• Journal of Life Science
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• v.29 no.4
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• pp.442-446
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• 2019

We recently reported the characteristics of Chrysanthemum boreale MAKINO essential oil (CBMEO) at different harvesting stages and its in vitro antioxidant, whitening, skin regeneration, and antiwrinkle properties. In the present study, we investigated the effectiveness of cosmetic creams containing 0.1% of CBMEO in terms of wrinkle reduction and safety. The participants were 22 women aged 42 to 60 y with natural wrinkles. All the participants applied the CBMEO-containing cream to the eye area for 8 weeks. Visual observations of the skin by a dermatologist were used to assess the safety of the product, and improvements in skin wrinkles (roughness) were analyzed using a skin visiometer. Neither the CBMEO-containing cream nor the placebo caused abnormal reactions, such as erythema or allergies, during the test period. The CBMEO-containing cream-exposed test regions showed a greater reduction in the roughness index as compared with those of the placebo-exposed control regions. The R1, R2, and R3 indices showed a statistically significant decrease in the test regions as compared with the placebo control regions after using the cream for 2 weeks (p<0.05). Therefore, this study demonstrated that CBMEO-containing cosmetics are safe for human use and that they have skin wrinkle improvement properties. In the future, CBMEO may be a promising product for use in the development of functional anti-wrinkle cosmetics.

• International Journal of Oral Biology
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• v.37 no.4
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• pp.175-180
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• 2012

Skin-derived precursor cells (SKPs) are multipotent, sphere-forming and embryonic neural crest-related precursor cells that can be isolated from dermis. It is known that the properties of porcine SKPs can be enhanced by leukemia inhibitory factor (LIF) which is an essential factor for the generation of embryonic stem cells in mice. In our present study, to enhance or maintain the properties of murine SKPs, LIF was added to the culture medium. SKPs were treated with 1,000 IU LIF for 72 hours after passage 3. Quantitative real time RT-PCR was then performed to quantify the expression of the pluripotent stem cell specific genes Oct4, Nanog, Klf4 and c-Myc, and the neural crest specific genes Snai2 and Ngfr. The results show that the expression of Oct4 is increased in murine SKPs by LIF treatment whereas the level of Ngfr is decreased under these conditions. Interestingly, LIF treatment reduced Nanog expression which is also important for cell proliferation in adult stem cells and for osteogenic induction in mesenchymal stem cells. These findings implicate LIF in the maintenance of stemness in SKPs through the suppression of lineage differentiation and in part through the control of cell proliferation.

• Proceedings of the KSR Conference
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• 2001.10a
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• pp.558-561
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• 2001

SIP(Soil cement Injected Precast pile) that inserts a precast pile after injecting a cement paste into a boring has been applied rapidly through the change of construction circumstances. But there isnt any logical equation of a bearing capacity fitted to SIP yet. So Meyerhof equation has mainly been used to predict a bearing capacity in a design stage instead. But it has shortcomings such as lack of confidence because it has derived not from a theory but from an experience obtained from the result of SPT (Standard Penetration Test) and because a penetration depth tends to be deeper by an excessive design that depends on an end bearing capacity of a pile more than a skin frictional resistance. In this study, thereupon, a direct shear test in the laboratory was performed to both SM and SC soils in variable conditions to verify skin friction properties for the purpose of presenting some reasons capable of reducing penetration depths. Through the tests, soil to soil of SM in cohesion, rough panel to soil of SM in friction angle and soil to soil of SM in shear strength tended to be high. And a shear strength increased as its total unit weight increased in all cases.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.501-506
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• 1997

This is to investigate the physical properties of the commercially available Soft, Thomas, Minerva, and Philadelphia cervical braces which are widely used in orthopedics, neurosurgery, and rehabilitation medicine clinics as assisting devices or physical stabilization of cervical vertebrates, to use as a basic data or designing new type brace. Tensile strengths were observed by universal mechanical measuring device and Thomas brace required the highest stress to break by tensile stress. Durabilities against continuous frictional forces were also determined, and Minerva brace demonstrated the longest frictional time until being perforated. and Thomas/minerva braces are superior to the other braces in the effect of the material property on the skin tissue, as the animal test. According to these results, polyethylene is recommendable as a frame and preparation of pores in the material is favorable to provide ventilation to skin.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2005.05a
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• pp.354-359
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• 2005

The objective of this research work is to investigate into static characteristics of ISB panels with the pyramidal structure as a internally structured material. In order to investigate the behavior of material deformation and fracture characteristics, several tensile tests have been carried out for the ISB panel and skin sheet. Through the results of the experiments, the mechanical properties of ISB panel and skin sheet and fracture characteristics have been obtained. In addition, the mechanical properties of the ISB panel have been compared with that of the skin sheet by the view point of a specific modulus, a specific yield strength and a specific strength. From the results of the comparision, it has been shown that the ISB panel has an excellent static characteristics.

• Parasites, Hosts and Diseases
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• v.62 no.2
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• pp.217-225
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• 2024

This study evaluated the potential repellent and acaricidal effects of 4 essential oils (clove, eucalyptus, lavender, and mint) against the Asian longhorned tick Haemaphysalis longicornis, a vector of various tick-borne diseases in medical and veterinary contexts. Selected for their potential repellent and acaricidal properties, the 4 essential oils were tested on adult and nymph H. longicornis ticks at different concentrations. The experiment assessed mortality rates and repellency, particularly during tick attachment to host skin. There was a significant increase (P<0.05) in tick mortality and repellency scores across all groups. At a 1% concentration, adult tick mortality ranged from 36% to 86%, while nymph mortality ranged from 6% to 97%. Clove oil exhibited notable efficacy, demonstrating high mortality rates of nymphs and adults. Clove oil also displayed strong repellency properties, with a repellency index of 0.05, surpassing those of mint, eucalyptus, and lavender oils. Clove oil showed the highest effectiveness in deterring nonattached adult ticks (90%) and nymphs (95%) when applied to skin. Clove oil was the most effective against adult and nymph ticks, achieving mortality rates of 86% and 97%, respectively, and led to the highest nonattachment rates when applied to skin. In conclusion, essential oils such as clove, eucalyptus, lavender, and mint oils present promising results for tick population control.

• Journal of Fashion Business
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• v.22 no.4
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• pp.106-117
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• 2018

The present study was conducted to investigate dyeing properties and functionality of silk fabrics dyed with extracts from buckwheat skin. Comparative results of color strength(K/S) values of dyed silk fabrics were studied to quantify the effects of dye concentrations, dyeing temperatures, dyeing time and the pH; the effect of mordants; and color changes. And also evaluated the fastness, antimicrobial property, ultraviolet protection properties of the dyed and mordanted silk fabrics. The color strength(K/S) values of silk generally increased depending on the increasing dye concentration, dyeing temperature, and dyeing time. And the highest color strength values were obtained at a dye concentration of 100%(v/v), a dyeing temperature of $90^{\circ}C$, a dyeing of time 80 minutes, and a dyebath of pH 2. The color fastness to light of dyed and mordanted silk fabrics were found to be good, and the drycleaning and rubbing fastness were excellent. The fade of washing fastness was not good, however, the stain of washing fastness and perspiration fastness showed relatively good grade. The Al, Cu, Fe mordanted silk fabrics(except Fe for Klebsiella pneumoniae) showed 99.9% reduction rate. The ultraviolet protection properties of the mordanted fabrics were generally improved. Moreover, the Cu and Fe mordnared fabrics showed very exceptional ultraviolet protection factors.

• Korean Journal of Materials Research
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• v.34 no.2
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• pp.95-104
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• 2024

Nanoparticles are commonly used to avoid the opaque white color of TiO₂ based sunscreen. However, a dispersing agent is typically required because of the tendency of the nanoparticles (NPs) to agglomerate. Stearic acid is one kind of dispersing agent often used for sunscreen products. However, according to the MSDS data sheet on stearic acid, stearic acid is highly hazardous to aquatic life and causes irritation on human skin. To avoid this problem, in this study a safer organic dispersing agent extracted from Korean seaweed has been studied to disperse TiO₂ nanoparticles, and further use as an active agent in sunscreen products. The presence of phytochemicals in seaweed extract, especially alginate, can disperse TiO₂ nanoparticles and improve TiO₂ dispersion properties. Results show that seaweed extract can improve the dispersion properties of TiO₂ nanoparticles and sunscreen products. Reducing the agglomeration of TiO₂ nanoparticles improves sunscreen properties, by making it less opaque white in color, and increasing UV protection value. It was also confirmed that adding seaweed extract into sunscreen products had no irritating effects on the human skin, making it more desirable for cosmetics application.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.35 no.4
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• pp.63-74
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• 2022

Objectives : Skin aging is generally characterized by wrinkles, sagging, loss of elasticity roughness, pigmentation and dryness. This changes is caused by reducing the elements constituting the extracellular matrix contributing to the physiological properties of the skin, such as collagen fiber, elastic fiber, and hyaluronic acid. Adequate skin hydration is important to maintain normal skin function and reduce skin aging. The present study is objective to observe skin moisturizing effects of Unripe apple(UA, Immature fruit of Malus pumila Mill) in vivo and its underlying molecular mechanisms. Methods : ICR mice were orally administerd UA(100, 200 and 400mg/kg/day) for 8 weeks, and skin water contents and the expression of transforming growth factor (TGF)-𝛽1, ceramide, hyaluronan and collagen type I(COL1) were measured in dorsal back skin of the mice. Gene expression of hyaluronan synthase(HAS1, HAS2, HAS3), collagen synthase(COL1A1, COL1A2) and TGF-𝛽1 were also determined by realtime RT-PCR. Results : Skin water contents and the expression of TGF-𝛽1, ceramide, COL1 and hyaluronan were significantly increased in UA group(100, 200 and 400mg/kg/day) compared to vehicle control. The mRNA expression of HAS isoform(HAS1, HAS2, HAS3), COL1A1, COL1A2, and TGF-𝛽1 were also significantly increased by UA. Conclusions : UA has skin moisturizing effects and enhancement activities in skin function related components(COL1, hyaluronan, ceramide and TGF-𝛽1). These results suggested that UA can be a developing candidate for developing alternative skin protective agent or functional food ingredient.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.1
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• pp.55-61
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• 1997

In order to effectively utilize the fish and squid skin wastes derived from marine processing manufacture, the skin wastes of some pelagic fishes such as yellowfin sole, red cod, cod, Allaska pollack and flying squid were screened for the raw material of edible gelatin and studied some properties of those gelatins. The content of total collagen in the red cod skin was the highest (28.4 g/100 g wet skin), while that in the flying squid skin was the lowest (11.1 g/100 g wet skin) and those of another fishes were similar. Acid soluble collagens in the skins of the fishes and flying squid were $68.9\~84.8\%\;and\;44.3\%$, respectively. But showed no difference in the amino acid composition between acid soluble and insoluble collagens. Those collagens were consisted $\alpha\;and\;\beta$ chain and $\alpha$ chains extracted from fish skins except red cod and flying squid skins were hetero. The collagen of yellowfin sole skin exhibited slightly higher denaturation temperature $(25.4^{\circ}C)$ and also physical properties such as gel strength, melting point and gelling point were better than those of the other species.