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Voltage-Dependent Inactivation of Calcium Currents in the Mouse Eggs

  • Park, Young-Geun;Yang, Young-Seon;Yum, Myung-Kul;Hong, Seong-Geun
    • The Korean Journal of Physiology
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    • v.25 no.2
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    • pp.125-131
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    • 1991
  • Inactivation properties of Ca current in the unfertilized eggs of mouse were studied by using the whole cell voltage clamp technique and single microelectrode voltage clamp technique. Membrane potential was held at -80 mV and step depolarization was applied from -50 mV to 50 mV for $200{\sim}500\;ms$. Peak of inward Ca currents was $-2{\sim}-4\;nA$ at a membrane Potentials from -20 mV to 0 mV and outward currents were not observed within the membrane voltage range studied $(-50{\sim}50\;mV)$. Inward currents were fully inactivated within 200 ms after the onset of step depolarization. As the membrane became depolarized, time constant of inactivation (${\tau}$) was decreased but remained around $20{\sim}30\;ms$ beyond 10 mV. When $Ca^{2+}$ was used as a charge earlier, inactivation of inward $Ca^{2+}$ current also occured and time course of inactivation was similar to that of $Ca^{2+}$ currents as charge carrier. In the bathing solution containing high potassium $(131\;mM\;K^+)$, process of inactivation was not changed except a parallel decrease of value for the entire range of membrane potential. Steady-state inactivation of the $current(h_{\infty})$ obtained from the double pulse experiment showed the voltage-dependent change. These results suggested that inactivation of Ca currents in the unfertilized eggs of mouse was voltage-dependent.

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A study on the PWM(pulse witdh modulation) current source Inverter with utility (태양광발전 연계 시스템에 의한 PWM 전류형 인버어터에 관한 연구)

  • Hwang, Lak-Hoon;Choi, Ho-Kyu;Sin, Yang-Ho;Lee, Chun-Sang;Kim, Ju-Rae;Jo, Sang-Rou;Jo, Moon-Taeck
    • Proceedings of the KIEE Conference
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    • 2001.07b
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    • pp.1020-1022
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    • 2001
  • because the output of solar cell is direct, it is necessary to install D/A converter system for A.C load, and in case of driving utility line system, it is possible to drive system relation when the system supplies sinusodal current ant voltage having unit power factor. As the characteristics of the soar cell output the is influenced by dailysunight charge, for more electric power it is essential to control the direction toward the san so that the driving point of solar cell can always operate near maximum output point. PWM modulation device among electric power converters must have stable modulation at anytime when it includes noise-factors such as noise-wave and noises on electric voltage wave, a synchronous signal system. In dealing with synchronous signal for control and control signal by microprocessor, it is necessary to compensate it because there is time difference between sample paint and carrier wave. On this papers, single phase PWM current type invertor controled the solar cell having typical voltage dropping character has optimun short current in short, reduces D.C reactance, composes controller for modulation and keeps lower harmonic and high power factor keeping maximum output of solar cell according daily sunlight charge variation.

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Ultra-Low Powered CNT Synaptic Transistor Utilizing Double PI:PCBM Dielectric Layers (더블 PI:PCBM 유전체 층 기반의 초 저전력 CNT 시냅틱 트랜지스터)

  • Kim, Yonghun;Cho, Byungjin
    • Korean Journal of Materials Research
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    • v.27 no.11
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    • pp.590-596
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    • 2017
  • We demonstrated a CNT synaptic transistor by integrating 6,6-phenyl-C61 butyric acid methyl ester(PCBM) molecules as charge storage molecules in a polyimide(PI) dielectric layer with carbon nanotubes(CNTs) for the transistor channel. Specifically, we fabricated and compared three different kinds of CNT-based synaptic transistors: a control device with $Al_2O_3/PI$, a single PCBM device with $Al_2O_3/PI:PCBM$(0.1 wt%), and a double PCBM device with $Al_2O_3/PI:PCBM$(0.1 wt%)/PI:PCBM(0.05 wt%). Statistically, essential device parameters such as Off and On currents, On/Off ratio, device yield, and long-term retention stability for the three kinds of transistor devices were extracted and compared. Notably, the double PCBM device exhibited the most excellent memory transistor behavior. Pulse response properties with postsynaptic dynamic current were also evaluated. Among all of the testing devices, double PCBM device consumed such low power for stand-by and its peak current ratio was so large that the postsynaptic current was also reliably and repeatedly generated. Postsynaptic hole currents through the CNT channel can be generated by electrons trapped in the PCBM molecules and last for a relatively short time(~ hundreds of msec). Under one certain testing configuration, the electrons trapped in the PCBM can also be preserved in a nonvolatile manner for a long-term period. Its integrated platform with extremely low stand-by power should pave a promising road toward next-generation neuromorphic systems, which would emulate the brain power of 20 W.

A Case of Severe Aconitine Intoxication with Ventricular Tachycardia, Successfully Treated by a Combination of Two Anti-arrhythmic Drugs (두 가지 항부정맥 약제를 병용 투여하여 성공적으로 치료한 심실빈맥이 동반된 부자중독 1례 보고)

  • Ryoo, Seung-Mok;Sohn, Chang-Hwan;Oh, Bum-Jin;Kim, Won;Lim, Kyoung-Soo
    • Journal of The Korean Society of Clinical Toxicology
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    • v.9 no.2
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    • pp.105-108
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    • 2011
  • Aconitine is an anti-inflammatory agent with therapeutic uses in oriental medicine as an analgesic and for treatment of stroke. Because of its sodium channel effect, aconitine can promote undesirable, wide complex tachyarrhythmia. If tachycardia develops during use of aconitine, class Ia and class III anti arrhythmic drugs can be utilized for treatment. However there are no single anti-arrhythmia agents which are uniformly effective. We report a case, characterized by wide complex tachyarrhythmia and severe hypotension, which was successfully treated by simultaneous injections of amiodarone and lidocaine. A 59-year-old woman exhibiting clinical signs of drowsiness as a result of ingesting 6 g of aconitine, was admitted to the emergency department. Initially, wide complex tachyarrhythmia (ventricular tachycardia and pulse rate of 180 beats/min) and severe hypotension (blood pressure of 53/26 mmHg) was observed. After simultaneous injection of amiodarone and lidocaine, the patient's rhythm pattern changed to an accelerated junctional rhythm with ventricular premature complex. Two hours later, the patient's heart pattern became a sinus rhythm. As demonstrated by this case, simultaneous injections of amiodarone and lidocaine can be useful in treating ventricular arrhythmia induced by aconitine.

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TID and SEGR Testing on MOSFET of DC/DC Power Buck Converter (DC/DC 강압컨버터용 MOSFET의 TID 및 SEGR 실험)

  • Lho, Young Hwan
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.42 no.11
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    • pp.981-987
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    • 2014
  • DC/DC switching power converters are commonly used to generate a regulated DC output voltage with high efficiency. The DC/DC converter is composed of a MOSFET (metal-oxide semiconductor field effect transistor), a PWM-IC (pulse width modulation-integrated circuit) controller, inductor, capacitor, etc. It is shown that the variation of threshold voltage and the breakdown voltage in the electrical characteristics of MOSFET occurs by radiation effects in TID (Total Ionizing Dose) testing at the low energy ${\gamma}$ rays using $^{60}Co$, and 5 heavy ions make the gate of MOSFET broken in SEGR (Single Event Gate Rupture) testing. TID testing on MOSFET is accomplished up to the total dose of 40 krad, and the cross section($cm^2$) versus LET(MeV/mg/$cm^2$) in the MOSFET operation is studied at SEGR testing after implementation of the controller board.

Improving Wave Propagation Performance of an Ultrasonic Waveguide for Heat Isolation (열 차단용 초음파 도파관의 전파성능 향상 연구)

  • 최인석;전한용;김인수;김진오
    • The Journal of the Acoustical Society of Korea
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    • v.22 no.7
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    • pp.545-553
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    • 2003
  • This paper is concerned with protecting piezoelectric transducers used in an ultrasonic flowmeter from the high temperature of hot fluid in a pipe by using a waveguide and with improving the propagation of ultrasonic longitudinal vibration in the waveguide. Waveguide material has been chosen for efficient insulation of heat transferred in the waveguide, and the minimum length of the waveguide for protecting piezoelectric transducer has been estimated. Forced response of the longitudinal vibration in a uniform circular rod has been obtained and the length of the waveguide has been selected for maximum amplitude. Longitudinal vibration response of a conically-tapered rod excited at a natural frequency has been obtained to confirm that wave motion is amplified as the cross-sectional size of the waveguide decreases along the axial direction. The fact that dispersion of a pulse wave in a waveguide is reduced as the cross-sectional radius is decreased has been examined theoretically and confirmed experimentally by using a single-rod waveguide. A bundle-type waveguide has proven to be a practical one through the evaluation of the wave propagation performance.

Strain Analysis of Longitudinal Reinforcing Steels of RC Bridge Piers Under Shaking Test (진동대 실험에 의한 RC교각의 주철근 변형률 분석)

  • Hong, Hyun-Ki;Yang, Dong-Wook;Chung, Young-Soo
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.11a
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    • pp.93-96
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    • 2008
  • The near fault ground motion(NFGM) is characterized by a single long period velocity pulse of large magnitude. NFGM's have been observed in recent strong earthquakes, Turkey Izmit (1999), Japan Kobe(1995), Northridge(1994), etc. These strong earthquakes have caused considerable damage to infrastructures because the epicenter was close to the urban area, called as NFGM. Extensive research for the far fault ground motion(FFGM) have been carried out in strong seismic region, but limited research have been done for NFGM in low or moderate seismic regions because of very few records. The purpose of this study is to investigate and analyze the effect of near-fault ground motions on RC bridge piers without lap-spliced longitudinal reinforcing steels. The seismic performance of two RC bridge piers under near-fault ground motions was investigated on the shake table. In addition, Two of four identical RC bridge piers were tested under a quasi-static load, and the others were under a pseudo-dynamic load. The respectively two RC bridge pier is comparatively subjected to Pseudo-dynamic loadings and Quasi-Static loadings. This paper indicated that more gives bigger ultimate strain of longitudinal steels to be fractured at bigger PGA motion.

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A Study on the Comparison between an Optical Fiber and a Thermal Sensor Cable for Temperature Monitoring (온도 모니터링을 위한 광섬유 센서와 온도센서 배열 케이블의 비교 연구)

  • Kim, Jung-Yul;Kim, Yoo-Sung;Song, Yoon-Ho
    • Proceedings of the Korean Geotechical Society Conference
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    • 2006.03a
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    • pp.1100-1109
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    • 2006
  • In this study, two different technologies which can measure temperature simultaneously at many points are introduced. One is to use a thermal sensor cable that is comprised of addressable thermal sensors connected in parallel within a single cable. The other is to use an optic fiber with Distributed Temperature Sensing (DTS) system. The difference between two technologies can be summarized as follows. A thermal sensor cable has a concept of 'point sensing' that can measure temperature at accurate position of a thermal sensor. So the accuracy and resolution of temperature measurement are up to the ability of the thermal sensor. Whereas optic fiber sensor has a concept of 'distributed sensing' because temperature is measured by ratio of Stokes and anti-Stokes component intensities of Raman backscatter that is generated when laser pulse travels along an optic fiber. It's resolution is determined by measuring distance, measuring time and spatial resolution. The purpose of this study is that application targets of two temperature measurement techniques are checked in technical and economical phases by examining the strength and weakness of them. Considering the functions and characteristics of two techniques, the thermal sensor cable will be suitable to apply to the assessment of groundwater flow, geothermal distribution and grouting efficiency within 300m distance. It is expected that the optic fiber sensor can be widely utilized at various fields (for example: pipe line inspection, tunnel fire detection, power line monitoring etc.) which need an information of temperature distribution over relatively long distance.

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A Stereo Audio DAC with Asymmetric PWM Power Amplifier (비대칭 펄스 폭 변조 파워-앰프를 갖는 스테레오 오디오 디지털-아날로그 변환기)

  • Lee, Yong-Hee;Jun, Young-Hyun;Kong, Bai-Sun
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.45 no.7
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    • pp.44-51
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    • 2008
  • A stereo audio digital-to-analog converter (DAC) with a power amplifier using asymmetric pulse-width modulation (PWM) is presented. To adopt class-D amplifier mainly used in high-power audio appliances for head-phones application, this work analyzes the noise caused by the inter-channel interference during the integration and optimizes the design of the sigma-delta modulator to decrease the performance degradation caused by the noise. The asymmetric PWM is implemented to reduce switching noise and power loss generated from the power amplifier. This proposed architecture is fabricated in 0.13-mm CMOS technology. The proposed audio DAC including the power amplifier with single-ended output achieves a dynamic range (DR) of 95-dB dissipating 4.4-mW.

A comparative evaluation of $CO_2$ and erbium-doped yttrium aluminium garnet laser therapy in the management of dentin hypersensitivity and assessment of mineral content

  • Belal, Mahmoud Helmy;Yassin, Abdulaziz
    • Journal of Periodontal and Implant Science
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    • v.44 no.5
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    • pp.227-234
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    • 2014
  • Purpose: Dentin hypersensitivity is a potential threat to oral health. Laser irradiation may provide reliable and reproducible treatment but remains controversial. The present study aimed to evaluate the effects of $CO_2$ or erbium-doped yttrium aluminium garnet (Er:YAG) laser therapy, and to assess mineral content. Methods: Eighteen human single-rooted teeth affected with advanced periodontitis were obtained. Buccal and lingual surfaces were planed to form 36 specimens. Ethylenediaminetetraacetic acid gel (24%) was applied to remove the smear layer and simulate hypersensitive teeth. The experimental groups were: group 1, control (no irradiation); group 2, $CO_2$ laser (repetitive pulsed mode, 2 W, $2.7J/cm^2$); and group 3, Er:YAG laser (slight contact mode, 40 mJ/pulse and 10 Hz). To evaluate dentinal tubule occlusion, six specimens per group (2-mm thickness) were prepared and observed using scanning electron microscopy (SEM) for calculation of the occlusion percentage. To evaluate the mineral content, six specimens per group (0.6-mm thickness) were used, and then the levels of Ca, K, Mg, Na, and P were measured by inductively coupled plasma-atomic emission spectrometry. In addition, the surface temperature of the specimens during laser irradiation was analyzed by a thermograph. Results: The SEM photomicrographs indicated melted areas around exposed dentinal tubules and a significantly greater percentage of tubular occlusion in the $CO_2$ and Er:YAG laser groups than the control, and in the Er:YAG group than the $CO_2$ laser group. In addition, no significant differences were noted among the experimental groups for the mineral elements analyzed. The $CO_2$ laser group showed an evident thermal effect compared to the Er:YAG group. Conclusions: $CO_2$ and Er:YAG laser are effective in treating dentin hypersensitivity and reducing its symptoms. However, the Er:YAG laser has a more significant effect; thus, it may constitute a useful conditioning item. Furthermore, neither $CO_2$ nor Er:YAG lasers affected the compositional structure of the mineral content.