• Biomolecules & Therapeutics
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• 제3권3호
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• pp.192-198
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• 1995

The affinity of mequitazine, a non-sedating antihistamine, for muscarinic receptors was evaluated in the guinea-pig ventricle and ileum by in vitro binding techniques and functional studies. In binding studies, [$^3$H]quinuclidinyl benzilate (QNB) identified a single class of muscarinic receptors with similar apparent $K_{D}$ value of about 100 pM in two tissues. Mequitazine inhibited [$^3$H]QNB binding to muscarinic receptors competitively. Analysis of the mequitazine inhibition curve of [$^3$H]QNB binding to ventricular microsome and ileal homogenate indicated the presence of a single homogeneous binding site with Ki value of 25 nM and 18 nM, respectively. In functional studies, mequitazine caused parallel rightward shifts of concentration-response curves for carbachol and histamine in the isolated guinea-pig ileum. The slope values obtained from Schild plot analysis for the antagonistic action of mequitazine on muscarinic and histamine $H_1$-receptors were not significantly different from unity. The p $A_2$values of mequitazine for muscarinic and histamine $H_1$-receptors were about 7.6 ( $K_{M}$= 25.1 nM) and 8.88 ( $K_{H}$= 1.32 nM), respectively. These results indicate that the muscarinic receptor blocking action of mequitazine is 15 times less potent than the $H_1$receptor blocking action, but high concentration of this drug may cause the peripheral muscarinic receptor blocking effect.t.t.t.

• Journal of Pharmaceutical Investigation
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• 제5권1호
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• pp.28-40
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• 1975

Polyporus would used as diuretics. Then, for the purpose of experimentally certifying the above mention, the effect on the renal function of dog was investigated, utilizing clearance technique. Water and alcohol extracts, when injected intravenously, produced significant increases of urinary sodium and potassium, osmolar and free water clearances, and urine flow, while glomerular filtration rate and renal plasma flow remained unchanged. During diuresis produced by furosemide, addition of water extract reduced the action of furosemide and markedly renal plasma flow. It would appear that these compounds are capable of action by a different mechanism or a different site. water extract, when infused directly into a renal artery, reduced the urine flow of experimental kidney as well as renal plasma flow, and the contralateral kidney exhibited diuresis, whereas amounts of sodium and potassium excreted in urine increased on both kidney. It is surmised from those observations that Polyporus induces diuresis by inhibition the reabsorptive mechanism of renal tubules through some endogeneous humoral substances, in addition, directly reduces the renal plasma flow.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.361-369
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• 2022

Unsafe actions and behaviors of workers cause most accidents at construction sites. Nowadays, occupational safety is a top priority at construction sites. However, this problem often requires money and effort from investors or construction owners. Therefore, decreasing the accidents rates of workers and saving monitoring costs for contractors is necessary at construction sites. This study proposes an unsafe behavior detection method based on a skeleton model to classify three common unsafe behaviors on the scaffold: climbing, jumping, and running. First, the OpenPose method is used to obtain the workers' key points. Second, all skeleton datasets are aggregated from the temporary size. Third, the key point dataset becomes the input of the action classification model. The method is effective, with an accuracy rate of 89.6% precision and 90.5% recall of unsafe actions correctly detected in the experiment.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 1999년도 추계학술발표회
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• pp.28-31
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• 1999

The purpose of this study is to see the effect of microbial population and dynamics of the indigeonous microorganisms on hydrocarbon contaminated areas. The microbial structures and activities to determine the microbial capabilities of the contaminated sites are very important for the remedial action technology selection. Throughout microbial studies on different conditions by ETS(Electron Transport System) and microbial activity analysis, it was found that aeration and water contents are the most important factors in this site remediation. According to test results, Burkholderia spp. was dominant species, and acclimation is also an important factor for the accerelated biodegradation.

• 한국조경학회지
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• 제23권3호
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• pp.94-105
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• 1995

Purposes of this study were to apply and examine that the importance-performance analysis(IPA) could be a useful park management tool. The IPA is an easily-applied technique developed in marketing field to measure attribute importance and performance. It displays them simultaneously on a 4-quardrant action grid; therefore, park managers can upgrade current services and address marketing strategies for various user segments. The children's grand park was selected as a study are. Two different types of questionaires were utilized for data analyses. They were collected from one respondent by on-site distribution or by mail survey, because attribute importance and performance should be rated before and after visiting a park, respectively. Then, total data was segmented systematically by 2 variables-age and benefit sought. Action grids from order to meet the needs of each segment. Several comments on both data collection methods and segment variables selection were described to improve the IPA in recreation settings for future researches.

• 한국조경학회지
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• 제22권1호
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• pp.17-26
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• 1994

Based on the data gathered by on-site survey at six universities, this study examines the relationships between the level of knowledge about regulations and depreciative behavioral intentions in National Park management. 558 students are participated in the survey. Among those agreeing to take part in the survey, 54.5% are males and 45.5% are females. Generally most students are very interested in the environmental problem in national parks. The mean of knowledge about regulations in national parks score 57, and females have higher mean scores than male student. In all four dilemmas, significant negative correlations are observed between the likelyhood of a prosocial action and the likelyhood of an antisocial action. In other words, the more likely the intention to obey a regulation in any dilemma situlation, the less likely the intention to disobey a regulation, and vice-versa.

• 한국지하수토양환경학회지:지하수토양환경
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• 제16권1호
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• pp.32-41
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• 2011

By using a newly developed Korean risk-based corrective action (K-RBCA) software (K-RBCA) and the RBCA Tool Kit, risk assessment was performed on a site that was contaminated with aromatic hydrocarbons and heavy metals. Eight chemicals including benzene, ethylbenzene, xylenes, naphthalene, benz(a) anthracene, benzo(b) fluoranthene, benzo(a) pyrene, and arsenic that exceeded the US EPA Soil Screening Level were chosen as the target pollutants. A conceptual site model was constructed based on the site-specific effective exposure pathways. According to the RBCA Tool Kit the carcinogenic risk of arsenic was larger than $10^{-6}$, which is the generally acceptable carcinogenic risk level. The K-RBCA estimated the same level of carcinogenic risk for arsenic. With the RBCA Tool Kit, the carcinogenic risk of benzo(a) pyrene was estimated to be about $1.3{\times}10^{-6}$. However, with the K-RBCA benzo(a) pyrene did not exhibit any risk. The inconsistency between the softwares was attributed to the different fundamental settings (i.e., medium division) between the two softwares. While the K-RBCA divides medium into surface soil, subsurface soil, and groundwater, the RBCA Tool Kit divides medium into only soil and groundwater. These differences lead to the different exposure pathways used by the two softwares. The K-RBCA considers the exposure pathways in surface soil and subsurface soil separately to estimate risk, however, the RBCA Tool Kit considers the surface soil and subsurface soil as one and uses the integrated exposure pathways to estimate risk. Thus the resulting risk is higher when the RBCA Tool Kit is used than when the K-RBCA is used. The results from this study show that there is no significant difference in the risks estimated by the two softwares, thus, it is reasonable to use the K-RBCA we developed in risk assessment of soil and groundwater. In addition, the present study demonstrates that the assessor should be familiar with the characteristics of a contaminated site and the assumptions used by a risk assessment software when carrying out risk assessment.

• 한국화재소방학회논문지
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• 제30권3호
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• pp.62-66
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• 2016

화력발전소는 중대형사고의 발생위험이 높은 고위험군 건물로 다양한 원인에 의하여 크고 작은 화재 등이 발생하고 있어 화력발전소 현장에서는 '화력발전분야 현장조치 행동 매뉴얼'을 배포하고 정기적인 교육 및 훈련을 통하여 화재 등 재난발생률을 최소화하기 위하여 힘쓰고 있다. 그러나 현재 국내 5개 화력발전회사에서 사용되는 교육자료는 대부분 가독성 낮은 인쇄물(Hard Capy) 형태이며, 발전화사별, 사업소별로 상이하게 구성된 점이 있어 표준화 작업이 요구된다. 그러므로 본 연구에서는 국가 중대 기반시설인 발전소의 재난대응력을 향상하기 위한 방법으로 '화력발전분야 현장조치 행동 매뉴얼'의 '유류화재 전기화재 건물화재 설비화재 가스누출 대응 SOP' 5개 부분에 대하여 매뉴얼 표준화 작업을 진행하고, 이를 바탕으로 인쇄물(Hard Capy)형 재난매뉴얼을 보완할 수 있는, 스토리뷰잉(Story-viewing) 기법을 적용한 시각화 기반 화력발전분야 안전교육 콘텐츠를 제안하고자 한다.

• 한국지리정보학회지
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• 제16권2호
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• pp.30-46
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• 2013

본 논문은 생태마을 입지분석에 필요한 표준화된 분석요소와 평가기준을 정립하고, GIS를 이용한 생태마을 입지분석 모델을 개발하여 실제 적용한 결과를 제시하였다. ArcGIS 모델빌더(Model Builder)를 활용하여 개발된 모델은 사용자가 GIS 프로그램에 익숙하지 않더라도 쉽게 사용할 수 있도록 사용자 편의성을 최대한 고려하였다. 이를 위해 첫째, 기존연구 분석을 바탕으로 크게 자연환경 요소, 인문/사회적 요소, 법제적 요소로 분류되는 18개의 보편적이고 정량적인 생태마을 입지분석 요소와 평가기준을 선정하였고, 각 요소의 등급화 및 점수화 방안을 제시하였다. 둘째, ArcGIS 모델빌더를 활용하여 18개 입지분석 요소의 주제도 작성과정과 생태마을 입지로 적합한 지역을 도출하는 중첩분석 연산과정을 체계적으로 정리한 생태마을 입지분석 모델을 개발하였다. 셋째, 개발된 모델의 유효성을 검증하기 위하여 포항시 북구를 테스트 사이트로 생태마을 입지분석을 수행하였다.

• Weed & Turfgrass Science
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• 제3권3호
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• pp.165-173
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• 2014

국내에 등록된 제초제의 효율적 사용을 위해서 제초제저항성관리위원회에서 제시한 제초제 작용기작별 분류를 기초로 23그룹으로 분류하였다. 세부그룹으로는 acetyl CoA carboxylase 억제제, acetolactate synthase 억제제, photosystem과 억제제, protoporphyrinogen oxidase 억제제, carotenoid biosynthesis 억제제, enolpyruvyl shikimate-3-phosphate synthase 억제제, glutamine synthetase 억제제, dihydropteroate synthetase 억제제, 세포분열 저해제(mitosis inhibitors), cellulose 생합성억제제, oxidative phosphorylation uncouplers, 지방산 및 지질생합성 억제제, synthetic auxins, auxin transport 억제제, potential nucleic acid Inhibitors 혹은 non-descript mode of action으로 나누었다. 이와 같은 그룹화 기준을 토대로 국내 등록되어 사용중인 논 제초제 성분들을 그룹화 하였다. 따라서, 이러한 약제 작용기작 관련 정보를 농약사용자에게 제공함으로써 특정약제의 연용과 중복사용을 방지하여 국내에서 제초제 저항성잡초 발생 문제를 줄일 수 있을 것으로 기대된다.