• 대한화장품학회지
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• 제23권2호
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• pp.63-70
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• 1997

It has been observed that local increase in melanin synthesis or uneven distribution can cause local hyperpigmintation or spot. Pigmentary disorders are caused by various factors, including inflammation, imbalance of hormones, and genetic disorder. Recently the harmfulness of Ultraviolet radiation is increasing due to destruction of ozone layer. Excessive exposure to UV radiation caused post-inflammatory pigmentation. Most women want to avoid uneven skin pigmentation. To satisfy this desire many cosmetic companies have been developing melanogenesis inhibitors and finding promising active agents for use in cosmetic preparations for skin whitening. In cosmetic preparations, many inhibitors such as kojic acid, arbutin, ascorbic acid, and licorice extracts6 have been used as whitening purpose. Plant extracts having an inhibitory effect on melanin formation may be a good choice for cosmetic purpose because of their relatively lower side effects. Therefore, we screened 285 plant extracts for their inhibitory activity in tyrosinase. Of the plant extracts, ramulus mori extracts showed potent tyrosinase inhibition activity. We also identified the active compound in the extract.

• The Journal of Korean Physical Therapy
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• 제4권1호
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• pp.13-18
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• 1992

Most of the electromagnetic agents used in physical therapy rely for their effects on tissue heating and photoreaction of the body. Infrared and untraviolet light on the other hand, owns its place in medicine because it produces direct photochemial reaction when it interacts with the body. This study was carried out to investigate and review for photoreaction of the akin. The results were an follows. 1. The effects of the infrared are heat production, increasing metabolism, increasing circulation, vasodilatation and pigmentation. 2. Directed photoreactions are divided into acute reaction and chronic reaction, and the acute reaction makes pigmentation from $290\~320nm$ of ultraviolet ray. 3. Ultraviolet ray formated pigmentations, which are melanoblasts excited from ultraviolet ray and received chemical stimulation, that make melanin granule. 4. If exposured with long duration, at ultraviolet ray, it makes skin thickening and epithelioma. 5. Indirected photoreaction is made by existenced hypersensitivity of photoreaction or lack of photodefence structure. 6. The phototoxic reactions are synthesized by chemical reaction of excitement from ultraviolet ray also this time analysis, synthesis and polymerization from energy of a circumferenced substance. 7. Sunscreen substances are P-amino benzoic acid and oxidate titan.

• 한국정보통신학회논문지
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• 제25권1호
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• pp.81-87
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• 2021

본 연구에서는 다양하게 피부치료가 가능한 V-IPL 방식을 도입하여 피부치료 시스템을 설계하여 실험하였고, 또한 병변에 따라 플래쉬 램프를 순차적으로 점등시키는 새로운 방식인 방전 방식을 이용하였으며, 기존의 LC 가변방식과 스위칭소자의 스위칭모드 제어방식을 활용하여 펄스 형상제어를 시스템에 구성하였다. 그 결과 마이크로프로세서를 이용하여 펄스폭이 1[㎛]까지 가변이 가능하였고, 깊이와 넓이에 따른 병변에 플래쉬 램프를 순차 점등시키므로써 펄스형상 및 펄스모양을 보다 다양하게 할 수 있었다. 그리고 펄스폭을 약 1~100[ms]까지 다양하게 긴 펄스를 만들 수 있었으며, 기존의 제품은 One pulse(pulse width : 1~40ms)이지만 제안한 제품은 Three pulse(pulse width : 1~100ms)로 특별한 차이가 있었다.

• 대한본초학회지
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• 제37권2호
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• pp.23-31
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• 2022

Objectives : The purpose of this research was to find out the efficacy of Castanea crenata Inner Shell (CCIS) on the skin by comparing the difference effect between only MTS (microneedle therapy system) and the CCIS essence application after MTS treatment. Methods : The present author performed once a week and total 3 times of MTS treatment. The treatment time took about 5 ~ 10 minutes and the depth of the needle was adjusted according to the participant's skin condition. In the control group, essence base was applied after MTS and in the experimental group, CCIS powder dissolved essence was applied. One week after each treatment, the change of skin condition was measured. Two weeks after the end of the clinical trial, the skin condition was checked again. Results : In the case of the test group and the control group, there was a significant decrease in thermography temperature and there was a significant increase in skin tone. In the case of pores and pigmentation, there was no significant difference on both group. In the case of moisture, there was a significant increase only in the test group. Conclusion : The MTS treatment itself showed good effects on thermography temperature and skin tone. But in the case of the moisture effect, it was much better when the CCIS essence was applied to the skin after MTS treatment. This study suggests that CCIS essence increases the efficacy of MTS on the point of moisture.

• Asian-Australasian Journal of Animal Sciences
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• 제17권9호
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• pp.1309-1314
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• 2004

The red carotenoid, astaxanthin was studied to improve the meat quality of broiler chickens. Astaxanthin pigmented chickens and delayed oxidation of lipid in them. Two sources of astaxanthin were used to pigment broiler chickens in a five-wk feeding trial: biological astaxanthin (BA) from the red yeast, Xanthophyllomyces dendrorhous, and chemical astaxanthin (CA) from chemical synthesis. The concentrations of CA (45 mg/kg feed) and BA (22.5 mg/kg feed) were set to give similar levels of pigmentation. The colorimetric values (a and b) of breast muscles were significantly changed by astaxanthin (p${\leq}$0.01). Absorption and accumulation of BA were higher than those of CA, probably due to the high contents of lipids in the yeast (17%). Lipid peroxide formation in skin was significantly decreased by astaxanthin (p${\leq}$0.05). This result indicated that the production of lipid peroxides in the carcasses of broiler chickens during storage could be delayed by astaxanthin. Therefore, astaxanthin could be used as an antioxidant as well as a colorant for broiler chickens.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.617-629
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• 2003

A recent development in cosmetics has been the pursuit of wrinkling in the skin. The cosmetics composed of anti-wrinkle agent stand out from the point of view of environmental contamination and pollution. Among them, Indole-3-acetic acid (IAA), studied with wrinkling pigmentation and swelling conditions in the area of the eye, showed clinically significant reduction in depth of lines during one month trial using skin treatment. But, IAA has shown some problems when used in cosmetic formulations, such as stability, permeability and toxicity. The results of the clinical examination were shown that its permeability and toxicity didn't matter. To increase the stability of IAA, antioxidants such as Licorice, ubiquinone, tocopherol, Baicalin, ferulic acid, BHT, ascorbic acid, sodium metabisulfite, and so on were employed in cosmetic formulations. Our main purpose is the study for the stability efficiency and effect of each other of cream formulations containing optimal dosage antioxidants (o/w type emulsion), This study evaluated wrinkle reduction effect of IAA, which is used in cosmetics.

• 한국응용과학기술학회지
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• 제35권1호
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• pp.62-69
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• 2018

건강 식품인 병아리콩을 화장품의 원료로 활용하기 위하여 Bacillus subtilis Natto 균주로 병아리콩을 발효한 낫토를 마스크 팩에 적용하여 피부개선 효과를 연구하였다. 병아리콩 낫토를 동결건조하여 얻은 분말을 paste 제형으로 얼굴 마사지 팩에 적용하였다. 50~60대 여성을 대상으로 낫토 팩의 피부개선 효과를 조사하였다. 낫토 팩의 처치 횟수가 증가함에 따라 피부가 개선되며 4회 처치 후 개선효과가 두드러졌다. 4회 처치 후 수분 함량과 피지 분비량이 각각 $8.4{\pm}3.6%p$와 $4.0{\pm}2.3%p$ 증가하였고, 피부 모공과 주름도 각각 $1.8{\pm}0.3%p$와 $1.8{\pm}0.9%p$ 감소하였다. 피부 색소침착은 $1.3{\pm}0.2%p$ 감소되었고, 피부 톤은 55.2%에서 55.9%로 $0.7{\pm}0.2%p$ 밝아졌다. 병아리콩을 발효하여 얻은 낫토 발효물이 보습, 모공, 주름, 색소침착, 피지분비, 피부톤 등의 피부개선 효과가 있으며, 다양한 기능성 화장품의 원료로 활용 가능성을 확인하였다.

• 약학회지
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• 제41권4호
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• pp.456-461
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• 1997

Tyrosinase is known to accelerate the melanin polymer biosynthesis in melanocyte, so tyrosinase inhibitors hinder the melanin polymer biosynthesis and are useful not only for th e material used in cosmetics as skin-whitening agents but also as the remedy for disturbances in pigmentation. During our search for new melanin biosynthesis inhibitors from natural sources, 130 higher plants were tested for the inhibitory effect against tyrosinase activity by the mushroom tyrosinase assay. Among them, Carex humilis ($IC_{50}$, 10vg/ml), Sophora flavescence ($IC_{50},\;20{\sim}50{mu}g/ml$) and Styrax japonica ($IC_{50},\;10{\mu}g/ml$) inhibited the tyrosinase activity strongly.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.215.2-215.2
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• 2003

Tyrosinase is an important enzyme involved in the transition steps from tyrosine to melanin. Inhibition of the tyrosinase activity could block melanin formation from tyrosine and thus prevent melanin pigmentation on skin. This may contribute to the development of new whitening agent that would be useful in the prevention of pigmentation. in this study, we isolated tyrosinase inhibitory compound from BuOH fraction of Potentilla bifurca L. var. glabrata Lehm by activity guided fractionation method. Based on spectroscopic data, the active compound was identified as a quercetin 4"-O- glucopyranoside.

• The Korean Journal of Physiology and Pharmacology
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• 제25권1호
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• pp.15-26
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• 2021

Peptides are short chain of amino acids linked by peptide bonds. They are widely used as effective and biocompatible active ingredients in cosmetic industry. In this study, we developed novel peptide mixture and identified its anti-pigmentation effect on melanocytes and keratinocytes. Our results revealed that peptide mixture inhibited melanosome biogenesis through the regulation of microphthalmia-associated transcription factor, a key factor of melanogenesis in melanocytes. And we observed that peptide mixture inhibited melanosome uptake through the reduction of protease-activated receptor 2, a phagocytosis-related receptor in keratinocytes. Furthermore, peptide mixture activated autophagy system resulting in degradation of transferred melanosomes in keratinocytes. The anti-pigmentation effect of multi-targeting peptide mixture was assessed in a human skin equivalent model (MelanoDerm). Melanin contents in epidermal layer were significantly decreased by topical treatment of peptide mixture, suggesting that it can be applied as a novel cosmetics material having a whitening function.