the difference effect between only MTS (microneedle therapy system) and the CCIS essence application after MTS treatment. Methods : The present author performed once a week and total 3 times of MTS treatment. The treatment time took about 5 ~ 10 minutes and the depth of the needle was adjusted according to the participant's skin condition. In the control group, essence base was applied after MTS and in the experimental group, CCIS powder dissolved essence was applied. One week after each treatment, the change of skin condition was measured. Two weeks after the end of the clinical trial, the skin condition was checked again. Results : In the case of the test group and the control group, there was a significant decrease in thermography temperature and there was a significant increase in skin tone. In the case of pores and pigmentation, there was no significant difference on both group. In the case of moisture, there was a significant increase only in the test group. Conclusion : The MTS treatment itself showed good effects on thermography temperature and skin tone. But in the case of the moisture effect, it was much better when the CCIS essence was applied to the skin after MTS treatment. This study suggests that CCIS essence increases the efficacy of MTS on the point of moisture.

• 한국멀티미디어학회논문지
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• 제24권11호
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• pp.1492-1499
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• 2021

Skin prick test is widely used in diagnosing allergic sensitization to common inhalant or food allergens, in which positivities are manually determined by calculating the areas or mean diameters of wheals and erythemas provoked by allergens pricked into patients' skin. In this work, we propose a segmentation algorithm over U-Net, one of the FCN models of deep learning, to help us more objectively grasp the erythema boundaries. The performance of the model is analyzed by comparing the results of automatic segmentation of the test data to U-Net with the results of manual segmentation. As a result, the average Dice coefficient value was 94.93%, the average precision and sensitivity value was 95.19% and 95.24% respectively. We find that the proposed algorithm effectively discriminates the skin's erythema boundaries. We expect this algorithm to play an auxiliary role in skin prick test in real clinical trials in the future.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.250-250
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• 1996

Eye irritation, primary skin irritation and skin sensitization tests for Aloewhite were tested in New Zealand White rabbits and Hartley guinea pig. In primary skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and primary Irritation Index(PII) was 0.47, indicating Aloewhite as mildly irritating material, In ocular irritation test, any injury on iris, conjunctival membrane, and cornea in New Zealand White rabbits was not observed. No injuries of the ocular mucous membrane were also recorded. Skin sensitization was tested in guinea Peg after intradermal and epicutaneous induction and graded I with zero % sensitization rate. These results indicate that Aloewhite was not considered to be irritant in test organs of animals.

• 한국양봉학회지
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• 제33권4호
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• pp.277-282
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• 2018

Ethanol extracted propolis (EEP) was mixed with honey (honeypolis) to dissolve well in water and in vitro skin irritation test was conducted. In vitro method is designed to predict and classify the skin irritation potential of a chemical by assessment of its effect on $EpiDerm^{TM}$, a reconstituted three-dimensional human epidermis model. Cytotoxicity is expressed as the reduction of mitochondrial dehydrogenase activity measured by formazan production from MTT after a 60 min exposure period. In this study under the given conditions honeypolis showed no irritant effects. Honeypolis meets acceptance criteria if: mean absolute OD 570 nm of the three negative control tissues is ${\geq}0.8$ and ${\leq}2.8$, mean relative tissue viability of the three positive control tissues is ${\leq}20%$, standard deviation of relative tissue viability obtained from each three concurrently tested tissues is ${\leq}18%$. Honeypolis is therefore classified as "non-irritant" in accordance with UN GHS "No Category".

• Natural Product Sciences
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• 제27권4호
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• pp.300-306
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• 2021

Chronic ultraviolet (UV) radiation causes photoaging, which represents skin damage, disrupts skin barrier function, and promotes wrinkle formation. We investigated that the polysaccharide extract of an edible basidiomycetous white jelly mushroom, Tremella fuciformis, (TF-Glucan^®) exhibited statistically photoprotective activity by inhibiting matrix metalloproteases (MMPs) and increasing collagen synthesis, and an anti-inflammatory activity by inhibiting nitric oxide and pro-inflammatory cytokines at the concentrations of less than 1000 ㎍/ml, which is not cytotoxic (p < 0.05). Additionally, TF-Glucan^® increased the expression of involucrin and filaggrin to prevent the disruption of UVB-induced barrier function (p < 0.05). TF-Glucan^® was assessed as a safe material by the human primary skin irritation (1, 3, 5%), human repeated insult patch test (no sensitization at 5%), 3T3 NRU phototoxicity assay (no phototoxicity, PIF < 2, MPE < 0.1), eye irritation test test by BCOP (no category, IVIS ≤ 3) and local lymph node assay (negative at 10, 25, 50%) for identifying potential skin sensitizing. These results suggest that TF-Glucan^® may be useful as an anti-photoaging ingredient for developing cosmeceuticals.

• 대한화장품학회지
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• 제39권2호
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• pp.105-115
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• 2013

국내의 주름개선 혹은 미백 효능을 평가하기 위한 인체시험 방법은 식약청 가이드라인에 근거하여 시행 되어왔으며, 인체시험에서 육안평가 및 기기평가 결과에 대해 시험군과 대조군 간의 효과를 비교하기 위해서 unpaired t-test를 주로 이용하였고, 시술 전후의 효과를 비교하기 위해서 paired t-test를 이용하였다. 설문평가 결과에 대해서는 빈도분석을 이용한 기술통계법이 이용되고 있다. 미국 및 유럽의 임상 평가기관에서도 이와 유사한 시험법 및 통계분석 방법을 이용하고 있다. 그러나 동일 개체에 대하여 처치를 반복 적용하여 얻은 자료는 서로 관련성이 높아 이를 감안한 분석법을 적용해야 한다. 따라서 본 연구에서는 화장품 분야에서는 처음으로 기능성 화장품 중 주름 개선 및 미백 효능 시험의 육안평가 및 기기평가 자료에 대해 repeated measures ANCOVA (RM ANCOVA)와 repeated measures ANOVA (RM ANOVA)를 적용하여 통계 방법의 타당성 여부를 검증함으로서 현재의 인체시험 방법에 적합한 새로운 통계분석 방법을 제시하였다.

• 산경연구논집
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• 제10권8호
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• pp.25-32
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• 2019

Purpose - This study aims to explore women's beauty industry market and growth development by identifying the main factors of women's perception of skin health care. Research design, data, and methodology - The survey was conducted on women aged 20 to 60 living in Seoul. For the statistical analysis, frequency analysis, t-test and one-way ANOVA were conducted, and significant differences in p<0.05 were tested through the multiple range test of the Scheffe. The factor analysis was conducted to verify the validity of questions, and the reliability was determined by the coefficient of Cronbach's α. Results - The lower the age, the higher the perception of the skin, and women pay a higher price for skin health as a provisional customer. 'Acne care' was the most common skin condition (32.8%), 'life style' (79.8%) was the most important part of skin care. Final education was the highest level of skin care for women with a professional background (M=3.41) (F=4.028, p<.05). Conclusions - The differences in the recognition of health knowledge by age, marital status, and household monthly income were significant, but there was no difference between jobs and final education. Customers who use less skin care than customers who frequently use the skin care center were more aware of skin health, and women who have a high awareness of skin are more interested in aging and regenerating due to the skin care.

• Toxicological Research
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• 제32권4호
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• pp.311-316
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• 2016

Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDerm$^{TM}$ skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time according to the test guidelines. Cell viabilities of EpiDerm$^{TM}$ skins were measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide based method. FeNPs, AlNPs, TNPs, and AgNPs were non-corrosive because the viability was more than 50% after 3 min exposure and more than 15% after 60 min exposure, which are the non-corrosive criteria. All NPs were also non-irritants, based on viability exceeding 50% after 60 min exposure and 42 hr post-incubation. Release of interleukin 1-alpha and histopathological analysis supported the cell viability results. These findings suggest that FeNPs, AlNPs, TNPs, and AgNPs are 'non-corrosive' and 'non-irritant' to human skin by a globally harmonized classification system.