• Biomolecules & Therapeutics
• /
• v.3 no.3
• /
• pp.192-198
• /
• 1995

The affinity of mequitazine, a non-sedating antihistamine, for muscarinic receptors was evaluated in the guinea-pig ventricle and ileum by in vitro binding techniques and functional studies. In binding studies, [$^3$H]quinuclidinyl benzilate (QNB) identified a single class of muscarinic receptors with similar apparent $K_{D}$ value of about 100 pM in two tissues. Mequitazine inhibited [$^3$H]QNB binding to muscarinic receptors competitively. Analysis of the mequitazine inhibition curve of [$^3$H]QNB binding to ventricular microsome and ileal homogenate indicated the presence of a single homogeneous binding site with Ki value of 25 nM and 18 nM, respectively. In functional studies, mequitazine caused parallel rightward shifts of concentration-response curves for carbachol and histamine in the isolated guinea-pig ileum. The slope values obtained from Schild plot analysis for the antagonistic action of mequitazine on muscarinic and histamine $H_1$-receptors were not significantly different from unity. The p $A_2$values of mequitazine for muscarinic and histamine $H_1$-receptors were about 7.6 ( $K_{M}$= 25.1 nM) and 8.88 ( $K_{H}$= 1.32 nM), respectively. These results indicate that the muscarinic receptor blocking action of mequitazine is 15 times less potent than the $H_1$receptor blocking action, but high concentration of this drug may cause the peripheral muscarinic receptor blocking effect.t.t.t.

• Journal of Pharmaceutical Investigation
• /
• v.5 no.1
• /
• pp.28-40
• /
• 1975

Polyporus would used as diuretics. Then, for the purpose of experimentally certifying the above mention, the effect on the renal function of dog was investigated, utilizing clearance technique. Water and alcohol extracts, when injected intravenously, produced significant increases of urinary sodium and potassium, osmolar and free water clearances, and urine flow, while glomerular filtration rate and renal plasma flow remained unchanged. During diuresis produced by furosemide, addition of water extract reduced the action of furosemide and markedly renal plasma flow. It would appear that these compounds are capable of action by a different mechanism or a different site. water extract, when infused directly into a renal artery, reduced the urine flow of experimental kidney as well as renal plasma flow, and the contralateral kidney exhibited diuresis, whereas amounts of sodium and potassium excreted in urine increased on both kidney. It is surmised from those observations that Polyporus induces diuresis by inhibition the reabsorptive mechanism of renal tubules through some endogeneous humoral substances, in addition, directly reduces the renal plasma flow.

• International conference on construction engineering and project management
• /
• 2022.06a
• /
• pp.361-369
• /
• 2022

Unsafe actions and behaviors of workers cause most accidents at construction sites. Nowadays, occupational safety is a top priority at construction sites. However, this problem often requires money and effort from investors or construction owners. Therefore, decreasing the accidents rates of workers and saving monitoring costs for contractors is necessary at construction sites. This study proposes an unsafe behavior detection method based on a skeleton model to classify three common unsafe behaviors on the scaffold: climbing, jumping, and running. First, the OpenPose method is used to obtain the workers' key points. Second, all skeleton datasets are aggregated from the temporary size. Third, the key point dataset becomes the input of the action classification model. The method is effective, with an accuracy rate of 89.6% precision and 90.5% recall of unsafe actions correctly detected in the experiment.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
• /
• 1999.10a
• /
• pp.28-31
• /
• 1999

The purpose of this study is to see the effect of microbial population and dynamics of the indigeonous microorganisms on hydrocarbon contaminated areas. The microbial structures and activities to determine the microbial capabilities of the contaminated sites are very important for the remedial action technology selection. Throughout microbial studies on different conditions by ETS(Electron Transport System) and microbial activity analysis, it was found that aeration and water contents are the most important factors in this site remediation. According to test results, Burkholderia spp. was dominant species, and acclimation is also an important factor for the accerelated biodegradation.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.23 no.3
• /
• pp.94-105
• /
• 1995

Purposes of this study were to apply and examine that the importance-performance analysis(IPA) could be a useful park management tool. The IPA is an easily-applied technique developed in marketing field to measure attribute importance and performance. It displays them simultaneously on a 4-quardrant action grid; therefore, park managers can upgrade current services and address marketing strategies for various user segments. The children's grand park was selected as a study are. Two different types of questionaires were utilized for data analyses. They were collected from one respondent by on-site distribution or by mail survey, because attribute importance and performance should be rated before and after visiting a park, respectively. Then, total data was segmented systematically by 2 variables-age and benefit sought. Action grids from order to meet the needs of each segment. Several comments on both data collection methods and segment variables selection were described to improve the IPA in recreation settings for future researches.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.22 no.1
• /
• pp.17-26
• /
• 1994

Based on the data gathered by on-site survey at six universities, this study examines the relationships between the level of knowledge about regulations and depreciative behavioral intentions in National Park management. 558 students are participated in the survey. Among those agreeing to take part in the survey, 54.5% are males and 45.5% are females. Generally most students are very interested in the environmental problem in national parks. The mean of knowledge about regulations in national parks score 57, and females have higher mean scores than male student. In all four dilemmas, significant negative correlations are observed between the likelyhood of a prosocial action and the likelyhood of an antisocial action. In other words, the more likely the intention to obey a regulation in any dilemma situlation, the less likely the intention to disobey a regulation, and vice-versa.

• Journal of Soil and Groundwater Environment
• /
• v.16 no.1
• /
• pp.32-41
• /
• 2011

By using a newly developed Korean risk-based corrective action (K-RBCA) software (K-RBCA) and the RBCA Tool Kit, risk assessment was performed on a site that was contaminated with aromatic hydrocarbons and heavy metals. Eight chemicals including benzene, ethylbenzene, xylenes, naphthalene, benz(a) anthracene, benzo(b) fluoranthene, benzo(a) pyrene, and arsenic that exceeded the US EPA Soil Screening Level were chosen as the target pollutants. A conceptual site model was constructed based on the site-specific effective exposure pathways. According to the RBCA Tool Kit the carcinogenic risk of arsenic was larger than $10^{-6}$, which is the generally acceptable carcinogenic risk level. The K-RBCA estimated the same level of carcinogenic risk for arsenic. With the RBCA Tool Kit, the carcinogenic risk of benzo(a) pyrene was estimated to be about $1.3{\times}10^{-6}$. However, with the K-RBCA benzo(a) pyrene did not exhibit any risk. The inconsistency between the softwares was attributed to the different fundamental settings (i.e., medium division) between the two softwares. While the K-RBCA divides medium into surface soil, subsurface soil, and groundwater, the RBCA Tool Kit divides medium into only soil and groundwater. These differences lead to the different exposure pathways used by the two softwares. The K-RBCA considers the exposure pathways in surface soil and subsurface soil separately to estimate risk, however, the RBCA Tool Kit considers the surface soil and subsurface soil as one and uses the integrated exposure pathways to estimate risk. Thus the resulting risk is higher when the RBCA Tool Kit is used than when the K-RBCA is used. The results from this study show that there is no significant difference in the risks estimated by the two softwares, thus, it is reasonable to use the K-RBCA we developed in risk assessment of soil and groundwater. In addition, the present study demonstrates that the assessor should be familiar with the characteristics of a contaminated site and the assumptions used by a risk assessment software when carrying out risk assessment.

• Fire Science and Engineering
• /
• v.30 no.3
• /
• pp.62-66
• /
• 2016

There have been happening small and big fires due to the various causes in the thermal power plants which are the high risk buildings with the high possibility of big sizes of accidents, so the people in the power plants distribute the workers "the site action manuals in thermal power plants" and try to minimize the rate of disasters like fires through the regular education and training. However, in the Five Thermal Power Plants in Korea, there are no the standard of "the site action manuals" and Furthermore, the present educational manuals are mostly the hard copies with poor readability. So the standardization of the manuals are definitely needed. Therefore, in this research, we proceed the standardization of the manuals for the five areas of the site action manual s in the thermal power plants which are oil fires, electric fires, building fires, facility fires and gas leaking reaction SOP to improve the reaction power on the disasters in the power plants which are the national significant infrastructures, thus by using the manual, we propose the safety education contents for the thermal power plants based on the visualization technology using story-viewing method to complement the hard copy type disaster manuals.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.16 no.2
• /
• pp.30-46
• /
• 2013

Using ArcGIS Model Builder, with emphasis on the importance of ecology and user friendliness, a model for site selecting tool is developed. This tool is developed by establishing standardized method for data selection and analysis with evaluation criteria using GIS. For this task, our first action was to objectively define and establish 18 elements to evaluate the potentiality of the site based on extensive literature reviews. These 18 elements reflect environmental, social/cultural and legal aspects that may influence the decision process to select the desired site. Secondly, using ArcGIS Model Builder, 18 analytical elements were made into thematic mapping which represent systematically organized graphic input to the model with automatic double check system and overlay analysis capability. Thirdly, to validate the effectiveness of the developed model, site location analysis was performed using the actual site, Buk-ku, Pohang.

• Weed & Turfgrass Science
• /
• v.3 no.3
• /
• pp.165-173
• /
• 2014

This review study was conducted to recommend the effective use of herbicide mixtures in Korea. The herbicide ingredients by Herbicide Resistancce Action Committee (HRAC) was classified into 23 groupes according to the mode of action (acetyl CoA carboxylase inhibitors, acetolactate synthase, photosystem I and II inhibitors, protoporphyrinogen oxidase inhibitors, carotenoid biosynthesis inhibitors, enolpyruvyl shikimate-3-phosphate synthase inhibitors, glutamine synthetase inhibitors, dihydropteroate synthetase inhibitors, mitosis inhibitors, cellulose inhibitors, oxidative phosphorylation uncouplers, fatty acid and lipid biosynthesis inhibitors, synthetic auxins, auxin transport inhibitors and potential nucleic acid inhibitors or non-descript mode of action). The rice herbicide mixtures registered in Korea were classified based on the guideline of HRAC. Accordingly, such a classification system for resistance management can help to avoid continuous use of the herbicide having the same mode of action in the same field.