• Title/Summary/Keyword: short-term

Search Result 5,959, Processing Time 0.038 seconds

Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice

  • Park, Jong Hee;Ha, Hunjoo
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.19 no.3
    • /
    • pp.269-274
    • /
    • 2015
  • Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$ )-induced nuclear factor-${\kappa}B$ (NF-${\kappa}B$) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-${\kappa}B$ signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases.

Factors related to the short-term and long-term intentions of healthy eating among Chinese adults living in Shanghai and parts of Anhui Province of China using the theory of planned behavior (계획적 행동이론 기반 상하이 및 안후이성 거주 중국 성인의 건강한 식행동의 장단기 의도와 관련된 요인)

  • Liu, Ani;Lee, Seungwoo;Hwang, Ji-Yun
    • Journal of Nutrition and Health
    • /
    • v.55 no.1
    • /
    • pp.188-199
    • /
    • 2022
  • Purpose: This study investigated the relationship between 3 major constructs of the theory of planned behavior (TPB), i.e., attitude, subjective norms and perceived behavioral control (PBC) and past experience of healthy eating and intentions of healthy eating in the short-term and long-term in adults living in Shanghai and parts of Anhui Province, China. Methods: The online study questionnaire for this cross-sectional study was based on previously validated items. A total of 408 Chinese adults (aged 18-64 years) residing in Shanghai and parts of Anhui Province, China were included to examine relationships between 3 major constructs of TPB and past experience of healthy eating, and short-term and long-term intentions of healthy eating. Multiple linear regression model adjusted for age and body mass index (BMI) was employed to test relationships. Results: Only PBC among 3 major constructs of TPB was significantly related to short-term (p < 0.001) and long-term (p = 0.002) intention of healthy eating after adjustment for age and BMI. Past experience of healthy eating was more significantly related to long-term intention (p < 0.001) compared to short-term (p = 0.020) intention of healthy eating. The short-term and long-term intention models explained 70.5% and 48.8% of the variance, respectively. Conclusion: PBC is a potential determinant of both short-term and long-term behavioral intention of healthy eating regardless of past experience of healthy eating in adults residing in Shanghai and parts of Anhui Province, China. Our results indicate that programs promoting healthy eating to Chinese adults incorporate PCB to perform healthy eating under his or her control.

Travel Behavior Analysis for Short-term Railroad Passenger Demand Forecasting in KTX (KTX 단기수요 예측을 위한 통행행태 분석)

  • Kim, Han-Soo;Yun, Dong-Hee
    • Proceedings of the KSR Conference
    • /
    • 2011.05a
    • /
    • pp.1282-1289
    • /
    • 2011
  • The rail passenger demand for the railroad operations required a short-term demand rather than a long-term demand. The rail passenger demand can be classified according to the purpose. First, the rail passenger demand will be use to the restructure of line planning on the current operating line. Second, the rail passenger demand will be use to the line planning on the new line and purchasing the train vehicles. The objective of study is to analyze the travel behavior of rail passenger for modeling of short-term demand forecasting. The scope of research is the passenger of KTX. The travel behavior was analyzed the daily trips, origin/destination trips for KTX passenger using the ANOVA and the clustering analysis. The results of analysis provide the directions of the short-term demand forecasting model.

  • PDF

A Study on the Demand Forecasting by using Transfer Function with the Short Term Time Series and Analyzing the Effect of Marketing Policy (단기 시계열 제품의 전이함수를 이용한 수요예측과 마케팅 정책에 미치는 영향에 관한 연구)

  • Seo, Myeong-Yu;Rhee, Jong-Tae
    • IE interfaces
    • /
    • v.16 no.4
    • /
    • pp.400-410
    • /
    • 2003
  • Most of the demand forecasting which have been studied is about long-term time series over 15 years demand forecasting. In this paper, we set up the most optimal ARIMA model for the short-term time series demand forecasting and suggest demand forecasting system for short-term time series by appraising suitability and predictability. We are going to use the univariate ARIMA model in parallel with the bivariate transfer function model to improve the accuracy of forecasting. We also analyze the effect of advertisement cost, scale of branch stores, and number of clerk on the establishment of marketing policy by applying statistical methods. After then we are going to show you customer's needs, which are number of buying products. We have applied this method to forecast the annual sales of refrigerator in four branch stores of A company.

Estimation of Occurrence Frequency of Short Term Air Pollution Concentration Using Texas Climatological Model (Texas Climatological Model에 의한 短期 大氣汚染濃度 發生頻度의 推定)

  • Lee, Chong-Bum
    • Journal of Korean Society for Atmospheric Environment
    • /
    • v.4 no.2
    • /
    • pp.67-71
    • /
    • 1988
  • To estimate the probability of short term concentration of air pollution using long term arithmetic average concentration, the procedure was developed and added to Texas Climatological Model version 2. In the procedure, such statistical characteristics that frequency distribution of short term concentration may be approximated by a lognormal distribution, were applied. This procedure is capable of estimating not only highest concentration for a variety of averaging times but also concentrations for arbitrary occurrence frequency. Evaluation of the procedure with the results of short term concentrations calculated by Texas Episodic Model version 8 using the meteorological data and emission data in Seoul shows that the procedure estimates concentrations fairly well for wide range of percentiles.

  • PDF

Economic Security of Household: The Comparison of Short-term and Long-term Indicators (가계의 경제적 안정도: 단기지표와 장기지표의 비교)

  • 김강자
    • Journal of Families and Better Life
    • /
    • v.11 no.1
    • /
    • pp.107-118
    • /
    • 1993
  • A dimension of well-being economic security was analyzed and compared with economic adequacy. Again it was tested whether two indicators of economic security(short-term vs. long-term) yield same distribution across all household groups. Economic Security was defined as the household ability to sustain a given level of consumption in the case of economic emergency; specifically loss of income. Measure of 8 different kinds of economic security were constructed from household net worth including and excluding home equity. Data were taken from the 1988 U.S. Consumer Expenditure Survey and 2148 households were selected to test hypotheses concerning the economic security of American households Empirical results showed a very low level of economic security in general. The first hypothesis that distribution of economic adequacy and economic security are same across all population groups was rejected. On the average security measure rather than adequacy measure was favor to white female-headed households and households who have old and highly educated house-holder. The second hypothesis that the indicators of long-term and short-term economic security yield the same results across all household was not rejected. In general the level of economic security was relatively higher when long-term indicator was used than short-term indicator was however the direction and relative size of effect of income and each control variable was almost same.

  • PDF

Short- and Long-Term Effects of Stock Split Disclosure: Exploring Determinants (주식분할 공시에 대한 장·단기 효과: 결정요인 분석을 중심으로)

  • Jin-Hwon Lee;Kyung-Soon Kim
    • Asia-Pacific Journal of Business
    • /
    • v.14 no.1
    • /
    • pp.73-91
    • /
    • 2023
  • Purpose - The purpose of this study is to re-examine the disclosure effect of stock splits and long-term performance after stock splits using stock split data over the past 10 years, and infer the motivation (signal or opportunism) of stock splits. In addition, we focus on exploring the determinants of the short- and long-term market response to stock splits. Design/methodology/approach - We measure the short-term market response to a stock split and the long-term stock performance after the stock split announcement using the event study method. We analyze whether there is a difference in the long-term and short-term market response to a stock split according to various company characteristics through univariate analysis and regression analysis. Findings - In the case of the entire sample, a statistically significant positive excess return is observed on the stock split announcement date, and the excess return during the 24-month holding period after the stock split do not show a difference from zero. In particular, the difference between short-term and long-term returns on stock splits is larger in companies with a large stock split ratio, small companies, large growth potential, and companies with a combination of financial events after a stock split. Research implications or Originality - The results of this study suggest that at least the signal hypothesis for a stock split does not hold in the Korean stock market. On the other hand, it suggests that there is a possibility that a stock split can be abused by the manager's opportunistic motive, and that this opportunism can be discriminated depending on the size of the stock split, corporate characteristics, and financing plan.

Effect of Short-term and Long-term Preservation on Motion Characteristics of Garole Ram Spermatozoa: A Prolific Microsheep Breed of India

  • Joshi, Anil;Bag, Sadhan;Naqvi, S.M.K.;Sharma, R.C.;Rawat, P.S.;Mittal, J.P.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.14 no.11
    • /
    • pp.1527-1533
    • /
    • 2001
  • Garole is a prolific, rare, less known and small size Indian sheep breed found in low and humid Sunderban region of West Bengal. Although information on stored Garole ram liquid semen upto 24 h is available, but there is a need to further investigate the short-term and long-term preservability of Garole ram semen for extensive utilization of this valuable germplasm by artificial insemination. The aim of the present study was to apply computer-assisted sperm analysis technique for assessing the motion characteristics of Garole ram semen stored (i) in liquid state at refrigeration temperature for short-term preservation upto 48 h and (ii) in frozen state at $-196^{\circ}C$ for long-term preservation after packaging in mini straws. Short-term preservation had a significant effect on motility (p<0.01) as the motility progressively decreased from 90.1% at 0 h to 85.5% and 73.2% after 24 and 48 h of storage, respectively. Although the decline in rapid moving sperms was also significant (p<0.01) on storage but the decrease was more pronounced at 48 h as compared to 24 h of storage period. Storage of chilled semen had also a significant effect on % linearity (p<0.05), % straightness (p<0.01), sperm velocities (p<0.01), amplitude of lateral head displacement (p<0.01) and beat frequency (pO.Ol) of spermatozoa. The replication had a significant effect for all the variables except average path and straight line velocity. However, the interactions of short-term storage and replication were non-significant for most of the variables except % of medium moving sperms, sperm velocities and beat frequency. On long-term preservation of Garole ram spermatozoa under controlled conditions the mean post-thaw recovery of 70.4 and 71.4% motile spermatozoa was achieved having 48.8 and 48.9% of rapidly motile spermatozoa, respectively in both the replicates. The effect of replication on cryopreservation was significant (p<0.05) on amplitude of lateral head displacement and beat frequency, but there was no significant effect on motility, rapidly motile spermatozoa, linearity, straightness and sperm velocities of frozen-thawed spermatozoa. It can be concluded from these results that an average 70% motility can be achieved on storage of Garole ram semen in chilled liquid state upto 48 h or in liquid nitrogen after freezing under controlled conditions in straws. However, further studies are required to evaluate the fertility of short-term and long-term preserved Garole ram semen for extensive use of this prolific sheep breed.

Component Outsourcing Contracts in a Two-Component Assembly System (두 가지 부품으로 구성된 조립시스템에서 부품 아웃소싱 계약에 대한 고찰)

  • Kim, Eun-Gab
    • IE interfaces
    • /
    • v.22 no.2
    • /
    • pp.165-173
    • /
    • 2009
  • This paper considers a two-component assembly system that makes different types of purchasing contracts by component type and studies the issue of coordinating those contracts. Acquisition of type 1 component is based on the long-term contract. In contrast, type 2 component is intermittently purchased under the sort-term contract. We identify the structural properties of the optimal short-term contract and investigate how the changes in system parameters affect the optimal performance. To provide managerial insights, we compare the short-term and long-term contracts for type 2 component and discuss the conditions that make the short-term contract preferable to the long-term contract. We also present a result which shows that coordinating the contracts of type 1 and type 2 components can be significantly profitable over uncoordinating them.

Trade Liberalization and Customs Revenue in Vietnam

  • LE, Thi Anh Tuyet
    • The Journal of Asian Finance, Economics and Business
    • /
    • v.7 no.8
    • /
    • pp.213-224
    • /
    • 2020
  • The study assesses the impact of trade liberalization factors on changes in customs revenues in Vietnam. Research data was conducted between 2002 and 2017 on the official website of the Government's Web Portal and The World Bank. This paper uses the vector error correction model to estimate the short-term and long term relationship between data series. The results have proven that tariff reductions have a positive effect on short-term and long-term customs revenues in Vietnam. However, the implementation of other international commitments on trade liberalization has positive short-term and long-term negative impacts on customs revenues in Vietnam. The study's results also show that exchange rate has no effect on changes in customs revenues in the short term but it has a strong impact on increasing customs revenues in the long run. Based on these findings, the article also suggests a number of policies to ensure customs revenues in Vietnam in future. In order to ensure customs revenues, the government of Vietnam should: (1) having some policy to improve the efficiency of customs management in Vietnam; (2) Building appropriate VND exchange rate policy; (3) Establishing reasonable non - tariff barriers to prevent fraud and ovations cause losses in customs revenues.