• Title/Summary/Keyword: skin permeability

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Effect of Propionic Acid Additive on Preparation of Phase Inversion Polysulfone Membrane (폴리설폰 상전환막의 제조에 있어 프로피오닉산 첨가제의 영향)

  • Han, Myeong-Jin;Choi, Seung-Rag;Park, So-Jin;Seo, Bum-Kyoung;Lee, Kune-Woo;Nam, Suk-Tae
    • Membrane Journal
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    • v.18 no.4
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    • pp.317-324
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    • 2008
  • Polysulfone membranes were prepared via the phase inversion process. With propionic acid as a nonsolvent additive, polysulfone casting solutions were solidified in an isopropanol bath. Propionic acid (PA) worked as a thermodynamic enhancer for phase separation and as a rheological suppressor for kinetic hindrance. Morphology of the prepared membranes significantly varied with propionic acid content in the casting solution. The dense skin layer, which was identified in the membrane prepared without PA, almost disappeared in the membrane prepared trom PA 10wt%. With 30wt% PA, the membrane revealed the morphological gradient from a nodular skin structure to a sponge-like substructure, including the finger-like cavity. Water permeability increased with PA content, and polyethylene glycol rejection decreased with the nonsolvent content.

Antimicrobial Effect of Supercritical Robinia pseudo-acacia Leaf Extracts and Its Transdermal Delivery System with Cell Penetrating Peptide

  • Heo, Soo Hyeon;Park, Su In;Lee, Jinseo;Kim, Miok;Shin, Moon Sam
    • International Journal of Advanced Culture Technology
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    • v.8 no.1
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    • pp.226-235
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    • 2020
  • In this paper, we present to evaluate physiological activity of Robinia pseudo-acacia leaf and its skin penetration using liposome and cell penetrating peptide. After extraction with Robinia pseudo-acacia leaf using the distilled water and supercritical, various physiological activities were examined. In antioxidants experiments, the total concentration of polyphenol compounds was determined to be 56.88 mg/g in hydrothermal extract, 45.07 mg/g in supercritical extract. The DPPH radical scavenging ability at 1,000 ㎍/mL was 33.97% in supercritical extract. The scavenging effect on SOD experiment at 500 ㎍/mL was 76.41% in supercritical extract. In the antimicrobial experiments, the hydrothermal extract had no effect, but supercritical extract represented maximum clear zone of 14.00 mm in Staphylococcus aureus strain. Liposome containing the RSE (Robinia pseudo-acacia leaf supercritical extract) reduced particle size and stabilized zeta potential. In the epidermal permeability experiment, it was confirmed that the permeation of liposome containing the RSE and cell penetrating peptides was remarkable.

The Analysis on the Work Environment and Working Clothes Wearing Conditions of Shipyard Painters (조선소 도장작업자의 작업환경 및 작업복 착의실태 분석)

  • Bae, Hyun-Sook;Park, Hye-Won;Park, Gin-Ah
    • Journal of the Korean Society of Clothing and Textiles
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    • v.34 no.3
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    • pp.518-528
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    • 2010
  • This study analyzes the work environment and the work clothes wearing conditions of shipyard painters. In addition to this, three types of experimental painting work clothes were evaluated by painters in terms of the material performance and wearing functions. The findings on the harmful painting work environmental factors were organic solvents, noise, heavy dust, high temperatures, and noxious fumes. The body parts damaged during painting operations were the skin, arms, whole body, and face. In general, the satisfaction with the wearing performance of work clothes for painting was low especially in regards to sweat absorbency, sweat permeability, body protection, covering, and the work motion suitability. The satisfaction with the wearing sense of painting working clothes (regardless of the type of material) was high in the order of movement comfort> sensual comfort> physiological comfort. The satisfaction in overall comfort according to the types of material was high in the order of nylon> SMS nonwoven fabric> SF nonwoven fabric.

Preparation and Evaluation of $PGE_1$ Urethral Suppositories ($PGE_1$ 요도좌제의 제조 및 평가)

  • Park Somin;Choi Myeongsin;Han Kyuwon;Kim Kil-Soo
    • YAKHAK HOEJI
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    • v.49 no.4
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    • pp.260-267
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    • 2005
  • [ $PGE_1$ ] is an endogenous substance of potent vasodialator as well as inhibitor of platelet aggregation. It has been used therapeutically in peripheral arterial occlusive disease and impotence. Intracavernous injection of $PGE_1$ for erectile dysfunction has been established for several years as a treatment option for erectile dysfunction of diverse etiologies, but this mode of administration is limited by penile discomfort, pain at the injection site, inconvenience and noncompliance. As the matter of worse, the $\beta-hydroxy$ moiety of $PGE_1$ is extremely susceptible to dehydration in solution to give inactive $PGA_1$ and $PGB_1$. For the improvement of stability, rapid absorption at action site and the convenience of application, $PGE_1$ was formulated as urethral suppositories of three types of formulations, such as PEG, witepsol, and the mixture of PEG and witepsol. The stability test of $PGE_1$ and the release test in urinary suppositories were performed. Futhermore, the effect of enhancers and vehicle composition on the penetration of $PGE_1$ through excised rat skin was evaluated by permeability coefficient and enhancement ratio.

Pharmacological and Biochemical studies on Telescopium telescopium - a marine mollusk from the Mangrove regions

  • Samanta, SK;Adhikari, D;Karmakar, S;Dutta, A;Roy, A;Manisenthil, KT;Roy, D;Vedasiromoni, JR;Sen, T
    • Advances in Traditional Medicine
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    • v.8 no.4
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    • pp.386-394
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    • 2008
  • The tissue extract (TTE) of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal, India, was extensively screened for pharmacological and biochemical properties. Telescopium telescopium (TTE) produced significant lysis of washed rat erythrocytes (both direct and indirect), produced haemorrhagic lesions in the skin and also released haemoglobin (in vitro tissue damage) from different tissue samples. TTE was found to produce pro-inflammatory effects when injected into the rat hind paw and also increased peritoneal vascular permeability. Furthermore, intravenous administration of TTE produced a decrease in blood pressure (hypotensive effect) in anaesthetized rats. The extract produced potent esterase activity, as was evident from the breakdown of FDA with subsequent release of fluorescein (in vitro). TTE also demonstrated prominent cholinesterase, phospholipase, phosphatase and protease activities.

Manufacturing and Application of Natural Surfactants for Cosmetics (화장품용 천연계면활성제의 제조 및 이용 최신기술)

  • Kim, Hyung-Won
    • Journal of Adhesion and Interface
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    • v.14 no.4
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    • pp.197-211
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    • 2013
  • Surfactants which have ability to decrease surface tension through surface activation between the interfaces are used as essential major raw materials for detergents and cosmetics. Typical synthetic detergents such as EO (ethylene oxide), LAB (linear alkylbenzene) are made from chemical surfactant derived from petrochemicals, therefore, they are responsible for major environment contaminations and ecosystem destruction, especially of rivers and also cause atopic dermatitis through strong skin stimulus of these small molecular's powerful permeability and lead to cancers if they get into organs through capillary. Now worldwide interest is increasing to develop new natural surfactants and biosurfactants as ecological, biodegradabl, harmless and multi-functional new amphiphillic materials which replace these synthetic surfactants.

Magneto-impedance effect of CoFeSiBNi amorphous magnetic films (CoFeSiBNi 아몰퍼스 합금의 자기-임피던스 효과)

  • Lee, Seung-Hun;Park, Byung-Kyu;Hwang, Sung-Woo;Moon, Sung
    • Journal of Sensor Science and Technology
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    • v.16 no.5
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    • pp.389-393
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    • 2007
  • Soft ferromagnetic materials are very useful for many sensors using magnetic materials demanding high permeability, low coercivity and low hysteresis loss. Among them, FeCoSiBNi amorphous magnetic films show a good impedance change (about 5.01 %/Oe, at 10 MHz) by the exterinal magnetic field in this experiment. The magnetic films are produced by melt-spun method, one of the rapid solidification process. Ribbon shape wires were made from the films, and let them annealed in DC magnetic field to increase the maximum Giant Magneto Impedance ratio. Field annealing decreases the stress and changes the effective anisotropy. Thus, we can find that the impedance change (200.47 %) is improved and the fabricated magnetic wire has characteristics of good sensor element.

Multilamellar Liquid Crystals for the Stabilization of Retinoids (레티노이드 안정화를 위한 다중층 액정제제)

  • Yoon, Moung-Seok;Chung, Youn-Bok;Han, Kun
    • Journal of Pharmaceutical Investigation
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    • v.29 no.4
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    • pp.279-285
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    • 1999
  • Retinoids in anti-wrinkle cosmetics are widely used for the treatment of the photoaging skin these days, but very unstable in the presence of water. Multilamellar liquid crystal vesicles consisted of $poly(oxyethylene)_{15}oleyl$ ether $(POE_{15}OE)$ or $poly(oxyethylene)_{15}stearyl$ ether $(POE_{15}SE)$, cetostearyl alcohol (CSA) and cholesterol or oils were prepared to increase the stability of retinyl acetate or retinyl palmitate. $POE_{15}SE-CSA-Water$ systems were more unstable than $POE_{15}SE-CSA-Water$ systems due to the bended structure of oleyl groups. For the modification of vesicles, cholesterol was added. The enthalpy values were decreased reaching to zero and the water permeability of systems was decreased, but the stabilizaton of retinyl acetate was not greatly improved. The stability of retinyl acetate may depend on its location in the structure. Various oils were added for further stabilization and isopropyl myristate was most effective. In practice, retinyl palmitate showed better stability in the same vesicle than retinyl acetate, and the improved vesicles could be used for the anti-wrinkle cosmetics

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Characterization of Edible Film Fabricated with Channel Catfish Ictalurus punctatus Gelatin by Cross-Linking with Transglutaminase

  • Oh, Jun-Hyun
    • Fisheries and Aquatic Sciences
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    • v.15 no.1
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    • pp.9-14
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    • 2012
  • The objectives of this research were to improve the film-forming properties of Channel Catfish Ictalurus punctatus skin gelatin (CSG) by cross-linking with transglutaminase (TG), determine and optimize the TG reaction time, and characterize the mechanical and barrier properties of CSG edible film. Cross-linking of CSG was performed by TG for 0, 10, 20, 30, and 40 min at $50^{\circ}C$, and the reaction was confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The color and mechanical and barrier properties of edible films fabricated with CSG cross-linked with TG were characterized. Gelatin yields from the extraction ranged from 18.2% to 23.3%. SDS-PAGE exhibited dark bands at 120 and 250 kDa, indicating successful TG-mediated cross-linking. The color of CSG film was not affected by TG cross-linking. The tensile strength of CSG films cross-linked with TG decreased from 42.59 to 21.73 MPa and the percent elongation increased from 42.92% to 76.96% as reaction times increased from 0 to 40 min. There was no significant difference in water vapor permeability of CSG films.

Anaphylactic Shock Care during General Anesthesia -A Case Report- (전신마취 도중 유발된 아나필락시스 -증례보고-)

  • Choi, Byung-Ho;Sul, Sung-Han;Yoo, Jae-Ha
    • Journal of The Korean Dental Society of Anesthesiology
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    • v.6 no.2 s.11
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    • pp.121-126
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    • 2006
  • Generalized anaphylaxis is a most dramatic and acutely life-threatening allergic reaction. Most fatalities from anaphylaxis occur within the first 30 minutes postantigenic exposure. The mechanism of generalized anaphylaxis is the reaction of IgE antibodies to an allergen that causes the release of histamine, bradykinin, and others. These chemical mediators cause the contraction of smooth muscles of the respiratory and intestinal tracts, as well as increased vascular permeability. Four major clinical symptoms are recognized: skin reactions, smooth muscle spasm (gastrointestinal and genitourinary tracts and respiratory smooth muscle), respiratory distress, and cardiovascular collapse. Epinephrine is the drug of choice for the management. Its syrnpathomimetic effects directly counteract most aspects of the attack. Respiration must be immediately supported by the establishment of a patent airway along with artificial ventilation. The circulation should be supported and the existing hypotension overcome by placing the victim in a position to allow gravity to aid venous return and by administering intravenous fluids, vasopressors, and corticosteroids. When an imperceptible pulse is evident, external cardiac compression must also be instituted. This is a case report of anaphylactic shock care during general anesthesia, possibly due to penicillin, pancuronium and others.

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