• Journal of Microbiology and Biotechnology
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• v.34 no.4
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• pp.940-948
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• 2024

Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on anti-inflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.12 no.4
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• pp.336-342
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• 2019

With the entry of an aging society, the average life span of accreditation has been extended. Therefore, interest in the appearance of men and women in modern society has increased. It is the wrinkles of the face that can judge the most outwardly. People tend to have various kinds of treatments to have a clean, wrinkle-free and resilient healthy skin regardless of sex. There is a lot of practice of lifting procedures in one of the procedures. A suture using a melting thread is a method of lifting by squeezing it into the skin as a non-incision type centering on a region where the thread can be fixed in the skin by injecting it into the subcutaneous fat layer. To evaluate the lifting efficacy of Cog - type suture for the improvement of skin wrinkles, preclinical experiments were conducted. We developed a wrinkle evaluation program using Labview. Data from preclinical experiments were used at 8 weeks after suturing. The average wrinkle depth was 415.6 mm in the control group. At 8 weeks, the depth of wrinkles was deepened to 888.3mm due to the aging process of the control group. On the other hand, the depth of the wrinkles before surgery was 640.3 mm in the suture group. It was confirmed that the depth of wrinkles decreased to 566.5mm at 8th week after the suture operation.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.3
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• pp.27-36
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• 2022

Purpose : This study was aimed to analyze the effects of cosmetics containing Persicaria perfoliata water extract (PPWE) on the skin moisturizing and improvement of skin condition in clinical trials. Methods : Clinical trial was conducted for five weeks after IRB approval at Dong-Eui University. Out of a total of 64 people, 15 people each were assigned to four groups as follows; control group A, B, C and the experimental group A that using cosmetic containing PPWE. Skin condition was measured two times, before and after clinical trial, by a professional skin analyzer, SDM (skin diagnosis system). Moisture and oil value of participants was analyzed twice, each morning and evening, using a portable device on their cheeks. In addition, the survey was investigated subjective satisfaction on change in skin condition and the satisfaction on the use of cosmetics. Result : The experimental group exhibited subjectively significant changes before and after clinical trials on skin its dryness (p=.039), blush (p=.017), and redness (p<.001). In addition, subjective evaluation was also the highest satisfaction in aspects of number of application (p=.003), amount of application (p=.002), moisture maintenance, and skin scratching frequency. The satisfaction on the use of cosmetics was the highest in the intention to repurchase (p=.045), recommendation willingness to others (p=.020), and intention to use various products (p=.001). Skin moisture of the clinical trial participants using the SDM, moisture level and elasticity of the experimental group increased by 12.94 and 10.28. Moisture level, which was measured by a portable device, was the most potently increased in the experimental group. Conclusion : Consequently, PPWE containg cosmetics exhibited the effects of moisturization and attenuated skin dryness in clinical trials, which might be utilized as a fundamental data to develop numerous lines of cosmetics.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.4
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• pp.331-339
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• 2023

In this study, in vitro and clinical studies were conducted to assess the anti-inflammatory effects and skin improvement effects, including moisturizing, sebum secretion-regulating, skin barrier function enhancing, and soothing of Helianthus annuus (Sunflower) seed oil. In in vitro study using cultured human epidermal keratinocytes induced with inflammation by lipopolysaccharide, significant decreases in inflammatory cytokines interleukin-6, interleukin-8, and tumor necrosis factor alpha was revealed, indicating the anti-inflammatory effects of H. annuus (Sunflower) seed oil. Additionally, the results of clinical study on subjects with sensitive skin demonstrated improved skin hydration, regulation of sebum secretion, enhanced skin barrier function, as well as amelioration of skin redness and acne, indicating positive effects on overall skin conditions after application of H. annuus (Sunflower) seed oil containing test product for 4 weeks. Results of this study demonstrated the potential of H. annuus (Sunflower) seed oil as an ingredient for cosmetic, targeting consumers with sensitive skin.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.2
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• pp.75-84
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• 2015

Objectives : The purpose of this study is to report the oriental medical treatment on erythema multiforme caused by acute tonsillitis. Methods : Patient who has been ill Acute tonsillitis suffers from erythema, edema, pruritus, burning sensation of systemic skin. The patient was admitted to Dunsan oriental hospital for 7 days and was treated with oriental medicine(acupuncture, herbal-medicine, and vapor treatment). To evaluate the results of this treatment, the improvement of symptoms(erythema, pruritus, burning sensation) was identified by patient's subjective expression and in lesion-symptom improvement. Results : The symptoms caused by acute tonsillitis on total skin were improved. Conclusions : This study shows that the oriental medical treatment effects on the erythema multiforme caused by acute tonsillitis. Also, the public suggests that the correlation between the skin and tonsil.

• Journal of Korea Multimedia Society
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• v.22 no.2
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• pp.271-280
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• 2019

Recently, hearing loss patients have been increasing to excessive use of various multimedia devices. One of the hearing rehabilitation systems, bone conduction hearing aid can be used to conductive deafness patients efficiently. However, the conventional bone conduction hearing systems has some problems such as skin diseases, repulsion of patients, and vibration power reduction by skin damping. In this paper, to overcome the conventional problems, we proposed power improvement method by curved beam diaphragm. The proposed method is skin attachment system which is non-implantable, and then the power of transducer is improved by the proposed method. In order to improve the vibration power of diaphragm, variable that has correlation with displacement are extracted, the diaphragm designed by extracted variable. To verify efficient of the proposed method, experiment conducted by finite element analysis. As a result of, the proposed method confirmed improved power to compare with the conventional method and proposed method.

• Journal of Sasang Constitutional Medicine
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• v.34 no.4
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• pp.68-80
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• 2022

Objectives This study is to report a significant improvement in a Taeeumin patient with systemic contact dermatitis after eating urushiol chicken by herbal medicine treatment. Methods The patient had complaints of erythema, swelling, pruritus, scaly skin, and facial flushing. We treated the patient with an herbal medicine 'Galgeunhaegi-tang' for three months. We evaluated the treatment outcome of systemic contact dermatitis using the Three Item Severity(TIS) score every visit and facial flushing by Image color summarizer at the first and last visit. Results After the treatment, the severity of the patient's skin complaints lessened from moderate to mild. The Image color summarizer showed a minor decrease in the normalized red color level and a significant increase in the brightness level and facial color percentage. Conclusions The patient diagnosed with systemic contact dermatitis, treated with Galgeunhaegi-tang for three months, showed a significant improvement in skin complaints with brighter and even facial color.

• CELLMED
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• v.13 no.5
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• pp.18.1-18.3
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• 2023

Objective: A case report on the improvement of patients with acanthosis nigricans by Ortho-Cellular Nutrition Therapy (OCNT). Methods: A 23-year-old Korean male who has begun to have the symptoms of acanthosis nigricans two years ago has been experiencing more severe symptoms in the past year. Results: Skin pigmentation and lichenification symptoms improved after Ortho-Cellular Nutrition Therapy (OCNT). Conclusion: Ortho-Cellular Nutrition Therapy (OCNT) is effective in relieving the symptoms of patients with acanthosis nigricans.

• Proceedings of the Korean Geotechical Society Conference
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• 2001.03a
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• pp.355-362
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• 2001

Since micropiles were conceived in Italy in the early 1950s, which have been widely used for In-situ reinforcement, bearing pile or the concept of combination in the world-wide. The meaning of micropiles usually differs from that of a general deep foundation. Because the load capacity of it was mainly affected by skin friction. Also, it could be obtained the improvement effects of load capacity or ground's rigidity by the unitary behavior of ground and micropiles. In this study, The model tests were peformed on the dense sand where micropiles are set to the vertical direction. Strip footing was used in it. Steel bars of dia. 2 and 4㎜ were used in model tests of which the sand was attached on the surface, and the length of it was changed as 2B to 6B(where, B is width of strip footing) Through this process, the load capacity were analyzed from the test results in the relationship between load and displacement.

• Journal of Ginseng Research
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• v.35 no.2
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• pp.149-154
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• 2011

In order to determine the efficacy of functional foods, objective measurement of the severity of atopic dermatitis (AD) after taking foods is important. The aim of this study was to conduct an objective evaluation of whether Korean red ginseng (KRG) might be helpful for improvement of skin condition and serum IgE in patients with AD. Thirty atopic patients (18 females and 12 males) participated in this study. Patients took KRG for 16 weeks. Bioengineering methods, including the corneometer and evaporimeter, were used at the start of the study and after 8 weeks and 16 weeks. In addition, we assessed serum IgE levels and the severity scoring of the atopic dermatitis (SCORAD) index. Transepidermal water loss and skin hydration showed significant improvement after 16 weeks. A significant decrease in the SCORAD index, as well as in serum IgE level, was observed after 16 weeks. Our results demonstrated that KRG may be helpful as a functional food for patients with AD.