• Investigative Magnetic Resonance Imaging
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• 제22권3호
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• pp.158-167
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• 2018

Purpose: To investigate the surgical, perfusion, and molecular characteristics of glioblastomas which influence long-term survival after treatment, and to explore the association between MR perfusion parameters and the presence of MGMT methylation and 1p/19q deletions. Materials and Methods: This retrospective study was approved by our institutional review board. A total 43 patients were included, all with pathologic diagnosis of glioblastoma with known MGMT methylation and 1p/19q deletion statuses. We divided these patients into long-term (${\geq}60\;months$, n = 7) and short-term (< 60 months, n = 36) survivors, then compared surgical extent, molecular status, and rCBV parameters between the two groups using Fisher's exact test or Mann-Whitney test. The rCBV parameters were analyzed according to the presence of MGMT methylation and 1p/19q deletions. We investigated the relationship between the mean rCBV and overall survival using linear correlation. Multivariable linear regression was performed in order to find the variables related to overall survival. Results: Long-term survivors (100% [7 of 7]) demonstrated a greater percentage of gross total or near total resection than short-term survivors (54.5% [18 of 33]). A higher prevalence of 1p/19q deletions was also noted among the long-term survivors (42.9% [3 of 7]) than the short-term survivors (0.0% [0 of 36]). The rCBV parameters did not differ between the long-term and short-term survivors. The rCBV values were marginally lower in patients with MGMT methylation and 1p/19q deletions. Despite no correlation found between overall survival and rCBV in the whole group, the short-term survivor group showed negative correlation ($R^2=0.181$, P = 0.025). Multivariable linear regression revealed that surgical extent and 1p/19q deletions, but not rCBV values, were associated with prolonged overall survival. Conclusion: While preoperative rCBV and 1p/19q deletion status are related to each other, only surgical extent and the presence of 1p/19q deletion in GBM patients may predict long-term survival.

• STI Policy Review
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• 제9권1호
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• pp.55-76
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• 2018

This study analyzed the effect of the government R&D subsidy program on long-term firm survival. In order to estimate the average treatment effect for the treated group, we used the survival analysis and matching method by constituting a comprehensive dataset of more than 90,000 observations. The analysis results show that the government R&D subsidy has a negative impact on long-term firm survival. In particular, not only the subsidy does not have a statistically significant effect on firm survival in the relatively short-term, the survival probability of the subsidized firms is statistically significantly lower than the non-subsidized firms after six years. These results can be seen as weakening the justification of government R&D support. There may be problems in the subsidy policy itself and the process of selection of subsidy awardees; however, the more fundamental problem is that the subsidy policy is concluded as the one-time event. Admittedly, it would be difficult for the government to precisely manage the subsidized projects over a long term period. However, in the case of a project in which short-term performance is detected, it would be necessary to provide a step-by-step support to strengthen the firm's competitiveness through further support and continuous development of performance. Of course, mid- and long-term evaluations of subsidy support policy should be performed in parallel with such phased support.

• 대한한의학회지
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• 제32권4호
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• pp.75-82
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• 2011

Objectives: This case report aimed to evaluate whether oriental medical treatment was effective on ADHD through a records review of a local oriental medical clinic. Methods: We reviewed clinical charts of a local oriental medical clinic between December 2007 and September 2010 to select ADHD patients. Among those patients, for comparison before and after treatment, we selected cases which had at least twice Stroop test results and 2 months of treatment. Baseline, 3-month and 6-month Stroop test results were compared. Oriental medical treatment consisted of 2 months' herbal medicine, periodic acupuncture and exercise. Results: 1. 3-month data showed that subjects were 12 and improved word score and word-color score of Stroop test. 2. 6-month data showed that subjects were 20 and improved word score, color score, and word-color score of Stroop test. Conclusions: 1. Relatively short term herbal medication and exercise are effective on the word score and word-color score of the Stroop test. 2. After short term herbal medication, continuous exercise maintained the effects of short term oriental medical treatment. 3. We need to consider the balance of left and right as an important point of exercise, but further study is needed.

• Nuclear Engineering and Technology
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• 제54권12호
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• pp.4534-4550
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• 2022

Integrated severe accident codes should be capable of simulating not only specific physical phenomena but also entire plant behaviors, and in a sufficiently fast time. However, significant uncertainty may exist owing to the numerous parametric models and interactions among the various phenomena. The primary objectives of this study are to present best-practice uncertainty and sensitivity analysis results regarding the evolutions of severe accidents (SAs) and fission product source terms and to determine the effects of mitigation measures on them, as expected during a short-term station blackout (STSBO) of a reference pressurized water reactor (optimized power reactor (OPR)1000). Three reference scenarios related to the STSBO accident are considered: one base and two mitigation scenarios, and the impacts of dedicated severe accident mitigation (SAM) actions on the results of interest are analyzed (such as flammable gas generation). The uncertainties are quantified based on a random set of Monte Carlo samples per case scenario. The relative importance values of the uncertain input parameters to the results of interest are quantitatively evaluated through a relevant sensitivity/importance analysis.

• 대기
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• 제26권4호
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• pp.599-615
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• 2016

This study investigates the accuracy of short-term ocean predictions during the development of ocean stratification for the Korea Meteorological Administration (KMA) Global Seasonal Forecast System version 5 (GloSea5) as well as the effect of atmosphere-ocean coupling on the predictions through a series of sensitive numerical experiments. Model performance is evaluated using the marine meteorological buoys at seas around the Korean peninsular (KP), Tropical Atmosphere Ocean project (TAO) buoys over the tropical Pacific ocean, and ARGO floats data over the western North Pacific for boreal winter (February) and spring (May). Sensitive experiments are conducted using an ocean-atmosphere coupled model (i.e., GloSea5) and an uncoupled ocean model (Nucleus for European Modelling of the Ocean, NEMO) and their results are compared. The verification results revealed an overall good performance for the SST predictions over the tropical Pacific ocean and near the Korean marginal seas, in which the Root Mean Square Errors (RMSE) were $0.31{\sim}0.45^{\circ}C$ and $0.74{\sim}1.11^{\circ}C$ respectively, except oceanic front regions with large spatial and temporal SST variations (the maximum error reached up to $3^{\circ}C$). The sensitive numerical experiments showed that GloSea5 outperformed NEMO over the tropical Pacific in terms of bias and RMSE analysis, while NEMO outperformed GloSea5 near the KP regions. These results suggest that the atmosphere-ocean coupling substantially influences the short-term ocean forecast over the tropical Pacific, while other factors such as atmospheric forcing and the accuracy of simulated local current are more important than the coupling effect for the KP regions being far from tropics during the development of ocean stratification.

• 한국도로학회논문집
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• 제7권4호
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• pp.203-210
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• 2005

바인더의 노화로 인한 성능변화는 침입도 또는 점도시험을 실시하여 판정하여왔다. 기존의 시험방법으로 아스팔트 바인더의 점탄성 특성과 실제거동을 평가할 수 없기 때문에 새로운 분석방법이 요구되어 왔다. 본 연구에서는 기존시험 방법을 사용하여 침입도지수와 잔류침입도를 판정하였고, 양방향 반복회전 모드와 일방향 반복회전 모드 시험을 실시하여 단기 노화된 아스팔트 바인더의 유변학적 특성을 분석하였다. 시험결과 단기 노화된 아스팔트 바인더는 시험주기(frequency) 즉, 차량속도의 변화에 따라 서로 다른 복합계수와 위상각을 나타냈으며 단기 노화 전후의 크리프 컴플라이언스 및 전단점도 시험결과에도 영향을 미치는 것으로 나타나서 포장 설계시 이러한 특성이 고려되어야 한다.

• 한국운동역학회지
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• 제27권2호
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• pp.83-90
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• 2017

Objective: To investigate the effect of short-term vibration frequencies on muscle force generation capabilities. Method: Six healthy participants were recruited for this study and only their dominant leg was tested. The subjects were tested under five conditions of vibration frequencies with constant amplitude: 0 Hz (no vibration), 30 Hz, 60 Hz, and 90 Hz, and the vibration amplitude was 10 mm for all frequency conditions. The vibration was applied to the rectus femoris (RF). The subjects were then instructed to maintain a steady-state isometric knee joint torque (100 Nm) for the first 6 s. After the steady-state torque production, the subjects were required to produce isometric knee joint torque by leg extension as hard as possible with a start signal within the next 3 s. The vibration was applied for ~4 s starting from 1 s before initiation of the change in the steady-state knee joint torque. Results: The results showed that the maximum voluntary torque (MVT) of the knee joint increased with the vibration frequencies. On average, the MVTs were 756.47 Nm for 0 Hz (no vibration) and 809.61 Nm for 90 Hz. There was a significant positive correlation (r = 0.71) between the MVTs and integrated electromyograms (iEMGs). Further, the co-contraction indices (CCIs) were computed, which represent the ratio of the iEMGs of the antagonist muscle to the iEMGs of all involved muscles. There was a significant negative correlation (r = 0.62) between the CCIs and MVTs, which was accompanied by a significant positive correlation (r = 0.69) between the iEMGs of the vibrated muscle (RF). There was no significant correlation between the MVTs and iEMGs of the antagonist muscle. Conclusion: The results of this study suggest that the short-term vibration on the muscle increases the level of muscle activation possibly owing to the increased Ia afferent activities, which enhances the muscle force generation capability.

• 한국대기환경학회지
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• 제15권5호
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• pp.545-554
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• 1999

We would like to develop a short-term model to predict the time-related concentration of ozone whose reaction mechanism is complex. The paper targets Seoul where an ozone alert system has recently been employed. In order to develop a short-term prediction model for ozone, we suggested the Ozone Peak Indicator(OPI), an equivalent of the potential daily maximum ozone concentration, with precursors being the only limiting factor, and we calculated the Ozone Peak Indicarot as OPI={$rac{(O_3)_{max}cdot(H_{eH})_{max}(Rad)_{max}$ to preclude the influence of mixing height and solar radiation on the daily maximum ozone concentration. The OPI on the day of the prediction is to be calcultated by using the relation between OPI and the initial value of precursors. The basic prediction formula for time-related ozone concentration was established as $O_3(1)={(OPI)cdot Rad(t-2)H_{eH}}$, using the OPI, solar radiation two hours before prediction and mixing height. We developed, along with the basic formula for predicting photochemical oxidants, "SEOM"(Seoul Empirical Oxidants Model), a Fortran program that helps predict solar radiation and mixing height needed in the prediction of ozone pollution. When this model was applied to Seoul and an analysis of the correlation between the observed and the predicted ozone concentrations was made through SEOM, there appeared a very high correlation, with a coefficient of 0.815. SEOM can be described as a short-term prediction model for ozone concentration in large cities that takes into account the initial values of precursors, and changes in solar radiation and mixing height. SEOM can reflect the local characteristics of a particular and region can yield relatively good prediction results by a simple data input process.t process.

• 한국실천공학교육학회논문지
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• 제4권1호
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• pp.13-21
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• 2012

본 연구는 직업훈련교사에 대한 단기교육의 만족도를 결정짓는 요인을 살펴보는 것을 목적으로 하며, 이를 위하여 개발도상국 직업훈련교사에 대한 국내초청 단기교육의 사례를 분석하였다. 실증분석은 2008년부터 2011년까지 개발도상국 직업훈련교사들의 직업능력역량 강화를 위하여 한국산업인력공단에서 주관하는 'ODA 국내초청 직업훈련 프로그램'에 참가한 개발도상국 직업훈련교사 226명의 설문지에 대해서 실시되었다. 실증분석결과 훈련 전수요조사 정도가 높을수록, 훈련기간이 길수록, 훈련생의 전공과 일치되고 학습수준에 적합할수록 직업훈련 단기교육에 대한 만족도가 높았다. 본 연구의 결과를 토대로 ODA 국내초청연수와 직업훈련교사 단기교육에 대한 시사점을 도출하면, 교육생의 인적특성을 고려한 프로그램이 개발되어야 하고, 교육생의 초기 학습 수준과 적성을 반영할 수 있는 세분화된 교육과정개발이 필요하다고 요약될 수 있다.

• 한국빅데이터학회지
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• 제4권2호
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• pp.35-45
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• 2019

욕설과 비속어를 포함한 악성 댓글에 대한 피해는 최근 언론에 나오는 연애인의 자살뿐만 아니라 사회 전반에서 다양한 형태로 증가하고 있다. 이 논문에서는 양방향 장단기 메모리 신경망 모델을 이용하여 욕설을 검출하는 기법을 제시하였다. 웹 크룰러를 통해 웹상의 댓글을 수집하고, 영어나 특수문자 등의 사용하지 않은 글에 대해 불용어 처리를 하였다. 불용어 처리된 댓글에 대해 문장의 전·후 관계를 고려한 양방향 장단기 메모리 신경망 모델을 적용하여 욕설 여부를 판단하고 검출하였다. 양방향 장단기 메모리 신경망을 사용하기 위해 검출된 댓글에 대해 형태소 분석과 벡터화 과정을 거쳤으며 각 단어들에 욕설 해당 여부를 라벨링하여 진행하였다. 실험 결과 정제하고 수집된 총 9,288개의 댓글에 대해 88.79%의 성능을 나타내었다.