• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.5
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• pp.103-110
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• 2020

In the recent seismic design code KDS 41 17 00, selection and modification procedures of ground motions which are used for nonlinear dynamic analyses were adopted. However, its practical applications are still limited due to the lack of literatures. This paper introduces case studies which used site-response analyses to select and modify ground motions for nonlinear dynamic analyses. Based on the case studies, design criterion for site-response analyses were reviewed thoroughly in the viewpoint of practical applications. It was found that design requirements related with bedrock motions are too conservative that ground motions are selected and modified in the excessive manner. It is especially true for low-rise building structures with period ranges including acceleration-sensitive regions. Even though surface motions have shown appropriate responses, such building structures have to re-select and re-modify ground motions based on pre-analysis procedures rather than post-ones according to the current seismic design code. Also, it was observed that building structures with soft soils under strong ground motions need more comprehensive investigations on soil properties and efficient analysis methods in order to perform site-response analyses. This is due to the fact that lack of reliabilities on soil properties and analysis methods could result in unstable site-responses.

• Proceedings of the Ginseng society Conference
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• 2004.12a
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• pp.7-11
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• 2004

We previously reported that ginseng inhibited NMDA receptors in cultured hippocampal neurons. Here, we further examined the detailed mechanism of ginseng-mediated inhibition using its main active ingredient, ginsenoside Rg$_3$. Co-application of ginsenoside Rg$_3$ with increasing concentrations of NMDA did not change the EC$_{50}$ of NMDA to the receptor, suggesting ginsenoside Rg$_3$ inhibits NMDA receptors without competing with the NMDA-binding site. Ginsenoside Rg$_3$-mediated inhibition also occurred in a distinctive manner from the well-characterized NMDA receptor open channel blocker, MK-801, However, ginsenoside Rg$_3$ produced its effect in a glycine concentration-dependent manner and shifted the glycine concentration-response curve to the right without changing the maximal response, suggesting the role of ginsenoside Rg$_3$ as a competitive NMDA receptor antagonist. We also demonstrated that ginsenoside Rg$_3$ significantly protected neurons against NMDA insults. Therefore, these results suggest that ginsenoside Rg$_3$ protects NMDA-induced neuronal death via a competitive interaction with the glycine-binding site of NMDA receptors in cultured hippocampal neurons.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.872-879
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• 2010

High rock-fill embankment is relatively flexible, which makes crest of embankment subject to excessive amplification in displacement due to earthquake loading. To overcome problems related with site response in high embankment, it is essential to evaluate shear-wave velocity profile of the embankment with improved accuracy and reliability. In this aspect, an experimental research was performed to answer how to perform surface-wave tests and to analyze measurements at an embankment site with a sloping ground surface. Unlike flat ground surface, sloping ground may hamper and slow down propagation of surface waves due to multiple reflections and refractions in embankment. To figure out this reasoning for the effect of multiple reflections and refractions due to sloping surface, surface wave tests were performed at a reservoir embankment of Chung-Song in North KyeongSang Province. Parameters involved in surface wave tests at non-flat surface, including source directionality, geometry-related constraint and frequency components in source function, were investigated using field measurements.

• Biomolecules & Therapeutics
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• v.2 no.2
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• pp.114-119
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• 1994

[$^3$H]Ouabain binding parameters ( $K_{D}$ and $B_{max}$) to control rat ventricular strips and Langendorff preparations which were not previously exposed to ouabain were compared with those to both preparations that had been first exposed to a complete ouabain dose range of dose-response curve (10$^{-8}$ to 10$^{4}$M). In rat ventricular strips and Langendorff perfused heart preparations, cumulative dose-response curves of ouabain revealed biphasic positive inotropic effects, a "low-dose" effect and a "high-dose" effect with E $d_{50}$ values of 0.5 $\mu$M and 35 $\mu$M ouabain, respectively. The "low-dose" effect in ventricular strip disappeared or was diminished significantly when the ouabain dose-response curve was repeated after the washout of the effects of the first dose-response curve, whereas there were no significant differences in the maximal "high-dose"effect in both exposures to oubain. However, both of the control and ouabain-preexposed Langendorff perfused hearts revealed the same low-dose effects. The $K_{D}$ value for [$^3$H] ouabain binding and the ouabain binding site concentration ( $B_{max}$) estimated by [$^3$H]ouabain displacement assay in control preparations were 230 nM and 2 pmol/mg protein, respectively. [$^3$H]Ouabain binding parameters were not changed by repeated exposure to high concentrations of ouabain. These results suggest that digitalis receptor desensitization in the rat ventricular strip may due to the change of post-receptor events induced by ouabain binding to a high affinity site ($\alpha$$_2$isoform).).).).).

• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.4 s.44
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• pp.29-42
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• 2005

Total 350 borehole profiles were selected from the database of borehole logs in Seoul, for the site-specific seismic evaluation at two 4km${\times}$4km plain areas. Equivalent-linear site response analyses for the selected 350 sites were conducted based on shear wave velocity (Vs) Profiles, which were determined from the N-Vs correlation established using borehole seismic testing results in the inland areas of Korea. Most sites were categorized as site classes C and D based on the mean Vs to 30 m in depth (Vs30) ranging from 250 to 550 m/s. The she periods of the plains in Seoul ranging between 0.1 and 0.4 sec were significantly lower than those of the western US, from which the site coefficients in Korea were derived. For plains in Seoul, the site coefficients, Fa's and Fv's specified in the Korean seismic design guide, underestimate the ground motion in short-period (0.1-0.5 sec) band and overestimate the ground motion in mid-period (0.4-2.0 sec) band, respectively, because ol the differences in the geotechnical conditions between Seoul and the western US, although the Fa's in several sites overestimate the motion due to the base Isolation effect resulted from the soft layer in soil deposit.

• YAKHAK HOEJI
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• v.22 no.3
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• pp.163-174
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• 1978

Plantaginis seed has been applied in Chinese medicine a as well as in folk remedy. It was advocated that Plantaginis S Semeη exerts good therapeutic effects as anti-inflammatory, antitussive, obstipant and diuretic agent in some cases of alimentary, respiratory a and renal disorders. This study was carried out in order to r re-evaluate the pharmacological action, especially the hypotensive a action of Plantaginis Semen and to elucidate the mechanism of its a action, making use of Plantaginis Semen methanol extract (PME), because its basic pharmacological action, i. e., hypotensive action is n not clear. 1) PME, when administered into intravenous route, elicited the h hypotensive response dependent on the dose of PME given to the rabbit anesthetized with urethane. 2) This hypotensive response of P PME was inhibited by atropine and potentiated by physostigmine, but not influ$\varepsilon$need by vagotomization. 3) Depressor effect of PME was blocked by chlorisondamine, phentolamine, and bethanicline, while not altered by cyproheptadine, diphenhydramine and propran¬olol. 4) The secondary pressor response after blocking the depressor e effect of PME by chlorisondamine was produced, but this pressor response was deminished by atropine. 5) PME augmented the pressor e effect of norepinephrine and angiotensin, on the other hand, reduced b blood pressure elevated by carotid occlusion reflex. 6) These observa¬t tions suggest that PME may induce the hypotensive response via dual mechanisms of parasympathomimetic and sympatholytic action, that the positions of this action are cholinergic peripheral site and sympathetic ganglia respectively, and that PME may possess the pressor activity caused by stimulation of "atropine-sensitive site" which seems to existsin the sympathetic ganglia.

• Earthquakes and Structures
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• v.26 no.5
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• pp.401-416
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• 2024

Long-span structures, such as bridges, can experience different seismic excitations at the supports due to spatially variability of ground motion. Regarding current bridge designing codes, it is just EC 2008 that suggested some regulations to consider it and in the other codes almost ignored while based on some previous studies it is found that the effect of mentioned issue could not be neglected. The current study aimed to perform a comprehensive study about the effect of spatially varying ground motions on the dynamic response of a reinforced concrete bridge under asynchronous input motions considering soil-structure interactions. The correlated ground motions were generated by an introduced method that contains all spatially varying components, and imposed on the supports of the finite element model under different load scenarios. Then the obtained results from uniform and non-uniform excitations were compared to each other. In addition, the effect of soil-structure interactions involved and the corresponding results compared to the previous results. Also, to better understand the seismic response of the bridge, the responses caused by pseudo-static components decompose from the total response. Finally, an incremental dynamic analysis was performed to survey the non-linear behavior of the bridge under assumed load scenarios. The outcomes revealed that the local site condition plays an important role and strongly amplifies the responses. Furthermore, it was found that a combination of wave-passage and strong incoherency severely affected the responses of the structure. Moreover, it has been found that the pseudo-static component's contribution increase with increasing incoherent parameters. In addition, regarding the soil condition was considered for the studied bridge, it was found that a combination of spatially varying ground motions and soil-structure interactions effects could make a very destructive scenarios like, pounding and unseating.

• Structural Engineering and Mechanics
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• v.36 no.1
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• pp.111-127
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• 2010

This paper studies the effects of spatially varying ground motions on the responses of a bridge frame located on a canyon site. Compared to the spatial ground motions on a uniform flat site, which is the usual assumptions in the analysis of spatial ground motion variation effects on structures, the spatial ground motions at different locations on surface of a canyon site have different intensities owing to local site amplifications, besides the loss of coherency and phase difference. In the proposed approach, the spatial ground motions are modelled in two steps. Firstly, the base rock motions are assumed to have the same intensity and are modelled with a filtered Tajimi-Kanai power spectral density function and an empirical spatial ground motion coherency loss function. Then, power spectral density function of ground motion on surface of the canyon site is derived by considering the site amplification effect based on the one dimensional seismic wave propagation theory. Dynamic, quasi-static and total responses of the model structure to various cases of spatially varying ground motions are estimated. For comparison, responses to uniform ground motion, to spatial ground motions without considering local site effects, to spatial ground motions without considering coherency loss or phase shift are also calculated. Discussions on the ground motion spatial variation and local soil site amplification effects on structural responses are made. In particular, the effects of neglecting the site amplifications in the analysis as adopted in most studies of spatial ground motion effect on structural responses are highlighted.

• Journal of the Earthquake Engineering Society of Korea
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• v.17 no.5
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• pp.209-217
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• 2013

In order to verify the reliability of numerical site response analysis program, both soil free-field and base rock input motions should be provided. Beside the field earthquake motion records, the most effective testing method for obtaining the above motions is the dynamic geotechnical centrifuge test. However, need is to verify if the motion recorded at the base of the soil model container in the centrifuge facility is the true base rock input motion or not. In this paper, the appropriate input motion measurement method for the verification of seismic response analysis is examined by dynamic geotechnical centrifuge test and using three-dimensional finite difference analysis results. From the results, it appears that the ESB (equivalent shear beam) model container distorts downward the propagating wave with larger magnitude of centrifugal acceleration and base rock input motion. Thus, the distortion makes the measurement of the base rock outcrop motion difficult which is essential for extracting the base rock incident motion. However, the base rock outcrop motion generated by using deconvolution method is free from the distortion effect of centrifugal acceleration.

• Geomechanics and Engineering
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• v.23 no.6
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• pp.575-585
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• 2020

In this numerical study, the 2D dynamic behavior of a clayey basin and its effect on damage pattern over basin edge are investigated. To attain this goal, a fully nonlinear time domain analysis method has been applied. Then, the fragility curves of the considered two typical industrial structures for that certain point are estimated using the acceleration time histories recorded at each surface point. The results show that the use of the damage related parameters in site effect analyses, instead of amplification curves, can yield more realistic estimation of the basin dynamic response. In a distance about 150 m from outcrop at the basin edge, the differences between fragility curves increase when increasing the distance from outcrop with respect to the reference rock site. Outside this region and towards the basin center, they tend to occur in rather single curves. Furthermore, to connect the structural damage to the basin edge effect, the earthquake demand value at different points for two typical structures was evaluated. It was seen that the probability of occurrence of damage increases over 250 m from outcrop, while the effect of the basin edge was limited to 150 m in case of the basin edge evaluation by using fragility curves.