Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Pharmacological and Biochemical studies on Telescopium telescopium - a marine mollusk from the Mangrove regions

  • Samanta, SK (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Adhikari, D (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Karmakar, S (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Dutta, A (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Roy, A (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Manisenthil, KT (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Roy, D (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Vedasiromoni, JR (Drug Development Division, Indian Institute of Chemical Biology) ;
  • Sen, T (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University)
  • Published : 2008.12.31
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Abstract

The tissue extract (TTE) of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal, India, was extensively screened for pharmacological and biochemical properties. Telescopium telescopium (TTE) produced significant lysis of washed rat erythrocytes (both direct and indirect), produced haemorrhagic lesions in the skin and also released haemoglobin (in vitro tissue damage) from different tissue samples. TTE was found to produce pro-inflammatory effects when injected into the rat hind paw and also increased peritoneal vascular permeability. Furthermore, intravenous administration of TTE produced a decrease in blood pressure (hypotensive effect) in anaesthetized rats. The extract produced potent esterase activity, as was evident from the breakdown of FDA with subsequent release of fluorescein (in vitro). TTE also demonstrated prominent cholinesterase, phospholipase, phosphatase and protease activities.

Keywords

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