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On-chip Power Supply Noise Measurement Circuit with 2.06mV/count Resolution (2.06mV/count의 해상도를 갖는 칩 내부 전원전압 잡음 측정회로)

  • Lee, Ho-Kyu;Jung, Sang-Don;Kim, Chul-Woo
    • Journal of IKEEE
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    • v.13 no.4
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    • pp.9-14
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    • 2009
  • This paper describes measurement of an on-ship power supply noise in mixed-signal integrated circuits. To measure the on-chip power supply noise, we can check the effects of analog circuits and compensate it. This circuit consists of two independent measurement channels, each consisting of a sample and hold circuit and a frequency to digital converter which has a buffer and voltage controlled oscillator(VCO). The time-based voltage information and frequency-based power spectrum density(PSD) can be achieved by a simple analog to digital conversion scheme. The buffer works like a unit-gain buffer with a wide bandwidth and VCO has a high gain to improve resolution. This circuit was fabricated in a 0.18um CMOS technology and has 2.06mV/count. The noise measurement circuit consumes 15mW and occupies $0.768mm^2$.

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Imported Malaria in United Arab Emirates: Evaluation of a New DNA Extraction Technique Using Nested PCR

  • Sultan, Doaa M.;Khalil, Marwa M.;Abdouh, Ahmed S.;Doleh, Wafaa F.;AI Muthanna, Abdul Aziz M.
    • Parasites, Hosts and Diseases
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    • v.47 no.3
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    • pp.227-233
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    • 2009
  • Local malaria transmission in the United Arab Emirates (UAE) came to an end in 1997. Nevertheless, UAE has been subjected to substantial importation of malaria cases from abroad, concerning both UAE nationals and immigrants from malarious countries with a total number of 2,119 cases in 2007. To evaluate a new DNA extraction technique using nested PCR, blood samples were collected from 132 individuals who presented to Infectious Diseases Department in Rashid Hospital, Dubai, and Central Department of Malaria Control with fever and persistent headache. Giemsa-stained blood films and ELISA test for malaria antibodies were carried out for detection of Plasmodium infection. Plasmodium infections were identified with the genus-specific primer set and species differentiation using nested PCR. A rapid procedure for diagnosis of malaria infections directly from dried blood spots using for the first time DNA extract from FTA Elute cards was evaluated in contrast to extraction techniques using FTA classic cards and rapid boiling technique. Our new simple technique for DNA extraction using FTA Elute cards was very sensitive giving a sensitivity of 100% compared to 94% using FTA classic cards and 62% in the rapid boiling technique. No complex preparation of blood samples was required prior to the amplification. The production cost of DNA isolation in our PCR assay was much less incomparable to that of other DNA extraction protocols. The nested PCR detected plasmodial infection and could differentiate P. falciparum from P. vivax, and also detected the mixed infection.

One-step microwave synthesis of magnetic biochars with sorption properties

  • Zubrik, Anton;Matik, Marek;Lovas, Michal;Stefusova, Katarina;Dankova, Zuzana;Hredzak, Slavomir;Vaclavikova, Miroslava;Bendek, Frantisek;Briancin, Jaroslav;Machala, Libor;Pechousek, Jiri
    • Carbon letters
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    • v.26
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    • pp.31-42
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    • 2018
  • Adsorption is one of the best methods for wastewater purification. The fact that water quality is continuously decreasing requires the development of novel, effective and cost available adsorbents. Herein, a simple procedure for the preparation of a magnetic adsorbent from agricultural waste biomass and ferrofluid has been introduced. Specifically, ferrofluid mixed with wheat straw was directly pyrolyzed either by microwave irradiation (900 W, 30 min) or by conventional heating ($550^{\circ}C$, 90 min). Magnetic biochars were characterized by X-ray powder diffraction, $M{\ddot{o}}ssbauer$ spectroscopy, textural analysis and tested as adsorbents of As(V) oxyanion and cationic methylene blue, respectively. Results showed that microwave pyrolysis produced char with high adsorption capacity of As(V) ($Q_m=25.6mg\;g^{-1}$ at pH 4), whereas conventional pyrolysis was not so effective. In comparison to conventional pyrolysis, one-step microwave pyrolysis produced a material with expressive microporosity, having a nine times higher value of specific surface area as well as total pore volume. We assumed that sorption properties are also caused by several iron-bearing composites identified by $M{\ddot{o}}ssbauer$ spectroscopy ([super] paramagnetic $Fe_2O_3$, ${\alpha}-Fe$, non-stoichiometric $Fe_3C$, ${\gamma}-Fe_2O_3$, ${\gamma}-Fe$) transformed from nano-maghemite presented in the ferrofluid. Methylene blue was also more easily removed by magnetic biochar prepared by microwaves ($Q_m=144.9mg\;g^{-1}$ at pH 10.9) compared to using conventional techniques.

Feasibility Analysis of Rapid Quality Evaluation Method for Blast Furnace Slag Using Hydrometer (Hydrometer를 이용한 고로슬래그 미분말의 분말도 품질 신속평가 가능성 분석)

  • Han, Cheon-Goo;Joo, Eun-Hui
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.6 no.1
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    • pp.43-49
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    • 2018
  • The aim of the research is to analyze the feasibility of rapid quality evaluation method for blast furnace slag using hydrometer based on the former research of the prediction method for concrete compressive strength using hydrometer. Using this method, it is expected to provide a new application for blast furnace slag quality evaluation easily and rapidly during the receiving inspection. According to the experimental results, the settling time period of hydrometer was delayed with increased fineness of blast furnace slag. By using the regression equation of y = 198 120 x - 193 936(R=0.9398) obtained from the correlation between density of suspension at three minutes and fineness, it was possible to evaluate the quality of blast furnace slag fineness rapidly. Therefore, for ready-mixed concrete receiving inspection, the suggested method can be used as a cheap, a simple, and a rapid inspection method.

Characteristics of Interior Space and Planning for Elderly Day Care Center in Korea (우리나라 노인주간보호시설의 실내공간 특성과 계획안)

  • 이선주;권오정
    • Journal of Families and Better Life
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    • v.21 no.1
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    • pp.1-12
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    • 2003
  • Day care center for the elderly is an alternative for community care for frail elderly who need social participation and physical cares and services outside the family. The purpose of this study was to identify the present situation of day care center for the elderly and to suggest desirable interior space plans for elderly day care center. Data were collected by two ways; a mail survey and case studies of existing day care centers. Five cases of day care centers were analyzed to find out Physical and space problems, available programs and services. Also, the staffs in 96 day care centers for the elderly in nationwide were selected for a mail survey and 68.8 percentage of all was collected and analyzed. From the result of case studies, narrow space and lack of accessibility features for wheelchair or other prosthetic devices were the major problems. From the result of a mail survey analysis, the elderly users were over 73 years old, and high proportion had suffered from dementia and apoplexy Also, staffing ration was 1:7 In other words, one staff was caring of 7 old people, and supporting staff was insufficient. Therefore, supportive, therapeutic environment Was more important issue to improve quality of care. Separate program room and outdoor space, lounging space, treatment room by gardening, separate counselling room, bedroom, a simple kitchen unit, staff office, separate physical treatment room, resting room for staff was indicated more necessarily. When priority of planning interior space was safety followed by accessability and convenience, it was also reported that sire of each room was generally narrow. The most serious problem in interior space was the lack and narrowness of space, and accessible features for mobility. Based on the literature review and the findings of this study, two types of floor plans for elderly day care center were suggested;‘a mixed type for the elderly with and without dementia’and‘a separate type for the elderly with dementia.’The main goals for designing interior space for two types of elderly day care center were to provide safe environment, encouraging environment for remaining abilities of users, sanitary environment, therapeutic environment, familiar environment, and socially-encouraging environment. The recommendations for further studies were suggested.

The Effects of Cystic Tyroid Lesions by Ethanol-Instillation (갑상선 낭종 환자에서 Ethanol 경화술의 효과)

  • Lee Hui-Seop;Kim Sang-Woon;Lee Soo-Jung;Shim Min-Chul;Kwun Koing-Bo
    • Korean Journal of Head & Neck Oncology
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    • v.11 no.1
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    • pp.18-23
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    • 1995
  • We analyzed the results of ethanol sclerotherapy in 47 patients with cystic thyroid lesion. Cytologic study showed all of the lesions to be benign. The patients were followed clinically and ultrasonically I month and 3 or more months after ethanol sclerotherapy. If the cystic lesions recurred, repeated treatment was offered. In 4 patients with pure cystic lesion, all of the patents had almost total resolution of the cystic lesions. In 43 patients with mixed cystic lesion, 16(37.2%) patients had almost total resolution of the cystic lesions, 10(23.3%) patients showed a decrease' in the cystic lesion of <50%, but 11(25.6%) patients it did not change in size. Overall, in 30(63.8%) patients the cystic lesion decreased in size. Eleven patients who were not effective by sclerotherapy or follicular proliferation by cytology were converted to surgery. Although no severe complication were observed, there were complication of severe pain in I patient and a drunken feeling in I patient. If the malignancy must be excluded by repeated cytologic examination of aspirated fluid, we consider instillation of ethanol into the cystic lesions of the thyroid to be a simple, safe, economical and effective treatment.

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Studies on Distributions and Morphological Characteristics of Calanthe discolor, C. sieboldii, and C. bicolor Native to Cheju Province (제주 자생 새우란, 금새우란, 왕새우란의 분포와 외형적 특성에 관한 연구)

  • Hyun, Myung-Ryuk;Choi, Ji-Yong;Suh, Jung-Nam;So, In-Sup;Lee, Jong-Suk
    • Horticultural Science & Technology
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    • v.17 no.4
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    • pp.497-499
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    • 1999
  • Distribution analysis on natural habitats for the genus Calanthe in Mt. Halla of Cheju province revealed that C. discolor and C. sieboldii were found mostly in the range of 120~400 m and 300~600 m above the sea level, respectively. C. bicolor was found in 300~400 m where both C. discolor and C. sieboldii were overlapped. The present morphological assessments showed that C. discolor had the smallest sizes of leaves and floral parts, C. had the largest, while C. bicolor had the intermediate between the above mentioned two species. Flower colors of C. discolor were brownish red and simple white, and that of C. sieboldii was merely golden yellow, whereas C. bicolor had a diverse mixed colors originated from the other two species. The specific distribution of natural habitats and morphological characteristics of three Calanthe species led the suggestion that C. bicolor can be regarded as new species derived originally from natural hybridization between C. discolor and C. sieboldii.

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Hydrographic Analysis of Surface Water Using Radium Isotopes Signature in the East and South China Sea in Summer (여름철 동중국해 및 남중국해 표층수의 Ra 동위원소를 이용한 수계분석)

  • Yang, Han-Soeb;Lee, Tong-Sup
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.4 no.4
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    • pp.305-311
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    • 1999
  • This study aims to decipher surface water mass interaction in summer in the South China Sea and East China Sea by radium isotope distribution pattern. Salinity and activity ratio of radium ($^{228}Ra/^{226}Ra$) showed gradual changes, which were adequate to apply simple two end-member mixing between Kuroshio surface water and Changjiang Dilute Water for the East China Sea and the former and Nearshore Diluted Watermass (NDW) for the South China Sea. Two tracer methods, salinity and Ra isotope ratio, were compared for East China Sea. Results showed remarkable consistency for waters near Kuroshio, however, discrepancy were noticeable after Tsushima Warm Current branching. Mixing with subsurface waters may cause the discrepancy. When mixed with subsurface waters, salts and radium isotope ratio are expected to be biased in opposite direction, i. e. prone to underestimate the fraction of less saline water in the case of salts and vice versa for Ra isotope ratio. Taking the mean values of two different results seems more realistic to estimate fraction of end-members.

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Development of a Rapid Diagnostic Test Kit to Detect IgG/IgM Antibody against Zika Virus Using Monoclonal Antibodies to the Envelope and Non-structural Protein 1 of the Virus

  • Kim, Yeong Hoon;Lee, Jihoo;Kim, Young-Eun;Chong, Chom-Kyu;Pinchemel, Yanaihara;Reisdorfer, Francis;Coelho, Joyce Brito;Dias, Ronaldo Ferreira;Bae, Pan Kee;Gusmao, Zuinara Pereira Maia;Ahn, Hye-Jin;Nam, Ho-Woo
    • Parasites, Hosts and Diseases
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    • v.56 no.1
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    • pp.61-70
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    • 2018
  • We developed a Rapid Diagnostic Test (RDT) kit for detecting IgG/IgM antibodies against Zika virus (ZIKV) using monoclonal antibodies to the envelope (E) and non-structural protein 1 (NS1) of ZIKV. These proteins were produced using baculovirus expression vector with Sf9 cells. Monoclonal antibodies J2G7 to NS1 and J5E1 to E protein were selected and conjugated with colloidal gold to produce the Zika IgG/IgM RDT kit (Zika RDT). Comparisons with ELISA, plaque reduction neutralization test (PRNT), and PCR were done to investigate the analytical sensitivity of Zika RDT, which resulted in 100% identical results. Sensitivity and specificity of Zika RDT in a field test was determined using positive and negative samples from Brazil and Korea. The diagnostic accuracy of Zika RDT was fairly high; sensitivity and specificity for IgG was 99.0 and 99.3%, respectively, while for IgM it was 96.7 and 98.7%, respectively. Cross reaction with dengue virus was evaluated using anti-Dengue Mixed Titer Performance Panel (PVD201), in which the Zika RDT showed cross-reactions with DENV in 16.7% and 5.6% in IgG and IgM, respectively. Cross reactions were not observed with West Nile, yellow fever, and hepatitis C virus infected sera. Zika RDT kit is very simple to use, rapid to assay, and very sensitive, and highly specific. Therefore, it would serve as a choice of method for point-of-care diagnosis and large scale surveys of ZIKV infection under clinical or field conditions worldwide in endemic areas.

A Study on Analysis of Residual Antibiotics and Prop Acid in Honey (벌꿀중의 잔유항생물질 및 Propionic Acid 분석011 관한 조사연구)

  • 전상수
    • Journal of environmental and Sanitary engineering
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    • v.5 no.2
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    • pp.63-80
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    • 1990
  • A sensitive and simple analytical system for the simultaneous determination of residual oxytetracycline, tetracycline, and doxycycline in honey was described, and that the analytical method for determination of residual propionic acid in honey was established. Experimental subjects were purchased four kinds of honey, native kind honey, acaccia honey, mixed floral honey, chestnut honey in Kyung Sang Nam Do. Several microbiological methods are available to determine tetracycline antibiotecs(TCs) in foods but their precision apears to be variable and the specificity is questionable. These methods are considered to be not suitable for analysis of tetracycline antibiotics in honey because honey itself has bacteriostatic action. For determination of tetracycline antibiotics in honey, therefore the High Performance Liquid Chromatography(HPLC) method was applied, and the propionic acid were determined by Gas Chromatography(5.C). Ethylacetate, as an extract solvent, was found to be suitable for seperation of TCs in honey, but methanol and acetone were not. The recoverly rate of Oxytetracycline(OTC), Tetracycline(TC), Doxycycline(DC) from honey spiked at a level of 10 $\mu $g/g were 97%, 89%, and 91%, respectively. The cailbration curve in TCs was linear expression from 2$\mu $g/ml to 10$\mu $g/ml. As the results of analysis, the residual tetracycline antibiotics were not detected in the 100 samples of honey. The recovery rate of propionic acid from honey spiked at level of 10$\mu $g/g was 98.3% , and the calibra lion curves were linear expression from 21$\mu $g/ml to 101$\mu $g/ml. As the results of analysis, the residual propionic acid was not detected in the 100 samples of honey. Retention time(min) of OTC, DC, and TC were 3.35, 4.61, and 5.30 minutes at the conditions of table 2, respectively, and retention time(min) of propionic acid was 3.50 minutes at the conditions of table 3. The residual TCs and propionic acid were not detected in the 100 samples of honey, but there is a possibility that antibiotics or propionic acid will be to remain in honey if they are used during product period in order to prevent putrefaction of honey-bee.

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