• 한국신재생에너지학회:학술대회논문집
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• 2008.05a
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• pp.572-575
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• 2008

Flow-field design has much influence over the performance of proton exchange membrane fuel cell (PEMFC) because it affects the pressure magnitude and distribution of the reactant gases. To obtain the pressure magnitude and distribution of reactant gases in four kinds of flow-field designs without additional measurement equipment, computational fluid dynamics (CFD) analysis was performed. After the CFD analysis, the performance values of PEMFC according to the flow-field configurations were measured via a single cell test. As expected, the pressure differences due to different flow-field configurations were related to the PEMFC performance because the actual performance results showed the same tendency as the results of the CFD analysis. A large pressure drop resulted in high PEMFC performance. So, the single serpentine configuration gave the highest performance. On the other hand, the parallel flow-field configuration gave the lowest performance because the pressure difference between inlet and outlet was the lowest.

• Dementia and Neurocognitive Disorders
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• v.17 no.4
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• pp.131-136
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• 2018

Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP, PSEN1, PSEN2, ABCA7, and SORL1. Genome-wide association studies have found risk genes such as ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-HLA-DRB1, INPP5D, MEF2C, MS4A6A/MS4A4E, NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1. ABCA7, SORL1, TREM2, and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.

• Journal of the Korean Ceramic Society
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• v.43 no.12 s.295
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• pp.788-797
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• 2006

An anode-supported SOFC single cell having $5{\mu}m$ thin electrolyte was fabricated cost-effectively by tape casting, laminating, and co-filing of anode (NiO-YSZ), cathode (LSM-YSZ), and electrolyte (YSZ) components. The optimal slurry compositions of the green tapes for SOFC components were determined by an analysis of the mean diameter, the slurry viscosity, the tensile strength/strain of the green tapes, and their green microstructures. The single cells with a dense electrolyte and porous electrodes could be co-fired successfully at $1325\sim1350^{\circ}C$ by controlling the contents of pore former and the ratio of coarse YSZ and fine YSZ in the anode and the cathode. The single cell co-fired at $1350^{\circ}C$ showed $100.2mWcm^{-2}$ of maximum power density at $800^{\circ}C$ but it was impossible to apply it to operate at low temperature because of low performance and high ASR, which were attributed to formation of the secondary phases in the cathode and the interface between the electrolyte and the cathode.

• The Transactions of the Korean Institute of Power Electronics
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• v.27 no.6
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• pp.526-534
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• 2022

The modular multilevel converter (MMC) has been widely applied to various industrial areas because of its various advantages and structural characteristics. Therefore, many methods for synthesizing the output voltage of MMC have been studied. Among these methods, phase-shifted pulse width modulation (PSPWM) is frequently used in MMC systems because it has diverse merits, such as excellent output qualities even with a small number of cells and uniform power distribution among cells. In this study, the total harmonic distortion (THD) of the output voltage is analyzed in accordance with the number of cells in one arm of a single-delta bridge cell MMC in order to compare PSPWM methods in terms of the THD of the output voltage. The physical characteristics of the triangle and sawtooth carrier waves used for the PSPWM and the mathematical modeling of output voltage are introduced. Then, the obtained results are verified through real-time simulation of a 1 MW single-delta bridge cell MMC system.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.1
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• pp.1-11
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• 1997

We examine the DS/SSMA system which is employing coherent BPSK with RAKE receiver. We adop Nakagami m-distribution as a multipath fading model. First, we analyze the performances of the system in the single cell environment and obtain the other-cell interference according to power control error. And considering the other-cell interference into the analysis of single cell system, we examine the cellular CDMA network. The average BER and outage probability are the figures of merit that characterize the system performance. The required BER, 1E-3, and required outage probability are the figures of merit that characterize the system performance. The requeired BER, 1E-3, and required outage probability, 1% for the voice transmission is considered to acquire the capacity of system.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2005.11a
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• pp.198-201
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• 2005

This study investigates the difference between single-cell and multi-cell cross-sections of thin-walled beams. The variationally and asymptotically consistent theory is used in order to model the two-cell thin- walled beam. The theory is based on an asymptotical analysis of two-dimensional shell energy. In addition, the method allows for the development of closed-form expressions for the displacement, stress field and beam stiffness coefficients. The numerical results show the difference between the cross-sectional stiffness of single-cell and that of multi-cell.

• Molecules and Cells
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• v.44 no.3
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• pp.136-145
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• 2021

Senescent cells that gradually accumulate during aging are one of the leading causes of aging. While senolytics can improve aging in humans as well as mice by specifically eliminating senescent cells, the effect of the senolytics varies in different cell types, suggesting variations in senescence. Various factors can induce cellular senescence, and the rate of accumulation of senescent cells differ depending on the organ. In addition, since the heterogeneity is due to the spatiotemporal context of senescent cells, in vivo studies are needed to increase the understanding of senescent cells. Since current methods are often unable to distinguish senescent cells from other cells, efforts are being made to find markers commonly expressed in senescent cells using bulk RNA-sequencing. Moreover, single-cell RNA (scRNA) sequencing, which analyzes the transcripts of each cell, has been utilized to understand the in vivo characteristics of the rare senescent cells. Recently, transcriptomic cell atlases for each organ using this technology have been published in various species. Novel senescent cells that do not express previously established marker genes have been discovered in some organs. However, there is still insufficient information on senescent cells due to the limited throughput of the scRNA sequencing technology. Therefore, it is necessary to improve the throughput of the scRNA sequencing technology or develop a way to enrich the rare senescent cells. The in vivo senescent cell atlas that is established using rapidly developing single-cell technologies will contribute to the precise rejuvenation by specifically removing senescent cells in each tissue and individual.

• Korean Journal of Animal Reproduction
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• v.27 no.3
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• pp.225-231
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• 2003

Transgenic mice containing Diphtheria Toxin-A (DT-A) gene fused to proximal lck promoter sequences was used for analysis of DT-A gene expression and thymocyte development. The diphtheria toxin gene was expressed in thymus, spleen and liver of transgenic mice confirmed by RT-PCR and Northern blotting. A FACS analysis with thymocyte cell surface antigens antibodies (CD4 and CD8) showed that the number of peripheral mature single positive thymocytes ($CD4^{+}\;and\;CD8^{+}$ cells) T-cells was severely reduced in transgenic mice compared to that in the non-transgenic littermates. A relative portion of $CD8^{+}$ single positive thymocytes was about 33.2% in transgenic peripheral T-cells while 50.6% in wild type. Reduction of $CD4^{+}$ cell numbers in transgenic mice was observed (5.9% in transgenic versus 10.3% in non-transgenic). The data from analysis of these transgenic mice indicate that the proximal lck promoter regulated the expression of DT-A gene at high level in developing thymocytes and the DT-A disrupted developing thymocytes in transgenic mice.

• Molecules and Cells
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• v.46 no.2
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• pp.69-70
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• 2023

• Composites Research
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• v.34 no.1
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• pp.30-34
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• 2021

This paper present a three-dimensional unit cell finite element analysis to predict the pull-out behavior of a single stitch in a composite laminate. The stitching process used for this study correspond to the I-fiber stitching method that has been studied by the Composite Structures Lab (CSL) as a new through-thickness reinforced method. A total of six cases were analyzed, which were divided in two groups by the stitching yarn used, 6k and 12k. Each group of cases have three different thickness according to the amount of plies; 16 plies, 32 plies and 64 plies. The finite element analysis used the cohesive zone method to characterize the single stitch reinforcement in the interface. Due to the complexity of the load vs displacement curves taken from the experimental results, a bilinear and trilinear bridging laws were implemented in the models. The cohesive parameters used for each case showed a good agreement with the experimental data and can be used for future studies.